Abstract: The present invention relates to a method for the preparation of polyquaternium-1, wherein an aprotic polar solvent is used as the reaction medium, and a solid polyquaternium-1 having a low degree of polydispersity.
Type:
Application
Filed:
June 19, 2013
Publication date:
July 16, 2015
Applicant:
ALFRED E. TIEFENBACHER (GMBH & CO. KG)
Inventors:
Stefan Becker, Uwe Eilitz, Gunnar Göthe, Jens Flemming
Abstract: The present invention relates to a process for the synthesis of the anti-inflammatory agent 5-chloro-3-(4-methanesulfonylphenyl)-6?-methyl-[2,3?]bipyridine, referred to as compound of formula (1) or etoricoxib, which is a pharmaceutically active ingredient inhibiting cyclooxygenase-2. In particular, the application concerns a novel process of making the compound of formula (1) by oxidizing a compound of formula (4).
Type:
Grant
Filed:
January 11, 2013
Date of Patent:
May 5, 2015
Assignees:
Alfred E. Tiefenbacher (GmbH & Co. KG), Shanghai Golden Pharmatech Co. Ltd.
Inventors:
Zhenmin Mao, Tian Lan, Lanfang Liu, Long Yan, Stefan Becker
Abstract: The invention concerns a transdermal therapeutic system with a carbamate cholinesterase inhibitor for the treatment of mild to moderate Alzheimer's disease dementia and/or Parkinson's disease dementia.
Type:
Application
Filed:
January 10, 2013
Publication date:
July 11, 2013
Applicants:
AMW GMBH, ALFRED E. TIEFENBACHER (GMBH & CO. KG)
Inventors:
ALFRED E. TIEFENBACHER (GmbH & Co. KG), AMW GmbH
Abstract: Candesartan cilexetil-containing granules which include a sugar alcohol and a binder and which are produced by granulation with an alcoholic granulating liquid. The granules are suitable for producing tablets in which the candesartan cilexetil is present in a form stabilized with regard to decomposition.
Type:
Grant
Filed:
October 27, 2008
Date of Patent:
June 5, 2012
Assignees:
Zhejiang Huahai Pharmaceutical Co., Ltd., Alfred E. Tiefenbacher GmbH & Co. KG
Abstract: Candesartan cilexetil-containing granules which include a sugar alcohol and a binder and which are produced by granulation with an alcoholic granulating liquid. The granules are suitable for producing tablets in which the candesartan cilexetil is present in a form stabilized with regard to decomposition.
Type:
Application
Filed:
October 27, 2008
Publication date:
October 21, 2010
Applicants:
HUAHAI ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD., ALFRED E. TIEFENBACHER GMBH & CO. KG