Patents Assigned to Alcon Laboratories, Inc.
  • In vivo polymerizable ophthalmic compositions and methods of using
    Patent number: 6180687
    Abstract: In vivo polymerizable intraocular lens compositions which comprise substituted fluoroalkyl or perfluoroalkyl monomers having anionic, cationic, and/or nonionic surface active functionality in the unsaturated fluorophobic ends. The compositions are preferably cured by UV photoinitiation and are useful in repairing torn or detached retinal tissue or forming intraocular lenses in situ.
    Type: Grant
    Filed: May 17, 1999
    Date of Patent: January 30, 2001
    Assignees: Alcon Laboratories, Inc., University of Southern Mississippi
    Inventors: Mark E. Hammer, Steven T. Charles, John C. Lang, Robert Y. Lochhead, Lon J. Mathias
  • Treatment of glaucoma and ocular hypertension
    Patent number: 6177427
    Abstract: Compositions of non-steroidal glucocorticoid antagonists for treating glaucoma or ocular hypertension and methods for their use are disclosed.
    Type: Grant
    Filed: July 1, 1999
    Date of Patent: January 23, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Abbot F. Clark, Raymond E. Conrow
  • Gelling ophthalmic compositions containing xanthan gum
    Patent number: 6174524
    Abstract: Ophthalmic drug delivery vehicles which are administrable as a liquid and which gel upon contact with the eyes are disclosed. The vehicles contain xanthan gum.
    Type: Grant
    Filed: March 26, 1999
    Date of Patent: January 16, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Rajan Bawa, Rex E. Hall, Bhagwati P. Kabra, James E. Teague
  • Method of inhibiting cytokine release from human ocular cells
    Patent number: 6174914
    Abstract: Ophthalmic formulations containing as an active ingredient 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid or a pharmaceutically acceptable salt thereof are useful for inhibiting cytokine release (e.g., IL-6 and IL-8) from human ocular cells. Such formulations can be used to treat or prevent ocular neovascularization and non-allergic inflammatory disorders such as dry-eye, keratitis, blepharitis, uveitis and inflammation related to infection.
    Type: Grant
    Filed: June 15, 1999
    Date of Patent: January 16, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: John M. Yanni, Daniel A. Gamache, Lori K. Weimer
  • Topical use of kappa opioid agonists to treat otic pain
    Patent number: 6174878
    Abstract: Compositions and methods for treating otic pain are disclosed. In particular, the invention discloses compositions and methods of using kappa opioid agonists locally for the prevention or alleviation of otic pain.
    Type: Grant
    Filed: August 31, 1999
    Date of Patent: January 16, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Daniel A. Gamache, John M. Yanni
  • Use of carbon dioxide and carbonic acid to clean contact lenses
    Patent number: 6171404
    Abstract: Simple, efficacious, easily manufacturable, convenient to use and cost-effective contact lens care cleaning compositions comprising carbon dioxide and carbonic acid as cleansing agents are disclosed. The compositions do not require abrasive agents such as polymeric beads, nor ocularly irritating agents such as enzymes or surfactants in order to effectively clean proteinaceous and nonproteinaceous deposits from the surface of contact lenses. Also disclosed is a one-step cleaning and disinfecting regimen, whereby an effervescent tablet composition capable of generating carbon dioxide and carbonic acid is dissolved in a disinfecting solution or rinsing/disinfecting/storage solution.
    Type: Grant
    Filed: April 22, 1999
    Date of Patent: January 9, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Rajkumar Bhatia, Alok K. Kulshreshtha, Geoffrey R. Owen, Yusuf Ali
  • 13-Thia prostaglandins for use in glaucoma therapy
    Patent number: 6172109
    Abstract: 13-thia prostaglandins are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic, pharmaceutical compositions comprising said prostaglandins.
    Type: Grant
    Filed: June 3, 1998
    Date of Patent: January 9, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Paul W. Zinke, Mark R. Hellberg
  • Combination therapy for lowering and controlling intraocular pressure
    Patent number: 6172054
    Abstract: Angiostatic agents and another IOP lowering compound are combined in ophthalmic compositions to treat glaucoma and ocular hypertension. Methods for treating glaucoma and ocular hypertension are also disclosed.
    Type: Grant
    Filed: June 15, 1995
    Date of Patent: January 9, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventor: Abbot F. Clark
  • Conformationally rigid aryl prostaglandins for use in glaucoma therapy
    Patent number: 6169111
    Abstract: Conformationally rigid aryl prostaglandins are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic pharmaceutical compositions comprising said prostaglandins.
    Type: Grant
    Filed: May 12, 1999
    Date of Patent: January 2, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Paul W. Zinke, John E. Bishop, Thomas R. Dean, Mark R. Hellberg
  • Combinations of DP and FP type prostaglandins for lowering IOP
    Patent number: 6166073
    Abstract: Compositions containing DP-agonist and FP-agonists prostaglandin agonists and methods of their use in treating glaucoma or ocular hypertension are disclosed.
    Type: Grant
    Filed: August 2, 1999
    Date of Patent: December 26, 2000
    Assignee: Alcon Laboratories, Inc.
    Inventors: Thomas R. Dean, Mark Hellberg, Verney L. Sallee
  • 14-aza prostaglandins for the treatment of glaucoma and ocular hypertension
    Patent number: 6160013
    Abstract: 14-Aza analogs of PGF.sub.2.alpha., PGD.sub.2, and PGE.sub.2 and methods of their use in treating glaucoma and ocular hypertension are disclosed.
    Type: Grant
    Filed: November 30, 1999
    Date of Patent: December 12, 2000
    Assignee: Alcon Laboratories, Inc.
    Inventor: Robert D. Selliah
  • Method of reducing glare associated with multifocal ophthalmic lenses
    Patent number: 6158862
    Abstract: A multifocal ophthalmic lens having a dye or dyes that block the transmission of near UV and/or blue light.
    Type: Grant
    Filed: December 4, 1997
    Date of Patent: December 12, 2000
    Assignee: Alcon Laboratories, Inc.
    Inventors: Anilbhai S. Patel, William M. Graham
  • Surgical handpiece tip
    Patent number: 6156036
    Abstract: A surgical handpiece tip with at least two coaxially spaced electrically conductive tubes. The tubes are separated by an electrical insulator. The interior of the inner tube is used for aspiration of liquefied tissue. The distal portion of the interior tube terminates just inside of the outer tube so as to form a boiling region. Electrical current is passed between the inner and outer tube to rapidly boil any surgical fluid in the boiling region. The boiling fluid rapidly expands out of the ring between the tubes and contacts the targeted tissue, thereby liquefying the tissue and allowing the tissue to be aspirated.
    Type: Grant
    Filed: June 11, 1999
    Date of Patent: December 5, 2000
    Assignee: Alcon Laboratories, Inc.
    Inventors: Glenn Sussman, Martin J. Padget, Donald M. Cohen
  • Use of certain anionic amino acid based surfactants to enhance antimicrobial effectiveness of topically administrable pharmaceutical compositions
    Patent number: 6146622
    Abstract: Anionic amino acid based surfactants are used to enhance antimicrobial effectiveness in topically administrable pharmaceutical compositions containing at least one active ingredient, a cationic preservative and an anionic polyelectrolyte, such as carboxyvinyl polymers, xanthan gum, polystyrene sulfonic acid polymers and cationic exchange resins.
    Type: Grant
    Filed: September 21, 1999
    Date of Patent: November 14, 2000
    Assignee: Alcon Laboratories, Inc.
    Inventors: Ernesto J. Castillo, Steven Howard Gerson, Wesley Wehsin Han
  • Asymmetric intraocular lens injection cartridge
    Patent number: 6143001
    Abstract: A lens injector cartridge having an asymmetric bore. The asymmetric bore initiates the folding of the lens on one side only, thereby reducing the amount of energy imparted to the lens and the potential for damage to the lens. The gentle folding of the lens also assists in positioning the travel of the haptics down the bore, thereby reducing the potential for damage to the haptics.
    Type: Grant
    Filed: October 1, 1999
    Date of Patent: November 7, 2000
    Assignee: Alcon Laboratories, Inc.
    Inventors: Kyle Brown, Thomas M. Heyman
  • Use of borate-polyol complexes in ophthalmic compositions
    Patent number: 6143799
    Abstract: Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions containing typical borate buffers and unexpectedly increase the antimicrobial efficacy of other antimicrobial agents when used in combination. In addition, use of the borate-polyol complexes avoids the incompatibility problem typically associated with the combination of borate buffer and polyvinyl alcohol; therefore, the compositions disclosed herein may also contain polyvinyl alcohol.
    Type: Grant
    Filed: July 2, 1998
    Date of Patent: November 7, 2000
    Assignee: Alcon Laboratories, Inc.
    Inventors: Masood Chowhan, Nissanke L. Dassanayake
  • Methods of sterilizing polymers
    Patent number: 6139794
    Abstract: Methods of heat sterilizing polymers are disclosed. The methods involve the preparation of a polymer suspension in an water-miscible organic liquid and subsequent application of moderate heat for a period of time sufficient to sterilize the polymer.
    Type: Grant
    Filed: July 28, 1998
    Date of Patent: October 31, 2000
    Assignee: Alcon Laboratories, Inc.
    Inventors: Bahram Asgharian, Alok K. Kulshreshtha
  • Alkyl trypsin compositions and methods of use in contact lens cleaning and disinfecting systems
    Patent number: 6139646
    Abstract: Improved stability, liquid enzyme compositions containing an alkylated trypsin and methods involving the combined use of these compositions with an aqueous composition are disclosed for the cleaning or simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.
    Type: Grant
    Filed: October 18, 1999
    Date of Patent: October 31, 2000
    Assignee: Alcon Laboratories, Inc.
    Inventors: Bahram Asgharian, Bor-Shyue Hong, Ronald P. Quintana
  • Articles coated with in vivo polymerizable ophthalmic compositions
    Patent number: 6124037
    Abstract: Coatings for surgical instruments which comprise substituted fluoroalkyl or perfluoroalkyl monomers having anionic, cationic, and/or nonionic surface active functionality in the unsaturated fluorophobic ends.
    Type: Grant
    Filed: January 23, 1998
    Date of Patent: September 26, 2000
    Assignees: Alcon Laboratories, Inc., University of Southern Mississippi
    Inventors: Mark E. Hammer, Steven T. Charles, John C. Lang, Robert Y. Lochhead, Lon J. Mathias
  • Shielded female connector
    Patent number: D435652
    Type: Grant
    Filed: March 30, 1999
    Date of Patent: December 26, 2000
    Assignee: Alcon Laboratories, Inc.
    Inventors: Nader Nazarifar, Richard A. Rossback, Gary P. Sorensen