Patents Assigned to Ajinomoto Co., Inc.
  • FEED ADDITIVE COMPOSITION FOR RUMINANTS
    Publication number: 20210321642
    Abstract: Feed additive compositions for ruminants containing (A) at least one member selected from the group consisting of hydrogenated vegetable oil and hydrogenated animal oil each having a melting point of higher than 50° C. and lower than 90° C.; (B) not less than 0.05 wt % and not more than 6 wt % of lecithin; (C) not less than 30 wt % and less than 65 wt % of a biologically active substance; (D) not less than 0.01 wt % and less than 0.8 wt % of a natural vegetable oil; and not less than 0.1 wt % and less than 6 wt % of water exhibit high protection in the rumen and are also superior in dissolution in the lower gastrointestinal tract.
    Type: Application
    Filed: June 29, 2021
    Publication date: October 21, 2021
    Applicant: AJINOMOTO CO., INC.
    Inventors: Susumu SHIBAHARA, Sachiko YONEMARU, Koji HAGA, Yuki MIYAZAWA, Takaaki SATO
  • Azide group-containing Fc protein
    Patent number: 11149074
    Abstract: The present invention provides a means capable of efficiently manufacturing a fused substance of an Fc protein and a substance of interest (for example, a peptide). Specifically, the present invention provides an azide group-containing Fc protein represented by formula (1): N3-La-Phe-Lb-Fc??(1) wherein N3 represents an azide group; La represents a bond or a divalent group; Phe represents a residue of phenylalanine or a derivative thereof; Lb represents a lysine residue or an arginine residue, or a peptide linker containing two or more amino acid residues having a lysine residue or an arginine residue at/on the N-terminus; and Fc represents an Fc protein; and the like.
    Type: Grant
    Filed: November 1, 2018
    Date of Patent: October 19, 2021
    Assignee: Ajinomoto Co., Inc.
    Inventors: Shigeo Hirasawa, Masumi Taki
  • Method for Producing Basic L-Amino Acids or Salts Thereof By Fermentation of an Enterobacteriaceae Bacterium
    Publication number: 20210317487
    Abstract: The present invention provides a method for producing a basic L-amino acid such as, for example, L-ornithine L-citrulline, L-arginine, L-histidine, and L-lysine by fermentation using a bacterium belonging to the family Enterobacteriaceae which has been modified to overexpress a gene encoding a protein having L-methionine/branched-chain amino acid exporter activity.
    Type: Application
    Filed: June 22, 2021
    Publication date: October 14, 2021
    Applicant: AJINOMOTO CO., INC.
    Inventors: Mikhail Kharisovich Ziyatdinov, Yulia Georgievna Rostova, Olga Nikolaevna Igonina, Andrei Viacheslavovich Kniazev
  • Mutant glutathione synthetase and method for producing gamma-glutamyl-valyl-glycine
    Patent number: 11142755
    Abstract: A mutant glutathione synthetase (GSHB) suitable for generating ?-Glu-Val-Gly, and a method for producing ?-Glu-Val-Gly using the same are provided. ?-Glu-Val-Gly is produced by using a mutant GSHB having a mutation at such a position as V7, N13, I14, N15, K17, F22, F95, M165, N199, Y200, P202, I274, T285, and P287.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: October 12, 2021
    Assignee: AJINOMOTO CO., INC.
    Inventors: Ayako Sato, Eri Higashiura, Misato Okamoto, Takayuki Ito, Erika Watanabe, Uno Tagami, Yuki Oda, Tatsuki Kashiwagi, Masayuki Sugiki
  • AGENT FOR IMPROVING MUSCLE QUALITY
    Publication number: 20210308084
    Abstract: Muscle quality-improving agents containing one or more selected from the group consisting of isoleucine, glycine, and cystine can prevent a decline in muscle quality, improve muscle quality even when exercise is limited, and can effectively enhance the effect of exercise even when the exercise is of a level free of undue efforts.
    Type: Application
    Filed: June 16, 2021
    Publication date: October 7, 2021
    Applicant: AJINOMOTO CO., INC.
    Inventors: Kyoko MIURA, Mai NAKAZAWA, Yoshiro KITAHARA
  • COMPOUND HAVING AFFINITY SUBSTANCE TO ANTIBODY, CLEAVABLE PORTION, AND REACTIVE GROUP, OR SALT THEREOF
    Publication number: 20210300972
    Abstract: Compounds having an affinity substance to an antibody, a cleavable portion, and a reactive group, or a salt thereof, are represented by the following Formula (I): A-L-B—R??(I) wherein A is an affinity substance to an antibody, L is a cleavable linker that is a divalent group comprising a cleavable portion, B is (a) a divalent group comprising a bioorthogonal functional group or (b) a divalent group comprising no bioorthogonal functional group, and R is a reactive group to the antibody, wherein the affinity substance to an antibody is a polypeptide comprising a glutamine residue (Q) at an N-terminal.
    Type: Application
    Filed: April 27, 2021
    Publication date: September 30, 2021
    Applicant: Ajinomoto Co., Inc.
    Inventors: Kei YAMADA, Yoshihiko MATSUDA, Kazutoshi TAKAHASHI, Natsuki SHIKIDA, Kazutaka SHIMBO, Hayato NAGANO
  • LIGASE MUTANT
    Publication number: 20210301280
    Abstract: Ligase mutants of the following (1), (2), or (3): (1) a ligase mutant comprising an amino acid sequence showing 95% or more identity to the amino acid sequence of SEQ ID NO: 1, and having a nucleic acid-linking activity; (2) a ligase mutant comprising an amino acid sequence showing 90% or more identity to the amino acid sequence of SEQ ID NO: 2, and having a nucleic acid-linking activity; or (3) a ligase mutant comprising an amino acid sequence showing 97% or more identity to the amino acid sequence of SEQ ID NO: 3, and having a nucleic acid-linking activity, have excellent properties.
    Type: Application
    Filed: March 23, 2021
    Publication date: September 30, 2021
    Applicant: AJINOMOTO CO., INC.
    Inventors: Miwa KONISHI, Shohei KAJIMOTO, Yusuke HAGIWARA, Yasuhiro MIHARA, Shogo NAKANO, Tomoharu MOTOYAMA, Sohei ITO
  • SINTERED BODY FOR ADSORPTION, PRODUCTION METHOD THEREFOR, AND ADSORPTION DEVICE
    Publication number: 20210291142
    Abstract: To adsorb a substance to be treated in a fluid (7) with a higher adsorption capacity and lower pressure loss, an adsorptive sintered compact (20) includes powder adsorbent materials (1a, 1b), and resin structures (2) in which voids (3) are formed in a three-dimensional network. The powder adsorbent materials (1a, 1b) include free adsorbent materials (1a) free-movably contained in the voids (3) between the resin structures (2), and fixed adsorbent materials (1b) fixed to a surface (2a) of the resin structure (2) and/or at least partly embedded inside the resin structure (2), and the powder adsorbent materials (1a, 1b) are at least one of powdered activated carbon, powdered activated clay, and zeolite.
    Type: Application
    Filed: June 3, 2021
    Publication date: September 23, 2021
    Applicants: AJINOMOTO CO., INC., NIPPON FILCON CO., LTD.
    Inventors: Makoto Seino, Hideyuki Yano, Toshifumi Katoh
  • METHOD FOR EVALUATING PANCREATIC CANCER, PANCREATIC CANCER EVALUATING APPARATUS, PANCREATIC CANCER EVALUATING METHOD, PANCREATIC CANCER EVALUATING PROGRAM PRODUCT, PANCREATIC CANCER EVALUATING SYSTEM AND INFORMATION COMMUNICATION TERMINAL APPARATUS
    Publication number: 20210287802
    Abstract: A method of evaluating pancreatic cancer includes (I) an obtaining step of obtaining amino acid concentration data on a concentration value of an amino acid in blood collected from a subject to be evaluated, and (II) an evaluating step of evaluating a state of pancreatic cancer in the subject by calculating a value of a formula using the amino acid concentration data of the subject obtained at the obtaining step and the formula previously established for evaluating the state of pancreatic cancer, including an explanatory variable to be substituted with the concentration value of the amino acid.
    Type: Application
    Filed: May 4, 2021
    Publication date: September 16, 2021
    Applicant: Ajinomoto Co., Inc.
    Inventors: Nobukazu ONO, Atsuko SHINHARA, Takahiko MURAMATSU, Shinya KIKUCHI, Hiroshi YAMAMOTO, Koichi SHIRAISHI, Kazuhiro KATAYAMA, Nobuyasu FUKUTAKE, Masahiko HIGASHIYAMA, Shinichi OHKAWA, Makoto UENO, Yohei MIYAGI, Naoyuki OKAMOTO
  • CULTURE ADDITIVE, CULTURE MEDIUM AND CULTURE METHOD FOR ANIMAL CELLS
    Publication number: 20210284971
    Abstract: By using an additive for culturing animal cells that contains an amino acid or glucose, or an amino acid and glucose; or a medium for culturing animal cells that contains an amino acid or glucose, or an amino acid and glucose in addition to a medium component; or a method for culturing animal cells that includes culturing the animal cells using the aforementioned medium, or adding the aforementioned additive to a culture, the proliferation ability of animal cells can be improved particularly when the animal cells are cultured using a serum-free medium or a low albumin medium.
    Type: Application
    Filed: March 26, 2021
    Publication date: September 16, 2021
    Applicant: AJINOMOTO CO., INC.
    Inventors: Takuya MATSUMOTO, Shimpei OGAWA, Shumpei FUROMITSU, Yusuke OHYA, Kotoe KOSEKI, Takuya HIGUCHI, Megumi NISHIYAMA
  • CLEANSING MATERIAL COMPOSITION
    Publication number: 20210283034
    Abstract: Cleansing material compositions which contain an acyl acidic amino acid or a salt thereof, an amphoteric surfactant, and hydroxypropyl starch phosphate, and have a pH of 5.3 or less are useful for facial cleansing.
    Type: Application
    Filed: June 3, 2021
    Publication date: September 16, 2021
    Applicant: AJINOMOTO CO., INC.
    Inventors: Naoaki IKEDA, Shun KOBAYASHI
  • Method for producing fibroin-like protein
    Patent number: 11117937
    Abstract: A method for producing a fibroin-like protein is provided. A fibroin-like protein is produced by a method of culturing Escherichia coli having a gene encoding the fibroin-like protein in a medium, inducing expression of the gene encoding the fibroin-like protein, and collecting the fibroin-like protein, wherein accumulation of an organic acid at the time of inducing the expression is reduced, and wherein the gene is expressed under control of a tryptophan promoter.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: September 14, 2021
    Assignees: AJINOMOTO CO., INC., SPIBER INC.
    Inventors: Kentaro Nakase, Yoshinori Takashima, Takeshi Nagahiko
  • Support, adhesive sheet, laminated structure, semiconductor device, and method for manufacturing printed wiring board
    Patent number: 11121020
    Abstract: A method for manufacturing a printed wiring board which includes: Step (A) of laminating an adhesive sheet including a support and a resin composition layer bonded to the support to an inner layer board so that the resin composition layer is bonded to the inner layer board; Step (B) of thermally curing the resin composition layer to form an insulating layer; and Step (C) of removing the support, in this order, in which the support satisfies a condition (MD1): a maximum expansion coefficient EMD in an MD direction at 120° C. or more is less than 0.2% and a condition (TD1): a maximum expansion coefficient ETD in a TD direction at 120° C. or more is less than 0.2% below, when being heated under predetermined heating conditions, does not lower the yield even when the insulating layer is formed by thermally curing the resin composition layer with a support attached to the resin composition layer.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: September 14, 2021
    Assignee: Ajinomoto Co., Inc.
    Inventors: Masanori Ohkoshi, Hirohisa Narahashi, Eiichi Hayashi
  • METHOD FOR PRODUCING CYCLIZED PEPTIDE HAVING INTRAMOLECULAR S-S BOND
    Publication number: 20210277063
    Abstract: Cyclized peptides having a crosslinked structure by one or more intramolecular S—S bonds may be prepared by: (1-A) as to a completely protected linear peptide having two or more SH groups as functional groups on the peptide, removing protecting groups of all functional groups other than the protected SH groups in the peptide, (1-B) protecting all SH groups of the linear peptide having two or more SH groups as the functional groups on the peptide by forming a temporary S—S bond, and (2) subjecting the peptide obtained by step (1-A) and step (1-B) to a folding step under oxidation and reduction conditions to obtain the cyclized peptide by re-forming an S—S bond in the peptide molecule.
    Type: Application
    Filed: May 13, 2021
    Publication date: September 9, 2021
    Applicant: AJINOMOTO CO., INC.
    Inventors: Daisuke TAKAHASHI, Tatsuji INOMATA, Yuki SHINOHARA
  • EVALUATING METHOD, CALCULATING METHOD, EVALUATING APPARATUS, CALCULATING APPARATUS, EVALUATING PROGRAM, CALCULATING PROGRAM, RECORDING MEDIUM, EVALUATING SYSTEM, AND TERMINAL APPARATUS FOR MILD COGNITIVE IMPAIRMENT
    Publication number: 20210278421
    Abstract: An evaluating method includes an evaluating step of evaluating a state of mild cognitive impairment for a subject to be evaluated, using (i) at least one value of concentration values of Put, ?-ABA, Ala, Arg, Asn, Cit, Glu, Gln, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, Val, Taurine, 1-MeHis, 3-MeHis, aAAA, aAiBA, ADMA, Allyl Cys, bABA, bAiBA, Cystathionine, Cysteic acid, EtGly, GABA, hArg, Hypotaurine, Hypro, Kyn, Pyrazole-1-Ala, MCSO, MeCys, N6-AcLys, N8-AcSpd, Opthalmic acid, PEA, Pipecolic acid, Sar, SDMA, Spd, Spm, and Thioproline and test values of Alb, Folate, WBC, RBC, Hb, Ht, and PLT in blood of the subject, or (ii) a value of a formula including an explanatory variable to be substituted with the at least one value, calculated using the at least one value and the formula.
    Type: Application
    Filed: March 25, 2021
    Publication date: September 9, 2021
    Applicant: AJINOMOTO CO., INC.
    Inventors: Takeshi IKEUCHI, Yuki YANO, Hiroko KONDO, Wataru SATO, Naoko ARASHIDA, Satoko UENO, Rumi NISHIMOTO, Masashi HARADA
  • Method for producing phytosphingosine or sphinganine
    Patent number: 11111511
    Abstract: A method for producing an objective substance such as phytosphingosine and sphinganine using yeast is provided. An objective substance is produced by cultivating yeast having an ability to produce the objective substance and modified so that the expression and/or activities of proteins encoded by LCB4 and CKA2 genes are reduced in a culture medium, and collecting the objective substance from cells of the yeast and/or the culture medium.
    Type: Grant
    Filed: February 16, 2018
    Date of Patent: September 7, 2021
    Assignees: AJINOMOTO CO, INC., EVOLVA SA
    Inventors: Markus Schwab, Maud Babau, David Fischer, Anaelle Hatsch, Sabina de Andrade Pereira Tavares, Curt Aime Friis Nielsen, Jens Klein, Corina Daniela Wirdnam
  • Method for Producing Target Substance by Bacterial Fermentation
    Publication number: 20210269842
    Abstract: The present invention provides a method for producing a target substance, the biosynthetic pathway of which is ATP-dependent, such as, for example, amino acids, nucleosides, nucleotides, isoprenoids, and peptides, by fermentation of a bacterium which has been modified to overexpress a gene encoding a protein having H+-translocating membrane-bound pyrophosphatase activity, such as, for example, the hppA gene native to R. rubrum or a variant thereof.
    Type: Application
    Filed: April 2, 2021
    Publication date: September 2, 2021
    Applicant: AJINOMOTO CO., INC.
    Inventors: Ekaterina Andrianova, Maria Kharchenko, Natalia Zakataeva, Elvira Voroshilova, Aleksander Krylov, Evgeniya Malykh, Sergei Mashko, Natalia Stoynova, Mikhail Baboshin, Lyubov Golubeva, Ekaterina Kovaleva, Mikhail Shupletsov
  • Method for Producing RNA
    Publication number: 20210269840
    Abstract: A method for producing RNA is provided. Objective RNA is produced by culturing a coryneform bacterium having an expression unit for the objective RNA, which has been modified so that the activity of ribonuclease III is reduced, in a medium, to express the objective RNA and accumulate the objective RNA in cells of the bacterium, and collecting the objective RNA from the cells.
    Type: Application
    Filed: May 21, 2021
    Publication date: September 2, 2021
    Applicant: AJINOMOTO CO., INC.
    Inventors: Shuhei Hashiro, Hisashi Yasueda, Mayu Mitsuhashi, Sergei Vladimirovich Mashko, Aleksandr Aleksandrovich Krylov, Yuliya Sergeevna Lobanova
  • RESIN COMPOSITION
    Publication number: 20210261768
    Abstract: Resin compositions including (A) a hollow organic polymer particle, (B) an epoxy resin, and (C) a curing agent provide cured products having a superior smear removal properties.
    Type: Application
    Filed: February 19, 2021
    Publication date: August 26, 2021
    Applicant: AJINOMOTO CO., INC.
    Inventor: Masatoshi WATANABE
  • METHOD FOR PRODUCING ORGANIC COMPOUND-ENCAPSULATING FERRITIN
    Publication number: 20210253651
    Abstract: An organic compound-encapsulating ferritin may be prepared by: (1) mixing an organic compound with ferritin in a buffer to obtain a mixture of the organic compound and ferritin; and (2) incubating the mixture in the buffer, wherein the buffer has a pH of 3 or more and less than 13, and the buffer has a pH of 3 or more and less than 7 when the organic compound has a pKa less than 7, and has a pH of 6 or more and less than 13 when the organic compound has a pKa of 7 or more.
    Type: Application
    Filed: April 28, 2021
    Publication date: August 19, 2021
    Applicant: Ajinomoto Co., Inc.
    Inventors: Ippei INOUE, Yuichi NAKAHARA