Patents Assigned to Alcon Laboratories
  • Use of certain sulfamoyl-substituted phenethylamine derivatives to reverse drug-induced mydriasis
    Patent number: 5288759
    Abstract: Certain sulfamoyl-substituted phenethylamine derivatives have been found to be useful in reversing or inhibiting drug-induced mydriasis. This application is especially useful in the area of diagnostics for eye examinations.
    Type: Grant
    Filed: August 27, 1992
    Date of Patent: February 22, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventor: Louis DeSantis, Jr.
  • Use of combinations of viscoelastics during surgery
    Patent number: 5273056
    Abstract: A method for conducting ocular surgery using different viscoelastic agents is disclosed.
    Type: Grant
    Filed: June 12, 1992
    Date of Patent: December 28, 1993
    Assignee: Alcon Laboratories, Inc.
    Inventors: Richard N. McLaughlin, Ole J. Lorenzetti
  • Pharmaceutical compositions and methods of treatment to prevent and treat corneal scar formation produced by laser irradiation
    Patent number: 5271939
    Abstract: Methods for preventing and treating corneal haze resulting from exposure of the eye to laser irradiation are disclosed. The methods include administration of compositions of wound healing modulators to the eye. Compositions for use in preventing and treating the corneal haze are also disclosed.
    Type: Grant
    Filed: April 10, 1992
    Date of Patent: December 21, 1993
    Assignee: Alcon Laboratories, Inc.
    Inventors: Stella M. Robertson, Herman M. Kunkle, Jr.
  • Sulfonamides useful as carbonic anhydrase inhibitors
    Patent number: 5240923
    Abstract: Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.
    Type: Grant
    Filed: October 9, 1991
    Date of Patent: August 31, 1993
    Assignee: Alcon Laboratories, Inc.
    Inventors: Thomas R. Dean, Hwang-Hsing Chen, Jesse A. May
  • Anti-inflammatory compounds for ophthalmic use
    Patent number: 5223493
    Abstract: Anti-inflammatory compounds, a method of treating inflamed ocular tissue and compositions of these compounds are described. The compounds are derivatives and analogues of known steroid compounds (e.g., dexamethasone) and are advantageously characterized in that they do not cause any significant increase in intraocular pressure during chronic use.
    Type: Grant
    Filed: March 17, 1992
    Date of Patent: June 29, 1993
    Assignee: Alcon Laboratories, Inc.
    Inventor: John J. Boltralik
  • Use of monoacyl phosphoglycerides to enhance the corneal penetration of ophthalmic drugs
    Patent number: 5221696
    Abstract: The use of monoacyl phosphoglycerides to enhance the penetration of topically applied ophthalmic drugs through the corneal epithelium is described.
    Type: Grant
    Filed: February 7, 1991
    Date of Patent: June 22, 1993
    Assignee: Alcon Laboratories, Inc.
    Inventors: Tai-Lee Ke, Eugene R. Cooper, Douglas F. Hager, Jamieson C. Keister
  • Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
    Patent number: 5212162
    Abstract: Ophthalmic compositions comprising combinations of gelling polysaccharides and finely-divided drug carrier substrates which become relatively more viscous on contact with the eye are disclosed. These ophthalmic compositions are both comfortable and long-lasting Ophthalmic compositions further comprising a pharmaceutically active drug are also disclosed, as are methods of use.
    Type: Grant
    Filed: March 25, 1992
    Date of Patent: May 18, 1993
    Assignee: Alcon Laboratories, Inc.
    Inventors: Paul J. T. Missel, John C. Lang, Rajni Jani
  • Control of post-surgical intraocular pressure using clonidine derivatives
    Patent number: 5212196
    Abstract: A method of controlling intraocular pressure by nonchronic, topical administration of a clonidine derivative immediately prior and post trauma to the affected eye.
    Type: Grant
    Filed: July 24, 1992
    Date of Patent: May 18, 1993
    Assignee: Alcon Laboratories, Inc.
    Inventors: Betty R. House, Joseph M. DeFaller, Billie M. York
  • Bicomposite intraocular lenses
    Patent number: 5211662
    Abstract: Bicomposite intraocular lenses and methods for their manufacture are disclosed. Bicomposite, hydrogel intraocular lenses with one or more haptic portions having a lower water content than the corresponding optic portions, and methods for their manufacture are disclosed. The bicomposite lenses are manufactured by (i) preparing a bicomposite button of hydrogel material containing one or more polymers or copolymers; (ii) lathing the button to produce a dehydrated intraocular lens with an optic and at least one haptic; and (iii) hydrating the lens.
    Type: Grant
    Filed: March 5, 1991
    Date of Patent: May 18, 1993
    Assignee: Alcon Laboratories, Inc.
    Inventors: Graham D. Barrett, Barry Stevens
  • Ophthalmic solution
    Patent number: 5209927
    Abstract: Disclosed is a liquid ophthalmic composition of unique rheological and lubricating properties comprising, inter alia, a polyanionic polymer for use as a long lasting artificial tear. Also disclosed is a method of treatment comprising topically administering the composition when indicated for relief of dry eye syndrome, foreign body sensation, burning, hyperemia, corneal staining, and the like.
    Type: Grant
    Filed: June 17, 1991
    Date of Patent: May 11, 1993
    Assignee: Alcon Laboratories, Inc.
    Inventors: Philip D. Gressel, Robert E. Roehrs, Robert G. Harris
  • Methods using antiallergics and antihistamines
    Patent number: 5192780
    Abstract: Compositions of an antiallergic compound and an antihistamine for preventing and treating ophthalmic allergic responses are disclosed. Methods for preventing and treating ophthalmic allergic responses with the compositions are also disclosed.
    Type: Grant
    Filed: July 23, 1991
    Date of Patent: March 9, 1993
    Assignee: Alcon Laboratories, Inc.
    Inventors: Billie M. York, Stella M. Robertson, John M. Yanni
  • Anti-glaucoma compositions
    Patent number: 5182102
    Abstract: Ophthalmic pharmaceutical compositions useful in controlling elevated intraocular pressure associated with glaucoma and ocular hypertension are described. The compositions comprise a combination of a beta-blocker to reduce the production of aqueous humor and carbachol to enhance the outflow of aqueous humor. A method of controlling elevated intraocular pressure with those compositions is also described.
    Type: Grant
    Filed: July 12, 1991
    Date of Patent: January 26, 1993
    Assignee: Alcon Laboratories, Inc.
    Inventors: Louis DeSantis, Jr., Rajni Jani
  • Methods for controlling intraocular pressure with transition metal complexes
    Patent number: 5177105
    Abstract: Methods for lowering elevated intraocular pressure resulting from the instillation to the eye of sodium hyaluronate during surgery by administration of transition metal complexes are disclosed.
    Type: Grant
    Filed: January 14, 1992
    Date of Patent: January 5, 1993
    Assignee: Alcon Laboratories, Inc.
    Inventors: Hans R. Moll, Mark T. DuPriest
  • Prostaglandin combinations in glaucoma therapy
    Patent number: 5173507
    Abstract: Disclosed is the use of combinations of the prostaglandins PGF.sub.2.alpha. and PGE.sub.2 and their respective derivatives, and pharmaceutically accceptable salts and esters thereof in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic, pharmaceutical compositions comprising said combinations.
    Type: Grant
    Filed: February 4, 1982
    Date of Patent: December 22, 1992
    Assignee: Alcon Laboratories, Inc.
    Inventors: Louis M. DeSantis, Verney L. Sallee
  • Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
    Patent number: 5153211
    Abstract: Disclosed are substituted or unsubstituted planar tricyclic fluorene or nuclear analogs thereof, spiro-coupled to a five-membered ring containing a secondary amide, and the pharmaceutically acceptable salts thereof. These compounds are useful, inter alia in the treatment of diabetes. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when indicated for, inter alia, long term, prophylactic treatment of the diabetes syndrome. A particularly preferred class of compounds comprise difluoro-dialkoxy substituted spiro-(9H-fluorene-9,4'-imidazolidine)-2',5-diones.
    Type: Grant
    Filed: August 27, 1991
    Date of Patent: October 6, 1992
    Assignee: Alcon Laboratories, Inc.
    Inventor: Billie M. York, Jr.
  • Thiophene sulfonamides useful as carbonic anhydrase inhibitors
    Patent number: 5153192
    Abstract: Thiophene sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.
    Type: Grant
    Filed: November 27, 1990
    Date of Patent: October 6, 1992
    Assignee: Alcon Laboratories, Inc.
    Inventors: Thomas R. Dean, Hwang-Hsing Chen, Jesse A. May
  • Intermediates in the preparation of chiral spirofluorenehydantoins
    Patent number: 5151544
    Abstract: Disclosed is a process for the synthesis of enantiomerically pure R and S isomers of 2,7-difluoro-4-methoxyspiro[9H-fluorene-9,4-imidazolidene]-2',5'-dione from 2,7-difluoro-4-methoxyfluorenone. Intermediate amino acid esters and urea esters and their preparation are also described.
    Type: Grant
    Filed: May 25, 1990
    Date of Patent: September 29, 1992
    Assignee: Alcon Laboratories, Inc.
    Inventors: Mark T. DuPriest, Raymond E. Conrow, Daniel Kuzmich
  • Combination of tobramycin and fluorometholone for topical ophthalmic use
    Patent number: 5149693
    Abstract: Disclosed are pharmaceutical compositions comprising tobramycin and fluorometholone or fluorometholone acetate for topical ophthalmic delivery and methods of treatment comprising administering said composition when indicated for infection and control of inflammatory response for optimal wound healing and normalization of the eye.
    Type: Grant
    Filed: November 22, 1989
    Date of Patent: September 22, 1992
    Assignee: Alcon Laboratories, Inc.
    Inventors: Gerald D. Cagle, Thomas O. McDonald, Allan L. Rosenthal
  • Combination of tobramycin and dexamethasone for topical ophthalmic use
    Patent number: 5149694
    Abstract: Disclosed are pharmaceutical compositions comprising tobramycin and dexamethasone for topical ophthalmic delivery and a method of treatment comprising administering said composition when indicated for infection and control of inflammatory response for optimal wound healing and normalization of the eye.
    Type: Grant
    Filed: November 22, 1989
    Date of Patent: September 22, 1992
    Assignee: Alcon Laboratories, Inc.
    Inventors: Gerald D. Cagle, Thomas O. McDonald, Allan L. Rosenthal
  • Ultraviolet absorbing hydrogels
    Patent number: 5133745
    Abstract: Two compounds, which are derivatives of 2(2-hydroxyphenyl) 2H-benzotriazole, are copolymerized with hydrogel forming monomers to form ultraviolet absorbing hydrogels. These hydrogels have many potential applications. For instance, they can be used to make contact lenses and intraocular lenses which are particularly useful for aphakics.
    Type: Grant
    Filed: April 24, 1991
    Date of Patent: July 28, 1992
    Assignee: Alcon Laboratories, Inc.
    Inventors: Joseph J. Falcetta, Joonsup Park, Christina G. Smith