Abstract: The novel compounds of formula I:
(R1, R2, R3, L1, L2 and Hal are defined in the specification) show selective fungicidal activity. These compounds may be processed with carriers, and optionally an adjuvant, to produce fungicidal compositions.
Abstract: This invention relates to novel modified host cells which express heterologous fused proteins and methods of screening for test samples having peptide-binding activity; wherein the modified host cell comprises: (a) a gene sequence encoding a heterologous fusion protein; said fusion protein comprising a first peptide of a peptide binding pair, or segment of said first peptide, which is joined to either a DNA binding domain or its corresponding transcriptional activation domain of a transcriptional activation protein; (b) a gene sequence encoding a heterologous fusion protein, said fusion protein comprising a second peptide of the peptide binding pair in (a), or a segment thereof, fused to either a DNA binding domain or its corresponding transcriptional activation domain, whichever one is not employed in (a); (c) a reporter gene operatively associated with the transcriptional activation protein, or a portion thereof; (d) optionally, a deletion or mutation in the chromosomal DNA of the host cell for the transcri
Type:
Grant
Filed:
May 6, 1999
Date of Patent:
September 4, 2001
Assignee:
American Cyanamid Company
Inventors:
Kathleen H. Young, Bradley A. Ozenberger
Abstract: The present invention is concerned with a vaccine for combating B. bronchiseptica infection in susceptible animals (such as dogs and swine), containing proteins or polypeptides typical of the fimbrial protein of B. bronchiseptica, or containing recombinant polynucleotides having as part thereof a polynucleotide coding for the protein or polypeptide, and also is concerned with the preparation of said proteins, polypeptides and polynucleotides.
Abstract: The invention relates to methods for protecting cereal crops from injury caused by a herbicidally effective amount of a herbicide, in particular, herbicides selected from the group consisting of AHAS-inhibiting, ACCase-inhibiting and HPPD-inhibiting herbicides, which comprises applying to the crop plant, the seed of the crop, or the soil surrounding the crop or crop seed an effective non-phytotoxic antidotal amount of a benzothiazole derivative of formula I
wherein
A represents an alkyl, alkoxy, haloalkoxy, hydroxy, cyano or nitro group or a group of the formula
in which W represents O or S, and R represents a hydroxy, thiol, alkoxy, thioalkyl, amino, alkylamino or dialkylamino group; and
X represents CH or N;
Also included are safened herbicidal compositions comprising a herbicidally effective amount of a herbicide and an effective nonphytotoxic antidotal amount a benzothiazole derivative of formula I.
Type:
Grant
Filed:
January 18, 2000
Date of Patent:
August 28, 2001
Assignee:
American Cyanamid Co.
Inventors:
Dale Lester Shaner, Helmut Siegfried Baltruschat, Norbert Nelgen
Abstract: The invention relates to a process for the preparation of substituted pyrimidines of formula I,
wherein
R1, R2, R3, R4 and X are as defined in claim 1, which comprises reacting an amidine of formula II,
or a salt thereof, with a 3,3-disubstituted vinylcarbonyl compound of formula III
wherein L represent a halogen atom or a group of formula —X—R2,
(a) in an inert solvent, in the presence of a base and a compound of formula IV
H—X—R2 (IV)
in the event that L represent a halogen atom, or
(b) in an inert solvent and in the presence of a base, in the event that L represents a group of formula —X—R2.
Abstract: Hydroxamic acids having the formula
are useful in treating disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
Abstract: The novel compounds of formula I:
wherein
(R1, R2, R3, A, X, L and n through L5 are defined in the specification) show high fungicidal activity. The new compounds are processed with carriers and adjuvants to fungicidal compositions.
Abstract: The present invention provides a method for the synergistic control of undesirable plants such as Ipomoea, Cyperus, Sida and Euphorbia which comprises applying to the plants or their locus a synergistically effective amount of a combination of glyphosate and an imidazolinone compound. Further provided are synergistic herbicidal compositions comprising glyphosate and an imidazolinone compound.
Type:
Grant
Filed:
September 14, 1999
Date of Patent:
August 21, 2001
Assignee:
American Cyanamid Co.
Inventors:
Timothy Malefyt, Robert M. Watkins, Frederick P. Salzman
Abstract: The invention relates to fungicidal composition comprising an acceptable carrier and/or surface active agent and synergistically effective amounts of
(a) at least one azolopyrimidine of formula I
in which R1 through R2, L, A and n have the meaning given in claim 1;
(b) and at least one melanin biosynthesis inhibitor (MBI), preferably a phenoxyamide of formula II
wherein R5 through R9, Y and m have the meaning given in claim 2; and to a method of controlling the growth of phythopathogenic fungi at a locus which comprises applying synergistically effective amounts of at least one azolopyrimidine of formula I (a) and at least one MBI (b) to the locus.
Abstract: A container for use in a closed application system includes a valve mounted to a discharge opening of the container and rotatable with the container for controlling the discharge of material from the container. The valve includes an element for engaging corresponding structure in a receptacle for receiving the contents of the container. The element engages and locks the valve in the receptacle when the valve is opened and the contents are being discharged from the container into the receptacle. The valve element and the corresponding structure on the receptacle cooperate so that the container can only be received in and removed from the receptacle when the valve is closed. In this manner, the contents in the container can be discharged only when the container is received within the receptacle and the container is rotated in a direction to open the valve.
Abstract: This invention relates to novel modified host cells which express heterologous fused proteins and methods of screening for test samples having peptide-binding activity; wherein the modified host cell comprises: (a) a gene sequence encoding a heterologous fusion protein; said fusion protein comprising a first peptide of a peptide binding pair, or segment of said first peptide, which is joined to either a DNA binding domain or its corresponding transcriptional activation domain of a transcriptional activation protein; (b) a gene sequence encoding a heterologous fusion protein, said fusion protein comprising a second peptide of the peptide binding pair in (a), or a segment thereof, fused to either a DNA binding domain or its corresponding transcriptional activation domain, whichever one is not employed in (a); (c) a reporter gene operatively associated with the transcriptional activation protein, or a portion thereof; (d) optionally, a deletion or mutation in the chromosomal DNA of the host cell for the transcri
Type:
Grant
Filed:
March 8, 1999
Date of Patent:
June 26, 2001
Assignee:
American Cyanamid Company
Inventors:
Kathleen H. Young, Bradley A. Ozenberger
Abstract: The present invention provides a purified preparation containing, for example, a polynucleic acid encoding at least one polypeptide selected from the group consisting of proteins encoded by one or more open reading frames (ORF's) of an Iowa strain of porcine reproductive and respiratory syndrome virus (PRRSV), antigenic regions of such proteins which are at least 5 amino acids in length and which effectively protect a porcine host against a subsequent challenge with a PRRSV isolate, and combinations thereof in which amino acids non-essential for antigenicity may be conservatively substituted. The present invention also concerns a polypeptide encoded by such a polynucleic acid; a vaccine comprising an effective amount of such a polynucleic acid or protein; antibodies which specifically bind to such a polynucleic acid or protein; methods of producing the same; and methods of protecting a pig against a PRRSV and treating a pig infected by a PRRSV.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
June 26, 2001
Assignees:
Iowa State University Research Foundation, Inc., American Cyanamid Company
Inventors:
Prem S. Paul, Xiang-Jin Meng, Patrick Halbur, Igor Morozov
Abstract: This invention provides compounds of formula 1 having the structure
wherein:
X, R1, R2, R3, R4, Z, X, and n are as defined hereinbefore in the specification, which are useful as antineoplastic agents and in the treatment of certain kidney diseases, such as polycystic kidney disease.
Type:
Grant
Filed:
July 29, 1998
Date of Patent:
June 26, 2001
Assignee:
American Cyanamid Company
Inventors:
Allan Wissner, Hwei-Ru Tsou, Bernard D. Johnson, Philip R. Hamann, Nan Zhang
Abstract: The present invention provides N-biphenylthiohydrazone derivatives of formula I
and compositions and methods for the use thereof in the control of insect and acarid pests and for the protection of crops therefrom.
Type:
Grant
Filed:
December 3, 1998
Date of Patent:
June 5, 2001
Assignee:
American Cyanamid Company
Inventors:
Robert Eugene Diehl, David Allen Hunt, Susan Hensen Trotto
Abstract: The present invention relates to arylpyrrole particles which are prepared by a process in which the particles are aged and milled, and pesticidal suspension concentrate compositions comprising them. The size of the particles of this invention remains surprisingly stable during storage.
Type:
Grant
Filed:
April 6, 1999
Date of Patent:
June 5, 2001
Assignee:
American Cyanamid Co.
Inventors:
Mimi Yih-Pei Chou Schaaf, Steven Brunt, Jian James Xu, Andrew Evelyn Goldsmith, Anthony Francis Walker, Patrick C. Mowery, Edward S. Donoghue, Srinivasan Rajan
Abstract: The present invention relates to 2-aryl-&Dgr;2-1,3,4-(oxa and thia)diazoline compounds having the structural formula
and compositions and methods comprising those compounds for the control of insect and acarid pests.
Type:
Grant
Filed:
November 5, 1999
Date of Patent:
May 22, 2001
Assignee:
American Cyanamid Company
Inventors:
James Jan Takasugi, Brian Lee Buckwalter