Abstract: The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.

Abstract: A medical implant is disclosed. The medical implant includes a body having a first end having a first cross-sectional dimension, a second end having a second cross-sectional dimension, and a tapered portion extending between the first end and the second end. The first cross-sectional dimension is larger than the second cross-sectional dimension. In some embodiments, the body comprises multiple layers.

Abstract: The present invention is directed to an ophthalmic emulsion. The emulsion has a unique combination of ingredients that promotes the stability of small oil droplets within the emulsion. The emulsion also includes a mucoadhesive polymer that aid in delivering a lipid to the ocular surface.

Abstract: Disclosed are adjustable intraocular lenses and methods of adjusting intraocular lenses post-operatively. In one embodiment, an adjustable intraocular lens can comprise an optic portion and one or more haptics. The optic portion can comprise an anterior element, a posterior element, and a fluid-filled optic chamber. At least part of the optic portion can be made of a composite material. The base power of the optic portion can be configured to change in response to an external energy directed at the composite material.

Abstract: Systems and methods for optimizing the application of pulse width modulation (PWM) in a voltage signal for delivering a current in a valve used to alternatively deliver pressurized gas to and vent from chambers in a vitrectomy probe used to drive a cutter.

Abstract: An intraocular lens inserter can include a drive device with controllable advance motion. The drive device may include an actuator device and an energy device. The actuator device may include a piston rod that uses the advance motion to push an intraocular lens from a cartridge for insertion into an eye of an animal. The energy device may act upon the actuator device to generate the advance motion. The actuator device may include a dampening medium to control the advance motion, such as by controllably dampening the advance motion.

Abstract: A system of visualizing a target site in an eye, using a polarization sensitive optical coherence tomography (PS-OCT) device, includes a controller having at least one processor and at least one non-transitory, tangible memory on which instructions are recorded. The target site is one or more vitreous opacities in the vitreous humor of the eye. The controller is configured to receive PS-OCT data and determine at least one parameter corresponding to birefringence properties of collagen fibrils in the vitreous humor based on the PS-OCT data. The at least one parameter includes respective spacing of the collagen fibrils. The controller is configured to determine a respective location of the one or more vitreous opacities when the at least one parameter is outside a predefined range and generate a control signal adapted for guiding a treatment beam at the respective location of the one or more vitreous opacities.

Abstract: A digital ocular system includes a housing, an eye piece having a lens assembly. A display screen, a proximity sensor, and a processor. The lens assembly includes a front lens through which a user of the digital ocular system views a target object. The display screen is positioned within the housing cavity. The proximity sensor, which is connected to the housing, detects when user is within a predetermined standoff distance of the front lens, and outputs an electronic sensor signal when the user is outside of the predetermined standoff distance, i.e., not detected. The processor is configured to adjust an output state of the display screen via a display control signal in response to the electronic sensor signal.

Abstract: A system for spatially binding images from multiple modalities includes a controller having at least one processor and at least one non-transitory, tangible memory. The controller is adapted to receive first and second imaging datasets of a target site from a first and a second modality. The controller is adapted to extract a first feature set in the first imaging dataset, via a first neural network. A second feature set is extracted from the second imaging dataset, via a second neural network. Feature pairs are generated by matching respective datapoints in the first feature set and the second feature set. The controller is adapted to determine a coordinate transformation between the feature pairs and generate at least one spatially bound image of the target site based in part on the coordinate transformation.

Abstract: An intraocular lens (IOL) configured to support a first optic for functioning as a single lens IOL and configured to support a second optic for functioning as a dual optic IOL. The base includes a first optic for providing a base power. A recess in an anterior rim of the base is configured for positioning a radial extension of a second optic. The geometry of the recess is configured to securely couple to the radial extension to prevent rotation of the second optic relative to the base and prevent tilting of the second optic relative to an optic axis.

Abstract: An apparatus for eye surgery may comprise a nozzle having a delivery lumen, an implant bay coupled to the nozzle, an implant disposed in the implant bay, and an actuator coupled to the implant bay. The actuator may comprise a housing, a plunger disposed within the housing, a bore through the plunger, a first coupling proximate to a first end of the plunger, and a second coupling integral to the housing. The bore may be fluidly coupled to the implant bay. The first coupling may be configured to receive a hydraulic driver and fluidly couple a working fluid in the hydraulic driver to the bore. A portion of the plunger may be slidingly disposed through the second coupling. In some embodiments, the second coupling may be configured to retain a drive coupling of the hydraulic driver in a fixed position relative to the housing.

Abstract: An ophthalmic lens comprising an anterior surface and a posterior surface, at least one of the anterior surface and posterior surface including a first surface region corresponding to a photopic aperture of a pupil and a second surface region corresponding to a difference between the photopic aperture and a mesopic aperture of the pupil. A first microstructure pattern formed in a the first surface region, the first microstructure pattern introducing a phase perturbation into an optical path of incoming light such that a full depth of focus for photopic vision is provided.

Abstract: Described herein is a cost-effective and time-efficient method for producing photochromic contact lenses, in particular, preferably photochromic silicone hydrogel contact lenses, from a polymerizable composition comprising an unique selection and combination of main polymerizable components, a photochromic compound and a visible-light photoinitiator, based on the Lightstream Technology™. This invention also provides photochromic contact lenses or more preferably photochromic silicone hydrogel contact lenses made according to a method of the invention. A photochromic contact lens of the invention is capable of undergoing a reversible color change upon exposure to UV-irradiation or high-energy-violet light (HEVL) (with wavelengths from 380 nm to 440 nm).

Abstract: Disclosed herein are systems and methods for compensating for a tilt of an intraocular lens (IOL) and systems and methods for adjusting the IOL. For example, one of the methods can comprise capturing one or more optical coherence tomography (OCT) images of an eye of a subject when the IOL is implanted within the eye of the subject. The method can also comprise generating a fixation target such that the fixation target is visible to the eye of the subject and moving the fixation target until a transverse plane of the IOL is perpendicular or substantially perpendicular to an optical axis of an ophthalmic system. The method can also comprise directing a laser beam generated by a laser of the ophthalmic system at the IOL.

Abstract: The present invention provides in one aspect azabicyclo and diazepine derivatives useful as modulators of muscarinic receptors. In another aspect, the present invention provides pharmaceutical compositions for treating ocular diseases, the compositions comprising at least one muscarinic receptor modulator.

Abstract: Techniques are disclosed for systems and methods to provide dry eye and/or tear film hydration monitoring in the context of ocular aberrometry. An ocular aberrometry system includes a wavefront sensor configured to provide wavefront sensor data associated with an optical target monitored by the ocular aberrometry system and a logic device configured to communicate with the wavefront sensor. The logic device is configured to receive ocular aberrometry output data including at least the wavefront sensor data provided by the wavefront sensor, determine a tear film hydration state associated with the optical target based, at least in part, on the received ocular aberrometry output data, and generate user feedback corresponding to the determined tear film hydration state based, at least in part, on the received aberrometry output data and/or the determined tear film hydration state.

Abstract: A robotic imaging system includes a camera configured to one or more images of a target site. The camera may be a stereoscopic camera configured to record a left image and a right image for producing at least one stereoscopic image of the target site. A robotic arm is operatively connected to the camera, the robotic arm being adapted to selectively move the camera relative to the target site. A sensor is configured to detect forces and/or torque imparted by a user for moving the stereoscopic camera and transmit sensor data. A controller is configured to receive the sensor data, the controller having a processor and tangible, non-transitory memory on which instructions are recorded. The controller is adapted to selectively execute an assisted drive mode, which includes determining a movement sequence for the robotic arm based in part on the sensor data and a damping function.

Abstract: Described herein are devices and methods for treating eye conditions. Described is an ocular implant including an elongate member having an internal lumen forming a flow pathway, at least one inflow port communicating with the flow pathway, and at least one outflow port communicating with the flow pathway. The elongate member is adapted to be positioned in the eye such that at least one inflow port communicates with the anterior chamber, at least one outflow port communicates with the suprachoroidal space to provide a fluid pathway between the anterior chamber and the suprachoroidal space when the elongate member is implanted in the eye. The elongate member has a wall material imparting a stiffness to the elongate member. The stiffness is selected such that after implantation the elongate member deforms eye tissue surrounding the suprachoroidal space forming a tented volume.

Abstract: A system, method, and apparatus for displaying a fused reconstructed image with a multidimensional image are disclosed. An example imaging system receives a selection corresponding to a portion of a displayed multidimensional visualization of a surgical site. At the selected portion of the multidimensional visualization, the imaging system displays a portion of a three-dimensional image which corresponds to the selected multidimensional visualization such that the displayed portion of the at least one of the three-dimensional image or model is fused with the displayed multidimensional visualization.