Patents Assigned to Alfred E. Tiefenbacher GmbH & Co. KG
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Publication number: 20230346709Abstract: The present invention relates to a tablet for oral administration containing valsartan and sacubitril, preferably as sodium salts or as a complex of valsartan disodium and sacubitril monosodium, preferably LCZ696. The tablet is prepared by dry-granulation or direct compression and contains a mesoporous inorganic stabilizer, e.g. mesoporous silica (Syloid®).Type: ApplicationFiled: April 25, 2023Publication date: November 2, 2023Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG)Inventors: Bala Ramesha Chary RALLABANDI, Vamshi Ramana PRATHAP, Krishna Mohan GOLLAPUDI, Bala Subramanian VELUSAMY, Srimannarayana BANDLA, Hendrik SCHLEHAHN, Dieter RUCHATZ
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Patent number: 11590127Abstract: The present invention relates to a gastro-resistant pharmaceutical composition comprising a solid solution prepared by hot-melt extrusion, whereby the solid solution contains posaconazole, an enteric polymer and a non-enteric polymer. The composition is preferably a granulate material that can be filled into a capsule or compressed into a tablet.Type: GrantFiled: June 2, 2021Date of Patent: February 28, 2023Assignee: ALFRED E. TIEFENBACHER (GMBH & CO. KG)Inventors: Vamshi Ramana Prathap, Venkatasimhadri Naidu Kalamata, Bala Ramesha Chary Rallabandi, Vinay Kumar Katakam, Hendrik Schlehahn
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Publication number: 20230056424Abstract: A pharmaceutical composition, which is an oral solid dosage form, containing a pharmaceutical agent comprising a dialkylamino- or a trialkylamino-group and one or more pharmaceutically acceptable excipient(s), wherein over a period of 2 weeks at 60° C. under open exposure (at any humidity between 30 and 75% rH), or 6 months at 40° C./75% rH in the primary packaging, or 6 months at 25° C./60% rH in the primary packaging the concentration of the corresponding N-nitroso-derivative of the pharmaceutical agent remains below 50 ppm (relative to the weight of the free base of the pharmaceutical agent in the pharmaceutical composition).Type: ApplicationFiled: July 15, 2022Publication date: February 23, 2023Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG)Inventors: Alexander DÖBBER, Manohar Reddy SAGILI, Chaitanya Yogananda GUJJAR, Venkatasimhadri Naidu KALAMATA, Ansgar FITZNER, Santhosh Kumar MANKALA, Bala Ramesha Chary RALLABANDI, Kiran Kumar MADALLAPALLI
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Publication number: 20220226247Abstract: The present invention relates to a solid unit dosage form for oral administration (tablet or granules) containing a solid dispersion of valsartan and sacubitril in a polymeric matrix. The solid dispersion is prepared by hot-melt extrusion and may contain the active ingredients preferably in a non-crystalline state. LCZ696, (pseudo)polymorphic forms thereof as well as the individual drugs, e.g. valsartan disodium and sacubitril monosodium, may be subjected to the hot-melt extrusion process.Type: ApplicationFiled: April 7, 2022Publication date: July 21, 2022Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG)Inventors: Bala Ramesha Chary RALLABANDI, Vamshi Ramana PRATHAP, Rajesh Krishna Mohan GOLLAPUDI, Hendrik SCHLEHAHN, Dieter RUCHATZ
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Publication number: 20220194901Abstract: The present invention relates to a crystalline form of amifampridine phosphate having an irregular or plate-like, not needle-like crystal habit and to a process for its manufacture.Type: ApplicationFiled: April 9, 2020Publication date: June 23, 2022Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG)Inventors: Ruslan STAVER, Michaelis SIMON
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Publication number: 20210283130Abstract: The present invention relates to a gastro-resistant pharmaceutical composition comprising a solid solution prepared by hot-melt extrusion, whereby the solid solution contains posaconazole, an enteric polymer and a non-enteric polymer. The composition is preferably a granulate material that can be filled into a capsule or compressed into a tablet.Type: ApplicationFiled: June 2, 2021Publication date: September 16, 2021Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG)Inventors: Vamshi Ramana PRATHAP, Venkatasimhadri Naidu KALAMATA, Bala Ramesha Chary RALLABANDI, Vinay Kumar KATAKAM, Hendrik SCHLEHAHN
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Patent number: 11058682Abstract: The present invention relates to a gastro-resistant pharmaceutical composition comprising a solid solution prepared by hot-melt extrusion, whereby the solid solution contains posaconazole, an enteric polymer and a non-enteric polymer. The composition is preferably a granulate material that can be filled into a capsule or compressed into a tablet.Type: GrantFiled: July 21, 2016Date of Patent: July 13, 2021Assignee: ALFRED E. TIEFENBACHER (GMBH & CO. KG)Inventors: Vamshi Ramana Prathap, Venkatasimhadri Naidu Kalamata, Bala Ramesha Chary Rallabandi, Vinay Kumar Katakam, Hendrik Schlehahn
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Patent number: 11020549Abstract: A dry powder inhalation device is disclosed. In one optional aspect, the device includes a housing, a base plate, a receptacle for a medicament and a mouthpiece. The base plate is engageable with the housing to form a main space with a main air inlet. The mouthpiece includes an inner conduit connected to its outlet and is engageable with the base plate to fluidly connect the inner conduit to the receptacle. The receptacle is fluidly connected to the main space, so that upon inhalation by a user, air can be drawn through the main air inlet into the main space and onward through the receptacle into the inner conduit. The mouthpiece and the base plate form an auxiliary space with an auxiliary air inlet, wherein the auxiliary space is fluidly connected to the main space.Type: GrantFiled: August 14, 2017Date of Patent: June 1, 2021Assignee: Alfred E. Tiefenbacher (GmbH & Co. KG)Inventors: David Ahern, Arron Danson, James Tibatts, Ewen Christie, Tim Evans
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Publication number: 20210085610Abstract: The present invention relates to a solid unit dosage form for oral administration (tablet or granules) containing a solid dispersion of valsartan and sacubitril in a polymeric matrix. The solid dispersion is prepared by hot-melt extrusion and may contain the active ingredients preferably in a non-crystalline state. LCZ696, (pseudo)polymorphic forms thereof as well as the individual drugs, e.g. valsartan disodium and sacubitril monosodium, may be subjected to the hot-melt extrusion process.Type: ApplicationFiled: March 29, 2018Publication date: March 25, 2021Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG)Inventors: Bala Ramesha Chary RALLABANDI, Vamshi Ramana PRATHAP, Rajesh Krishna Mohan GOLLAPUDI, Hendrik SCHLEHAHN, Dieter RUCHATZ
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Publication number: 20200276129Abstract: The present invention relates to a tablet for oral administration containing valsartan and sacubitril, preferably as sodium salts or as a complex of valsartan disodium and sacubitril monosodium, preferably LCZ696. The tablet is prepared by dry-granulation or direct compression and contains a mesoporous inorganic stabilizer, e.g. mesoporous silica (Syloid®).Type: ApplicationFiled: October 12, 2018Publication date: September 3, 2020Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG)Inventors: Bala Ramesha Chary RALLABANDI, Vamshi Ramana PRATHAP, Krishna Mohan GOLLAPUDI, Bala Subramanian VELUSAMY, Srimannarayana BANDLA, Hendrik SCHLEHAHN, Dieter RUCHATZ
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Patent number: 10307400Abstract: The present invention relates to an orally disintegrating tablet (ODT) containing asenapine maleate and to a process for preparing the ODT. In a first aspect, the present invention relates to an ODT containing asenapine maleate and low substituted hydroxypropylcellulose. In a second aspect, the present invention relates to an ODT containing crystalline asenapine maleate and the ODT is prepared using conventional tabletting techniques as direct compression and granulation. In a third aspect, the present invention relates to an ODT containing asenapine maleate and a carboxylic acid, and to the use of a carboxylic acid for enhancing storage stability of an asenapine maleate containing ODT.Type: GrantFiled: February 7, 2017Date of Patent: June 4, 2019Assignee: ALFRED E. TIEFENBACHER (GMBH & CO. KG)Inventors: Chaitanya Yogananda Gujjar, Bala Ramesha Chary Rallabandi, Pradip Shivraj Patwari, Ansgar Fitzner
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Publication number: 20180228798Abstract: The present invention relates to a gastro-resistant pharmaceutical composition comprising a solid solution prepared by hot-melt extrusion, whereby the solid solution contains posaconazole, an enteric polymer and a non-enteric polymer. The composition is preferably a granulate material that can be filled into a capsule or compressed into a tablet.Type: ApplicationFiled: July 21, 2016Publication date: August 16, 2018Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG)Inventors: Vamshi Ramana PRATHAP, Venkatasimhadri Naidu KALAMATA, Bala Ramesha Chary RALLABANDI, Vinay Kumar KATAKAM, Hendrik SCHLEHAHN
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Publication number: 20170157044Abstract: The present invention relates to a simple, robust and effective process for preparing a dry powder inhalation formulation containing at least one drug, preferably a highly active drug, more preferably Tiotropium bromide or Tiotropium bromide monohydrate, and a lactose carrier. The process is characterized in that a three-layered composition containing a drug layer in between layers of the lactose carrier is mixed and the obtained preblend is mixed with additional lactose carrier. The process combines a simple manufacturing procedure with an excellent content uniformity obtained over a wide range of mixing parameters.Type: ApplicationFiled: November 29, 2016Publication date: June 8, 2017Applicants: Alfred E. Tiefenbacher GmbH & Co. KG, Nanopharm Ltd.Inventors: Claudia Meyer, Robert Price, Jagdeep Shur
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Publication number: 20170143670Abstract: The present invention relates to an orally disintegrating tablet (ODT) containing asenapine maleate and to a process for preparing the ODT. In a first aspect, the present invention relates to an ODT containing asenapine maleate and low substituted hydroxypropylcellulose. In a second aspect, the present invention relates to an ODT containing crystalline asenapine maleate and the ODT is prepared using conventional tabletting techniques as direct compression and granulation. In a third aspect, the present invention relates to an ODT containing asenapine maleate and a carboxylic acid, and to the use of a carboxylic acid for enhancing storage stability of an asenapine maleate containing ODT.Type: ApplicationFiled: February 7, 2017Publication date: May 25, 2017Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG)Inventors: Chaitanya Yogananda GUJJAR, Bala Ramesha Chary RALLABANDI, Pradip Shivraj PATWARI, Ansgar FITZNER
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Patent number: 9656441Abstract: A transdermal patch includes a protective layer, a matrix layer, an adhesive layer, and a cover layer. The cover layer is at least partially bi-elastic, and the adhesive layer comprises an acrylic copolymer having hydroxyl functional groups. The matrix layer comprises a physiologically effective amount of buprenorphine or pharmaceutically acceptable salts thereof.Type: GrantFiled: January 8, 2015Date of Patent: May 23, 2017Assignee: ALFRED E. TIEFENBACHER ( GMBH & CO. KG)Inventors: John LeDonne, Claudia Meyer
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Patent number: 9597291Abstract: The present invention relates to an orally disintegrating tablet (ODT) containing asenapine maleate and to a process for preparing the ODT. In a first aspect, the present invention relates to an ODT containing asenapine maleate and low substituted hydroxypropylcellulose. In a second aspect, the present invention relates to an ODT containing crystalline asenapine maleate and the ODT is prepared using conventional tabletting techniques as direct compression and granulation. In a third aspect, the present invention relates to an ODT containing asenapine maleate and a carboxylic acid, and to the use of a carboxylic acid for enhancing storage stability of an asenapine maleate containing ODT.Type: GrantFiled: December 6, 2013Date of Patent: March 21, 2017Assignee: ALFRED E. TIEFENBACHER (GMBH & CO. KG)Inventors: Chaitanya Yogananda Gujjar, Bala Ramesha Chary Rallabandi, Pradip Shivraj Patwari, Ansgar Fitzner
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Patent number: 9475907Abstract: The present invention relates to a method for the preparation of polyquaternium-1, wherein an aprotic polar solvent is used as the reaction medium, and a solid polyquaternium-1 having a low degree of polydispersity.Type: GrantFiled: June 19, 2013Date of Patent: October 25, 2016Assignee: Alfred E. Tiefenbacher GmbH & Co., KGInventors: Stefan Becker, Uwe Eilitz, Gunnar Göthe, Jens Flemming
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Publication number: 20160199313Abstract: A transdermal patch includes a protective layer, a matrix layer, an adhesive layer, and a cover layer. The cover layer is at least partially bi-elastic, and the adhesive layer comprises an acrylic copolymer having hydroxyl functional groups. The matrix layer comprises a physiologically effective amount of buprenorphine or pharmaceutically acceptable salts thereof.Type: ApplicationFiled: January 8, 2015Publication date: July 14, 2016Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG)Inventors: John LeDONNE, Claudia MEYER
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Publication number: 20150328163Abstract: The present invention relates to an orally disintegrating tablet (ODT) containing asenapine maleate and to a process for preparing the ODT. In a first aspect, the present invention relates to an ODT containing asenapine maleate and low substituted hydroxypropylcellulose. In a second aspect, the present invention relates to an ODT containing crystalline asenapine maleate and the ODT is prepared using conventional tabletting techniques as direct compression and granulation. In a third aspect, the present invention relates to an ODT containing asenapine maleate and a carboxylic acid, and to the use of a carboxylic acid for enhancing storage stability of an asenapine maleate containing ODT.Type: ApplicationFiled: December 6, 2013Publication date: November 19, 2015Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG)Inventors: Chaitanya Yogananda GUJJAR, Bala Ramesha Chary RALLABANDI, Pradip Shivraj PATWARI, Ansgar FITZNER
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Patent number: D793546Type: GrantFiled: March 28, 2016Date of Patent: August 1, 2017Assignee: Alfred E. Tiefenbacher (GmbH & Co. KG)Inventors: Dave Ahern, Arron Danson, James Tibbatts, Ewen Christie, Tim Evans