Patents Assigned to Aktiebolaget Hassle
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Patent number: 5441968Abstract: The novel compounds of the formulas I and I' ##STR1## wherein F is in 5 or 6 position and ##STR2## wherein in both formulas R is the group --CH.sub.2 OCOOR.sup.1, wherein R.sup.1 is a straight or branched alkyl containing 1-6 carbon atoms or benzyl, or R.sup.1 is the group ##STR3## wherein n is 1-6 and physiologically acceptable salts thereof as well as intermediates, pharmaceutical compositions containing such compounds as active ingredient, and the use of the compounds in medicine.Type: GrantFiled: October 8, 1993Date of Patent: August 15, 1995Assignee: Aktiebolaget HassleInventors: Arne E. Brandstrom, Per L. Lindberg, Gunnel E. Sunden
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Patent number: 5274099Abstract: The novel compounds of the formulas I and I' ##STR1## wherein F is in 5 or 6 position and ##STR2## wherein in both formulas R is the group --CH.sub.2 OCOOR.sup.1, wherein R.sup.1 is a straight or branched alkyl containing 1-6 carbon atoms or benzyl, or R.sup.1 is the group --(CH.sub.2).sub.n ##STR3## --(CH.sub.2).sub.n COOH or --(CH.sub.2).sub.n SO.sub.3 H wherein n is 1-6 and physiologically acceptable salts thereof as well as intermediates, pharmaceutical compositions containing such compounds as active ingredient, and the use of the compounds in medicine.Type: GrantFiled: December 7, 1990Date of Patent: December 28, 1993Assignee: Aktiebolaget HassleInventors: Arne E. Brandstroom, Per L. Lindberg, Gunnel E. Sunden
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Patent number: 5270056Abstract: A particle containing a liquid-soluble active substance for release outside a human or animal body, said particle comprising a core with a coating thereon, said coating comprising a liquid soluble active substance, is characterized in that the core has an appearance differing from the appearance of the coating, and that the appearance of the core is initially concealed by the coating and appears after dissolution of the liquid-soluble active substance, thus indicating that the active substance in said coating has been dissolved. The invention has its foremost application on granules, tablets and similar drug releasing units which make part of a parenteral liquid administration device.Type: GrantFiled: August 30, 1991Date of Patent: December 14, 1993Assignee: Aktiebolaget HassleInventor: Bengt G. Berglund
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Patent number: 5246714Abstract: Controlled release preparation containing a number of insoluble beads applied with one or more pharmaceutically active compounds, a method for the production thereof and the use in a treatment where a controlled release of a pharmaceutically active compound is needed.Type: GrantFiled: May 13, 1992Date of Patent: September 21, 1993Assignee: Aktiebolaget HassleInventors: Lars-Erik D. Dahlinder, Mats O. Johansson, John A. Sandberg, John A. Sjogren
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Patent number: 5215974Abstract: Novel compounds of the formula ##STR1## pharmaceutical compositions containing such compounds as active ingredient, and the use of the compounds in medicine for treating gastric acid related diseases such as gastritis, gastric ulcer, duodenal ulcer and reflux esophagitis.Type: GrantFiled: February 8, 1991Date of Patent: June 1, 1993Assignee: Aktiebolaget HassleInventors: Tomas B. Alminger, Rolf A. Bergman, Bundgaard H., Per L. Lindberg, Gunnel E. Sunden
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Patent number: 5201705Abstract: A device for release of a solid substance into a flowing liquid during parenteral administration of the liquid to a patient includes a connector (1, with an inlet (6) and an outlet (12) for the liquid, and a valve assembly (4,5). The valve assembly has a valve core (5) which is rotatable between a bypass position and a working position. A releasable container (15), containing the solid substance, may be connected to the valve core (5). In the bypass position, liquid is conducted from the inlet to the outlet, by-passing the container (15). When the valve core (5) is moved to the working position, liquid is diverted into the container (15), for mixing with the solid substance, and then returned to the connector, where it then exits through the outlet (12).Type: GrantFiled: May 7, 1990Date of Patent: April 13, 1993Assignee: Aktiebolaget HassleInventors: Bengt G. Berglund, Billy N. Nilson, Ake S. Nilsson
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Patent number: 5155133Abstract: A compound of the formula ##STR1## and when appropriate in the form of a racemic mixture or in the form of a stereoisomeric component and the pharmaceutically acceptable salts thereof, in which formulan is an integer 0, 1 or 2Y is [CH.sub.2 ].sub.m, CHOH, CHOCH.sub.3, CHNHR or CHF,m is an integer 0 or 1 andR is hydrogen, methyl or ethyl,Z is hydrogen or a saturated or unsaturated, straight or branched alkyl group containing 1-3 carbon atoms,A is a group ##STR2## wherein R.sub.a is a straight or branched hydroxyalkyl or an alkyl group containing 1-5 carbon atoms and optionally substituted by one or more fluoro atoms,R.sub.c is a saturated or unsaturated, straight or branched alkyl group containing 1-4 carbon atoms and optionally substituted by one or more fluoro atoms,R.sub.a' is the same as Ra and independently of R.sub.a",R.sub.a" is the same as Ra and independently of R.sub.Type: GrantFiled: January 18, 1991Date of Patent: October 13, 1992Assignee: Aktiebolaget HassleInventors: Olle K. S. Almgren, Goran B. D. Duker, Gert C. Strandlund
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Patent number: 5149523Abstract: Almokalant (p-INN), 4-[3-]ethyl[3-(propylsulfinyl)propyl]amino[-2-hydroxypropoxy]-benzonitrile , having the formula ##STR1## is a member of a group of compounds useful in the treatment of cardiac arrhythmias. Enhanced stability, palatability, and technical properties of almokalant can be achieved when it is complexed as a salt with polystyrenesulfonic acid. Accordingly, the invention encompasses the almokalant salt and processes for the preparation of said salt. The invention further encompasses solid oral pharmaceutical dosage forms containing the almokalant-polystyrenesulfonate complex as well as methods for their manufacture as medicaments with action against cadiac arrhythmias.Type: GrantFiled: December 19, 1990Date of Patent: September 22, 1992Assignee: Aktiebolaget HassleInventors: Per J. Lundberg, Karin Wingstrand, Kjell H. Andersson, Leif Simonsson
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Patent number: 5106862Abstract: Novel compounds of the general formula I ##STR1## processes for its preparation, pharmaceutical compositions containing such compounds as the active ingredient and the use of the compounds in medicine.Type: GrantFiled: December 12, 1990Date of Patent: April 21, 1992Assignee: Aktiebolaget HassleInventors: Carin B. Briving, Stig A. I. Carlsson, Per L. Lindberg, Annie H. Mattsson, Mats P. Nordberg, Bjorn M. G. Wallmark
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Patent number: 5093342Abstract: Use of 5-methoxy-2[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-sulfinyl]-1H-benz imidazole or a pharmaceutically acceptable salt thereof in the treatment of infectious diseases, especially such caused by Campylobacter pylori.Type: GrantFiled: September 12, 1990Date of Patent: March 3, 1992Assignee: Aktiebolaget HassleInventors: Masaaki Tomoi, Yoshifumi Ikeda, Yoshiko Yokota
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Patent number: 5081154Abstract: The present invention relates to metoprolol succinate, a new therapeutically active compound, and pharmaceutical preparations comprising this new compound.Type: GrantFiled: September 28, 1990Date of Patent: January 14, 1992Assignee: Aktiebolaget HassleInventors: Curt H. Appelgren, Eva C. Eskilsson
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Patent number: 5075323Abstract: A method for the treatment of diseases related to an increased intraocular pressure in the eye comprising administration to a patient suffering therefrom an amount of a compound of the formula I ##STR1## or a pharmaceutically acceptable salt thereof.Type: GrantFiled: August 23, 1989Date of Patent: December 24, 1991Assignee: Aktiebolaget HassleInventors: Gordon L. Fain, David A. Lee, Per L. Lindberg, George Sachs
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Patent number: 5068272Abstract: A salt of 4-[3-[3-[ethyl-[3-(propylsulfinyl)propyl]amino]-2-hydroxyproproxy]-benzoni trile having the formula I ##STR1## with polystyrenesulponic acid, which is useful for the treatment of cardiac arrhythmia, process for the preparation of said salt as well as the use of said salt for the preparation of medicaments with action against cardiac arrhythmias.Type: GrantFiled: June 18, 1990Date of Patent: November 26, 1991Assignee: Aktiebolaget HassleInventor: Kjell H. Andersson
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Patent number: 5055490Abstract: 4-[3-[ethyl[3-((R*)-propylsulfinyl)propyl]amino]-2(R)-hydroxypropoxy]-benzo nitrile,4-[3-[ethyl[3-((S*)-propylsulfinyl)propyl]amino]-2(R)-hydroxypropoxy]-benzo nitrile,4-[3-[ethyl[3-((R*)-propylsulfinyl)propyl]amino]-2(S)-hydroxypropoxy]-benzo nitrile,4-[3-[ethyl[3-[((S*)-propylsulfinyl)propyl]amino]-2(S)-hydroxypropoxy]-benz onitrile andpharmaceutically acceptable salt thereof, processes for their preparation, as well as the use of said compounds for the preparation of medicaments with action against cardiac arrhythmias.Type: GrantFiled: June 18, 1990Date of Patent: October 8, 1991Assignee: Aktiebolaget HassleInventors: Olle K. S. Almgren, Kjell H. Andersson, Goran B. D. Duker, Bo R. Lamm, Gert C. Strandlund
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Patent number: 5049674Abstract: The novel compounds of the formulas I and I' ##STR1## wherein F is in 5 or 6 position and ##STR2## wherein in both formulas R is the group --CH.sub.2 OCOOR.sup.1, wherein R.sup.1 is a straight or branched alkyl containing 1-6 carbon atoms or benzyl, or R.sup.1 is the group ##STR3## --(CH.sub.2).sub.n COOH or --(CH.sub.2).sub.n SO.sub.3 H wherein n is 1-6 and physiologically acceptable salts thereof as well as intermediates, pharmaceutical compositions containing such compounds as active ingredient, and the use of the compounds in medicine.Type: GrantFiled: December 20, 1989Date of Patent: September 17, 1991Assignee: Aktiebolaget HassleInventors: Arne E. Brandstrom, Per L. Lindberg, Gunnel E. Sunden
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Patent number: 5039808Abstract: The novel compound 5-fluoro-2[[(4-cyclopropylmethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimid azole and physiologically acceptable salts thereof as well as intermediates, pharmaceutical compositions containing the compound as active ingredient, and the use of the compound in medicine.Type: GrantFiled: December 20, 1990Date of Patent: August 13, 1991Assignee: Aktiebolaget HassleInventors: Arne E. Brandstrom, Per L. Lindberg, Gunnel E. Sunden
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Patent number: 5034411Abstract: This application relates to novel 4 cyanophenyl derivatives which are useful for the treatment of cardiac arrhythmia and pharmaceutical compositions containing these compounds as the active ingredients.Type: GrantFiled: December 22, 1988Date of Patent: July 23, 1991Assignee: Aktiebolaget HassleInventors: Olle K. S. Almgren, Goran B. D. Duker, Gert C. Strandlund
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Patent number: 5025024Abstract: The novel compound 4-fluoro-2-[[(4-methoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole and physiologically acceptable salts thereof as well as intermediates, pharmaceutical compositions containing such compounds as active ingredient, and the use of the compound in medicine.Type: GrantFiled: December 20, 1989Date of Patent: June 18, 1991Assignee: Aktiebolaget HassleInventors: Arne E. Brandstrom, Per L. Lindberg, Gunnel E. Sunden
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Patent number: 5021433Abstract: Novel compounds of the formula ##STR1## pharmaceutical compositions containing such compounds as active ingredient with gastric and inhibiting effects.Type: GrantFiled: May 12, 1988Date of Patent: June 4, 1991Assignee: Aktiebolaget HassleInventors: Tomas B. Alminger, Hakan S. Larsson, Per L. Lindberg, Gunnel E. Sunden
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Patent number: 5019584Abstract: 5-Chloro-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole and physiologically acceptable salts thereof as well as an intermediate, pharmaceutical compositions containing such compound as active ingredient, and the use of the compound in medicine.Type: GrantFiled: December 20, 1989Date of Patent: May 28, 1991Assignee: Aktiebolaget HassleInventors: Arne E. Brandstrom, Per L. Lindberg, Carl I. Starke, Gunnel E. Sunden