Abstract: Soft and hard contact lenses are freed from deposits by rubbing them with a particulate organic polymer with a carrier, the polymer having a particular size in the range from about one micron to about 600 microns and a Rockwell hardness in the range of from about R120 to about M68, or a shore hardness in the range from about A15 to about D100.
Type:
Grant
Filed:
October 19, 1984
Date of Patent:
September 23, 1986
Assignee:
Alcon Laboratories, Inc.
Inventors:
Kai C. Su, Leslie F. Stebbins, Rajkumar P. Bhatia
Abstract: A contact lens cleaning solution containing an enzyme having proteolytic activity and a surfactant, and optionally also a chelating agent and urea, and a method of cleaning contact lenses utilizing this solution are described. The solution and method effectively remove deposits of proteinaceous material, mucins, lipids and calcium located either on or beneath the surface of the lens.
Abstract: Method of treating glaucoma comprising the topical or systemic application of an aldose reductase inhibitor; compositions comprising such inhibitors are also disclosed.
Abstract: Method of promoting healing of ocular wounds comprising the topical application of an aldose reductase inhibitor; compositions comprising such inhibitors are also disclosed.
Abstract: A nontoxic, aqueous, contact lens cleaning solution containing a mixture which includes a nonionic or weakly anionic surfactant, a chelating agent, a source of hydrated protons, and optionally also urea; and a method of chemically removing protein, lipid and calcium deposits from contact lens utilizing this solution are described.
Abstract: A method of controlling anterior segment ocular bleeding is described. The method utilizes various clonidine derivatives (e.g., p-aminoclonidine) as the hemostatic agent.
Type:
Grant
Filed:
December 14, 1984
Date of Patent:
May 6, 1986
Assignee:
Alcon Laboratories, Inc.
Inventors:
Louis M. DeSantis, Joseph M. deFaller, Billie M. York, Jr.
Abstract: Hemostatic-adhesive, collagen dressings in the form of dry-laid, non-woven, self-supporting webs of collagen fibers and methods for preparing those webs are disclosed. The webs are formed from a mass of hemostatic-adhesive, collagen fibers having a moisture content of from about 7% to about 15% by weight, and retain the hemostatic-adhesive properties of the mass of collagen fibers.
Abstract: The invention concerns a method and an apparatus for manufacturing a contact lens, through molding within water-tight molds. The polymerization of lenses is insured by arranging a number of molds within one or several sealed metallic chambers (9) constituting a resonant cavity of a unique mode for an ultra high frequency wave; these molds are positioned in an area of the cavity where the electromagnetic field approximately of ultra high frequency waves is homogeneous, and are distributed so that the amounts of basic composition to be polymerized act as a load fitted to the inside of said cavity.
Abstract: Xanthine derivatives are described which decrease the stinging associated with the application of ophthalmic acidic anti-inflammatory agents.
Abstract: A hand-held cannula assembly for irrigating and aspirating ophthalmic surgical sites includes an irrigation cannula circumscribed about an aspiration cannula and extending out through the forward end of the assembly from a reservoir for the irrigation fluid in the handle. Pressurized irrigation fluid is supplied to the reservoir through the rearward end of the handle and flows through openings in the irrigation cannula periphery into an annular flow passage between the two cannulas. An opening in the irrigation cannula issues the irrigation fluid at the surgical site. Aspiration fluid is drawn into the aspiration cannula which extends through the handle interior to an outflow opening at the rearward handle end.
Abstract: A tissue irrigating solution useful for irrigating animal tissue, such as ocular tissue and neuro tissue, during surgery, contains sodium, potassium, magnesium, calcium, chloride, and bicarbonate ions as well as dextrose and glutathione in proportions consistant with the osmotic stability and continued metabolism of the tissue cells. The irrigating solution is prepared by mixing a first basic solution which provides the bicarbonate and a second acidic solution which provides the calcium, magnesium, dextrose and glutathione. The first and second solutions may be stored as stable, sterile solutions for extended periods of time and mixed within 24 hours of use.
Type:
Grant
Filed:
February 22, 1984
Date of Patent:
October 29, 1985
Assignee:
Alcon Laboratories, Inc.
Inventors:
Michael E. Garabedian, Robert E. Roehrs
Abstract: The improved polymeric hydrogel suitable for use in forming soft contact lenses is described. The hydrogel is improved by means of its resistance to the formation of calcium, lipid and protein deposits thereon. This resistance is achieved by means of covalent modification of the hydrogel with a surfactant.
Abstract: Inhibition of aldose reductase activity with tetracyclic spiro-hydantoins, new tetracyclic spirohydantoin derivatives useful in the treatment of complications arising from diabetes mellitus, and a process for preparing spiro-imidazolidine-diones by reacting a mono- or di-fluorofluorene with an excess of oxygen and a tetralkyl- or arylalkyl-trialkyl-ammonium hydroxide are disclosed.
Abstract: Disclosed are substituted or unsubstituted planar tricyclic fluorene or nuclear analogs thereof, spiro-coupled to a five-membered ring containing a secondary amide, and the pharmaceutically acceptable salts thereof. These compounds are useful, inter alia, in the treatment of diabetes. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when indicated for, inter alia, long term, prophylactic treatment of the diabetes syndrome.
Abstract: This invention relates to ophthalmic compositions which comprise quaternary ammonium salt having the formula ##STR1## wherein X=a pharmaceutically acceptable anion, such compositions providing aqueous disinfecting solutions for contact lenses as well as a preserved ocular compositions including contact lens treating solutions comfort drop solutions, preserved saline solutions, ointments and other ocular medicaments.
Abstract: 2-(Trisubstituted phenylimino)-imidazole compounds also known as 2-(trisubstituted anilino)-1,3 diazacyclopentene-(2) compounds are used to lower intraocular pressure.
Abstract: Anti-acne preparations include finely divided, dispersed particles of benzoyl peroxide and finely divided, dispersed particles of salicylic acid in an aqueous gel formed from carboxy vinyl polymer resins. The gels are prepared without loss of salicylic acid by fully hydrating the resin in an aqueous medium and allowing the resin to gel in the absence of an alkaline neutralizing agent.
Type:
Grant
Filed:
October 5, 1981
Date of Patent:
April 30, 1985
Assignee:
Alcon Laboratories, Inc.
Inventors:
Nalinkant C. Damani, Haresh G. Bhagat, Ramon L. McElhaney
Abstract: The invention concerns a method for manufacturing a contact lens, through molding within water-tight molds. The polymerization of lenses is insured by arranging a number of molds within one or several sealed metallic chambers (9) constituting a resonant cavity of a unique mode for an ultra high frequency wave; these molds are positioned in an area of the cavity where the electromagnetic field approximately of ultra high frequency waves is homogeneous, and are distributed so that the amounts of basic composition to be polymerized act as a load fitted to the inside of said cavity.
Abstract: Soft and hard contact lenses are freed from deposits by rubbing them with a particulate organic polymer with a carrier, the polymer having a particular size in the range from about one micron to about 600 microns and a Rockwell hardness in the range of from about R120 to about M68, or a shore hardness in the range from about A15 to about D100.
Type:
Grant
Filed:
February 28, 1983
Date of Patent:
January 15, 1985
Assignee:
Alcon Laboratories, Inc.
Inventors:
Kai C. Su, Leslie F. Stebbins, Rajkumar P. Bhatia