Patents Assigned to Ambrx, Inc.
  • Formulations of Human Growth Hormone Comprising a Non-Naturally Encoded Amino Acid
    Publication number: 20110195899
    Abstract: Formulations of modified human growth hormone polypeptides are provided.
    Type: Application
    Filed: August 5, 2010
    Publication date: August 11, 2011
    Applicant: AMBRX, INC.
    Inventors: Anna-Maria A. HAYS PUTNAM, Ying BUECHLER, David C. LITZINGER
  • Non-Natural Amino Acid Replication-Dependent Microorganisms and Vaccines
    Publication number: 20110195483
    Abstract: Compositions and methods of producing vaccines, including methods wherein whole organism vaccines are provided with limited replication abilities, thereby increasing vaccine safety and efficacy, through the use of non-natural, unnatural, or non-naturally encoded amino acids.
    Type: Application
    Filed: September 28, 2009
    Publication date: August 11, 2011
    Applicant: AMBRX, INC.
    Inventors: Feng Tian, Brad Hehli
  • Modified Human Apolipoprotein A-1 and Their Uses
    Publication number: 20110178029
    Abstract: Modified human apolipoprotein A-I polypeptides and uses thereof are provided.
    Type: Application
    Filed: September 15, 2008
    Publication date: July 21, 2011
    Applicant: AMBRX, INC.
    Inventors: Nick Knudsen, Stuart Bussell, Vadim Kraynov
  • Modified FGF-21 Polypeptides and Their Uses
    Publication number: 20110172401
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Application
    Filed: March 18, 2011
    Publication date: July 14, 2011
    Applicant: AMBRX, INC.
    Inventors: Thomas P. CUJEC, Roberto MARIANI, Anna-Maria A. HAYS PUTNAM, William M. KEEFE, Nick KNUDSEN, Lillian Ho, Jason PINKSTAFF, Vadim KRAYNOV
  • Methods and Compositions Comprising Non-Natural Amino Acids
    Publication number: 20110144307
    Abstract: Disclosed herein are methods of detecting non-natural amino acids and polypeptides that include at least one non-natural amino acid. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of functionalities, including but not limited to oxime, carbonyl, and/or hydroxylamine groups. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, and methods for detecting such polypeptides.
    Type: Application
    Filed: October 11, 2010
    Publication date: June 16, 2011
    Applicant: AMBRX, INC.
    Inventors: Zhenwei MIAO, Feng TIAN, Anna-Maria A. HAYS PUTNAM, Ying BUECHLER
  • Methods for expression and purification of recombinant human growth hormone mutants
    Patent number: 7959926
    Abstract: The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH comprising non-naturally encoded amino acids and hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.
    Type: Grant
    Filed: October 17, 2007
    Date of Patent: June 14, 2011
    Assignee: Ambrx, Inc.
    Inventors: Ying Buechler, Ricky Lieu, Michael Ong, Stuart Bussell, Nick Knudsen, Ho Sung Cho
  • COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES
    Publication number: 20110124880
    Abstract: Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
    Type: Application
    Filed: January 13, 2011
    Publication date: May 26, 2011
    Applicant: Ambrx, Inc.
    Inventors: Zhenwei Miao, Junjie Liu, Thea Norman, Russell Driver
  • Methods for expression and purification of pegylated recombinant human growth hormone containing a non-naturally encoded keto amino acid
    Patent number: 7947473
    Abstract: The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH comprising non-naturally encoded amino acids and hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.
    Type: Grant
    Filed: January 31, 2008
    Date of Patent: May 24, 2011
    Assignee: AMBRX, Inc.
    Inventors: Ying Buechler, Ricky Lieu, Michael Ong, Stuart Bussell, Nick Knudsen, Ho Sung Cho
  • COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES
    Publication number: 20110118501
    Abstract: Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
    Type: Application
    Filed: January 13, 2011
    Publication date: May 19, 2011
    Applicant: Ambrx, Inc.
    Inventors: Zhenwei Miao, Junjie Liu, Thea Norman, Russell Driver
  • COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES
    Publication number: 20110118451
    Abstract: Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
    Type: Application
    Filed: January 13, 2011
    Publication date: May 19, 2011
    Applicant: Ambrx, Inc.
    Inventors: Zhenwei Miao, Junjie Liu, Thea Norman, Russell Driver
  • ACCELERANTS FOR THE MODIFICATION OF NON-NATURAL AMINO ACIDS AND NON-NATURAL AMINO ACID POLYPEPTIDES
    Publication number: 20110118450
    Abstract: Disclosed herein are accelerants for the formation of oxime-containing compounds from the reaction of a carbonyl-containing compound and a hydroxylamine-containing compound. The oxime-containing compound, the carbonyl-containing compound and the hydroxylamine-containing compound can each be a non-natural amino acid or a non-natural amino acid polypeptide. Also disclosed is the use of such accelerants to form oxime-containing compounds, the resulting oxime-containing compounds, and reaction mixtures containing such accelerants.
    Type: Application
    Filed: November 12, 2010
    Publication date: May 19, 2011
    Applicant: AMBRX, INC.
    Inventors: Feng Tian, Zhenwei Miao
  • Modified human growth horomone polypeptides and their uses
    Patent number: 7939496
    Abstract: Modified growth hormone polypeptide and uses thereof are provided.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: May 10, 2011
    Assignee: AMBRX, Inc.
    Inventors: Ho Sung Cho, Thomas O. Daniel, Richard D. DiMarchi, Anna-Maria Hays, Troy E. Wilson, Bee-Cheng Sim, David C. Litzinger
  • Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
    Patent number: 7928163
    Abstract: Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
    Type: Grant
    Filed: October 16, 2007
    Date of Patent: April 19, 2011
    Assignee: Ambrx, Inc.
    Inventors: Zhenwei Miao, Junjie Liu, Thea Norman, Russell Driver
  • Modified human plasma polypeptide or Fc scaffolds and their uses
    Patent number: 7919591
    Abstract: Modified human plasma polypeptides or Fc and uses thereof are provided.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: April 5, 2011
    Assignee: Ambrx, Inc.
    Inventors: Joseph Sheffer, Thea Norman, Richard D. Dimarchi, Anna-Maria A. Hays Putnam, Feng Tian, Stephanie Chu, Denise Krawitz, Ho Sung Cho
  • Accelerants for the modification of non-natural amino acids and non-natural amino acid polypeptides
    Patent number: 7888533
    Abstract: Disclosed herein are accelerants for the formation of oxime-containing compounds from the reaction of a carbonyl-containing compound and a hydroxylamine-containing compound. The oxime-containing compound, the carbonyl-containing compound and the hydroxylamine-containing compound can each be a non-natural amino acid or a non-natural amino acid polypeptide. Also disclosed is the use of such accelerants to form oxime-containing compounds, the resulting oxime-containing compounds, and reaction mixtures containing such accelerants.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: February 15, 2011
    Assignee: Ambrx, Inc.
    Inventors: Feng Tian, Zhenwei Miao
  • Compositions of aminoacyl-tRNA synthetase and uses thereof
    Patent number: 7883866
    Abstract: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: February 8, 2011
    Assignee: Ambrx, Inc.
    Inventors: Andrew Paulsel, Ho Sung Cho
  • Modified FGF-23 Polypeptides and Their Uses
    Publication number: 20110015345
    Abstract: Modified FGF-23 polypeptides and uses thereof are provided.
    Type: Application
    Filed: March 19, 2009
    Publication date: January 20, 2011
    Applicant: AMBRX, INC.
    Inventors: Jason Pinkstaff, Anna-Maria A Hays Putnam, Kristin S Eaton
  • Compositions of aminoacyl-tRNA synthetase and uses thereof
    Patent number: 7858344
    Abstract: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: December 28, 2010
    Assignee: Ambrx, Inc.
    Inventors: Andrew Paulsel, Ho Sung Cho
  • Compositions of aminoacyl-tRNA synthetase and uses thereof
    Patent number: 7846689
    Abstract: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: December 7, 2010
    Assignee: Ambrx, Inc.
    Inventors: Andrew Paulsel, Ho Sung Cho
  • Modified Insulin Polypeptides and Their Uses
    Publication number: 20100298212
    Abstract: Modified insulin polypeptides and their uses thereof are provided
    Type: Application
    Filed: November 20, 2008
    Publication date: November 25, 2010
    Applicant: AMBRX, INC.
    Inventors: Zhenwei Miao, Denise Krawitz, Vadim Kraynov, Tian Feng, Bee-Cheng Sim, Lillian Skidmore, Anna-Maria A. Hays Putnam, Nick Knudesen, Michael Deguzman