Patents Assigned to Alcon Laboratories
  • Use of TGF-.beta.3, to prevent or retard fistula closure following glaucoma filtration surgery
    Patent number: 5449671
    Abstract: The intraocular use of TGF-.beta..sub.3 in connection with glaucoma filtration surgery is described. A composition containing TGF-.beta..sub.3 is applied to the surgical site to suppress the production and/or alter the composition of extracellular matrix synthesized by fibroblasts at the surgical site, and thereby reduce the formation of scar tissue and consequent impairment of the outflow of aqueous humor through a fistula created during the surgery.
    Type: Grant
    Filed: September 29, 1993
    Date of Patent: September 12, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: Jon C. Nixon, Billie M. York
  • Anti-inflammatory compounds for ophthalmic use
    Patent number: 5446177
    Abstract: Anti-inflammatory compounds, a method of treating inflamed ocular tissue and compositions of these compounds are described. The compounds are derivatives and analogues of known steroid compounds (e.g., dexamethasone) and are advantageously characterized in that they do not cause any significant increase in intraocular pressure during chronic use.
    Type: Grant
    Filed: March 4, 1994
    Date of Patent: August 29, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventor: John J. Boltralik
  • Ophthalmic compositions comprising emedastine and methods for their use
    Patent number: 5441958
    Abstract: Topical ophthalmic compositions comprising 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)-benzimidazole and its ophthalmically acceptable acid addition salts have been found to be useful in treating allergic conjunctivitis and related ailments.
    Type: Grant
    Filed: December 8, 1993
    Date of Patent: August 15, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: John M. Yanni, Stella M. Robertson, Shigetoshi Okumura, Hitoshi Tanaka, Tadayuki Saito
  • Method of tuning ultrasonic devices
    Patent number: 5431664
    Abstract: A method of tuning ultrasonic transducers by using the admittance of the transducer as the tuning parameter rather than the phase angle. The admittance magnitude of a transducer is not related to the phase angle and thus, using the admittance of the transducer as the tuning parameter allows tuning over a broad bandwidth. In addition, transducer performance can be normalized against the variation in admittance magnitude and frequency location of the series and parallel resonance points by quantifying these variations and continually adjusting the operational set point as a function of transducer drive voltage during transducer operation.
    Type: Grant
    Filed: April 28, 1994
    Date of Patent: July 11, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: Alexander Ureche, Kurt D. Leukanech
  • Compounds having both potent calcium antagonist and antioxidant activity and use thereof as cytoprotective agents
    Patent number: 5424321
    Abstract: Compounds having both calcium antagonist and antioxidant activity are disclosed. The compounds are useful in preventing or alleviating damage to tissues at the cellular level. Methods of treatment which employ these properties of the compounds and corresponding pharmaceutical compositions are also disclosed.
    Type: Grant
    Filed: December 8, 1993
    Date of Patent: June 13, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: Mark R. Hellberg, George Barnes, Robert J. Collier, Jr.
  • Preparation of carbonic anhydrase inhibitors
    Patent number: 5424448
    Abstract: A process for synthesizing carbonic anhydrase inhibitors is disclosed.
    Type: Grant
    Filed: January 14, 1994
    Date of Patent: June 13, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: William D. Dean, Paul W. Zinke, Steven J. Sproull, Michael E. Deason, Raymond E. Conrow, Anura P. Dantanarayana
  • Anti-inflammatory glucocorticoid compounds for topical ophthalmic use
    Patent number: 5420120
    Abstract: Topically administrable C-21 thioether glucocorticoid steroid derivatives are disclosed as effective anti-inflammatory agents for the treatment of ophthalmic inflammatory disorders. These C-21 thioether derivatives do not cause a significant increase in intraocular pressure as a side effect.
    Type: Grant
    Filed: December 17, 1993
    Date of Patent: May 30, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventor: John J. Boltralik
  • Elongated curved cavitation-generating tip for disintegrating tissue
    Patent number: 5417654
    Abstract: An improved tip for use with a device for disintegrating tissue located in a predominantly liquid environment. The tip is connected to an oscillation generator, which results in ultrasonic oscillating movement along the tip axis. When placed within the posterior capsule of an eye, the tip causes the tissue of the natural lens in close proximity to disintegrate. The tip has an elongated curved portion having a convex front surface, a concave rear surface and a rear-facing end surface. The elongated curve of the tip and the rear facing end surface allow easy access to all areas of the capsular bag, some of which were relatively unreachable with known ultrasonic tips.
    Type: Grant
    Filed: February 2, 1994
    Date of Patent: May 23, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventor: Charles D. Kelman
  • Use of diamines to disinfect and clean contact lenses
    Patent number: 5415837
    Abstract: Certain alkenyl diamines, the use of same for disinfecting and cleaning contact lenses and preserving ophthalmic products, and associated ophthalmic compositions are described.
    Type: Grant
    Filed: October 25, 1993
    Date of Patent: May 16, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: Rolf Schafer, Ronald L. Schlitzer, Nissanke L. Dassanayake
  • Use of TGF-.beta..sub.3 to reduce the formation of scar tissue in response to corneal trauma
    Patent number: 5411940
    Abstract: The use of TGF-.beta..sub.3 to reduce the formation of scar tissue as a result of trauma to the cornea of the eye is described. The invention is particularly directed to the use of TGF-.beta..sub.3 to reduce the formation of scar tissue in connection with ophthalmic surgical procedures involving the cornea, such as laser irradiation of the cornea. A composition containing TGF-.beta..sub.3 is applied to the site of the trauma to alter the production and composition of extracellular matrix synthesized by fibroblasts, and thereby reduce the formation of scar tissue and consequent impairment of vision.
    Type: Grant
    Filed: September 29, 1993
    Date of Patent: May 2, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: Jon C. Nixon, Billie M. York
  • Hyaluronic acid compositions and methods
    Patent number: 5409904
    Abstract: Disclosed are solutions useful in surgery comprising a viscous or viscoelastic substance in an aqueous vehicle which is characterized as physiologically compatible; also disclosed are methods of using such solutions, implanting such viscous or viscoelastic substances, while minimizing the traumatic effect of surgery at the cellular level.
    Type: Grant
    Filed: November 16, 1992
    Date of Patent: April 25, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: Gerald Hecht, Ole J. Lorenzetti
  • Ophthalmic composition
    Patent number: 5407926
    Abstract: Pharmaceutical compositions useful in the treatment of ophthalmic inflammation and methods of treating ophthalmic inflammation with those compositions are disclosed. The compositions contain a combination of a glucocorticoid and an angiostatic steroid. The angiostatic steroid substantially prevents any significant increases in intraocular pressure which might otherwise be experienced by the patient as a side effect of the glucocorticoid component of the compositions. The therapeutic interaction of the two components therefore allows the potent anti-inflammatory properties of the glucocorticoids to be utilized without fear of elevating intraocular pressure.
    Type: Grant
    Filed: October 23, 1992
    Date of Patent: April 18, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventor: Abbot F. Clark
  • Physiological tear compositions and methods for their preparation
    Patent number: 5403598
    Abstract: Non-preserved physiological tear compositions comprise the ionic components of normal human tear film in substantially the same amounts and proportions. Novel methods of preparation of these compositions and novel packaging allow the maintenance of the bicarbonate concentration in these compositions.
    Type: Grant
    Filed: January 6, 1994
    Date of Patent: April 4, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: Robert E. Beck, Haresh G. Bhagat, Philip D. Gressel, Fred M. Killinger
  • Use of carrageenans in topical ophthalmic compositions
    Patent number: 5403841
    Abstract: Topical ophthalmic compositions of carrageenans which are administrable as a drop but which become more viscous or gel upon instillation in the eye are disclosed. Methods for use of the compositions as topical ophthalmic vehicles for pharmaceutically active agents, and alone as lubricants or tear supplements, are also disclosed.
    Type: Grant
    Filed: August 18, 1993
    Date of Patent: April 4, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: John C. Lang, Jamieson C. Keister, Paul J. T. Missel, Dimitri J. Stancioff
  • Pharmaceutical compositions and methods of treatment of the cornea in conjunction with laser irradiation
    Patent number: 5401509
    Abstract: Methods for preventing and treating corneal haze resulting from exposure of the eye to laser irradiation are disclosed. The methods include administration of compositions of wound healing modulators to the eye. Compositions for use in preventing and treating the corneal haze are also disclosed.
    Type: Grant
    Filed: July 25, 1994
    Date of Patent: March 28, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: Stella M. Robertson, Herman M. Kunkle, Jr.
  • Pharmaceutical compositions and methods of treatment of the cornea following laser irradiation
    Patent number: 5401510
    Abstract: Methods for preventing and treating corneal haze resulting from exposure of the eye to laser irradiation are disclosed. The methods include administration of compositions of wound healing modulators to the eye. Compositions for use in preventing and treating the corneal haze are also disclosed.
    Type: Grant
    Filed: July 25, 1994
    Date of Patent: March 28, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: Stella M. Robertson, Herman M. Kunkle, Jr.
  • Quaternary ammonium siloxane compounds and methods for their use
    Patent number: 5399737
    Abstract: Novel quaternary ammonium siloxane compounds and methods for their use are disclosed.
    Type: Grant
    Filed: April 4, 1994
    Date of Patent: March 21, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: Joonsup Park, Joseph J. Falcetta
  • Use of amidoamines in ophthalmic compositions
    Patent number: 5393491
    Abstract: Certain amidoamines, the use of same for disinfecting and cleaning contact lenses and preserving ophthalmic products, and associated ophthalmic compositions are described.
    Type: Grant
    Filed: September 22, 1993
    Date of Patent: February 28, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: Nissanke L. Dassanayake, Ronald L. Schlitzer, Joonsup Park
  • Surgical handpiece tip protector
    Patent number: D354283
    Type: Grant
    Filed: April 20, 1993
    Date of Patent: January 10, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: George W. Rhen, Jr., Gregory A. Auchter
  • Intraocular lens case
    Patent number: D360068
    Type: Grant
    Filed: March 22, 1994
    Date of Patent: July 11, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: Robert Hambleton, Stephen J. Van Noy