Abstract: The present disclosure provides an ophthalmic lens (such as an IOL) that is designed to enhance depth of focus for intermediate vision performance, while maintaining distance vision. The lens may include an optic having an anterior surface and a posterior surface disposed about an optical axis. One of the surfaces (e.g., the anterior surface) may have a surface profile involving a superposition of at least three structures or profiles, including a base structure, a phase shift structure having an inner region, an outer region and a transition region, and a zonal structure having an inner power zone and an outer transition zone.

Abstract: Systems, methods, and apparatuses for inserting an intraocular lens (IOL) into an eye, are provided. The apparatus comprises an IOL cartridge comprising a nozzle, a compartment, a plunger, and a plunger case. The nozzle is in fluid communication with the compartment, and the plunger case is in fluid communication with the compartment. The plunger is disposed within the plunger case. The plunger case includes flexible members extending from an outer surface of the plunger case. The IOL cartridge is configured to removably attach to a handpiece.

Abstract: Intraocular lens delivery devices and methods of use.

Abstract: A continuous additive fabrication system comprises a bath of photopolymer resin and a light source assembly having a light source and a motorized variable aperture. The light source assembly is operable to generate a focus point in the bath of photopolymer resin, the shape of the focus point at a curing plane within the bath of photopolymer resin corresponding to the shape of the motorized variable aperture. The continuous additive fabrication system further comprises a platform configured to support a build object and a drive mechanism (coupled to at least one of the platform and the light source assembly) configured to continuously move the curing plane through the bath of photopolymer resin. A size and/or shape of the motorized variable aperture is changed while the curing plane in continuously moved through the bath of photopolymer resin.

Abstract: An ophthalmic speculum includes arms, a locking mechanism, and an air-flow system. The arms include a first arm and a second arm. Each arm has a retractor shaped to conform to an eyelid of a pair of eyelids of an eye. The retractors are substantially symmetrical about a lateral axis. The locking mechanism is coupled to the arms. The locking mechanism moves the arms to allow the retractors to retract the pair of eyelids, and fixes the arms into place to maintain retraction of the pair of eyelids. The air-flow system is coupled to at least one arm, and moves air in a region disposed outwardly from a surface of the eye.

Abstract: Systems and methods are provided for in vivo pre-surgical characterization of lenses, such as cataractous lenses. A method comprises obtaining an electromagnetically-measured value related to the axial thickness of the lens, obtaining an ultrasound-measured value related to the axial thickness of the lens, calculating a relationship value based upon the electromagnetically-measured value and the ultrasound-measured value, and determining a mechanical property value based upon the calculated relationship value. The mechanical property may relate to lens hardness, rigidity, or density, or the amount of energy for a phacoemulsification procedure. A system may comprise an optical interferometer for measuring data to obtain the electromagnetically-measured value and an ultrasound biometer for measuring data to obtain the ultrasound-measured value.

Abstract: Projection of visible, non-treatment light onto an eye to illuminate specific areas of the surgical field is disclosed herein. A surgical system may include a surgical console; a microscope communicatively coupled to the surgical console; a camera communicatively coupled to the surgical console; and a projector operable to project light onto an eye. The projector may be communicatively coupled to the surgical console. A method for light projection may include collecting information from an eye using a camera; determining the light projection based, at least in part, on the collected information; and projecting visible, non-treatment light onto the eye using a projector.

Abstract: An ophthalmic lens includes an optic comprising an anterior surface, a posterior surface, and an optical axis. At least one of the anterior surface and the posterior surface has a surface profile including a base curvature and a plurality of morphed sinusoidal phase shift structures. The base curvature may correspond to a base optical power of the ophthalmic lens, and the morphed sinusoidal phase shift structures may be configured to extend depth of focus of the ophthalmic lens at intermediate or near viewing distances.

Abstract: A retina viewing system and method of using the same includes an ophthalmic microscope, a disposable lens attachment, and an electronic control unit (ECU). The microscope has an optical head and a set of internal focusing lenses, the latter providing the microscope with a variable working distance or focal length. The disposable lens attachment includes a resilient body with a proximal end connected to the optical head and a distal end connected to a high-power/high-diopter distal lens. The ECU executes instructions for viewing a retina or other intraocular anatomy of a patient eye. Execution of the instructions causes the ECU to automatically adjust the variable working distance or focal length of the microscope when viewing an image of the retina through the distal lens.

Abstract: Various systems and techniques for inserting an intraocular lens are disclosed. In particular implementations, a system and a technique for inserting an intraocular lens may include the ability to move, in response to a force being applied in a first direction along a longitudinal axis, a first plunger tip along the longitudinal axis and into a delivery cartridge to fold an intraocular lens and move in a second direction along the longitudinal axis in response to the applied force being reduced. The system and the technique may also include the ability to engage a second plunger tip and move, in response to a force being applied in the first direction along the longitudinal axis, the second plunger tip along the longitudinal axis and into the delivery cartridge to insert the intraocular lens.

Abstract: The present invention provides in one aspect azabicyclo and diazepine derivatives useful as modulators of muscarinic receptors. In another aspect, the present invention provides pharmaceutical compositions for treating ocular diseases, the compositions comprising at least one muscarinic receptor modulator.

Abstract: Described herein is a method for producing photochromic contact lenses, in particular, photochromic silicone hydrogel contact lenses. The method comprises a step of cast molding of a lens-forming composition including an iniferter to form an unprocessed contact lens having iniferter moieties covalently incorporated into its polymer matrix and a step of iniferter-induced graft-polymerization of a photochromic vinylic monomer to the polymer matrix only in its central region which is circular and concentric with the central axis of the unprocessed contact lens. The obtained photochromic contact lens has a central pupillary region that only can undergo a reversible color change upon exposure to UV/HEVL-radiation.

Abstract: The present disclosure provides an adaptive optics system including at least one active pixel sensor array that detects light and sends a signal to a processor. The adaptive optics system also includes a wavefront correction system including at least one wavefront control structure and the processor, and that executes instructions on the processor to produce a digital image in which at least one wavefront distortion in the light detected by the active pixel sensor array is partially or fully corrected. The disclosure also provides methods of using the adaptive optics system.

Abstract: A vitrectomy probe with combined vibration dampening and attenuating. The probe may include a variety of features to lessen the vibrations felt by a surgeon during a vitrectomy procedure. These may include minimizing the degree of flow restriction through a housing that facilitates cutter reciprocation by way of air pressure. Further, utilizing softer stops at a diaphragm that drives the cutter reciprocation may be of benefit as is strategically lessening compressive forces by seals at an extension tube coupled to the diaphragm where possible. The use of a softer gripping component that is actually held by the surgeon may be of benefit in terms of vibration attenuation.

Abstract: A surgical system corrects a surgical parameter based on a nomogram specific for a refractive laser surgery system to provide a nomogram-based corrected surgical parameter; stores the surgical parameter and the nomogram-based corrected surgical parameter as data for a patient or for one or both eyes of the patient; and compares the surgical parameter and nomogram-based corrected surgical parameter to generate a graphical representation of the surgical parameter, a target outcome parameter associated with the surgical parameter, or both, and the nomogram-based corrected surgical parameter, to generate a warning based on a comparison of the nomogram-based corrected surgical parameter to the surgical parameter or an absolute value, or both.

Abstract: An imaging system includes a housing assembly having a head unit configured to be at least partially directed towards a target site. An optical coherence tomography (OCT) module and a visualization module are located in the housing assembly and configured to respectively obtain OCT data and visualization data of the target site. The system includes a controller configured to generate a scanning pattern for a region of calibration selected in a calibration target. OCT data of the region of calibration is synchronously acquired. The controller is configured to obtain a projected two-dimensional OCT image of the region of calibration based on the OCT data, as an inverse mean-intensity projection. The controller is configured to register the projected two-dimensional OCT image to a corresponding view extracted from the visualization data, via a cascaded image registration process having a coarse registration stage and a fine registration stage.

Abstract: The present disclosure provides a system that may receive first sensor data associated with first measurements of multiple components of respective multiple medical systems; may determine first one or more classifiers based at least on first user input; may receive second sensor data associated with second measurements of the multiple components; may determine, based at least on the first one or more classifiers and based at least on the second sensor data, at least two services to be provided to respective at least a first two of the multiple medical systems; may receive third sensor data associated with third measurements of multiple components respectively associated with the at least the first two of the multiple medical systems; and may determine, without the first user input and without second user input, second one or more classifiers based at least on the third sensor data.

Abstract: Various arrangements of fluidics systems are disclosed. In one arrangement, an aspiration circuit for a fluidics system is disclosed that selectively controls aspiration. The aspiration circuit comprises an aspiration line operatively connected to a surgical instrument, an aspiration exhaust line operatively connected to a waste receptacle; an aspiration vent line connected at a first end to the aspiration line; and a selectively variable vent valve operatively connected to the aspiration vent line. The variable vent valve may be selectively moved to vary aspiration pressure within the aspiration line. Other fluidics systems are disclosed that include a selectively positionable irrigation valve that may also be incorporated into a fluidics system that includes a variable vent valve.

Abstract: Particles, compositions, and methods that aid particle transport in mucus are provided. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles including pharmaceutical agents that have a low water/aqueous solubility. In some embodiments, a surface coating includes a synthetic polymer having pendant hydroxyl groups on the backbone of the polymer, such as poly(vinyl alcohol) (PVA). Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

Abstract: The present disclosure relates generally to small-gauge instrumentation for surgical procedures, and more specifically, to vitreoretinal instruments for retinal repair and reattachment procedures, as well as associated methods of use. Certain embodiments of the present disclosure provide a curved or articulating probe configured to provide illumination, fluid aspiration, and endophotocoagulation. Accordingly, the probe enables aspiration of subretinal fluid that re-accumulates after initial drainage and during endophotocoagulation without the need to exchange surgical instruments or insert an additional instrument into the intraocular space. Furthermore, the combined functionalities of the probe enable a surgeon to simultaneously perform scleral depression with the surgeon's other hand while aspirating fluid and/or performing retinal endophotocoagulation.