Abstract: A novel device, method and kit for reconstitution of a solid or semi-solid pharmaceutical composition by a negative pressure differential includes (i) a first adapter with a first connector, a first peripheral wall wherein the first adapter is coupled to the first vial by means of a first connector; (ii) a second adapter with a second connector, a second peripheral wall wherein the second adapter is coupled to the second vial by means of a second connector; (iii) a transfer port wherein the transfer port includes a first end ending in first adapter to gain access to first vial and a second end ending in second adapter to gain access to second vial; wherein the first adapters and the second adapter are joined together in vertical direction by means of horizontal wall; wherein the adapter connected to the vials by means of the ends.

Abstract: Present invention provide a system and a method for recording, evaluating, screening and monitoring life style associated Non-communicable diseases related data of a subject via an Integrated Medical Device (IMD) in real time, and sharing the same on a server, either local or cloud based, for fast, active sharing of data by remote users anytime anywhere.

Abstract: An electro-mechanical box trainer for neurosurgery comprise: (i) a base part which comprises a rubberized working port (11) for insertion of endoscope (26) and tool (25) for manipulation, a microcontroller programmed motorized peg plate (14) placed at 45° degrees of inclination for defining a practice volume according to the neuroendoscopy, a membrane keypad to change the angle of rotation of said peg plate (14) along vertical axis, liquid crystal display (LED) array to illuminate the interior of the box and a removable base plate (6) to house the circuitry; and (ii) a removable part enclosed of five walls such as a front wall (18), two lateral walls (17 and 19), a back wall (20) and a top wall (23), comprises a housing to mount an auxiliary camera (32) to record all the task for evaluation and a slider at the back to adjust the camera focus.

Abstract: The invention provides single stranded DNA aptamers specific to M.tb MPT51 and uses thereof in rapid, robust, highly specific, and cost effective diagnosis of tuberculosis. The invention also provides methods and devices based on the aptamers of the invention for the diagnosis of tuberculosis. Advantageously, aptamers of the present invention can selectively detect as low as 2 ng of M.tb MPT51 and this activity remains unaltered in presence of anti-MPT51 antibodies. The developed device can give sample-to-answer within 30 minutes.

Abstract: A novel device, method and kit for reconstitution of a solid or semi-solid pharmaceutical composition by a negative pressure differential includes (i) a first adapter with a first connector, a first peripheral wall wherein the first adapter is coupled to the first vial by means of a first connector; (ii) a second adapter with a second connector, a second peripheral wall wherein the second adapter is coupled to the second vial by means of a second connector; (iii) a transfer port wherein the transfer port includes a first end ending in first adapter to gain access to first vial and a second end ending in second adapter to gain access to second vial; wherein the first adapters and the second adapter are joined together in vertical direction by means of horizontal wall; wherein the adapter connected to the vials by means of the ends.

Abstract: This invention relates to a thermoluminescent phosphor for the measurement of low radiation doses, including calcium sulphate (CaSO4), Dysprosium (Dy) and manganese (Mn), wherein Dy and Mn are present as dopants. A process for the preparation of a thermoluminescent phosphor is also provided. The process includes the steps of: separately dissolving calcium sulphate (CaSO4), Dysprosium chloride (DyCh) and Manganese chloride (MnC) in hot concentrated sulphuric acid, to obtain sulphuric acid solutions of CaSO4, DyCb and MnCb; mixing the solutions; and followed by slow evaporation of the solvent to obtain a powder of microcrystalline phosphor of CaSO4:Dy, Mn.

Abstract: The present invention pertains to the field of neurosurgery and describes new methods to reduce basilar invagination (BI) and atlanto-axial dislocation (AAD). The invention further discloses novel surgical instruments useful in reducing basilar invagination (BI) and atlanto-axial dislocation (AAD). The novel techniques disclosed include distraction, compression and extension reduction and dynamic distraction coupled with cable compression.

Abstract: The present invention relates to cell specific therapeutic modality by using a region of the PLAP Promoter. The invention further relates to specific expression of therapeutically PLAP useful sequences for specific transcriptional activation of this gene. The invention also relates to the PLAP region which may be used alone or in combination with other regions like enhancer sequences that augment cell or tumour specific gene expression.

Abstract: This invention relates to a high affinity recombinant humanized antibody fragment (scFv) specific for hepatitis B surface antigen having unique inter/intra chain bonding interaction because of 28 altered amino acid residues from the original mouse (5S) antibody and its chimeric Fab form, wherein fine tuning of the vernier zone residue makes it closer to the human sequence without any structural constraints.

Abstract: The present subject matter relates to a cardio pulmonary resuscitation (CPR) device (102) including a backboard (110) to support a subject, and a constriction element (112) to constrict the subject. The constriction element (112) is connected to a decompression element (118). The decompression element (118) is disposed to be placed along the circumference of a thoracic region of the subject and is adapted to adhere to the subject on deployment. Further, a sternum compression unit (120) is attached to the decompression element (118) such that the sternum compression unit (120) is disposed on a side of the decompression element (118). Further, the constriction element (112) is adapted to be constricted and to be slackened for delivering active sternum compression, active circumferential compression, active sternum decompression and active circumferential decompression.

Abstract: A novel recombinant chimera of DNA construct having esat-6 region of Mycobacterium tuberculosis and kinesin region of Leishmania donovani cloned together on two sides of self cleaving peptide in a DNA vaccine vector pVAX-1 wherein the chimeric construct is operatively linked to a transcriptional promoter thus capable of self replication and expression within the mammalian cell, and the process of preparation thereof comprising: analysis of the predicted protein sequence of kinesin motor domain and esat-6 domain using Promiscuous MHC Class-1 Binding Peptide Prediction Servers; amplification of gene coding for kinesin motor domain and esat-6 domain; cloning of kinesin esat-6 gene region in pGEM-T™ vector for sequence analysis; generation of chimeric construct by directional cloning in pVAX-1 vector.

Abstract: A novel recombinant chimera of DNA construct having esat-6 region of Mycobacterium tuberculosis and kinesin region of Leishmania donovani cloned together on two sides of self cleaving peptide in a DNA vaccine vector pVAX-1 wherein the chimeric construct is operatively linked to a transcriptional promoter thus capable of self replication and expression within the mammalian cell, and the process of preparation thereof comprising: analysis of the predicted protein sequence of kinesin motor domain and esat-6 domain using Promiscuous MHC Class-1 Binding Peptide Prediction Servers; amplification of gene coding for kinesin motor domain and esat-6 domain; cloning of kinesin esat-6 gene region in pGEM-T™ vector for sequence analysis; generation of chimeric construct by directional cloning in pVAX-1 vector.

Abstract: This invention relates to a high affinity recombinant humanized antibody fragment (scFv) specific for hepatitis B surface antigen having unique inter/intra chain bonding interaction because of 28 altered amino acid residues from the original mouse (5S) antibody and its chimeric Fab form, wherein fine tuning of the vernier zone residue makes it closer to the human sequence without any structural constraints.

Abstract: The present invention provides compounds and methods for the detection of anti-leishmanial antibodies in individuals suspected of infection with the protozoan parasite of the genus Leishmania, where the infectious agent is an Indian strain and similar or closely related to Indian Leishmania strains. The compounds provided include polypeptides as shown in SEQ ID NO: 5 or SEQ ID NO: 6 which are useful for the detection of anti-leishmanial antibodies in individuals where the immune responses are elicited against Leishmania species of Indian strains and similar or closely related to Indian Leishmania strains, the compounds are also useful as a vaccine and therapeutic agent to prevent and treat leishmaniasis. The present invention further provides a diagnostic kit consisting of antibody raised against polypeptides as shown in SEQ ID NO: 5 or SEQ ID NO: 6 for detecting leishmanial antigens.

Abstract: The invention relates to a recombinant chimeric Fab antibody comprising a recombinant Fd and a recombinant chimeric light chain which binds to hepatitis B surface antigen with high affinity, generated by fusing variable region genes (VH and VL) of an anti-HBsAg mouse antibody 5S and constant region genes of human, CH1 region of human IgGI and the CL region of human kappa chain, wherein mouse VL and human CL are linked by overlap PCR to generate chimeric light chain and mouse VH and CH1 are linked by overlap PCR to generate chimeric Fd.

Abstract: The invention relates to aqueous suspension of dried latex (DL) of Calotropis procera and to a method of preparation for the prevention/treatment of cancer. The DL suspension when administered orally in the X-myc mice—a transgenic mouse model of hepatocellular carcinoma (HCC), was effective in protecting the animals from the atypical mitosis and displastic/neoplastic changes occurring in vivo. Further, the DL suspension did not show any observable side effects when administered orally to the animals for 16 weeks. Further, the purified fractions of the latex were found to exhibit potent cytotoxic activity in in vitro cell culture system using two different cancer cell lines.

Abstract: The present invention relates to a process for identifying a novel target for use for the development of therapeutic modalities and drugs effective against tuberculosis comprising testing M. tuberculosis devR mutant strain for virulence in guinea pigs.

Abstract: The present invention provides compounds and methods for the detection of anti-leishmanial antibodies in individuals suspected of infection with the protozoan parasite of the genus Leishmania, where the infectious agent is an Indian strain and similar or closely related to Indian Leishmania strains. The compounds provided include polypeptides as shown in SEQ ID NO: 5 or SEQ ID NO: 6 which are useful for the detection of anti-leishmanial antibodies in individuals where the immune responses are elicited against Leishmania species of Indian strains and similar or closely related to Indian Leishmania strains, the compounds are also useful as a vaccine and therapeutic agent to prevent and treat leishmaniasis. The present invention further provides a diagnostic kit consisting of antibody raised against polypeptides as shown in SEQ ID NO: 5 or SEQ ID NO: 6 for detecting leishmanial antigens.

Abstract: The present invention relates to a novel oligonucleotide primers having SEQ ID NO: 1, SEQ ID No: 2, SEQ ID NO: 3 and SEQ ID NO: 4 for amplification of the kinesin-related gene of Leishmania species. The invention also provides a method for detecting and differentiating visceral leishmaniasis (VL) and post kala-azar-dermal leishmaniasis (PKDL) causing strains of Leishmania donovani in a sample, comprising isolating DNA from a sample; amplifying the target region from the DNA using novel oligonucleotide primers and heat stable DNA polymerase to obtain amplified fragments; separating the amplified fragments and analyzing the fragments to detect and differentiate VL and PKDL causing strains of Leishmania donovani based on the banding pattern of the amplified fragments. In addition, the invention provides a diagnostic kit for detection and differentiation of VL and PKDL causing strains of the Leishmania donovani.

Abstract: The present invention relates to a method of processing clinical samples for diagnosing bacterial infections by smear microscopy, culture or PCR as well as a kit for performing the said method. This invention also pertains to two sets of primers specific for the DevR gene of M. tuberculosis as well as to a method of using said primers for screening patients for tuberculosis by PCR.