Abstract: In various embodiments, a trocar cannula may be configured for insertion into an eye to facilitate insertion and removal of instruments during surgery. The cannula may be affixed to an overcap (to inhibit rotation of the overcap relative to the cannula) that includes a seal. In some embodiments, the seal may be overmolded into the overcap or may include a wafer that is fixed between the cannula and the overcap to inhibit rotation relative to the cannula and the overcap. In some embodiments, the cannula and overcap may snap together through a tab/slot interface in a permanent fashion such that the cannula and overcap may not be separated without damaging the cannula or overcap. In some embodiments, a vent cannula may be receivable in the slit of the seal for allowing fluids to vent from the eye through the cannula (which may include an indentation to frictionally engage the vent).

Abstract: An ophthalmic surgical laser system includes a laser engine, to generate a laser beam, a first Z scanner, to receive the generated laser beam, and to scan a focal spot of the laser system over a first Z interval along an optical axis of the laser system an XY scanner, to receive the laser beam output by the first Z scanner, and to scan the focal spot of the laser system in a direction essentially transverse to the optical axis of the laser system, and a second Z scanner, to receive the scanned laser beam from the XY scanner, and to scan the focal spot of the laser system over a second Z interval along the optical axis of the laser system.

Abstract: Embodiments of this disclosure provide an apparatus and method for gas and debris management. The apparatus comprises a surgical cassette, wherein the surgical cassette is at least partially formed of a cassette material defining a chamber. The surgical cassette has a floor and a plurality of walls. The apparatus also has a drain conduit with a drain entry and a drain exit. The drain entry is connected to the chamber near the floor. The drain conduit has a top portion and a bottom portion. The apparatus also has an aspiration conduit. The aspiration conduit has an aspiration port and an aspiration exit. The aspiration conduit is in liquid communication with the chamber and the drain conduit. At least a portion of the top portion of the drain conduit is positioned above at least a portion of the aspiration exit.

Abstract: The present invention is related to pharmaceutical compositions that include a phosphonium antimicrobial agent. In a preferred embodiment, the present invention relates to an otic, nasal or ophthalmic composition (e.g., an aqueous ophthalmic solution) that includes a phosphonium salt compound as an antimicrobial agent. The compositions typically possess sufficient antimicrobial activity to satisfy USP preservative efficacy requirements and/or similar preservative standards (e.g., EP and JP).

Abstract: The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNF, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNF-mediated disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.

Abstract: RNA interference is provided for inhibition of phosphodiesterase type 4 mRNA expression for treating patients with a cAMP-related ocular disorder. Phosphodiesterase type 4 mRNA targets include mRNA for 4A, 4B, 4C, and 4D phosphodiesterase isoforms.

Abstract: Ophthalmic, otic and nasal compositions containing a new class of antibiotics (e.g., moxifloxacin) are disclosed. The compositions preferably also contain one or more anti-inflammatory agents. The compositions may be utilized to treat ophthalmic, otic and nasal conditions by topically applying the compositions to the affected tissues.

Abstract: The present disclosure relates in general to an apparatus and method for priming a liquid or surgical cassette. In one embodiment, an infusion system within the liquid cassette is primed using a forward flow of a liquid and a backward flow of the liquid. The forward flow of the liquid creates a first volume of liquid stored within an infusion conduit, which is connected to an infusion chamber via a first valve. The infusion conduit has an infusion port exposed to a non-liquid environment having a first pressure. A second pressure is created in the infusion chamber that is lower than the first pressure. Opening the first valve causes a second volume of liquid within the infusion conduit to flow over the first valve and towards the infusion chamber. The second volume of liquid is less than or equal to the first volume of liquid.

Abstract: A system for the removal of vitreous humor and other fluids from an eye and the reinjection of filtered vitreous humor into the eye is provided. The system comprises a hollow removal device, a filter, and an infusion device. The removal device includes an element configured to cut the vitreous humor and is configured to aspirate the vitreous humor from the eye. The filter is configured to create a filtered form of vitreous humor by separating the vitreous humor from undesired components in the vitreous humor. The infusion device is fluidly coupled to the filter and is configured to return the filtered form of vitreous humor into the eye.

Abstract: An exemplary surgical probe and methods of making the same are disclosed. An exemplary surgical probe may include a tubular body and a scissor assembly received at least partially within the body. The scissor assembly may include a first blade fixed to the tubular body that includes a body portion and an end portion. The scissor assembly may further include a second blade that is configured to move longitudinally within the tubular body. The body portions of the first and second blades may each define respective cross sections normal to a longitudinal axis of the tubular body. The cross sections may each define centrally disposed edges adjacent one another, and the cross sections may each be asymmetrical about a line substantially parallel to the centrally disposed edges.

Abstract: A process for producing an interface unit and also a group of such interface units are specified. The interface unit exhibits a first reference surface for beaming in radiation, a second reference surface for emitting the radiation, and an axis extending in the direction from the first to the second reference surface. The production process comprises the steps of setting an optical path length of the interface unit between the first and second reference surfaces along the axis and the fixing of the set optical path length of the interface unit. The optical path length of the interface unit is set in such a way that radiation of a defined numerical aperture beamed in at the first reference surface exhibits a focus location that is predetermined with respect to the second reference surface in the direction of the axis. A precise and uniform focus location with respect to the second reference surface is obtained.

Abstract: Disclosed is an exemplary surgical illumination system that includes a first laser configured to emit a first light beam having a first spectral range, and an illumination probe optically connectable to the first laser. The first laser may be configured as a supercontinuum laser. The surgical illumination system may include a second laser configured to emit a second light beam having a second spectral range, and a beam combiner for combing the first and second laser beams to form a third laser beam having a spectral range of the first and second lasers. The illumination probe includes a fiber optic cable for delivering at least a portion of the first light beam to a surgical site. The fiber optic cable includes a fiber optic core having a diameter of 100 microns or less.

Abstract: In some embodiments, a method of using feedforward to control a system component may include determining if a feedforward term exists in a feedforward table for a received operating set point. If a feedforward term does not exist, the system component may be incremented until the system is within a first acceptable tolerance of the desired set point. In some embodiments, a measure of steady state error may be determined and compared to a second acceptable tolerance. If within the acceptable tolerance, the corresponding feedforward term may be recorded in the feedforward table. In some embodiments, if the feedforward term exists for the operating set point, the system component may be controlled using controller output that corresponds to the feedforward term. When a change to the system is detected that is associated with possible changes to the feedforward values, new feedforward values may be generated for the feedforward table.

Abstract: An ophthalmic illuminator includes a one or more light combining stages arranged in series to augment a white light source with various color spectral bands. A first stage combines white light from a white light source with colored light from a first color source. Each subsequent stage in the series adds its own respective colored light. The color sources may be selectively turned on/off or driven with variable amounts of power. In this fashion, a combined light is produced by the final stage that represents a desired chromaticity and brightness as desired for a particular ophthalmic therapeutic procedure.

Abstract: The invention provides a delivery system comprising a cell penetrating peptide, a polyarginine peptide, and an interfering RNA molecule. The system can be used for delivering interfering RNA molecules into a cell in vivo or in vitro. Therapeutic uses for the delivery system are also provided.

Abstract: Disclosed is an exemplary surgical system employing a temperature controlled docking station. The surgical system may include an articulating arm that is selectively moveable within a range of positions. A tray for receiving items used in performing a procedure may be attached to the articulating arm. The docking station may be attached to the tray. The docking station may include a heating element for selectively heating the docking station, a temperature sensor for monitoring a temperature of the docking station, and a reader configured for collecting information associated with an article placed in the docking station. The surgical system may also include a controller operably connected to the heating element, the temperature sensor, and the reader. The controller may be configured to adjust a heat output of the heating element in response to a signal received from the temperature sensor and/or the reader.

Abstract: An intraocular lens injection device comprises a tubular housing with a plunger longitudinally disposed within the tubular housing. An electric drive system longitudinally translates the plunger so that its tip engages an insertion cartridge to fold and displace an intraocular lens disposed within and to inject the folded lens into the lens capsule of an eye. A control circuit is configured to start translation of the plunger, responsive to user input, to detect at least one fault condition based on a counter-electromotive force produced by the electric motor, and to stop translation of the plunger assembly responsive to the detected fault condition, which may comprise excessive resistance to forward or rearward translation of the plunger or insufficient resistance to forward translation of the plunger.

Abstract: In various embodiments, a phacoemulsification cutting tip with a straight shaft and an angled portion off of the straight shaft may include a hook on the angled portion to move an axis of rotation of the cutting tip closer to alignment with an extended centerline of the shaft. The cutting tip may be configured to torsionally rotate back and forth on an axis perpendicular to a centerline of the shaft (e.g., rotation around a y-axis). In some embodiments, lateral vibrations (e.g., side to side along an x-axis or z-axis perpendicular to the y-axis) that result from torsional rotation around the y-axis in a cutting tip without the hook may be reduced through use of the hook to balance the otherwise eccentrically weighted hook.

Abstract: Embodiments of the invention refer to a system for registering and tracking the position of a person's eye, in particular for refractive ophthalmic surgery. According to embodiments, the system is structured such that eye images containing at least the iris and the pupil of the eye are made at a first wavelength of light and that eye images containing scleral blood vessels are made at a different second wavelength of light. The invention furthermore refers to a corresponding method for registering and tracking the position of a person's eye.

Abstract: An infusion sleeve has a flexible tube enclosing a lumen. The tube has a plurality of wall segments, each wall segment located between the lumen and an exterior surface of the tube and extending parallel to a central axis of the tube. The plurality of wall segments includes at least two thick wall segments and at least two thin wall segments alternately arranged such that each thick wall segment is adjacent to two thin wall segments, and each thin wall segment is adjacent to two thick wall segments.