Abstract: An ion exchange chromatography apparatus includes a first stationary phase and a second stationary phase. The first stationary phase has at least one complexing agent functional group capable of forming a complex with at least one ion present in a sample that contains at least two ions when the sample contacts the first stationary phase. The second stationary phase is distinct from the first stationary phase and has at least one non-complexing agent functional group capable of exchanging with the ions present in the sample, other than the one complexed by the complexing agent functional group.

Abstract: An integrated suppressor and detector for suppressed ion chromatography includes a stationary phase, a fluid flow path, at least first and second regeneration electrodes, and at least first and second sensor electrodes. Methods of suppressed ion chromatography using the integrated suppressor and detector are also described.

Abstract: An apparatus and method for electrochemically modifying the retention of a species on a chromatography material is disclosed. The apparatus comprises a housing having an effluent flow channel adapted to permit fluid flow therethrough. The effluent flow channel comprises chromatography material. The apparatus further comprises first and second electrodes positioned such that at least a portion of the chromatography material is disposed between the first and second electrodes, and fluid flow through the apparatus is between, and in contact with, the first and second electrodes.

Abstract: An integrated suppressor and detector for suppressed ion chromatography includes a stationary phase, a fluid flow path, at least first and second regeneration electrodes, and at least first and second sensor electrodes. Methods of suppressed ion chromatography using the integrated suppressor and detector are also described.

Abstract: An apparatus and method for electrochemically modifying the retention of a species on a chromatography material is disclosed. The apparatus comprises a housing having an effluent flow channel adapted to permit fluid flow therethrough. The effluent flow channel comprises chromatography material. The apparatus further comprises first and second electrodes positioned such that at least a portion of the chromatography material is disposed between the first and second electrodes, and fluid flow through the apparatus is between, and in contact with, the first and second electrodes.

Abstract: An apparatus and method for electrochemically modifying the retention of a species on a chromatography material is disclosed. The apparatus comprises a housing having an effluent flow channel adapted to permit fluid flow therethrough. The effluent flow channel comprises chromatography material. The apparatus further comprises first and second electrodes positioned such that at least a portion of the chromatography material is disposed between the first and second electrodes, and fluid flow through the apparatus is between, and in contact with, the first and second electrodes.

Abstract: Methods and devices for continuous electrochemically suppressed ion chromatography are disclosed. In preferred aspect of the invention, a chromatography effluent comprising analyte ions and electrolyte is split into a first chromatography effluent flow stream and a second chromatography effluent flow stream. Electrolysis ions selected from the group consisting of hydronium ions and hydroxide ions are generated by the electrolysis of water. Electrolysis ions of the same charge as the electrolyte and the second chromatography effluent stream are flowed through a stationary phase thereby suppressing the electrolyte in the second chromatography effluent flow stream. The analyte ions are subsequently detected in the suppressed second chromatography effluent flow stream.

Abstract: Methods and devices for continuous electrochemically suppressed ion chromatography are disclosed. In preferred aspect of the invention, a chloromatography effluent comprising analyte ions and electrolyte is split into a first chromatography effluent flow stream and a second chromatography effluent flow stream. Electrolysis ions selected from the group consisting of hydronium ions and hydroxide ions are generated by the electrolysis of water. Electrolysis ions of the same charge as the electrolyte and the second chromatography effluent stream are flowed through a stationary phase thereby suppressing the electrolyte in the second chromatography effluent flow stream. The analyte ions are subsequently detected in the suppressed second chromatography effluent flow stream.

Abstract: Methods and devices for removing gas prior to detecting analyte ions are discolored. In one aspect of the invention, gas by-products from the suppression of the mobile phase are removed prior to detecting analyte ions at a detector. In another aspect, the amount of dissolved carbonic acid is reduced in a suppressed carbonate/bicarbonate mobile phase by removing carbon dioxide gas.

Abstract: The present invention is directed to a system for converting between single flow and split flow evaporative light scattering detection devices for detecting samples in a mobile phase. Included in the system is a evaporative light scattering detection device, a low temperature adaptor, and a connection tube for providing a fluid connection between the evaporative light scattering detection device and the low temperature adaptor.

Abstract: A system and method for electrochemically regenerated ion neutralization and concentration is disclosed. In one aspect of the invention, a system is provided comprising a HPLC column pump, a concentrator column, an analytical column, a suppressor, a detector, a mixed bed deionizing resin, a sample injector, and a neutralization cartridge.

Abstract: The present invention is directed to a device for evaporative light scattering detection that can be used for a wide range of sample types and mobile phases. The device may be quickly converted between a single flow and a split flow configuration through the use of a retractable impactor.

Abstract: An integrated suppressor and detector for suppressed ion chromatography includes a stationary phase, a fluid flow path, at least first and second regeneration electrodes, and at least first and second sensor electrodes. Methods of suppressed ion chromatography using the integrated suppressor and detector are also described.

Abstract: A system and method for electrochemically regenerated ion neutralization and concentration is disclosed. In one aspect of the invention, a system is provided comprising a HPLC column pump, a concentrator column, an analytical column, a suppressor, a detector, a mixed bed deionizing resin, a sample injector, and a neutralization cartridge.

Abstract: An apparatus and method for electrochemically modifying the retention of a species on a chromatography material is disclosed. The apparatus comprises a housing having an effluent flow channel adapted to permit fluid flow therethrough. The effluent flow channel comprises chromatography material. The apparatus further comprises first and second electrodes positioned such that at least a portion of the chromatography material is disposed between the first and second electrodes, and fluid flow through the apparatus is between, and in contact with, the first and second electrodes.

Abstract: The present invention relates to chromatography, and provides in a chromatography column new end fittings and an insert. Each end fitting is a plastics plug which is screwed to the end of the column tube, and inside the end fitting is a shoulder which is engaged by an insert. The insert fits neatly into the column tube so that it can be used to press against the column packing. The insert also embodies a cavity for a frit, and the end of the insert which projects into the column and seats against the column packing, has a skirt which is flared so that the pressure inside the column will spread the skirt which is of flexible plastics material into sealing contact with the column inner wall forming an effective seal. The insert may be in one piece plastics material component, or it may be in two pieces, a plastic piece embodying the skirt and stainless steel piece has the portion which engages the shoulder.

Abstract: The disclosed fitting connects a tubing end to a fluid conducting member which have a fluid port and end walls surrounding the port and a threaded portion surrounding the end wall. The fitting comprises a ferrule of resilient deformable material having a forward portion with a wide flat sealing surface which is adapted to mate with and sealingly engage the end wall surrounding the port. The ferrule has a throughbore with a diameter through its rearward portion being sufficient to receive the tubing end and the diameter through the forward portion being smaller than the tubing exterior thereby forming a tubing abutting shoulder within the ferrule. The ferrule is forced into sealing abuttment with the end wall of the fluid conducting member and into sealing engagement around the tubing by means of a fastener having a throughbore for receiving the tubing which is flared at its forward end to present conical walls for axially engaging the rearward end of the ferrule.

Abstract: A universal adapter coupling for liquid chromatography equipment, such as columns. The adapter coupling comprises two threaded segments which are matingly secured to one another and has an elongated sealing insert located in a central passage which extends axially between opposite ends of the holder. The insert protrudes from one of the ends of the holder and has a collar which is captured within a cavity in the holder. Ferrule seats are provided at opposite ends of the insert so that the adapter coupling can be used either as a female or a male coupling.

Abstract: A device for connecting one liquid chromatography device to another. The device comprises an elongated, cylindrical shaft having an integral ferrule seat at each end of the shaft. A central bore extends through the shaft and the integral ferrule seats to permit liquid to pass therethrough. An enlarged collar is located centrally on the shaft to aid in attaching the device to chromatography equipment. Because of the short length of the device and minimum size of the central bore, the device has a minimum of interceding volume so that the efficiency of connected devices is uneffected.

Abstract: A device for connecting one liquid chromatography device to another. The device comprises an elongated, cylindrical shaft having an integral ferrule seat at each end of the shaft. A central bore extends through the shaft and the integral ferrule seats to permit liquid to pass therethrough. An enlarged collar is located centrally on the shaft to aid in attaching the device to chromatography equipment. Because of the short length of the device and minimum size of the central bore, the device has a minimum of interceding volume so that the efficiency of connected devices is uneffected.