Abstract: The invention relates to neuroleptic/antidepressant 4-[4- or 6-(trifluoromethyl)-2-pyridinyl]-1-piperazinylalkyl substituted lactam derivatives having the general structure of formula I: ##STR1## wherein one of the groups R.sub.1 and R.sub.2 is CF.sub.3, and the other is hydrogen or CF.sub.3 ;R.sub.3 is hydrogen or (1-4 C) alkyl;n is an integer from 4 to 5; andm is an integer from 1 to 2; or pharmaceutically acceptable salts thereof.The invention also includes processes for making the compounds and their salts.

Abstract: A human monoclonal antibody having specificity for an epitope in a tumor associated antigen, said antibody produced by a cell line selected from the group consisting of Co6a3-1 (HB8493), Co7a4 (HB8494), Co28A32 (HB9380), Co16-86 (HB8496), and Co16-88 (HB8495).

Abstract: A heated liquid sampling probe for an automated sampling apparatus includes a sampling tube for drawing up a volume of liquid. The tube is connectable to an automated sampling apparatus including a chassis. A capacitance exists between the sampling tube and the chassis. An electrical heater is arranged for heating the tube and a volume of liquid contained therein. The electrical heater increases the capacitance between the tube and the chassis. A capacitance lowering mechanism is provided for lowering the increase in capacitance due to the heater.

Abstract: The invention relates to 5-isothiazolamine derivatives having the formula ##STR1## in which R.sub.1 is hydrogen, methyl, or ethyl, R.sub.2 and R.sub.3 are independently selected from hydrogen and alkyl, and the dotted line represents an optional bond, or a pharmaceutically acceptable acid addition salt thereof.The compounds have .alpha..sub.2 -adrenergic agonistic properties with little cardiovascular side-effects and minimal or no dopaminergic and cholinergic activity.

Abstract: In accordance with the present invention, there is provided a composition comprising the reaction product of particular (1).alpha.,.beta.-unsaturated dicarboxylic acid esters and (2) olefinically unsaturated compounds, wherein the resulting composition comprises a substantial amount of an intermediate molecular weight reaction product which is neither the well-known lower molecular weight alkenyl or alkyl succinic reaction product, nor the well-known polymerization reaction product, of (1) and (2). The compositions of the present invention are particularly suitable for use as lubricants and lubricant additives. In accordance with the present invention, there is also provided a process for the preparation of such compositions suitable for use as a lubricant or lubricant additive wherein components (1) and (2) are reacted in the presence of an effective amount of a polymerization inhibitor and/or in the absence of oxygen.

Abstract: The present invention pertains to a crosslinkable binder resin comprising an acrylate copolymer backbone having as pendant groups water soluble half esters of dicarboxylic acid and crosslinkable olefinic groups which contain an activated ethylenic unsaturation, such as (meth)acryloyl groups. The (meth)acryloyl groups can be crosslinked by polyfunctional crosslinking agents such as amino or blocked amino crosslinkers. The water-soluble half esters preferably are formed by the reaction of pendant hydroxy groups with unsaturated cyclic anhydrides (the unsaturation providing an additional crosslinking site). The (meth)acryloyl groups preferably are formed by the reaction of pendant epoxy groups with (meth)acrylic acid or derivatives thereof.

Abstract: A high solids coating composition suitable for use, for example, as a high performance automotive coating is provided, which comprises (1) a particular polyurethane polyol which is the reaction product of an asymmetric diol component and an isocyanate component, and (2) an hydroxyl groups-reactive crosslinking agent. When formulated as a one-pack coating preferably with an aminoplast crosslinking agent, these coating compositions possess a number of desirable properties including excellent acid etch resistance.

Abstract: Metallic objects such as conductive metal powders comprising metal such as copper, nickel, silver, cobalt and palladium can be treated to remove surface oxide layers by contacting with a combination of a chelating amine compound and a reducing catechol derivative at elevated temperature, preferably in a solution of ethylene glycol.

Abstract: A conductive metal-filled substrate is formed by intermingling copper or nickel particles into the substrate, contacting the metal particles with a specified developing agent, and heating the metal particles and the developing agent. The filled substrates are electrically conductive and are useful for a variety of uses such as EMI shielding.

Abstract: Dialysis membrane for hemodialysis in the form of membrane films, tubular films, or hollow filaments made of polysaccharide ethers, are characterized by the fact that the polysaccharide ether has a structure shown by the formula ##STR1## in which Cell is the skeleton of the unmodified cellulose molecule or of the chitin molecule, without hydroxyl groups in each case, s is 3 in the unmodified cellulose molecule and 2 in the chitin molecule, and x corresponds to the degree of etherification, which is in the range from 0.08 to (s-0.4).

Abstract: The invention relates to a benzhydryl derivative having the formula ##STR1## wherein each of the groups R.sub.1, R.sub.2, and R.sub.3 represents one to four substituents independently selected from the group consisting of hydrogen, lower alkyl, halogen, and CF.sub.3, and at least one of the groups R.sub.1, R.sub.2, and R.sub.3 is halogen or CF.sub.3 ;R.sub.4 represents hydrogen or methyl;n is 2, 3, or 4;m is 1, 2, or 3; andX represents O or S;or its pharmaceutically acceptable salts.The benzhydryl derivative of the invention can be used to treat patients who are suffering from diseases which are influenced by calmodulin.

Abstract: The invention relates to a filament yarn of aromatic polyamides which is impregnated with solid particles of a fluorine-containing polymer and/or graphite. The solid particles are incorporated into the yarn by very uniformly distributing them over the filaments in that the solid particles are applied to the yarn from an aqueous dispersion and the yarn is subjected to a blowing treatment while feeding them at an excess feed rate or not. The yarn thus impregnated is first of all intended to be processed into a packing material or rope.

Abstract: Polyarylene sulfide having a much reduced content of impurities is prepared by reacting an aromatic polyhalide with an alkali metal sulfide in the presence of a polar organic solvent and subjecting the resulting polyarylene sulfide subsequently to an acid treatment, filtration through a screen having a mesh size of 50-100 .mu., and washing with, successively, the same solvent as used in the preparation of the polymer, water, an organic or inorganic acid, and water. The resulting polyarylene sulfide has a sodium content of less than 20 ppm.

Abstract: The present invention relates to a process for the preparation of organic hydroxylamines as a result of the corresponding nitroderivative being hydrogenated in the presence of an inert solvent, a platinum catalyst, a nitrogen-containing base (in an amount of less than 10% by weight calculated on the amount of nitro derivative) and a tri- or pentavalent organic phosphorus compound. It has been found that if only use is made of the nitrogen-containing base or the phosphorus compound the yields of isolated hydroxyl amine are significantly reduced in comparison with those obtained with the present process.

Abstract: A catalytic composite and its use in the fluidized catalytic cracking of hydrocarbons in the absence of added hydrogen. The composite comprises a binder material, a crystalline aluminosilicate, preferably a Y-type zeolite, and diatomaceous earth. Optional ingredients are kaolin, barium titanate and discrete particles of porous alumina. Absent from the composite is a supported catalytically active metal or metal oxide. The catalytic composite of the invention achieves higher gasoline production with lower coke production as compared to FCC catalysts with no diatomaceous earth content.

Abstract: An instrument for monitoring the color change of an indicator element sealed within a sterile vessel and exhibiting a color change in response to a change in the pH of CO.sub.2 level within the sterile vessel as a result of microbacterial growth within a specimen contained in the sterile vessel. The present invention includes means for continuously monitoring the absolute value of the pH and or CO.sub.2 level within the vessel and or monitoring the rate of change of the absolute value of the pH level.

Abstract: The present invention relates to sulphated glycosamino glycuronan with antithrombotic activity consisting essentially of salts of dermatan sulphate, chondroitin sulphate and heparan sulphate, characterized bya) an average molecular weight between 4000 and 8000 daltons;b) a nitrogen content between 2.4 and 3.0%;c) a sulphur content between 7.5 and 9.5%;d) a sodium content between 9 and 11%;e) a dermatan sulphate content between 5 and 25%;f) a chondroitin sulphate content less than 9%;g) an anti-Xa activity between 11 and 20 .mu./mg; andh) an antithrombin III dependent antithrombin activity of less than 1 .mu./mg.

Abstract: The present invention relates to a device and method of detecting microorganisms in a rapid manner and increasing the number of microorganisms detected during the culturing of a sample by the addition of resinous and non-resin adsorbents and molecular sieves in the growth media. These agents have been found to neutralize or remove inhibitory and antimicrobial substances found in samples and media.

Abstract: An infrared touch screen device that is externally adaptable to a video monitor for serving as an input device to a computer connected to the monitor. A bezel is adapted to be releasably secured over a viewing end of a video monitor. A plurality of infrared emitters are disposed along the bezel to form a grid of vertical and horizontal infrared beams in the interior space of the bezel when the emitters are activated. A plurality of infrared sensors are disposed along the bezel. Each sensor is optically aligned with an oppositely disposed one of the emitters. An activating circuit is mounted on the bezel for sequentially activating, in a predetermined sequence, respective ones of the emitters. A scanning circuit is mounted on the bezel for sequentially scanning the sensors in a sequence corresponding to the predetermined sequence, the sensors each producing output signals corresponding to the presence and absence, respectively of an infrared beam emitted by an oppositely disposed infrared emitter.

Abstract: Diamines having a 1,1,3-trimethylphenylindane dicarboxylic moiety linked on both sides to phenylene diamine by an amide bond (PIDA diamines) are disclosed. By reacting these diamines with aromatic difunctional acid derivatives, amorphous polymers having high glass transition temperatures (Tg) can be prepared. If aliphatic diacid derivatives are used the resulting polymers have a lower Tg, but have the advantage of melt-processability. The PIDA-diamines can also be used in the preparation of polyimides, being reacted either with tri-or tetracarboxylic anhydrides or with imide group-containing acid derivatives.