Patents Assigned to Alfred E. Tiefenbacher GmbH & Co. KG
  • Patent number: 10307400
    Abstract: The present invention relates to an orally disintegrating tablet (ODT) containing asenapine maleate and to a process for preparing the ODT. In a first aspect, the present invention relates to an ODT containing asenapine maleate and low substituted hydroxypropylcellulose. In a second aspect, the present invention relates to an ODT containing crystalline asenapine maleate and the ODT is prepared using conventional tabletting techniques as direct compression and granulation. In a third aspect, the present invention relates to an ODT containing asenapine maleate and a carboxylic acid, and to the use of a carboxylic acid for enhancing storage stability of an asenapine maleate containing ODT.
    Type: Grant
    Filed: February 7, 2017
    Date of Patent: June 4, 2019
    Assignee: ALFRED E. TIEFENBACHER (GMBH & CO. KG)
    Inventors: Chaitanya Yogananda Gujjar, Bala Ramesha Chary Rallabandi, Pradip Shivraj Patwari, Ansgar Fitzner
  • Publication number: 20180228798
    Abstract: The present invention relates to a gastro-resistant pharmaceutical composition comprising a solid solution prepared by hot-melt extrusion, whereby the solid solution contains posaconazole, an enteric polymer and a non-enteric polymer. The composition is preferably a granulate material that can be filled into a capsule or compressed into a tablet.
    Type: Application
    Filed: July 21, 2016
    Publication date: August 16, 2018
    Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG)
    Inventors: Vamshi Ramana PRATHAP, Venkatasimhadri Naidu KALAMATA, Bala Ramesha Chary RALLABANDI, Vinay Kumar KATAKAM, Hendrik SCHLEHAHN
  • Publication number: 20170157044
    Abstract: The present invention relates to a simple, robust and effective process for preparing a dry powder inhalation formulation containing at least one drug, preferably a highly active drug, more preferably Tiotropium bromide or Tiotropium bromide monohydrate, and a lactose carrier. The process is characterized in that a three-layered composition containing a drug layer in between layers of the lactose carrier is mixed and the obtained preblend is mixed with additional lactose carrier. The process combines a simple manufacturing procedure with an excellent content uniformity obtained over a wide range of mixing parameters.
    Type: Application
    Filed: November 29, 2016
    Publication date: June 8, 2017
    Applicants: Alfred E. Tiefenbacher GmbH & Co. KG, Nanopharm Ltd.
    Inventors: Claudia Meyer, Robert Price, Jagdeep Shur
  • Publication number: 20170143670
    Abstract: The present invention relates to an orally disintegrating tablet (ODT) containing asenapine maleate and to a process for preparing the ODT. In a first aspect, the present invention relates to an ODT containing asenapine maleate and low substituted hydroxypropylcellulose. In a second aspect, the present invention relates to an ODT containing crystalline asenapine maleate and the ODT is prepared using conventional tabletting techniques as direct compression and granulation. In a third aspect, the present invention relates to an ODT containing asenapine maleate and a carboxylic acid, and to the use of a carboxylic acid for enhancing storage stability of an asenapine maleate containing ODT.
    Type: Application
    Filed: February 7, 2017
    Publication date: May 25, 2017
    Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG)
    Inventors: Chaitanya Yogananda GUJJAR, Bala Ramesha Chary RALLABANDI, Pradip Shivraj PATWARI, Ansgar FITZNER
  • Patent number: 9656441
    Abstract: A transdermal patch includes a protective layer, a matrix layer, an adhesive layer, and a cover layer. The cover layer is at least partially bi-elastic, and the adhesive layer comprises an acrylic copolymer having hydroxyl functional groups. The matrix layer comprises a physiologically effective amount of buprenorphine or pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: January 8, 2015
    Date of Patent: May 23, 2017
    Assignee: ALFRED E. TIEFENBACHER ( GMBH & CO. KG)
    Inventors: John LeDonne, Claudia Meyer
  • Patent number: 9597291
    Abstract: The present invention relates to an orally disintegrating tablet (ODT) containing asenapine maleate and to a process for preparing the ODT. In a first aspect, the present invention relates to an ODT containing asenapine maleate and low substituted hydroxypropylcellulose. In a second aspect, the present invention relates to an ODT containing crystalline asenapine maleate and the ODT is prepared using conventional tabletting techniques as direct compression and granulation. In a third aspect, the present invention relates to an ODT containing asenapine maleate and a carboxylic acid, and to the use of a carboxylic acid for enhancing storage stability of an asenapine maleate containing ODT.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: March 21, 2017
    Assignee: ALFRED E. TIEFENBACHER (GMBH & CO. KG)
    Inventors: Chaitanya Yogananda Gujjar, Bala Ramesha Chary Rallabandi, Pradip Shivraj Patwari, Ansgar Fitzner
  • Patent number: 9475907
    Abstract: The present invention relates to a method for the preparation of polyquaternium-1, wherein an aprotic polar solvent is used as the reaction medium, and a solid polyquaternium-1 having a low degree of polydispersity.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: October 25, 2016
    Assignee: Alfred E. Tiefenbacher GmbH & Co., KG
    Inventors: Stefan Becker, Uwe Eilitz, Gunnar Göthe, Jens Flemming
  • Publication number: 20160199313
    Abstract: A transdermal patch includes a protective layer, a matrix layer, an adhesive layer, and a cover layer. The cover layer is at least partially bi-elastic, and the adhesive layer comprises an acrylic copolymer having hydroxyl functional groups. The matrix layer comprises a physiologically effective amount of buprenorphine or pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: January 8, 2015
    Publication date: July 14, 2016
    Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG)
    Inventors: John LeDONNE, Claudia MEYER
  • Publication number: 20150328163
    Abstract: The present invention relates to an orally disintegrating tablet (ODT) containing asenapine maleate and to a process for preparing the ODT. In a first aspect, the present invention relates to an ODT containing asenapine maleate and low substituted hydroxypropylcellulose. In a second aspect, the present invention relates to an ODT containing crystalline asenapine maleate and the ODT is prepared using conventional tabletting techniques as direct compression and granulation. In a third aspect, the present invention relates to an ODT containing asenapine maleate and a carboxylic acid, and to the use of a carboxylic acid for enhancing storage stability of an asenapine maleate containing ODT.
    Type: Application
    Filed: December 6, 2013
    Publication date: November 19, 2015
    Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG)
    Inventors: Chaitanya Yogananda GUJJAR, Bala Ramesha Chary RALLABANDI, Pradip Shivraj PATWARI, Ansgar FITZNER
  • Publication number: 20150197603
    Abstract: The present invention relates to a method for the preparation of polyquaternium-1, wherein an aprotic polar solvent is used as the reaction medium, and a solid polyquaternium-1 having a low degree of polydispersity.
    Type: Application
    Filed: June 19, 2013
    Publication date: July 16, 2015
    Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG)
    Inventors: Stefan Becker, Uwe Eilitz, Gunnar Göthe, Jens Flemming
  • Patent number: 9024030
    Abstract: The present invention relates to a process for the synthesis of the anti-inflammatory agent 5-chloro-3-(4-methanesulfonylphenyl)-6?-methyl-[2,3?]bipyridine, referred to as compound of formula (1) or etoricoxib, which is a pharmaceutically active ingredient inhibiting cyclooxygenase-2. In particular, the application concerns a novel process of making the compound of formula (1) by oxidizing a compound of formula (4).
    Type: Grant
    Filed: January 11, 2013
    Date of Patent: May 5, 2015
    Assignees: Alfred E. Tiefenbacher (GmbH & Co. KG), Shanghai Golden Pharmatech Co. Ltd.
    Inventors: Zhenmin Mao, Tian Lan, Lanfang Liu, Long Yan, Stefan Becker
  • Publication number: 20130177606
    Abstract: The invention concerns a transdermal therapeutic system with a carbamate cholinesterase inhibitor for the treatment of mild to moderate Alzheimer's disease dementia and/or Parkinson's disease dementia.
    Type: Application
    Filed: January 10, 2013
    Publication date: July 11, 2013
    Applicants: AMW GMBH, ALFRED E. TIEFENBACHER (GMBH & CO. KG)
    Inventors: ALFRED E. TIEFENBACHER (GmbH & Co. KG), AMW GmbH
  • Patent number: 8193226
    Abstract: Candesartan cilexetil-containing granules which include a sugar alcohol and a binder and which are produced by granulation with an alcoholic granulating liquid. The granules are suitable for producing tablets in which the candesartan cilexetil is present in a form stabilized with regard to decomposition.
    Type: Grant
    Filed: October 27, 2008
    Date of Patent: June 5, 2012
    Assignees: Zhejiang Huahai Pharmaceutical Co., Ltd., Alfred E. Tiefenbacher GmbH & Co. KG
    Inventors: Qiaomei Wu, Huiyan Gao, Hao Chen, Qiping Yan, Junqing Peng, Gongyun Hu
  • Publication number: 20100267785
    Abstract: Candesartan cilexetil-containing granules which include a sugar alcohol and a binder and which are produced by granulation with an alcoholic granulating liquid. The granules are suitable for producing tablets in which the candesartan cilexetil is present in a form stabilized with regard to decomposition.
    Type: Application
    Filed: October 27, 2008
    Publication date: October 21, 2010
    Applicants: HUAHAI ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD., ALFRED E. TIEFENBACHER GMBH & CO. KG
    Inventors: Qiaomei Wu, Huiyan Gao, Hao Chen, Qiping Yan, Junqing Peng, Gongyun Hu
  • Patent number: D793546
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: August 1, 2017
    Assignee: Alfred E. Tiefenbacher (GmbH & Co. KG)
    Inventors: Dave Ahern, Arron Danson, James Tibbatts, Ewen Christie, Tim Evans