Abstract: High refractive index copolymers suitable for use in ophthalmic devices are disclosed. The copolymers comprise two or more aryl hydrophobic monomers and a non-polymerizable propylene oxide-ethylene oxide-propylene oxide block copolymer surfactant having a molecular weight of approximately 3600 and approximately 40% ethylene oxide units by weight. The copolymers have a reduced tendency to form glistenings when stored in water at physiological temperatures compared to similar copolymers lacking the non-polymerizable surfactant.

Abstract: A method for improving an accuracy of a prescription for laser-ablation corneal treatment includes the step of receiving a set of raw data comprising Hartmann-Shack image data obtained from a plurality of aberrometer measurements of a patient eye. The Hartmann-Shack data can include, for example, a dot pattern image for each measurement. A set of reconstructed wavefront data calculated from the set of raw data for the plurality of aberrometer measurements is also received. Data on a selected component of the set of raw data and in the set of reconstructed wavefront data are compared. If the selected component data differ more than a predetermined amount between the raw data and the reconstructed wavefront data, the raw data can be further manipulated prior to undertaking laser ablation. In addition, these data are removed from consideration for inclusion in the database of treatment outcomes.

Abstract: High refractive index copolymers suitable for use in ophthalmic devices are disclosed. The copolymers comprise a single aryl hydrophobic monomer as a device forming monomer. In addition, the copolymers comprise a non-polymerizable block copolymer surfactant. The copolymers have a reduced tendency to form glistenings when stored in water at physiological temperatures.

Abstract: Embodiments of the present invention provide a system and method for detecting the level of a fluid in a surgical cassette by projecting light from a linear light source into a wall of a cassette. Depending on the amount a light reflected or refracted in the cassette (i.e., due to the cassette material/fluid interface or cassette material/air interface (or other interface)) various portions of a linear sensor array will be more or less illuminated. By examining the illumination of the linear sensor array, the level of fluid in the chamber can be determined.

Abstract: A system for visualizing an eye of a patient during corneal surgery includes a processor and a first and second camera in signal communication with the processor. The cameras are positionable for focusing on a cornea positioned for surgery. A first and a second display and optics therefor are in signal communication with the processor and are positionable for viewing through a first and a second eyepiece of a stereo microscope, respectively. Software is resident on the processor for receiving a first and second corneal image from the first and second cameras, for processing the received first and second images for display, and for transmitting the processed first and second images to the first and the second displays, respectively, via the display optics. The displays can then be viewed by a surgeon through the microscope at least during the surgery.

Abstract: Methods for using aminopyrazine analogs to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of aminopyrazine analogs, are also disclosed.

Abstract: The invention provides methods for identifying immunobinders, such as scFv antibodies, capable of specifically binding to cell surface antigens, and compositions identified according to said methods.

Abstract: In one aspect, the present invention provides a method of designing an intraocular lens (IOL) to address variations of at least one ocular parameter in a population of patient eyes. The method can include establishing at least one eye model in which the ocular parameter can be varied over a range exhibited by the population. The eye model can be employed to evaluate a plurality of IOL designs in correcting visual acuity for eyes in the patient population. An IOL design that provides a best fit for visual performance over at least a portion of the parameter range can then be selected.

Abstract: The present invention provides a surgical footswitch that includes a base, a pedal, an encoder assembly, a wireless interface, and an internal power generator. The pedal mounts upon the base and pivots. The encoder assembly couples to the pedal. As the pedal pivots, the encoder assembly translates the mechanical signal of the pedal into a control signal based on the pedals position and/or orientation. The wireless interface couples the encoder assembly to receive the control signal. The wireless interface also couples the surgical footswitch to a surgical console operable to control and direct surgical equipment. The wireless interface passes the control signal from the encoder to the surgical console, which then directs the surgical equipment based on the control signal. This wireless interface eliminates the tangle of wires or tethers, which may be a hazard in the surgical theater.

Abstract: A surgical cassette having a chamber for fluidly coupling to a source of vacuum in a surgical console and a bubble breaking structure disposed within the chamber. The cassette protects the source of vacuum from liquid.

Abstract: Chromophores that absorb both UV and short wavelength visible light are disclosed. The chromophores are particularly suitable for use in intraocular lens materials.

Abstract: A transparent illuminated infusion cannula is provided for illuminating an area during eye surgery. An optical fiber may be spaced a certain distance away from the cannula such that fluid flow around the distal end of the fiber and into the transparent cannula may occur with a much higher flow rate than what had previously been possible. The fiber cannula airspace may be optimized so that the cross-sectional area of the fluid conduit remains substantially constant in order to achieve a best compromise between high light transmittance and high fluid flow rate.

Abstract: The present invention is an ophthalmic injection system with a limited reuse assembly and a tip segment. The tip segment is connectable to and removable from the limited reuse assembly. The tip segment includes a dispensing chamber, a plunger, and a housing. The dispensing chamber holds a quantity of a substance to be injected into an eye. The proximate end of the plunger has a first mechanical linkage interface. The limited reuse assembly of the ophthalmic injection system has a power source, a controller, a motor, a second mechanical linkage interface located on an end of the motor shaft; and a second housing. The first mechanical linkage interface is mateable with the second mechanical linkage interface such that when the tip segment is connected to the limited reuse assembly, the first mechanical linkage interface mates with the second mechanical linkage interface so that motion of the shaft results in motion of the plunger.

Abstract: The present invention relates to a formulation having antimicrobial activity comprising a N-halogenated amino acid and a anti-inflammatory compound. This specification also describes methods for treating a tissue infection comprising contacting the infected tissue with a pharmaceutically effective amount of a formulation comprising a N-halogenated amino acid and a anti-inflammatory compound. This specification further describes a method for treating respiratory infections comprising contacting the site of the respiratory infection with a pharmaceutically effective amount of a formulation comprising a N-halogenated amino acid and a anti-inflammatory compound.

Abstract: A cassette having an elastomeric sheet that is bonded or mechanically attached to a rigid substrate. A flow channel is molded into the rigid substrate that corresponds to a flow channel molded into the elastomeric sheet. The cassette is used in combination with a peristaltic pump having pump head rollers that are mounted radially from the axis of rotation of the pump motor so as to compress the elastomeric flow channels against the rigid substrate during operation. The flow channels molded into the rigid substrate have smooth, fluid lines free from sharp edges and abrupt direction changes and correspond with the fluid channels molded into the elastomeric sheet so as to provide a transition region with a relatively constant cross-section over its entire length that approximates the cross-sectional area of the flow channels molded into the rigid substrate and the fluid channel molded into the elastomeric sheet so that the entire fluid path is of relatively constant cross-sectional area.

Abstract: A method for measuring the optical properties of multifocal ophthalmic lenses. Collimated light is passed through an ophthalmic lens and onto an array of lenslets. Light exiting the array of lenslets is detected by a sensor. Blurred spots and/or double spots may represent diffractive zones of the wavefront. A centroid of the spot or a brighter of two spots may be used to determine the lateral position of the spot. Theoretical calculations, laboratory measurements, clinical measurements and experimental image spots may be generated, compared and cross-checked to determine a monofocal equivalent lens. A Modulation Transfer Function (MTF) may be used to evaluate and compare a diffractive lens and a monofocal equivalent lens.

Abstract: The present invention relates to methods for treating an infected tissue comprising treating the infected tissue with a formulation comprising a N-halogenated amino acid and a phosphine oxide or amine oxide. This specification also discloses methods for improving the antimicrobial activity of a formulation comprising a N-halogenated amino acid, the method comprising adding a phosphine oxide or amine oxide to said formulation.

Abstract: The present invention provides methods and kits for diagnosing and treating glaucoma.

Abstract: The invention provides apparatuses and methods for detecting corneal surface defects. The methods and/or an apparatus of the invention can be used to detect corneal surface diseases, such as dry eye.

Abstract: The use of SOD mimics particularly pentaazacycle Mn(II) complex SOD mimics, for the treatment of AMD, DR, and retinal edema is disclosed.