Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.

Abstract: Featured is a device for puncturing tissue of a body, such as the lamina cribosa and methods for treating a CVRO with such a puncturing device. The puncturing device includes a puncture member being generally configured and arranged to locally disrupt tissue proximal an area of the puncture site, to minimize the potential for damage to body parts or tissue immediately adjacent to this area of the puncture site and to facilitate perforation of the tissue at the puncture site. When the lamina cribosa is being punctured, the puncture member is more particularly configured and arranged to locally disrupt connective tissue of the lamina cribosa proximal to and surrounding the central retinal vein while minimizing the potential for structural damage to the central retinal vein. In an exemplary embodiment, the lamina cribosa is repeatedly punctured to strip/locally disrupt connective tissue surrounding the central retinal vein.

Abstract: An improved method of sterilizing the field of surgery prior to an ophthalmic surgical procedure is described. The invention eliminates the need for painful and potentially traumatic injections of antibiotics by utilizing sustained release compositions which allow the antibiotics contained therein to penetrate deeply into the eye, thereby ensuring a sterile field of surgery during intraocular surgical procedures. The compositions may also be utilized to prevent post-surgical infections.

Abstract: This invention is directed to the use of glutamate antagonists to treat the disorders of outer retina.

Abstract: This invention relates to reduced stinging, sustained release ophthalmic formulations and the method of treatment comprising administering such formulations topically to the eye when in need thereof.

Abstract: Isoquinolinesulfonyl compounds are used in ophthalmic compositions to treat glaucoma or other ischemic-borne ocular disorders such as retinopathies or optic neuropathies. These compounds vasodilate ocular blood vessels, lower IOP and prevent or reduce the progression of visual field loss.

Abstract: This invention relates to the compositions and methods for the treatment of corneal haze. The compositions and methods are particularly directed to the use of GAG synthesis inhibitors in the treatment of corneal haze.

Abstract: Improved stability, liquid enzyme compositions containing an alkylated trypsin and methods involving the combined use of these compositions with an aqueous composition are disclosed for the cleaning or simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.

Abstract: A method of treating glaucoma or ocular hypertension in a patient, which comprises administering to the patient a pharmaceutically effective amount of a compound of formula I:

Abstract: A method of treating glaucoma or ocular hypertension in a patient, which comprises administering to the patient a pharmaceutically effective amount of a compound of formula I:

Abstract: A tip for a liquefraction surgical handpiece uses at least two tubes. One tube is used for aspiration and another, smaller tube is used to inject heated surgical fluid for liquefying a cataractous lens. The distal portion of the injection tube terminates just inside of the aspiration tube so that heated fluid escaping the injection tube is reflected off of the internal wall of the aspiration tube prior to entering the eye. The internal wall is textured or roughened to further diffract the fluid stream. Such an arrangement prevents the injected fluid from directly entering the eye. The handpiece may also contain other tube, for example, for injecting relatively cool surgical fluid.

Abstract: Contact lens care compositions for the treatment of hard contact lenses arc disclosed. The compositions are useful for rinsing, cleaning, disinfecting and storing of hard contact lenses. The compositions contain an unique gelling system involving galactomannan polysaccharides and borates to allow for the conditioning of the lens when it is reinserted in the eye of the user. Methods of using these compositions are also disclosed.

Abstract: The invention provides pharmaceutical compositions containing calpain inhibitors and methods of using these calpain inhibitors to prevent or ameliorate ocular neural tissue disease or damage.

Abstract: A topical ophthalmic composition for the treatment of dry eye in humans, comprising one or more histamine H2 agonists, is disclosed.

Abstract: The present invention relates to the field of ophthalmology. In particular the invention relates to the field of ocular disorders including visual field loss and glaucoma using an isoquinolinesulfonyl compound, which lowers intraocular pressure (IOP) and produces dilation of ocular blood vessels.

Abstract: A surgical handpiece having an integrated aspiration pump and vacuum and/or flow sensor. Suitable pumps included micromachined peristaltic pumps and ultrasonic pumps.

Abstract: Methods and compositions for treating ocular conditions which find their etiology in compromised ocular blood flow with brinzolamide and brimonidine are disclosed.

Abstract: Compounds having ant-inflammatory and anti-oxidant activity are disclosed. The compounds are useful in preventing and treating inflammatory disorders through several mechanisms. Methods of treatment employing these properties of the compounds and corresponding pharmaceutical composition are disclosed.

Abstract: Methods for preventing or slowing visual field loss are disclosed.

Abstract: Cis-&Dgr;4 analogs of prostaglandins and methods of their use in treating glaucoma and ocular hypertension are disclosed.