Abstract: Methods, systems, and software for controlling infusion pressure, such as during a medical procedure, using systemic blood pressure are described. Systemic blood pressure, such as brachial arm blood pressure or radial artery blood pressure, may be used to estimate central retinal artery blood pressure to estimate critical closing pressure. Further, the disclosure relates to controlling infusion pressure to prevent an increase in intraocular pressure above the estimated critical closing pressure when such is not desired, and, when such is desired, using systemic blood pressure and infusion pressure to control an intentional increase in intraocular pressure above the estimated critical closing pressure to stop intraocular bleeding.

Abstract: An acoustic streaming fluid ejector includes a fluid filled chamber having an opening, a selectively vibrating flow generator having a sharp edge pointed toward the opening, and a driving device configured to vibrate one of the flow generator and the chamber to create a streaming fluid flow in a direction away from the sharp edge through the opening. Methods are also disclosed.

Abstract: An acoustic streaming valve arrangement induces flow in a glaucoma drainage device. The arrangement may include a selectively vibrating flow generator having a sharp edge and a driving device configured to selectively vibrate the flow generator to create a streaming fluid flow in a direction away from the sharp edge.

Abstract: Certain embodiments may include a laser system configured to emit collimated laser light, a beam diverging element configured to diverge the laser light to yield a range of propagation angles with a maximum angle greater than zero, and fiber coupling optics configured to direct the diverged laser light towards a spot of a cross-section of a fiber core of an optical fiber. As another example, certain embodiments may include a laser system configured to emit collimated laser light, a beam shaping element configured to shape the laser light into a beam with an elliptical cross-section, and fiber coupling optics configured to direct the diverged laser light towards a spot of a cross-section of a fiber core of an optical fiber, where the spot's center point is located at a distance from the cross-section's center point.

Abstract: Various systems and techniques may be used for moisturizing an eye during ocular surgery. In particular implementations, a system and a technique for moisturizing an eye may include the ability to determine whether an eye should be moisturized during ocular surgery and to activate a fluid control device if an eye should be moisturized. The activation of the fluid control device may allow fluid flow from a fluid reservoir to a fluid nozzle coupled to a nozzle mounting device adapted to hold the fluid nozzle stable relative to a patient's eye. The system and the technique may also include the ability to deactivate the fluid control device.

Abstract: Techniques, systems are described for performing laser eye surgery. In one aspect, a method for improving an optical function of an eye includes preparing the eye for surgery by determining an optical characteristic of the eye. Laser marking pulses are applied to generate a laser mark in a region of the eye in relation to the determined optical characteristic. Also, a surgical procedure is performed in a surgical region selected in relation to the generated laser mark.

Abstract: Various systems and techniques for inserting an intraocular lens are disclosed. In particular implementations, a system and a technique for inserting an intraocular lens may include the ability to move, in response to a force being applied in a first direction along a longitudinal axis, a first plunger tip along the longitudinal axis and into a delivery cartridge to fold an intraocular lens and move in a second direction along the longitudinal axis in response to the applied force being reduced. The system and the technique may also include the ability to engage a second plunger tip and move, in response to a force being applied in the first direction along the longitudinal axis, the second plunger tip along the longitudinal axis and into the delivery cartridge to insert the intraocular lens.

Abstract: An optical surgical probe includes a handpiece, a light guide within the handpiece, and a multi-spot generator at a distal end of the handpiece. The handpiece is configured to optically couple to a light source. The light guide is configured to carry a light beam from the light source to a distal end of the handpiece. The multi-spot generator includes a faceted optical element with a faceted end surface spaced from a distal end of the light guide. The faceted end surface includes at least one facet oblique to a path of the light beam.

Abstract: An acoustic streaming arrangement supplements irrigation flow to a surgical site. The acoustic streaming arrangement may include an irrigation conduit configured to carry an irrigation fluid to a surgical site, a selectively vibrating flow generator having a sharp edge, and a driving device configured to selectively vibrate the flow generator to create a streaming fluid flow in a direction away from the sharp edge through the irrigation conduit. Systems and methods are also disclosed.

Abstract: A guarded surgical knife handle includes a handle portion with a blade holder, a chamber within the handle portion, and a slot. The guarded surgical knife handle also includes a guard having an open distal end slidably mounted within the handle portion that can slide longitudinally between an unguarded position and a guarded position. The guard is sized to surround the blade in the guarded position. The guarded surgical knife handle also includes a latch that latches the guard when the guard is slid into the guarded position and a first button that disengages the latch. The guarded surgical knife handle includes a bias member that forces the guard in a proximal direction to an unguarded position when the latch is disengaged along with a second button extending through the slot used to slide the guard in a distal direction into the guarded position.

Abstract: An injection device has a dispensing chamber housing, a plunger, and a temperature control device. The dispensing chamber housing has a first part and a second part. The first part is thermally coupled to a needle. The second part is thermally coupled to the first part. The second part has an inner surface and an outer surface. The inner surface partially defines a dispensing chamber for holding a quantity of a substance. The plunger is engaged with an inner surface of the dispensing chamber housing, is capable of sliding in the dispensing chamber housing, and is fluidly sealed to the inner surface of the dispensing chamber housing. The temperature control device at least partially surrounds the dispensing chamber housing and is capable of altering a temperature of the substance in the dispensing chamber. The second part has a greater thermal coefficient than the first part.

Abstract: An intraocular lens (IOL) delivery device is disclosed. The device includes an intraocular lens cartridge having an internal coating wherein the coating includes a polymeric material that is compatible with a polymeric material of a material that forms the cartridge. Preferably, the polymeric material of the coating, the cartridge or both is a polyurethane material.

Abstract: A surgical system having feedback control for pneumatic actuators includes a pneumatic pressure source and a vitrectomy cutter having a cutting mechanism, a first pneumatic input port, and a second pneumatic input port. A pneumatic actuator is configured to direct pneumatic pressure to one of the first and second pneumatic input ports. A first pressure transducer is located and configured to detect actual pressure at the first pneumatic input port, and a second pressure transducer is located and configured to detect actual pressure at the second pneumatic input port. A controller communicates with the first and second pressure transducers and the pneumatic actuator. It is configured to change the pneumatic actuator actuation timing based on the data communicated from the first and second pressure transducers.

Abstract: Vitrectomy probes and system related thereto are disclosed herein. The disclosure describes various example vitrectomy probes having an adjustable cutting port size. Various example features are described for adjusting the size of the cutting port. Further, the disclosure provides examples for adjusting the size of the cutter port while the vitrectomy probe is in operation.

Abstract: The present invention is directed to the provision of pharmaceutical compositions. The compositions include a therapeutic agent and a relatively low amount of surfactant for providing higher bioavailability of the therapeutic agent. The compositions are particularly desirable as ophthalmic compositions in which the therapeutic agent is a prostaglandin such as travoprost and the surfactant is a vegetable oil such as castor oil.

Abstract: An intraocular pressure sensor system has a first pressure sensor located in an anterior chamber of an eye and a remote pressure sensor located remotely from the first pressure sensor. The remote pressure sensor measures or approximates atmospheric pressure. A difference between readings from the first pressure sensor and the remote pressure sensor approximates intraocular pressure.

Abstract: Various embodiments of a capsulotomy repair device include a resistive-heating element comprising an electrically resistive, superelastic wire forming a loop between first and second ends of the superelastic wire. The first and second ends of the loop may at least partially extend at an angle from a planar face defined by the loop, to an insulating portion, to form a transitional neck between the loop and the insulating portion. The capsulotomy repair device may be positioned in the eye relative to a capsularhexis perimeter to overlap tears in the capsularhexis perimeter to remove the tears by forming an adjusted capsularhexis perimeter by burning around the tear.

Abstract: In various embodiments, a surgical console may include a pneumatic valve to drive a pneumatic tool coupled to the surgical console. The console may further include a controller operable to control and adjust the valve open/close cycle times according to a valve duty cycle. The valve may switch between ports (valve open time for a first port and valve close time for a second port) such that a total valve time may approximately equal the valve open time plus the valve close time. The valve duty cycle may indicate a percentage of the total valve time for the controller to signal the valve to open and may include an adjustment that corresponds to a signal timing of the open and/or closed valve positions that will result in open and closed operating pressures above a predetermined threshold.

Abstract: scFv antibodies which specifically bind selected antigens and are obtainable by a method comprising (i) selecting from a pool of soluble and stable antibody frameworks a soluble and stable framework matching best the framework of a non-human antibody against the antigen with a certain binding specificity, (ii) either providing said soluble and stable framework with CDRs that bind specifically to said antigen, or mutating the framework of said non-human antibody towards the sequence of said soluble and stable framework, to generate scFv antibodies, (iii) testing the generated antibody for solubility and stability, and testing the generated antibody for antigen binding, and (iv) selecting an scFV that is soluble, stable and binds to the antigen specifically. Also provided are pharmaceutical compositions comprising said scFv antibody, methods of treatment and diagnosis for diseases related to over expression of antigens that are specifically bound by said antibody.

Abstract: A surgical probe, e.g. a vitrectomy probe, and methods of making the same are disclosed. An exemplary surgical probe may include a tubular body and a cutting tool that is received within the body. The tubular body may define a cutting aperture that is adjacent a first end of the body and a fluid passage that extends through the body from the cutting aperture to a second end of the body. The cutting tool may be received within the body and disposed within the fluid passage. The cutting tool is generally configured to allow fluid flow through the cutting tool. The cutting tool may include a body portion and a blade portion that is configured to cut material entering the cutting aperture. The body portion may extend only partially about an inner circumference of the tubular body.