Patents Assigned to American Cyanamid Company
  • Patent number: 8247211
    Abstract: The invention provides compounds of formula Wherein R1, R2, R3, R4, R5, R6a, R6b, R6c, R6d, R6e and R7 are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: August 21, 2012
    Assignees: American Cyanamid Company, Wyeth Holdings Corporation
    Inventors: Jason Arnold Lotvin, Mark Edward Ruppen
  • Publication number: 20110151546
    Abstract: The invention provides compounds of formula Wherein R1, R2, R3, R4, R5, R6a, R6b, R6c, R6d, R6e and R7 are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Application
    Filed: February 8, 2011
    Publication date: June 23, 2011
    Applicants: AMERICAN CYANAMID COMPANY, Wyeth Holdings Corporation
    Inventors: Jason Arnold Lotvin, Mark Edward Ruppen
  • Patent number: 6887661
    Abstract: Promising groups of environmetally-safe insecticides consist of analogues of insect hormones, such as juvenile hormone, and antagonists of such hormones. The traditional bioassay approach for screening potential juvenile hormone analogs and antagonists is slow, expensive and inefficient. A recombinant bHLH-PAS-juvenile hormone receptor, isolated from the methoprene-tolerant locus on Drosophila, provides the basis of in vitro and in vivo binding assays that can be used to discover new juvenile hormone-type targeted insecticides. Moreover, the nucleotide sequence of the Drosophila bHLH-PAS/JHR polypeptide provides tools for isolating juvenile hormone receptor genes from other insect species.
    Type: Grant
    Filed: April 14, 1998
    Date of Patent: May 3, 2005
    Assignees: American Cyanamid Company, Colorado State University Research Foundation
    Inventors: Thomas G. Wilson, Julia N. Heinrich
  • Patent number: 6831079
    Abstract: This invention provides novel formulations for vasopressin agonist compounds, or a pharmaceutically acceptable salt thereof, having the general structure: and processes for making them, the formulations comprising from about 1% to about 20% of active ingredient, from about 1% to about 18% of a surfactant component, from about 50% to about 80% of a component of one or more polyethylene glycols, from about 1% to about 20% of a component of one or more sucrose fatty acid esters and/or polyvinylpyrrolidone and, optionally, one or more preservatives or antioxidants.
    Type: Grant
    Filed: September 25, 2000
    Date of Patent: December 14, 2004
    Assignee: American Cyanamid Company
    Inventors: Joseph K. Yoon, Richard W Saunders, Mahdi Fawzi
  • Patent number: 6753417
    Abstract: The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than one of these species may aggregate to form the very high molecular weight form (i.e. greater than 200 kDa) of the UspA antigen. Compositions and both diagnostic and therapeutic methods for the treatment and study of M. catarrhalis are disclosed.
    Type: Grant
    Filed: September 12, 2001
    Date of Patent: June 22, 2004
    Assignees: Board of Regents, The University of Texas System, American Cyanamid Company
    Inventors: Eric J. Hansen, Christoph Aebi, Leslie D. Cope, Isobel Maciver, Michael J. Fiske, Ross A. Fredenburg
  • Patent number: 6746677
    Abstract: The invention relates to certain stable vaccine compositions comprising a macrocyclic lactone compound, a milbemycin compound, an avermectin compound or mixtures thereof; at least one antigen; a dispersing agent; an adjuvant; a water soluble organic solvent; and saline or water or mixtures thereof. The invention further relates to stable compositions as described above of a macrocyclic lactone compound, a milbemycin compound, an avermectin compound or mixtures thereof, but without an antigen. The invention also relates to a method for preventing or controlling helminthiasis, infection by acarids and arthropod endo-and ectoparasites and bacterial and viral disease in warm-blooded animals by the parenteral administration of compositions of the invention. The invention further relates to a process for the preparation of the invention compositions.
    Type: Grant
    Filed: October 8, 1999
    Date of Patent: June 8, 2004
    Assignee: American Cyanamid Company
    Inventors: Ramune Marija Cobb, Christopher Leigh Schwartzkoff
  • Patent number: 6673540
    Abstract: This invention relates to modified host cells which express heterologous fused proteins and methods of screening for test samples having peptide binding activity; wherein the modified host cell comprises: (a) a gene sequence encoding a heterologous fusion protein; the fusion protein comprising a first peptide of a peptide binding pair, or segment of the first peptide, which is joined to either a DNA binding domain or its corresponding transcriptional activation domain of a transcriptional activation protein; (b) a gene sequence encoding a heterologous fusion protein, the fusion protein comprising a second peptide of the peptide binding pair in (a), or a segment thereof, fused to either a DNA binding domain or its corresponding transcriptional activation domain, whichever one is not employed in (a); (c) a reporter gene operatively associated with the transcriptional activation protein, or a portion thereof; (d) optionally, a deletion or mutation in the chromosomal DNA of the host cell for the transcriptional a
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: January 6, 2004
    Assignee: American Cyanamid Company
    Inventors: Kathleen H. Young, Bradley A. Ozenberger
  • Publication number: 20030208066
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: March 17, 2003
    Publication date: November 6, 2003
    Applicant: American Cyanamid Company
    Inventors: Jeremy I.. Levin, James Ming Chen, Xue-Mei Du, Jay D. Albright, Arie Zask
  • Patent number: 6610310
    Abstract: Mucosal adjuvants for vaccines contain water-soluble polyanionic polymers which have anionic constitutional units obtained from acids such as acrylic acid, methacrylic acid, maleic acid, fumaric acid, ethylsulphonic acid, vinylsulphuric acid, vinylsulphonic acid, styrenesulphonic acid, vinylphenylsulphuric acid, 2-methacryloyloxyethane sulphonic acid, 3-methacryloyloxy-2-hydroxypropanesulphonic acid, 3-methacryl amido-3-methylbutanoic acid, acrylamidomethylpropanesulphonic acid, vinylphosphoric acid, 4-vinylbenzoic acid, 3-vinyl oxypropane-1-sulphonic acid, N-vinylsuccinimidic acid, and salts of the foregoing. The polyanionic polymers may further have hydrophobic constitutional repeating units, such as alkylesters, cycloalkylesters, hydroxyalkylesters, ethers, glycols, aromatic groups and salts thereof. The adjuvants containing the polyanionic polymers are used in vaccines for the induction or enhancement of mucosal immune responses.
    Type: Grant
    Filed: June 11, 1999
    Date of Patent: August 26, 2003
    Assignee: American Cyanamid Company
    Inventor: Luuk Hilgers
  • Publication number: 20030149063
    Abstract: This invention relates to a method of using novel 5-(arylsulfonyl)-,5- (arylsulfinyl), and 5-(arylsulfanyl)-thiazolidine-2,4-diones of Formula (I), wherein Ar, Ar′, R6, m and n are as defined in the specification as inhibitors of Ras FPTase, and may be used as an alternative to, or in conjunction with, traditional cancer therapy for treating ras- oncogene-dependent tumors, such as cancers of the pancreas, colon, bladder, and thyroid.
    Type: Application
    Filed: August 23, 2002
    Publication date: August 7, 2003
    Applicant: American Cyanamid Company
    Inventors: Joseph William Epstein, Semiramis Ayral-Kaloustian, Gary Harold Birnberg, Edward James Salaski, Gloria Jean Macewan, Katherine Cheung
  • Publication number: 20030149056
    Abstract: This invention provides compounds of Formula (I), represented by the structure 1
    Type: Application
    Filed: November 26, 2002
    Publication date: August 7, 2003
    Applicant: American Cyanamid Company
    Inventors: Allan Wissner, Hwei-Ru Tsou, Middleton Brawner Floyd, Bernard D. Johnson, Elsebe Geraldine Overbeek-Klumpers
  • Publication number: 20030144301
    Abstract: This invention relates to a method of using novel 5-(arylsulfonyl)-, 5-(arylsulfinyl)- and 5-(arylsulfanyl)thiazolidine-2,4-diones of Formula (1), wherein Ar, Ar′, R6, m and n are as defined in the specification as inhibitors of Ras FPTase, and may be used as an alternative to, or in conjunction with, traditional cancer therapy for treating ras- oncogene-dependent tumors, such as cancers of the pancreas, colon, bladder, and thyroid.
    Type: Application
    Filed: August 23, 2002
    Publication date: July 31, 2003
    Applicant: American Cyanamid Company
    Inventors: Semiramis Ayral-Kaloustian, Joseph William Epstein, Gary H. Birnberg, Edward James Salaski, Gloria Macewan, Katherine Cheung
  • Patent number: 6596512
    Abstract: A nematode dopamine tansporter cDNA has been cloned, sequenced, and expressed, and provides a convenient screening assay for antiparasitics, as well as psychoactive drugs.
    Type: Grant
    Filed: July 18, 2000
    Date of Patent: July 22, 2003
    Assignees: American Cyanamid Company, Vanderbilt University
    Inventors: Randy D. Blakely, Cecil M. Eppler
  • Patent number: 6592873
    Abstract: The present invention provides a purified preparation containing a polynucleic acid encoding at least one polypeptide selected from the group consisting of proteins encoded by one or more open reading frames (ORF's) of an Iowa strain of porcine reproductive and respiratory syndrome virus (PRRSV), proteins at least 80% but less than 100% homologous with those encoded by one or more of ORF 2, ORF 3, ORF 4 and ORF 5 of an Iowa strain of PRRSV, proteins at least 97% but less than 100% homologous with proteins encoded by one or both of ORF 6 and ORF 7 of an Iowa strain of PRRSV, antigenic regions of such proteins which are at least 5 amino acids in length and which effectively stimulate immunological protection in a porcine host against a subsequent challenge with a PRRSV isolate, and combinations thereof, in which amino acids non-essential for antigenicity may be conservatively substituted.
    Type: Grant
    Filed: September 1, 1994
    Date of Patent: July 15, 2003
    Assignees: Iowa State University Research Foundation, Inc., American Cyanamid Company
    Inventors: Prem S. Paul, Xiang-Jin Meng, Patrick Halbur, Igor Morozov, Melissa A. Lum
  • Publication number: 20030130238
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: November 1, 2002
    Publication date: July 10, 2003
    Applicant: American Cyanamid Company
    Inventors: Vincent Premaratna Sandanayaka, Efren Guillermo Delos Santos
  • Publication number: 20030104986
    Abstract: This invention relates to new antibiotics designated AA-896-A1, AA-896-A2, AA-896-A3, AA-896-A4, AA-896-A5, AA-896-A6, AA-896-B1, AA-896-B2, AA-896-B3, AA-896-B4, AA-896-B5, AA-896-B6, AA-896-B7, AA-896-C1, AA-896-C2, AA-896-C3, AA-896-C4, AA-896-C5, AA-896-D1, AA-896-D2, AA-896-D3 and AA-896-D4 derived from the microorganism Streptomyces spp. LL-AA896 which are useful an anti-bacterial agents.
    Type: Application
    Filed: April 25, 2002
    Publication date: June 5, 2003
    Applicant: American Cyanamid Company
    Inventors: Guy Thomas Carter, Jason Arnold Lotvin, Leonard Alexander McDonald
  • Publication number: 20030096849
    Abstract: The invention relates to compounds of Formula (I) wherein R1, (R2)v, R3 and n are defined in the specification and pharmaceutical compositions thereof, that inhibit the Ras farnesyl-protein transferase enzyme (FPTase), and may be used as an alternative to, or in conjunction with, traditional cancer therapy for the treatment of ras oncogene-dependent tumors, such as cancers of the pancreas, colon, bladder, and thyroid.
    Type: Application
    Filed: August 23, 2002
    Publication date: May 22, 2003
    Applicant: American Cyanamid Company
    Inventors: Edward James Salaski, Semiramis Ayral-Kaloustian, Joseph William Epstein
  • Publication number: 20030092610
    Abstract: The invention provides compounds of formula 1
    Type: Application
    Filed: April 25, 2002
    Publication date: May 15, 2003
    Applicant: American Cyanamid Company
    Inventors: Darren Robert Abbanat, Arthur Emery Bailey, Valerie Sue Bernan, Michael Greenstein, Jason Arnold Lotvin, Mark Edward Ruppen, Alan Gordon Sutherland, Haiyin He
  • Publication number: 20030087812
    Abstract: The invention provides compounds of formula 1
    Type: Application
    Filed: April 25, 2002
    Publication date: May 8, 2003
    Applicant: American Cyanamid Company
    Inventors: Darren Robert Abbanat, Valerie Sue Bernan, Russell George Dushin, Michael Greenstein, Haiyin He, Stanley Albert Lang, Howard Newman, Subas Sakya, Phaik-Eng Sum, Alan Gordon Sutherland, Ting-Zhong Wang, Jason Arnold Lotvin, Mark Edward Ruppen, Arthur Emery Bailey, Ping Cai, Bo Shen, Fangming Kong
  • Publication number: 20030087874
    Abstract: The invention provides compounds of the Formula 1 1
    Type: Application
    Filed: April 25, 2002
    Publication date: May 8, 2003
    Applicant: American Cyanamid Company
    Inventors: Ayako Yamashita, Emily Boucher Norton