Abstract: Gold sol coated with alkanethiols and alkanethiol derivatives, which provide groups on the sol available for the linking of binding moieties such as antibodies, antigens or ligands to the gold sol. Di- and tri-thiol compounds bound to gold sol also facilitate the adsorption of antibodies, antigens or ligands to the sol. The coating process, and test kits incorporating the coated sols are also included.

Abstract: Disclosed are stabilized dry chemical (e.g. pharmaceutical) compositions containing the water soluble acid addition salt of a poorly soluble basic compound (e.g. mianserin, apomorphine, chlorpromazine, imipramine, or promethazine); an excipient selected from the group consisting of microcrystalline cellulose, lactose, calcium hydrogen phosphate, and mixtures thereof; and a water soluble (>2 mg/ml) alkaline stabilizer. The resulting dry compositions are relatively more bioavailable and stable than compositions not containing the water soluble alkaline stabilizer, especially after high temperature (>45.degree.) granulation processes. The process for preparing the dry composition is also more "rugged" with the added water soluble alkaline stabilizer.

Abstract: The invention relates to an antiprogestin 17- spirofuran-3'-ylidene steroid having the formula ##STR1## p0 R.sub.1 is NR.sub.2 R.sub.3, lower acyl, OH, SH, O-lower alkyl or S(O).sub.n -lower alkyl wherein n is 0-2;R.sub.2 and R.sub.3 are independently selected from hydrogen and lower alkyl;R.sub.4 is hydrogen or lower alkyl;R.sub.5 is O, (H,H), (H,OH), (H,O-lower acyl), or NOH;R.sub.6 and R.sub.7 are both hydrogen, or one is hydrogen and the other lower alkyl; andthe twitched line represents an .alpha. or .beta. bond.

Abstract: Novel unsaturated peroxyketals useful as molecular weight regulators in polymerization reactions are disclosed. Also disclosed are a polymerization process employing these novel unsaturated peroxyketals as molecular weight regulators, polymers and oligomers made by this process and articles of manufacture comprising one or more polymers or oligomers made by this process. These molecular weight regulating peroxyketals provide the ability to introduce an epoxy functionality to the oligomer or polymer as well as an additional functionality, in a manner which gives a higher monomer conversion and less by-products than with comparable chain transfer regulators.

Abstract: A new series of bifunctional chelating agents useful for attaching metal ions to proteins, polypeptides and other polymers and methods for their preparation are described. These reagents are unique in their ability to bind a variety of metal ions and to yield a high metal ion concentration per protein molecule. Using these methods polymeric analogs of these bifunctional chelating agents called Starburst ligands can also be obtained. Protein metal chelates thus obtained will have useful radiophysical, chemical, fluorescent, photochemical and magnetic properties suitable for biomedical applications.

Abstract: A peroxide-vulcanized rubber composition which comprises the vulcanization reaction product of a rubber, an organic peroxide, a biscitraconimido compound and a radical scavenger, is disclosed. The peroxide-vulcanized rubber compositions of the disclosure have significantly improved physical properties. Also disclosed are a peroxide-vulcanization process carried out in the presence of a biscitraconimido compound and a radical scavenger to control the scorch time and the use of a biscitraconimido compound and a radical scavenger to control scorch time in the peroxide-vulcanization of rubber.

Abstract: In an optically non-linear (NLO) polymeric material a frequency doubling structure composed of alternatingly poled NLO polymer is made. This structure can be made by forming a layer of NLO polymer, effecting poling in it with the use of an electric field, partially removing the layer of NLO polymer by etching, such that in the polymer a grating structure is formed composed of etched grooves and projecting polymer parts, the width of the grooves matching that of the polymer parts, dividing the polymer layer containing the grating structure into at least two sections, and placing the two sections one on top of the other, such that grooves of the one section are back-filled by projecting polymer parts of the other section. To prevent the enclosure of air a filler may be added, preferably in the form of a solution of the NLO polymer.

Abstract: Thermotropic liquid crystalline copolyamides comprise: (a) a thermoplastic, aliphatic polyamide, such as nylon-6,6; and (b) a mesogen comprising an amide-linked aromatic group segment which is not completely para-linked (namely, is substantially ortho- or meta-linked or a mixture of ortho- and meta-linked) by an amide linkage to an alkylene amide group contained in the mesogen.

Abstract: The invention relates to tetrahydropyridinyldibenzazepine derivatives of the formula I ##STR1## wherein R.sub.1 is a substituent selected from the group consisting of hydrogen, halogen, and lower alkyl;R.sub.2 is selected from hydrogen, and unsubstituted or hydroxy substituted lower alkyl or lower alkenyl;X is O, S, or CH.sub.2 ;Y is HC.dbd.CH or S;or a pharmaceutically acceptable salt thereof.These compounds are dopamine antagonists and are therefore useful for the treatment of psychotic disorders such as schizophrenia, schizophreniform disorder, delusional disorder, acute manic states, senile and presenile psychotic states, toxic psychoses, psychoactive-substance induced psychoses, symptoms of severe restlessness, hyperexcitability and anxiety, motor disorders, among which Tourette's disorder and Huntington's chorea, nausea and vomiting, hiccup and dizziness.

Abstract: The invention is concerned with the MD18 and MD20 polypeptides of Marek's Disease virus which can be used to vaccinate poultry against MD.The invention also relates to nucleic acid sequences encoding the MD18 or MD20 polypeptides. Said sequences can be used for the preparation of a subunit or vector vaccine.

Abstract: A dialkyl dicarbonate is prepared by contacting an alkyl haloformate with an alkali metal carbonate in the presence of a solvating amount of a solvent. The process of the invention does not require a catalyst, is easy to carry out, does not employ particularly hazardous materials, does not require cumbersome purification steps, and provides a high yield of dicarbonate.

Abstract: The invention relates to a piperazine derivative having the formula ##STR1## wherein each .phi. is a phenyl group which may independently be substituted by one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, CF.sub.3, and halogen, and Y is O or S, or a pharmaceutically acceptable salt thereof. The piperazine derivatives have sigma receptor affinity, and may be used for the treatment of psychosis.

Abstract: The invention relates to the use of the benzo[b]-thiophene-2-carboximidamide derivative having formula I ##STR1## or pharmaceutically acceptable salts thereof, for the preparation of a medicament which is suitable for the treatment of heart failure, having high bioavailability without inducing nausea, vomiting and/or restlessness.

Abstract: The invention relates to 11-aryl steroid derivatives, having the structure ##STR1## wherein: R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are as described in the specificationand to processes for their preparation and to pharmaceuticals comprising these compounds.These compounds exhibit a strong anti-progestinic activity and a weak or non-existent anti-glucocorticoid activity.

Abstract: Disclosed are lyophilized gonadotropin containing preparations containing a dicarboxylic acid salt stabilizer. The particular proteins (e.g. LH, TSH, FSH, or HCG) are in admixture with, and at least partially capable of stabilization by, the particular stabilizer in lyophilized form. The preparations contain a sufficient amount of dicarboxylic acid salt to stabilize the protein in freeze-dried form for a desired time at a desired temperature. Typical dicarboxylic acid salts disclosed are the salts of citric, tartaric, and aspartic acids. The preparations preferably include a non-reducing disaccharide to increase the collapse temperature of the solution to be lyophilized. Methods of making the preparations in lyophilized form and the resulting injectable preparations are also disclosed.

Abstract: A salt analyzer is disclosed capable of measuring the conductivity of a saline solution when either contact or non-contact probes are used. In particular, the salt analyzer employs circuitry capable of switchably measuring the various electrical parameters necessary for determining the conductivity of a solution when either contact or non contact probes are used.

Abstract: An aramid yarn, preferably poly(p-phenylene terephthalamide), is coated with a water swellable superabsorbent material. The swelling value of the yarn is at least 60. The superabsorbent provides water blocking capability to the yarn, so that it is suitable for use as a strength member, for example, in water tight optical communication cables. The yarn is made by successively treating an aramid yarn with a water-in-oil emulsion, a superabsorbent material being present in the water phase of the emulsion, and removing the liquid components from the treated yarn by evaporation.

Abstract: Disclosed is a contraceptive regimen, and method of using the regimen, comprising 24 daily sequential dosage units of: a first phase comprising about 7 to 9 separate first dosage units containing a progestogen at a daily dosage equivalent in progestogenic activity to 100 desogestrel and an estrogen at a daily dosage equivalent in estrogenic activity to 25 .mu.g ethinyl estradiol ("EE"). A second phase of 7 to 9 second dosage units, each of the second dosage units containing a progestogen equivalent to 125 .mu.g desogestrel and an estrogen equivalent lent to 20 .mu.g EE. A third phase of 7 to 9 third dosage units, each unit containing a progestogen equivalent to 50 .mu.g desogestrel and an estrogen equivalent to 20 .mu.g EE. The kit generally has 28 daily dosage units wherein four of the daily dosage units contain no contraceptive steroid, or, alternatively, have only 24 dosage units with a four day "pill-free" period.

Abstract: The invention comprises liquid crystalline polyesters suited to be used as a medium for optical data storage, especially reversible (or erasable) optical data storage. The polyesters comprise the polycondensation product of an aliphatic dicarboxylic acid or a derivative thereof and propane diol which on its center carbon bears a mesogenic substituent comprising two rings, either alicyclic or aromatic. Preferably also the dicarboxylic acid or derivative thereof is mesogenically substituted. The invention further comprises a medium for optical data storage containing polyesters of the above type.

Abstract: This disclosure relates to aqueous peroxide emulsions and the use thereof in suspension (co)polymerization reactions. In particular, the aqueous peroxide emulsions comprise: a) 20-60% by weight of an organic peroxide which is liquid at -5.degree. C.; b) 2-20% by weight of an aliphatic monohydric alcohol having 1-4 carbon atoms and/or aliphatic glycol having 2-4 carbon atoms; c) a surfactant and/or a protective colloid; and d) water. The emulsions of the present disclosure may be transported while in a liquid state at a temperature of -10.degree. C. to -25.degree. C. with minimal decrease in active oxygen content.