Abstract: Disclosed are novel compounds having NPR-B agonistic activity. Preferred compounds are linear peptides containing 8-13 conventional or non-conventional L- or D-amino acid residues connected to one another via peptide bonds.

Abstract: An exemplary surgical probe and methods of making the same are disclosed. An exemplary surgical probe may include a tubular body and a scissor assembly received at least partially within the body. The scissor assembly may include a first blade fixed to the tubular body that includes a body portion and an end portion. The scissor assembly may further include a second blade that is configured to move longitudinally within the tubular body. The body portions of the first and second blades may each define respective cross sections normal to a longitudinal axis of the tubular body. The cross sections may each define centrally disposed edges adjacent one another, and the cross sections may each be asymmetrical about a line substantially parallel to the centrally disposed edges.

Abstract: Vascular endothelial growth factor A (VEGFA) is a chemical signal produced by cells that stimulates the growth of new blood vessels, and overexpression of VEGFA can lead to undesirable physiological conditions. Through the identification of new siRNA and modifications that improve the silencing ability of these siRNA in vivo, therapeutic compositions and methods have been invented to address the problems associated with this overexpression.

Abstract: Vitrectomy probes and system related thereto are disclosed herein. The disclosure describes various example vitrectomy probes having an adjustable cutting port size. Various example features are described for adjusting the size of the cutting port. Further, the disclosure provides examples for adjusting the size of the cutter port while the vitrectomy probe is in operation. Some implementations disclosed herein include a piezoelectric element operable to adjust a position of a stroke limiter to define a size of the cutter port.

Abstract: In various embodiments, an ophthalmic surgical instrument may include an aspiration tube, an irrigation/aspiration tip (formed of a first material such as plastic), and a patch, coupled to the irrigation/aspiration tip, made of a second material (e.g., silicone) having a higher coefficient of friction than the first material. In some embodiments, the patch may be placed on the irrigation/aspiration tip in a position to allow a user of the irrigation/aspiration tip to manipulate an intraocular lens (IOL) through contact between the patch and the IOL. For example, the patch may be positioned on a side of the irrigation/aspiration tip opposite an aspiration port or on a distal end of the irrigation/aspiration tip. In some embodiments, the patch may be formed separately and coupled to the irrigation/aspiration tip through an adhesive or may be molded onto the irrigation/aspiration tip. In some embodiments, the patch may include features to increase friction.

Abstract: Disclosed are novel compounds having NPR-B agonistic activity. Preferred compounds are linear peptides containing 8-13 conventional or non-conventional L- or D-amino acid residues connected to one another via peptide bonds.

Abstract: A glaucoma drainage device has a housing with an open outlet end. A tube is in fluid communication with the housing. An actuator is located in the housing. An actuation arm is located at least partially in the housing and is coupled to the actuator. A tapered arm is rigidly coupled to the actuation arm. A needle head is located opposite the tapered arm. A tapered end of the tapered arm is located at least partially in the tube. When the tapered arm is moved, it can clear an obstruction from the tube. When the needle head is moved, it can disperse aqueous or clear fibers from the drainage location.

Abstract: Pulse-generator circuits that permit independent control of pulse widths and the delays between successive pulses. In several embodiments, a pulse-generator subcircuit includes a transmission-line segment comprising first and second conductors, configured such that the first conductor is coupled to a first DC potential. The pulse-generator subcircuit further includes a terminating resistor coupled to a first end of the second conductor of the first transmission-line segment; this terminating resistor is matched to the characteristic impedance of the transmission-line segment. The pulse-generator subcircuit further includes first and second switches, controlled by first and second timing signals, respectively, and configured to selectively and independently connect respective first and second ends of the first conductor to a second DC potential.

Abstract: Embodiments of endo-illuminators and related methods are disclosed. One embodiment of an illuminator can comprise a cannula defining a passage, an optical element disposed at an end of the cannula, and an optical fiber running through the passage with the distal end of the optical fiber in contact with the optical element. The optical fiber includes at least a heat preconditioned distal portion that terminates in the distal end that is in contact with the optical element.

Abstract: RNA interference is provided for inhibition of tumor necrosis factor ? (TNF?) by silencing TNF? cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNF? converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNF? targets, in particular, is useful for treating patients having a TNF?-related condition or at risk of developing a TNF?-related condition such as the ocular conditions dry eye, allergic conjunctivitis, or ocular inflammation, or such as dermatitis, rhinitis, or asthma, for example.

Abstract: Hydraulic vitrectomy probes and methods and systems associated therewith are discussed. Example hydraulic vitrectomy probes may include a pressure multiplier that is operable to output a hydraulic pressure at a multiple of a received pneumatic pressure. Because of the incompressible nature of liquid, hydraulic vitrectomy probes are, among other things, more responsive, may be operated at higher cutting rates, provide improved patient safety, and have a form factor (e.g., size and/or shape) that may be more easily maneuvered by a surgeon.

Abstract: RNA interference is provided for inhibition of HIF1A mRNA expression for treating patients with ocular angiogenesis, particularly for treating retinal edema, diabetic retinopathy, sequela associated with retinal ischemia, posterior segment neovascularization (PSNV), and neovascular glaucoma, and for treating patients at risk of developing such conditions.

Abstract: The present invention relates to viscosity stabilized ophthalmic formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a diol alcohol such as sorbitol and, optionally, a pharmaceutically acceptable divalent cation salt such as magnesium chloride.

Abstract: The present invention relates to methods for treating an ophthalmic, otic, or nasal infection comprising treating the infected tissue with a composition comprising finafloxacin or a finafloxacin derivative. The present invention also relates to antimicrobial compositions comprising finafloxacin or a finafloxacin derivative. The compositions are suitable for the treatment of ophthalmic, otic, or nasal infections.

Abstract: The present invention relates to processes for purifying guar comprising combining borate and guar in an aqueous solution and treating the aqueous solution with an organic solvent to induce precipitation of purified guar. Another embodiment of the present invention is directed to ophthalmic formulations comprising purified guar produced by the processes described.

Abstract: Devices, systems, and associated methods that facilitate the injection and/or aspiration of precisely controlled volumes of fluids at precisely controlled rates are provided. In some implementations, an apparatus may include a syringe and a lead screw connected to a plunger of the syringe. A ratchet gear may be connected to the lead screw. A mechanism may also be included to oscillate a frame in a direction perpendicular to a longitudinal axis of the lead screw such that one or more pawls of the frame engage the teeth of the ratchet gear in a manner that results in rotation of the ratchet gear in a single direction for controlled linear displacement of the plunger.

Abstract: A method of testing visual performance includes determining a difficulty rating for each of a plurality of visual recognition tests. The method further includes displaying one of the visual recognition tests to a subject and receiving from the subject a response to the visual recognition test. After receiving the response to the visual recognition test, a subsequent visual recognition test is selected to have a difficulty rating determined based on the response received from the subject, the subsequent visual recognition test is displayed, and a response is received from the subject. The subsequent visual recognition tests are repeated until a predetermined number of responses is reached. A visual performance score is determined based on the set of responses received from the subject and the difficulty ratings for the visual recognition tests displayed to the subject is then output.

Abstract: A method for generating a radial alignment guide for an eye includes collecting preoperative corneal topography data. The data includes a corneal vertex location and a pupil center location for an eye that is not dilated. The method then includes locating a dilated pupil center for the eye after the eye is dilated. The method further includes determining an adjusted offset between the corneal vertex and the dilated pupil center and displaying alignment data on an image of the eye based on the adjusted offset.

Abstract: An improved viscoelastic composition useful in the performance of ophthalmic surgical procedures and especially cataract procedures is disclosed. The embodiments of the composition comprise combinations of sodium hyaluronate and chondroitin sulfate and exhibit an improved rheological profile.

Abstract: A surgical system that is able to sense the onset of an occlusion or other surgical event as well as when an occlusion breaks. To help avoid overheating of the tip, the system of the present invention predicts the temperature of the eye using irrigation flow rate and reduces the power to the handpiece automatically if an overheating situation is predicted. Alternatively or in addition, the system of the present invention monitors the power drawn by the handpiece, which is indicative of the cutting load on the tip, and automatically adjusts the power or stroke of the tip to compensate for increased loads on the tip.