Patents Assigned to AiCuris GmbH & Co. KG
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Publication number: 20110124618Abstract: The present invention relates to novel substituted (pyrazolylcarbonyl)imidazolidinones, methods for their preparation, their use for the treatment and/or prophylaxis of diseases, as well as their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of retroviral diseases, in humans and/or animals.Type: ApplicationFiled: September 17, 2010Publication date: May 26, 2011Applicant: AiCuris GmbH & Co. KGInventors: Kai THEDE, Susanne GRESCHAT, Steffen WILDUM, Daniela PAULSEN
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Patent number: 7919489Abstract: The invention relates to heterocyclylamide-substituted imidazoles and methods for their preparation, their use for the treatment and/or prophylaxis of diseases as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular for the use as antiviral agents, especially against cytomegaloviruses.Type: GrantFiled: August 20, 2007Date of Patent: April 5, 2011Assignee: Aicuris GmbH & Co. KGInventors: Holger Zimmermann, David Brueckner, Kerstin Henninger, Ulrich Rosentreter, Martin Hendrix, Joerg Keldenich, Dieter Lang, Martin Radtke, Daniela Paulsen, Armin Kern
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Patent number: 7897159Abstract: The invention relates to a method for the production of a pharmaceutical composition for treating cancer by combining Parapoxvirus ovis with at least one anticancer agent. The invention furthermore relates to a method for treating a patient afflicted with cancer comprising the administration of Parapoxvirus ovis in combination with at least one anticancer agent.Type: GrantFiled: May 19, 2008Date of Patent: March 1, 2011Assignee: Aicuris GmbH & Co. KGInventor: Olaf Weber
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Patent number: 7883713Abstract: The invention relates to the topical application of substituted thiazolyl amides in the treatment of herpes infections in humans, to preparations suitable for the topical application and to the production thereof.Type: GrantFiled: June 10, 2002Date of Patent: February 8, 2011Assignee: AiCuris GmbH & Co. KGInventors: Ulrich Betz, Tobias Laich, Wolfgang Bender, Ruediger Fischer, Martin Hendrix, Gerald Kleymann
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Patent number: 7867992Abstract: The invention relates to substituted quinolones and to processes for their preparation as well as to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.Type: GrantFiled: January 19, 2007Date of Patent: January 11, 2011Assignee: AiCuris GmbH & Co. KGInventors: Holger Zimmermann, Rudolf Schohe-Loop, Kerstin Henninger, Dieter Lang, Kai Thede, Chantal Fuerstner, David Brueckner, Daniela Paulsen, Thomas Roelle, Johannes Koebberling, Marcus Bauser
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Patent number: 7786079Abstract: The invention relates to nonadepsipeptides and methods for their preparation and their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases.Type: GrantFiled: April 19, 2007Date of Patent: August 31, 2010Assignee: AiCuris GmbH & Co. KG.Inventors: Franz Von Nussbaum, Nina Brunner, Rainer Endermann, Chantal Fuerstner, Elke Hartmann, Jacques Ragot, Guido Schiffer, Joachim Schuhmacher, Niels Svenstrup, Joachim Telser, Sonja Anlauf, Michael-Alexander Bruening
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Publication number: 20100216973Abstract: The invention relates to methods for the targeted production of lysobactin derivatives by combined chemical and enzymatic modifications. In particular, the invention relates to method for preparing lysobactin fragment 4-11 by chemical reduction and cleavage of the resultant product by chymotrypsin.Type: ApplicationFiled: May 5, 2010Publication date: August 26, 2010Applicant: AICURIS GMBH &Co. KGInventors: Franz Von Nussbaum, Werner Schroeder, Chantal Fuerstner
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Patent number: 7767704Abstract: The invention relates to the substituted imidazoles of formula (I) and to methods for producing the same, to their use in the treatment and/or prophylaxis of diseases and to their use for producing drugs for use in the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, especially against cytomegaloviruses.Type: GrantFiled: March 11, 2005Date of Patent: August 3, 2010Assignee: AiCuris GmbH & Co. KGInventors: Holger Zimmermann, David Brueckner, Dirk Heimbach, Martin Hendrix, Kerstin Henninger, Guy Hewlett, Ulrich Rosentreter, Joerg Keldenich, Dieter Lang, Martin Radtke
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Patent number: 7737120Abstract: The invention relates to methods for the targeted production of lysobactin derivatives by combined chemical and enzymatic modifications. In particular, the invention relates to method for preparing lysobactin fragment 4-11 by chemical reduction and cleavage of the resultant product by chymotrypsin.Type: GrantFiled: May 4, 2007Date of Patent: June 15, 2010Assignee: Aicuris GmbH & Co. KGInventors: Franz Von Nussbaum, Werner Schroeder, Chantal Fuerstner
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Patent number: 7727956Abstract: Nonadepsipeptides and methods for their preparation and their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases are described.Type: GrantFiled: April 19, 2007Date of Patent: June 1, 2010Assignee: Aicuris GmbH & Co. KGInventors: Franz Von Nussbaum, Nina Brunner, Rainer Endermann, Chantal Fuerstner, Elke Hartmann, Jacques Ragot, Guido Schiffer, Joachim Schuhmacher, Niels Svenstrup, Joachim Telser, Sonja Anlauf, Michael-Alexander Bruening
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Patent number: 7718611Abstract: The invention relates to cyclic nonapeptide amides and to methods for their preparation and to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially bacterial infectious diseases.Type: GrantFiled: May 4, 2007Date of Patent: May 18, 2010Assignee: AiCuris GmbH & Co. KGInventors: Franz Von Nussbaum, Nina Brunner, Chantal Fuerstner, Rainer Endermann, Jacques Ragot, Joachim Telser, Werner Schroeder, Sonja Anlauf, Joachim Schuhmacher, Elke Hartmann
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Patent number: 7666654Abstract: The invention relates to a method for preparing viral suspensions. The invention relates in particular to a method for preparing high-titer viral suspensions in cell cultures. Preferred methods include increasing the volume of the cell culture prior to infection with viral material and subsequent further steps of expanding the volume to a final volume which is distinctly larger than the maximum culture volume prior to infection.Type: GrantFiled: April 5, 2007Date of Patent: February 23, 2010Assignee: AiCuris GmbH & Co. KGInventors: Michael Pohlscheidt, Berthold Boedeker, Torsten Minuth, Heiner Apeler, Uwe Langer, Katrin Brabender, Dirk Otto-Brabender, Joachim Kerper, Hans-Juergen Henzler
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Patent number: 7655643Abstract: The invention relates to antibacterial macrocycles with substituted biphenyl and processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially of bacterial infections.Type: GrantFiled: June 15, 2006Date of Patent: February 2, 2010Assignee: AiCuris GmbH & Co. KGInventors: Rainer Endermann, Kerstin Ehlert, Siegfried Raddatz, Yolanda Cancho-Grande, Martin Michels, Stefan Weigand, Isabelle Adelt, Thomas Lampe
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Publication number: 20100022527Abstract: The present invention relates to novel substituted spirotetronic acids (I) in which R1 and R2, together with the carbon atom to which they are bonded, form a group of the formula (1), (2), (3) or (4), whereby * represents the carbon atom to which R1 and R2 are bonded, to methods for their preparation, their use for the treatment and/or prophylaxis of diseases, as well as their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of retroviral disorders, in people and/or animals.Type: ApplicationFiled: February 25, 2009Publication date: January 28, 2010Applicant: AiCuris GMBH & Co. KGInventors: Dirk HEIMBACH, Adrian TERSTEEGEN, Kai THEDE, Reinhold WELKER, Beate FAST, Arnold PAESSENS, Frank DITTMER, Rudolph SCHOHE-LOOP, Axel HARRENGA, Alexander HILLISCH, Kerstin HENNINGER, Walter HUEBSCH, Marcus BAUSER, Daniela PAULSEN, Alexander BIRKMANN, Thomas BRETSCHNEIDER, Reiner FISCHER, Susanne GRESCHAT, Andreas URBAN, Steffen WILDUM
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Patent number: 7531507Abstract: The invention relates to nonadepsipeptides and processes for their preparation, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases.Type: GrantFiled: November 4, 2005Date of Patent: May 12, 2009Assignee: AiCuris GmbH & Co. KGInventors: Franz Von Nussbaum, Nina Brunner, Rainer Endermann, Chantal Fuerstner, Elke Hartmann, Holger Paulsen, Jacques Ragot, Guido Schiffer, Joachim Schuhmacher, Niels Svenstrup, Joachim Telser, Sonja Anlauf, Michael-Alexander Bruening
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Publication number: 20080275018Abstract: The invention relates to antibacterial amide-macrocycles of formula (I), in which R26 represents hydrogen, halogen, amino or methyl, R7 represents a group of formula (II), (III), (IV) or (V), whereby R1 represents hydrogen or hydroxy and * is the linkage site to the carbon atom, R2 represents hydrogen or methyl and methods for their production, their use for the treatment and/or prophylaxis of diseases as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular of bacterial infections.Type: ApplicationFiled: September 28, 2007Publication date: November 6, 2008Applicant: AiCuris GmbH & Co. KGInventors: Rainer ENDERMANN, Kerstin EHLERT, Siegfried RADDATZ, Martin MICHELS, Yolanda CANCHO-GRANDE, Stefan WEIGAND, Karin FISCHER
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Patent number: 7446102Abstract: The invention relates to antibacterial amide macrocycles and processes for their preparation, their use for the treatment and/or prophylaxis of diseases and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially bacterial infections.Type: GrantFiled: March 23, 2007Date of Patent: November 4, 2008Assignee: AiCuris GmbH & Co. KGInventors: Rainer Endermann, Kerstin Ehlert, Christoph Freiberg, Siegfried Raddatz, Martin Michels, Yolanda Cancho-Grande, Joachim Schuhmacher, Stefan Weigand
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Patent number: 7368424Abstract: The invention relates to nonadepsipeptides and process for their preparation, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases.Type: GrantFiled: May 6, 2004Date of Patent: May 6, 2008Assignee: AiCuris GmbH & Co. KGInventors: Franz Von Nussbaum, Nina Brunner, Sonja Anlauf, Rainer Endermann, Chantal Fürstner, Elke Hartmann, Johannes Köbberling, Jacques Ragot, Guido Schiffer, Joachim Schuhmacher, Niels Svenstrup, Joachim Telser, Michael-Alexander Bruening
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Publication number: 20070099885Abstract: The invention relates to antibacterial macrocycles with substituted biphenyl and processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially of bacterial infections.Type: ApplicationFiled: June 15, 2006Publication date: May 3, 2007Applicant: AiCuris GmbH & Co. KGInventors: Rainer Endermann, Kerstin Ehlert, Siegfried Raddatz, Yolanda Cancho-Grande, Martin Michels, Stefan Weigand, Isabelle Adelt, Thomas Lampe
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Publication number: 20070099929Abstract: The invention relates to substituted thiophenes and processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, in particular for hepatitis C viruses.Type: ApplicationFiled: June 16, 2006Publication date: May 3, 2007Applicant: AiCuris GmbH & Co. KGInventors: Kai Thede, Tobias Wunberg, Timothy Lowinger, Diana Koletzki, Andreas Urban, Judith Baumeister, Kerstin Henninger