Patents Assigned to Alcon
  • Ophthalmic injection method
    Patent number: 7815603
    Abstract: A method of delivering a substance into an eye includes recognizing a connection between a tip segment and a limited reuse assembly; receiving dosage information from the tip segment; activating a temperature control device to alter a temperature of a substance to be delivered into an eye; receiving temperature information from a thermal sensor; using the temperature information to control the temperature control device; receiving an input indicating that the substance is to be delivered; and based on the dosage information, controlling an actuator to move a plunger to deliver the substance.
    Type: Grant
    Filed: August 1, 2007
    Date of Patent: October 19, 2010
    Assignee: Alcon Research, Ltd.
    Inventors: Bruno Dacquay, Cesario Dos Santos, James Foster, Robert Sanchez
  • PAI-1 BINDING MODULATORS FOR THE TREATMENT OF OCULAR DISORDERS
    Publication number: 20100260784
    Abstract: The invention concerns in one embodiment a method for treating glaucoma or elevated IOP in a patient comprising administering to the patient an effective amount of a composition comprising an agent that modulates PAI-1 binding to vitronectin. In another embodiment, the invention concerns a method of manufacturing a compound to be used as a treatment for glaucoma or elevated IOP comprising providing a candidate substance suspected of modulating PAI-1 binding, selecting the compound by assessing the ability of the candidate substance to decrease the amount of active PAI-1 in the trabecular meshwork of a subject suffering from glaucoma or elevated PAI-1, and manufacturing the selected compound.
    Type: Application
    Filed: June 25, 2010
    Publication date: October 14, 2010
    Applicant: ALCON RESEARCH, LTD.
    Inventors: Debra L. Fleenor, Iok-Hou Pang, Abbot F. Clark
  • Method of controlling a surgical system based on a rate of change of an operating parameter
    Patent number: 7811255
    Abstract: A surgical system that is able to sense the onset of an occlusion or other surgical event as well as when an occlusion breaks. To help avoid overheating of the tip, the system of the present invention predicts the temperature of the eye using irrigation flow rate and reduces the power to the handpiece automatically if an overheating situation is predicted. Alternatively or in addition, the system of the present invention monitors the power drawn by the handpiece, which is indicative of the cutting load on the tip, and automatically adjusts the power or stroke of the tip to compensate for increased loads on the tip.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: October 12, 2010
    Assignee: Alcon, Inc.
    Inventors: Mikhail Boukhny, Raphael Gordon, Michael D. Morgan, Ann Yadlowsky
  • Dosage control device
    Patent number: 7811252
    Abstract: An injection device includes a dispensing chamber, a plunger, a controller, a memory device resistant to sterilization, and a housing at least partially enclosing the dispensing chamber and the plunger. The dispensing chamber has an inner surface and an outer surface. The inner surface defines a cavity for receiving a quantity of a substance. The plunger is engaged with the inner surface of the dispensing chamber, is capable of sliding in the cavity of the dispensing chamber, and is fluidly sealed to the inner surface of the dispensing chamber. The controller controls the operation of the injection device. The controller reads dosage data from the memory device and operates the injection device to deliver a dosage corresponding to the dosage data.
    Type: Grant
    Filed: March 20, 2007
    Date of Patent: October 12, 2010
    Assignee: Alcon Research, Ltd.
    Inventors: Bruno Dacquay, Cesario Dos Santos, Casey Lind
  • Use of bradykinin and related BR agonists to treat ocular hypertension and glaucoma
    Patent number: 7807629
    Abstract: The invention provides methods for treating and/or preventing ocular disorders associated with increased intraocular pressure comprising administering a bradykinin B2 receptor agonist to a patient in need thereof.
    Type: Grant
    Filed: June 5, 2008
    Date of Patent: October 5, 2010
    Assignee: Alcon Research, Ltd.
    Inventor: Najam A. Sharif
  • Pressurized irrigation squeeze band
    Patent number: 7806865
    Abstract: A pressurized infusion device has a flexible band with first and second ends, a curved base, and a bag containing fluid. The bag is located between the flexible band and the curved base. The second end of the flexible band is coupled to a shaft. A motor is also coupled to the shaft. The motor is actuated to turn the shaft and produce tension in the band thereby changing the fluid pressure in the bag.
    Type: Grant
    Filed: May 20, 2009
    Date of Patent: October 5, 2010
    Assignee: Alcon Research, Ltd.
    Inventor: Daniel J. Wilson
  • Superoxide dismutase-2 expression for glaucoma diagnosis
    Patent number: 7807363
    Abstract: The present invention concerns a method for diagnosing or monitoring elevated intraocular pressure or glaucoma in a patient comprising providing a biological sample from the patient and measuring the expression level of a superoxide dismutase-2 (SOD-2) gene in the biological sample. The present invention also concerns methods for treating glaucoma or elevated intraocular pressure in a patient comprising administering to a patient an effective amount of an agent that modulates SOD-2 expression or SOD-2 activity.
    Type: Grant
    Filed: February 28, 2007
    Date of Patent: October 5, 2010
    Assignee: Alcon Research, Ltd.
    Inventors: Wan-Heng Wang, Loretta Graves McNatt, Abbot F. Clark, Peter G. Klimko
  • Diagnostics and therapeutics for glaucoma
    Patent number: 7807355
    Abstract: Methods and compositions for diagnosing and treating glaucoma are disclosed.
    Type: Grant
    Filed: January 6, 2006
    Date of Patent: October 5, 2010
    Assignees: Alcon, Inc., University of Iowa Research Foundation
    Inventors: Abbot F. Clark, John Fingert, Loretta McNatt, Edwin M. Stone, Wan-Heng Wang
  • ANTAGONISTS OF CI-M6P/IGF2R FOR PREVENTION AND TREATMENT OF CTGF-MEDIATED OCULAR DISORDERS
    Publication number: 20100247548
    Abstract: Antagonists of cation-independent mannose 6-phosphate/insulin-like growth factor-II receptor are provided for attenuation of CTGF signaling in a method of down-regulation of receptor signaling and downstream decreased signaling of connective tissue growth factor in ocular disorders involving inappropriate CTGF signaling. Ocular disorders involving inappropriate CTGF signaling include ocular hypertension, glaucoma, glaucomatous retinopathy, optic neuropathy, macular degeneration, diabetic retinopathy, choroidal neovascularization, and proliferative vitreoretinopathy, for example. Such disorders are treated by administering antagonists of the present invention.
    Type: Application
    Filed: June 9, 2010
    Publication date: September 30, 2010
    Applicant: Alcon Research, Ltd.
    Inventors: Allan R. Shepard, Debra L. Fleenor, Abbot F. Clark, Najam A. Sharif
  • Use of Beta-Adrenoceptor Antagonists for the Manufacture of a Medicament for the Treatment of Disorders of the Outer Retina
    Publication number: 20100249134
    Abstract: Compositions and methods for treating disorders of the outer retina with ?-adrenoceptor antagonists are disclosed.
    Type: Application
    Filed: June 9, 2010
    Publication date: September 30, 2010
    Applicant: ALCON, INC.
    Inventors: Robert J. Collier, Jr., Louis DeSantis, JR., Michael A. Kapin
  • UV-absorbers for ophthalmic lens materials
    Patent number: 7803359
    Abstract: UV absorbing compounds that are particularly useful in ophthalmic devices are disclosed.
    Type: Grant
    Filed: May 5, 2009
    Date of Patent: September 28, 2010
    Assignee: Alcon, Inc.
    Inventors: David L. Jinkerson, Joseph I. Weinschenk, III, W. Dennis Dean
  • Use of inhibitors of Jun N-terminal kinases to treat glaucoma
    Patent number: 7803824
    Abstract: Compositions and methods for lowering IOP and/or providing neuroprotection are disclosed. The compositions and methods are particularly directed to the use inhibitors of Jun N-terminal kinases (JNK) to lower IOP and/or provide neuroprotection.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: September 28, 2010
    Assignee: Alcon, Inc.
    Inventors: Debra L. Fleenor, Iok-Hou Pang
  • 1-alkyl-3-aminoindazoles
    Patent number: 7799930
    Abstract: Methods of making 1-alkylindazoles are described. The methods involve reacting a 2-alkylaminobenzonitrile with a nitrosating agent followed by reduction-cyclization of the resulting nitrosamine to form a 1-alkyl-3-aminoindazole. The 1-alkyl-3-aminoindazole can be deaminated to form a 1-alkylindazole which ultimately can be used to form desired indazoles which are preferably pharmaceutically active products. The process of the present invention further permits the formation of enantiomerically enriched or pure indazoles such as aminoalkyl indazoles.
    Type: Grant
    Filed: February 10, 2009
    Date of Patent: September 21, 2010
    Assignee: Alcon, Inc.
    Inventors: Pete Delgado, Raymond E. Conrow, W. Dennis Dean
  • Ophthalmic and otorhinolaryngological device materials
    Patent number: 7799845
    Abstract: Disclosed are soft, high refractive index, acrylic device materials. The materials comprise di-block or tri-block macromers containing a hydrophilic block in the polymer backbone. The materials have improved glistening resistance.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: September 21, 2010
    Assignee: Alcon, Inc.
    Inventor: Douglas C. Schlueter
  • 5-substituted 2-aminopyridine analogs for treating allergic and inflammatory diseases
    Patent number: 7799778
    Abstract: Methods for treating an allergic or inflammatory disease or other Syk-mediated disease or Syk-mediated condition characterized by administering a composition which contains a therapeutically effective amount of a 5-substituted 2-aminopyridine compound.
    Type: Grant
    Filed: January 12, 2006
    Date of Patent: September 21, 2010
    Assignee: Alcon, Inc.
    Inventors: Mark R. Hellberg, Steven T. Miller, Andrew Rusinko
  • Topical ophthalmic compositions containing tobramycin and dexamethasone
    Patent number: 7795316
    Abstract: Ophthalmic pharmaceutical compositions containing tobramycin, dexamethasone and deacetylated xanthan gum are described. The compositions provide longer ocular retention for enhanced ocular bioavailability of tobramycin and dexamethasone. In a preferred embodiment, the compositions also provide for improved suspension of dexamethasone. The concentration of ionizable species in the compositions is controlled so as to prevent precipitation of the xanthan gum as a result of ionic interactions between tobramycin and xanthan gum, while allowing for a restoration of viscosity upon topical application of the compositions to the eye. The use of deacetylated xanthan gum is disclosed, so as to avoid formulation instability caused by pH drift during storage.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: September 14, 2010
    Assignee: Alcon Research, Ltd.
    Inventor: Bhagwati P. Kabra
  • Smart connector system for surgical machine
    Patent number: 7796040
    Abstract: A smart connector system includes a machine connector disposed on a face of a surgical machine, an illumination ring located on the face of the surgical machine and disposed around a periphery of the machine connector, an RFID reader antenna located in close proximity to the machine connector and the face of the surgical machine, and an accessory connector adapted to couple with the machine connector. The accessory connector has an RFID tag antenna and is capable of attaching a tool to the surgical machine. When the accessory connector is brought within close proximity to the machine connector, a communications connection is established between the RFID tag antenna and the RFID reader antenna.
    Type: Grant
    Filed: October 20, 2008
    Date of Patent: September 14, 2010
    Assignee: Alcon, Inc.
    Inventors: Victor Mezhinsky, Argelio Olivera, Kirk Todd, Mark Hopkins, Fang Wen
  • Pharmaceutical Composition for Delivery of Receptor Tyrosine Kinase Inhibiting (RTKi) Compounds to the Eye
    Publication number: 20100226992
    Abstract: The present invention relates to development of efficacious pharmaceutical compositions in the form of intraocular suspensions comprising an anti-angiogenic compound in a therapeutically effective amount and a polyethylene glycol having a molecular weight of at least 2000, preferably at least 3000.
    Type: Application
    Filed: March 3, 2010
    Publication date: September 9, 2010
    Applicant: ALCON RESEARCH, LTD.
    Inventor: Bhagwati P. Kabra
  • Pharmaceutical Composition for Delivery of Receptor Tyrosine Kinase Inhibiting (RTKi) Compounds to the Eye
    Publication number: 20100227904
    Abstract: The present invention relates to development of efficacious pharmaceutical implant compositions comprising an active agent in a therapeutically effective amount and a polyethylene glycol having a molecular weight of at least 2000.
    Type: Application
    Filed: March 3, 2010
    Publication date: September 9, 2010
    Applicant: Alcon Research, Ltd.
    Inventors: Bhagwati P. Kabra, Malay Ghosh, Adrian Sauceda
  • Pharmaceutical Composition for Delivery of Receptor Tyrosine Kinase Inhibiting (RTKi) Compounds to the Eye
    Publication number: 20100227905
    Abstract: The present invention relates to development of efficacious pharmaceutical compositions in the form of aqueous solutions comprising an active agent in a therapeutically effective amount and a polyethylene glycol having a molecular weight of at least 2000.
    Type: Application
    Filed: March 3, 2010
    Publication date: September 9, 2010
    Applicant: ALCON RESEARCH, LTD.
    Inventors: Bhagwati P. Kabra, Malay Ghosh