Patents Assigned to American Cyanamid
  • Process for the preparation of 2,3-pyridinedicarboximides
    Patent number: 6316629
    Abstract: There is provided a process for the preparation of 2,3-pyridinedicarboximides having the structural formula I The 2,3-pyridinedicarboximides are useful as intermediates in the preparation of herbicidal 2-(2-imidazolin-2-yl)nicotinic acids, esters and salts.
    Type: Grant
    Filed: June 11, 1998
    Date of Patent: November 13, 2001
    Assignee: American Cyanamid Co.
    Inventors: Kenneth Alfred Martin Kremer, Wen-Xue Wu, Donald Roy Maulding
  • Acetylenic sulfonamide thiol tace inhibitors
    Patent number: 6313123
    Abstract: The compounds of formula B: which are useful in disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: November 6, 2001
    Assignee: American Cyanamid Company
    Inventors: Jeremy I. Levin, James M. Chen
  • Herbicidal 2-aryloxy-or 2-arylthio-6-arylpyrimidines
    Patent number: 6313072
    Abstract: The novel compounds of formula I: (A, B, R1, R2, R3, X and m are defined in the specification) show selective herbicidal activity. The new compounds can be prepared according to known methods and can be used as herbicides in agriculture and related fields.
    Type: Grant
    Filed: February 18, 1999
    Date of Patent: November 6, 2001
    Assignee: American Cyanamid Company
    Inventors: Stephen Scheiblich, Thomas Maier, Axel Kleemann, Helmut Siegfried Baltruschat
  • Herbicidal 3,5-difluoropyridines
    Patent number: 6310006
    Abstract: The invention relates to novel compounds of formula I: wherein R, A, B and X have the meaning given in claim 1; and the agronomically acceptable salts or N-oxides thereof, and to herbicidal compositions containing such compounds as active ingredients.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: October 30, 2001
    Assignee: American Cyanamid Company
    Inventors: Thomas Maier, Stefan Scheiblich, Helmut S. Baltruschat
  • USPA1 and USPA2 antigens of Moraxella catarrhalis
    Patent number: 6310190
    Abstract: The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than one of these species may aggregate to form the very high molecular weight form (i.e. greater than 200 kDa) of the UspA antigen. Compositions and both diagnostic and therapeutic methods for the treatment and study of M. catarrhalis are disclosed.
    Type: Grant
    Filed: June 21, 1999
    Date of Patent: October 30, 2001
    Assignees: Board of Regents, The University of Texas, American Cyanamid
    Inventors: Eric J. Hansen, Christoph Aebi, Leslie D. Cope, Isobel Maciver, Michael J. Fiske, Ross A. Fredenburg
  • Use of aryl-substituted pyrimidines as insecticidal and acaricidal agents
    Patent number: 6306866
    Abstract: There are provided compositions and methods comprising compounds of formula I: wherein R1, A, B, X, Y and Z have the meaning given in claim 1, for the control of insect and acarid pests.
    Type: Grant
    Filed: March 6, 1998
    Date of Patent: October 23, 2001
    Assignee: American Cyanamid Company
    Inventors: William Wakefield Wood, Linda Fleming, Salvatore John Cuccia
  • Adjuvant and vaccine compositions containing monophosphoryl lipid A
    Patent number: 6306404
    Abstract: The invention pertains to adjuvant and vaccine compositions of monophosphoryl lipid A, sugar and optionally an amine based surfactant, which when frozen and thawed or lyophilized and reconstituted reform a colloidal suspension having a light transmission of greater than or equal to 88% as measured spectrophotometrically.
    Type: Grant
    Filed: July 13, 1999
    Date of Patent: October 23, 2001
    Assignee: American Cyanamid Company
    Inventors: Vincent James LaPosta, John Hayward Eldridge
  • Process for the preparation of 1,1,1-trifluoro-2-aminoalkanes
    Patent number: 6307103
    Abstract: An improved process for the preparation of a 1,1,1-trifluoro-2-aminoalkane of formula I wherein R1 represents an optionally substituted alkyl group; which comprises hydrogenating the corresponding oxime of formula II wherein R1 has the meaning given above and the winding line indicates that the hydroxy group may be in the (E)- or (Z)-position with respect to the trifluoromethyl group, in the presence of Raney nickel and a diluent; the improvement wherein is, that said reaction is carried out in a diluent selected from an alkanol, a cyclic ether and an aromatic hydrocarbon.
    Type: Grant
    Filed: March 28, 2000
    Date of Patent: October 23, 2001
    Assignee: American Cyanamid Company
    Inventors: Hans-Peter Niedermann, Dieter Gutheil
  • Valve assembly for use with containers in a closed application system
    Patent number: 6305444
    Abstract: A container for use in a closed application system includes a valve mounted to a discharge opening of the container and rotatable with the container for controlling the discharge of material from the container. The valve includes an element for engaging corresponding structure in a receptacle for receiving the contents of the container. The element engages and locks the valve in the receptacle when the valve is opened and the contents are being discharged from the container into the receptacle. The valve element and the corresponding structure on the receptacle cooperate so that the container can only be received in and removed from the receptacle when the valve is closed. In this manner, the contents in the container can be discharged only when the container is received within the receptacle and the container is rotated in a direction to open the valve.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: October 23, 2001
    Assignee: American Cyanamid Company
    Inventor: Keith F. Woodruff
  • Stable arylpyrrole particles, process for their preparation and suspension concentrate compositions comprising them
    Publication number: 20010031879
    Abstract: The present invention relates to arylpyrrole particles which are prepared by a process in which the particles are aged and milled, and pesticidal suspension concentrate compositions comprising them. The size of the particles of this invention remains surprisingly stable during storage.
    Type: Application
    Filed: April 2, 2001
    Publication date: October 18, 2001
    Applicant: Intellectual Property Department American Cyanamid Company
    Inventors: Mimi Yih-Pei Chou Schaaf, Steven Brunt, Jian James Xu, Andrew Evelyn Goldsmith, Anthony Francis Walker, Patrick C. Mowery, Edward S. Donoghue, Srinivasan Rajan
  • 1- (3-Heterocyclylphenyl) isothiourea, -isourea, -guanidine and -amidine herbicidal agents
    Patent number: 6303783
    Abstract: There are provided 1-(3-heterocyclyphenyl)isothio-urea, -isourea, -guanidine and -amidine compounds of formula I Further provided are compositions and methods comprising those compounds for the control of undesirable plant species.
    Type: Grant
    Filed: August 4, 1999
    Date of Patent: October 16, 2001
    Assignee: American Cyanamid Co.
    Inventor: Gary Mitchell Karp
  • Fungicidal trifluorophenyl-triazolopyrimidines
    Patent number: 6297251
    Abstract: The novel compounds of formula I: (R1, R2 and Hal are defined in the specification) show selective fungicidal activity. The new compounds are processed with carriers and adjuvants to fungicidal compositions.
    Type: Grant
    Filed: December 8, 1999
    Date of Patent: October 2, 2001
    Assignee: American Cyanamid Co.
    Inventors: Klaus-Juergen Pees, Guido Albert
  • Substituted 3-cyanoquinolines
    Patent number: 6297258
    Abstract: This invention provides compounds of formula I having the structure wherein G1, G2, R1, R4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
    Type: Grant
    Filed: August 1, 2000
    Date of Patent: October 2, 2001
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Hwei-Ru Tsou, Dan M. Berger, Middleton B. Floyd, Jr., Philip R. Hamann, Nan Zhang, Philip Frost
  • Methods and apparatus for metering material
    Patent number: 6293438
    Abstract: Methods and apparatus are provided for dispensing materials, and in particular, granular chemical agricultural material, from a moving device driven over terrain to be treated with the material. The device has a metering system for dispensing the material including a rotatable apertured disk for metering material from a product container and dispensing the material in controlled metered quantities. The metering disk is removable from its operating position within the dispensing device for inspection, repair or replacement purposes, without disassembling the overall apparatus, and a guide is provided for returning the metering disk to its operating position within the dispensing device. The apertures in the metering disk are oriented so that each aperture partially overlaps each adjacent aperture to result in continuous flow of the metered material through the metering disk as it rotates.
    Type: Grant
    Filed: July 29, 1999
    Date of Patent: September 25, 2001
    Assignee: American Cyanamid Company
    Inventor: Keith F. Woodruff
  • Process for the preparation of 6-(arylcarbonyl)-4-oximo-dihydrobenzothiopyran herbicides and intermediates useful therein
    Patent number: 6294676
    Abstract: The present invention provides compounds of formula I and processes for the preparation and purification thereof. Compounds of formula I are useful as intermediates in the manufacture of 6-(arylcarbonyl)-4-oximino-dihydrobenzothiopyran herbicidal agents.
    Type: Grant
    Filed: December 15, 1999
    Date of Patent: September 25, 2001
    Assignees: American Cyanamid Company, Idemitsu Kosan Co., Ltd.
    Inventors: Robert Francis Doehner, Jr., Thomas Walter Drabb, Robert Paul Brigance
  • Processes for the preparation of 2-arylvinyl alkyl ether and 1,4-diaryl-2-fluoro-2-butene compounds
    Patent number: 6291721
    Abstract: An improved process for the preparation of 2-arylvinyl alkyl ether compounds of the structural formula I In addition, the present invention provides an improved process for the preparation of 1,4-diaryl-2-fluoro-2-butene compounds of the structural formula V
    Type: Grant
    Filed: August 12, 1999
    Date of Patent: September 18, 2001
    Assignee: American Cyanamid Co.
    Inventors: Yulin Hu, David Allen Hunt, Weiguo Liu
  • N-hydroxy-2-(alkyl, aryl, or heteroaryl, sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
    Patent number: 6288086
    Abstract: Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenases, stromelysins and gelatinases. TNF-&agr; converting enzyme (TACE), a pro-inflammatory cytokine, catalyzes the formation of TNF-&agr; from membrane bound TNF-&agr; precursor protein. It is expected that small molecule inhibitors of MMPs and TACE therefore have the potential for treating a variety of disease states.
    Type: Grant
    Filed: June 14, 2000
    Date of Patent: September 11, 2001
    Assignee: American Cyanamid Company
    Inventor: Aranapakam Mudumbai Venkatesan
  • 1,4-diaryl-2,3-difluoro-2-butene insecticidal and acaricidal agents
    Patent number: 6288011
    Abstract: Pesticidal 1,4-diaryl-2,3-difluoro-2-butene compounds having the structural formula I and compositions and methods comprising those compounds for the control of insect and acarid pests.
    Type: Grant
    Filed: November 11, 1998
    Date of Patent: September 11, 2001
    Assignee: American Cyanamid Co.
    Inventors: Terence James Bentley, Keith Douglas Barnes
  • Substituted 3-cyanoquinolines
    Patent number: 6288082
    Abstract: This invention provides compounds of formula I having the structure wherein G1, G2, R1, R4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
    Type: Grant
    Filed: September 24, 1999
    Date of Patent: September 11, 2001
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Hwei-Ru Tsou, Dan M. Berger, Middleton B. Floyd, Jr., Philip R. Hamann, Nan Zhang, Mark E. Salvati, Philip Frost
  • Imidazolinone haptens and antigens and enzyme conjugates prepared therefrom
    Publication number: 20010020087
    Abstract: The present invention provides an imidazolinone hapten having the structural formula 1
    Type: Application
    Filed: March 13, 2001
    Publication date: September 6, 2001
    Applicant: American Cyanamid Company
    Inventors: Rosie Bick-Har Wong, Joseph Luke Pont, Alvin Donald Crews