Abstract: The invention concerns an isochromane derivative having the general formula I ##STR1## in which R.sub.1 is one to four substituents independently selected from hydrogen, hydroxy, alkyl (1-4 C), alkoxy (1-4 C), halogen, or CF.sub.3, or as two adjacent substituents together a methylenedioxy group;R.sub.2 is one to four substituents independently selected from hydrogen, hydroxy, alkyl (1-4 C), alkoxy (1-4 C), halogen, or CF.sub.3, or as two adjacent substituents together a methylenedioxy group;R.sub.3 is one to four substituents independently selected from hydrogen, hydroxy, alkyl (1-4 C), alkoxy (1-4 C), halogen, or CF.sub.3, or as two adjacent substituents together a methylenedioxy group;R.sub.4 is selected from hydrogen or alkyl (1-4 C);A is a bond or an alkylene or alkylidene group with 1-6 carbon atoms;B is an alkylene or alkylidene group with 1-6 carbon atoms when Y is a bond, or B is an alkylene group with 2-6 carbon atoms when Y is a group selected from O, S, or NR.sub.5 ;X is CH or N; andR.sub.

Abstract: A process for the preparation of microcapsules containing biologically active material is disclosed. The process involves dissolving a polymer into a solvent into which the active material is also introduced; atomizing the resulting suspension or solution and collecting the droplets in a non-solvent for the polymeric droplets containing active material, resulting in coagulation. Subsequently, the coagulated droplets are hardened in a second non-solvent.

Abstract: Method for monitoring patients having connective tissue autoimmune diseases comprising contacting patient specimens with (U1)RNA and detecting immune complexes formed, the level of reaction indicating the severity of the disease.

Abstract: Disclosed are lyophilized gonadotropin containing preparations containing a dicarboxylic acid salt stabilizer. The particular proteins (e.g. LH, TSH, FSH, or HCG) are in admixture with, and at least partially capable of stabilization by, the particular stabilizer in lyophilized form. The preparations contain a sufficient amount of dicarboxylic acid salt to stabilize the protein in freeze-dried form for a desired time at a desired temperature. Typical dicarboxylic acid salts disclosed are the salts of citric, tartaric, and aspartic acids. The preparations preferably include a non-reducing disaccharide to increase the collapse temperature of the solution to be lyophilized. Methods of making the preparations in lyophilized form and the resulting injectable preparations are also disclosed.

Abstract: Gold sol coated with alkanethiols and alkanethiol derivatives, which provide groups on the sol available for the linking of binding moieties such as antibodies, antigens or ligands to the gold sol. Di- and tri-thiol compounds bound to gold sol also facilitate the adsorption of antibodies, antigens or ligands to the sol. The coating process, and test kits incorporating the coated sols are also included.

Abstract: The invention relates to sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type, of which N-sulfate, N-acetate, and hydroxy groups, are replaced by alkoxy, aryloxy, aralkoxy, or O-sulfate groups. The compounds have antithrombotic and smooth muscle cell proliferation inhibiting activities.

Abstract: Disclosed are dry pharmaceutical preparations containing potent steroidal medicinal agents in combination with an excipient capable of binding the agent to an extent greater than 80% and a having a demixing potential of less than 10% for said agent. Such excipients include spray-dried polyalcohols, granulated .alpha.-lactose monohydrate, or mixtures thereof. Also disclosed is a process of manufacturing stable tablets containing nearly identical amounts of at least one steroidal medicinal agent present in each tablet in an amount varying from 0.005 to 0.5 percent by weight of the tablet. Also disclosed is a dry mix consisting essentially of 1 to 100 parts, by weight, of at least one medicinal agent uniformly distributed throughout 2000 to 20,000 parts, by weight, of the described excipients. The mixture can be used to make dry dosage forms such as capsules, tablets, powders, and slugged granulates.

Abstract: A sample rack with at least one receptacle for the accommodation of respective sample tubes. At least one receptacle has a removable adapter sleeve located within it for receiving a corresponding sample tube. Additionally, locking means are included for fixedly engaging the adapter sleeve within the corresponding receptacle.

Abstract: The invention relates to sulfated glycosaminoglycanoid derivatives of the heparin and heparin sulfate type, of which N-sulfate, N-acetate, and hydroxy groups, are replaced by alkoxy, aryloxy, aralkoxy, or O-sulfate groups. The compounds have antithrombotic and smooth muscle cell proliferation inhibiting activities.

Abstract: The present invention is concerned with a vaccine for the protection of poultry against Marek's Disease. The cell free vaccine of the invention facilitates the handling of the vaccine and reduces the chance of physical abuse. The invention also relates to bivalent or polyvalent vaccines comprising in addition other viruses of the Marek's Disease virus group, i.e. HVT.

Abstract: A method for abating the incidence of cluster formation of reducible iron-containing material during the direct reduction of said material is disclosed. The method generally comprises contacting the reducible iron-containing material with a cluster-abating effective amount of a dispersion of a particulate material.

Abstract: A computer based system for testing an optical monitoring system includes a program having program instruction and optical monitoring system parameters, for implementing a plurality of tests of an optical monitoring system. A computer includes at least one processor for executing the program instructions, storage components for storing program instructions and test data, including the optical system parameters, a user input for inputting commands, and a display for displaying a menu of available test commands, test results and other data. An interface is provided for interfacing the optical monitoring system to tile computer for exchange of control and data signals. A fixture is provided for mounting the optical monitoring system during testing.

Abstract: Aqueous emulsions of a polymerization initiator are used for suspension (co)polymerization reactions. The aqueous emulsions contain: (a) an organic peroxide which is liquid at -5.degree. C.; (b) an aliphatic monohydric alcohol having 1-4 carbon atoms and/or aliphatic glycol having 2-4 carbon atoms; (c) a surfactant and/or a protective colloid; and (d) water. The emulsions may be transported while in a liquid state at a temperature of -10.degree. C. to -25.degree. C. with minimal decrease in active oxygen content.

Abstract: In a process for the preparation of 2-mercaptobenzothiazole from aniline, sulfur and carbon disulfide under pressure and for separation of the 2-mercaptobenzothiazole from the crude reaction product by cooling and recycling the desirable intermediates and by-products into the reactor together with aniline, sulfur and carbon disulfide, the reaction is carried out using a residence time in the reactor of at least one hour to a time before the 2-mercaptobenzothiazole product thus-formed begins to decompose into undesirable intermediate products. A maximum hydrogen sulfide pressure is maintained on quenching to a temperature ranging between 220 and 280.degree. C. by mixing the crude reaction product with carbon disulfide at a temperature sufficient to obtain a homogeneous quenched mixture. The hydrogen sulfide is removed completely only after crystallization of the 2-mercaptobenzothiazole.

Abstract: A cassette for storing and dispensing cuvettes and comprising an enclosable frame defining an interior volume for storing cuvettes. The frame includes a removable cover to aid in loading a plurality of cuvettes into the cassette. The frame also includes a side wall having a pivotally mounted door for pivoting between a closed position and an open position for dispensing the cuvettes from the cassette. And, the frame includes a locking mechanism for locking the door in the closed position to avoid an inadvertent dispensing of cuvettes. According to another aspect of the invention, a mechanism is provided for loading the cassette into an operative relationship with a machine for dispensing contents of the cassette for use by the machine. The loading mechanism includes a base adapted for being fixedly mounted on the machine. The loading mechanism also includes a holder for releasably holding the cassette.

Abstract: Industrial fabrics have controlled air permeability <120 l/dm.sup.2 .times. min and a very good ageing resistance. The air permeability value does not change by more than 15% in the ageing test. This fabric can be made by adapting production conditions for weaving, wet processing, and in particular, hot air treatment. The process is particularly suited for manufacturing air bag fabrics.

Abstract: A multilayer membrane for separating gas mixtures includes a polymer supporting membrane with a voids volume of more than 50% and a coating of two or more separating layers made of two or more different polymers. A hollow capillary serving as the supporting membrane is guided through the central bore of a spinneret. The spinneret has one or several concentric annular slits and/or annular grooves, through each of which a solution of one of the polymers forming the separating layers is applied to the supporting membrane. The spinneret terminates in a sealed chamber in which the solvent or solvents of the polymer solutions is/are evaporated and removed. The coated supporting membrane is drawn out of the chamber and wound up, possibly following aftertreatment with heat and/or liquids.

Abstract: A needle suitable for piercing a septum of a vacuum sealed container and through which a measured fluid sample from the container may be withdrawn. The needle is capable of withdrawing fluid from small sample volumes, such that the dead volume remaining in the sealed container is reduced. The needle has an elongated body having a longitudinal axis, an unobstructed bore therethrough along the longitudinal axis, a free end, and an end region adjacent said free end which has a slight conical taper toward said free end at a predetermined angle relative to the longitudinal axis. The free end includes an oblique cut through the conically tapered end region at an angle relative to the longitudinal axis being substantially larger than the predetermined angle of the taper so as to produce an elliptical opening at the free end. The elliptical opening lies along a plane diagonal to the longitudinal axis. This produces a toe or tip that is reduced in height allowing for a decrease in dead volume.

Abstract: An apparatus in which scattered light is measured, said apparatus having a light source aligned to direct illumination toward an interface between a sample container and an aqueous solution at an angle less than the critical angle. A detector to measure the scattered light is located at a place outside the envelope of the critical angle.

Abstract: This invention relates to human monoclonal antibody 81AV78 produced by a transformed B-cell line, having ATCC accession number CRL 10750 derived from B-cells of cancer patients actively immunized with autologous tumor antimen. This monoclonal antibody can be used in both diagnostic procedures and therapy for human cancers.