Patents Assigned to Amic AB
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Patent number: 9291558Abstract: A sensor comprising a substrate (100) having a first surface (105) and a second surface (110) is described. The first surface has at least one sensor site (115) provided thereon. The substrate is configured such that on excitation of a sample provided at the sensor site, luminescence originating from the sensor site propagates into the substrate, the second surface of the substrate being configured to selectively transmit the luminescence propagating within the substrates at angles greater than the critical angle out of the substrate where it may be detected by a detector (160) provided below the substrate.Type: GrantFiled: May 11, 2011Date of Patent: March 22, 2016Assignees: Dublin City University, Amic ABInventors: Jim Writser Peter Bakker, Ove Ohman, Dirk Kurzbuch, Thomas Ruckstuhl, Brian MacCraith, Stephen O'Driscoll
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Publication number: 20130236982Abstract: A sensor comprising a substrate (100) having a first surface (105) and a second surface (110) is described. The first surface has at least one sensor site (115) provided thereon. The substrate is configured such that on excitation of a sample provided at the sensor site, luminescence originating from the sensor site propagates into the substrate, the second surface of the substrate being configured to selectively transmit the luminescence propagating within the substrates at angles greater than the critical angle out of the substrate where it may be detected by a detector (160) provided below the substrate.Type: ApplicationFiled: May 11, 2011Publication date: September 12, 2013Applicants: AMIC AB, DUBLIN CITY UNIVERSITYInventors: Jim Writser Peter Bakker, Ove Ohman, Dirk Kurzbuch, Thomas Ruckstuhl, Brian MacCraith, Stephen O'Driscoll
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Publication number: 20130203183Abstract: An assay device for performing an assay on a liquid sample using a detection conjugate capable of binding to an antigen and containing a label. The device includes a substrate surface having a sample addition zone, a reaction zone and an absorbing zone, the zones being connected by at least one fluid passage, wherein the device has a first functionality verifying feature located between the sample addition zone and the reaction zone, and a second functionality verifying feature located within the absorbing zone. Both functionality verifying features are capable of undergoing a detectable change when contacted by the sample, in which the assay device further includes at least one alignment verification zone. There is further provided a kit of parts and a method of conducting an assay.Type: ApplicationFiled: December 12, 2012Publication date: August 8, 2013Applicant: AMIC ABInventor: ÅMIC AB
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Patent number: 8409523Abstract: An analysis device having at least one sample addition zone, at least one sink, and at least one flow path connecting the at least one sample addition zone and the at least one sink. The at least one flow path includes projections substantially vertical to the surface of the substrate and having a height (H), diameter (D) and reciprocal spacing (t1, t2) such that lateral capillary flow of a liquid sample is achieved. The device includes at least two reaction zones in series, wherein each reaction zone is adapted to facilitating measurement of a response originating from one and the same analyte, and wherein the reaction zones are positioned to allow calculation of the concentration of at least one analyte. Advantages include that a more accurate value can be calculated, variations are reduced, and an estimation of the uncertainty of the response can be calculated.Type: GrantFiled: July 1, 2010Date of Patent: April 2, 2013Assignee: Amic ABInventors: Ib Mendel-Hartvig, Gerd Rundström, Per Ove Öhman
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Patent number: 8343439Abstract: The present invention provides an assay device for performing an assay on a liquid sample using a detection conjugate capable of binding to an antigen and containing a label, said device comprising a substrate having a substrate surface, wherein the surface comprises projections substantially perpendicular to said surface, said projections having a height, diameter and distance capable of generating lateral capillary flow of a fluid in said passage, said surface comprising a sample addition zone, a reaction zone and an absorbing zone, said zones being connected by at least one fluid passage, wherein said device has a first functionality verifying feature located between the sample addition zone and the reaction zone, and a second functionality verifying feature located within the absorbing zone, and both functionality verifying features being features capable of undergoing a detectable change when contacted by the sample, said assay device further comprising at least one alignment verification zone.Type: GrantFiled: June 20, 2007Date of Patent: January 1, 2013Assignee: AMIC ABInventors: Per Ove Öhman, Ib Mendel-Hartvig, Tomas Lindström
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Publication number: 20120028818Abstract: A micro fluidic system includes a substrate, and, provided on said substrate, at least one flow path interconnecting with functional means in which liquid samples can be treated by desired procedures. The flow paths are laid out to form a pattern for the transport of liquid samples to and from said functional means. These flow paths comprise a plurality of micro posts protruding upwards from said substrate, the spacing between the micro posts being small enough to induce a capillary action in a liquid sample applied anywhere within any of said flow paths, so as to force said liquid to move from where said liquid sample was applied.Type: ApplicationFiled: August 19, 2011Publication date: February 2, 2012Applicant: AMIC ABInventors: Ove Per Öhman, Ib Mendel-Hartvig
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Publication number: 20110306519Abstract: In combination, a polymeric microarray support for an optical assay arrangement, that includes an optical detection instrument having a known depth of focus for detecting light emitted from said microarray support. The polymeric microarray support has a support surface made from a polymeric support material having a thickness varying over the area of the support surface by a thickness variation value. The said support includes formed microfeatures made up of grooves arranged to have a predetermined depth at the time of forming, the groove depth being selected based on the depth of focus of the optical detection instrument and the thickness of the support. The sum of the depth for the grooves and the thickness variation value of the polymeric support surface substantially corresponds to the depth of focus of the optical detection instrument in order to reduce noise, the polymeric support surface having attached thereto probe molecules to form binding sites.Type: ApplicationFiled: July 8, 2011Publication date: December 15, 2011Applicant: Amic ABInventors: Tomas Lindstrom, Ove Ohman
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Patent number: 8025854Abstract: The invention relates to a micro fluidic system comprising a substrate, and, provided on said substrate, at least one flow path interconnecting with functional means in which liquid samples can be treated by desired procedures. The flow paths are laid out to form a pattern for the transport of liquid samples to and from said functional means. These flow paths comprise a plurality of micro posts protruding upwards from said substrate, the spacing between the micro posts being small enough to induce a capillary action in a liquid sample applied anywhere within any of said flow paths, so as to force said liquid to move from where said liquid sample was applied.Type: GrantFiled: June 4, 2003Date of Patent: September 27, 2011Assignee: AMIC ABInventors: Ove Ohman, Ib Mendel-Hartvig
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Patent number: 8000001Abstract: The invention comprises a polymeric microarray support (1) for an optical assay arrangement (2) comprising optical means (3, 4, 6) for detection of light emitted from the support. The microarray support is provided with microfeatures comprising a surface enlarging pattern (5), i.e. grooves having a selected depth (8). The depth is selected such that the sum of the depth and of the variations in the thickness (7) of the support substantially corresponds to the depth of focus of the optical means.Type: GrantFiled: May 18, 2004Date of Patent: August 16, 2011Assignee: Amic ABInventors: Tomas Lindström, Ove Öhman
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Publication number: 20110117674Abstract: A method for the analysis of at least two analytes in a liquid sample, in which a substrate is provided wherein at least two different types of capturing molecules are immobilized on the substrate and wherein each type of capturing molecule has specific affinity for an analyte. The sample is contacted with capturing molecules, wherein for at least one analyte to be analyzed contact is induced between the capturing molecules and a labelled detection molecule with specific affinity for the analyte, and for at least one another analyte to be contact is induced between the capturing molecules and a labelled version of the analyte. A detectable signal is measured from the labelled detection molecule and the labelled analyte on the substrate, wherein the concentration of the labelled analyte is adapted to the concentration of the analyte in the sample.Type: ApplicationFiled: April 14, 2009Publication date: May 19, 2011Applicant: AMIC ABInventors: Jonas Melin, Christina Jönsson
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Publication number: 20110000791Abstract: A method for the manufacture of a capillary driven assay device, includes the steps of: a) providing a capillary substrate, b) modifying the hydrophilicity of the surface of the substrate, c) mixing a matrix and a capturing molecule in a solution to obtain a solution comprising capturing molecules covalently bound to the matrix, and d) depositing the solution in a distinct area in the at least one retaining zone. A capillary driven assay device is obtainable by the method permitting the substrate to be modified with one surface chemistry and capturing molecules to be deposited in an optimal matrix on desired areas. Less matrix material is consumed, permitting several different matrix materials to be used on one chip.Type: ApplicationFiled: July 1, 2010Publication date: January 6, 2011Applicant: AMIC ABInventors: Jonas Melin, Christina Jonsson
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Publication number: 20110003313Abstract: A conjugate, for use as a detection reagent in an immunoassay, is based on a hydrophilic monodisperse macromolecule, i.e. a macromolecule having a substantially uniform size and shape, the macromolecule forming a practically useful and manageable carrier, to which carrier at least one binding entity and at least one label are bound.Type: ApplicationFiled: July 1, 2010Publication date: January 6, 2011Applicant: AMIC ABInventors: Ib Mendel-Hartvig, Gerd Rundström
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Publication number: 20110003398Abstract: An analysis device having at least one sample addition zone, at least one sink, and at least one flow path connecting the at least one sample addition zone and the at least one sink. The at least one flow path includes projections substantially vertical to the surface of the substrate and having a height (H), diameter (D) and reciprocal spacing (t1, t2) such that lateral capillary flow of a liquid sample is achieved. The device includes at least two reaction zones in series, wherein each reaction zone is adapted to facilitating measurement of a response originating from one and the same analyte, and wherein the reaction zones are positioned to allow calculation of the concentration of at least one analyte. Advantages include that a more accurate value can be calculated, variations are reduced, and an estimation of the uncertainty of the response can be calculated.Type: ApplicationFiled: July 1, 2010Publication date: January 6, 2011Applicant: AMIC ABInventors: Ib Mendel-Hartvig, Gerd Rundström, Per Ove Öhman
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Publication number: 20100248394Abstract: A device for handling liquid samples, comprising a flow path with at least one zone for receiving the sample, and a transport or incubation zone, said zones connected by or comprising an area having projections substantially vertical to its surface, said device provided with a sink with a capacity of receiving said liquid sample, said sink comprising an area having projections substantially vertical to its surface, and said sink being adapted to respond to an external influence regulating its capacity to receive said liquid sample.Type: ApplicationFiled: June 8, 2010Publication date: September 30, 2010Applicant: AMIC ABInventors: Per Ove Ohman, Ib Mendel-Hartvig
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Publication number: 20100041154Abstract: The present invention provides an assay device for performing an assay on a liquid sample using a detection conjugate capable of binding to an antigen and containing a label, said device comprising a substrate having a substrate surface, wherein the surface comprises projections substantially perpendicular to said surface, said projections having a height, diameter and distance capable of generating lateral capillary flow of a fluid in said passage, said surface comprising a sample addition zone, a reaction zone and an absorbing zone, said zones being connected by at least one fluid passage, wherein said device has a first functionality verifying feature located between the sample addition zone and the reaction zone, and a second functionality verifying feature located within the absorbing zone, and both functionality verifying features being features capable of undergoing a detectable change when contacted by the sample, said assay device further comprising at least one alignment verification zone.Type: ApplicationFiled: June 20, 2007Publication date: February 18, 2010Applicant: AMIC ABInventors: Per Ove Öhman, Ib Mendel-Hartvig, Tomas Lindström
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Publication number: 20100009465Abstract: There is provided a method for the analysis of circulating antibodies comprising the steps: a) providing an analysis device comprising a substrate, and provided on said substrate at least one sample addition zone, at least one retaining zone, at least one sink, and at least one flow path connecting the sample addition zone, the retaining zone and the sink, wherein the flow path is open and comprises projections substantially vertical to the surface of said substrate and having a height (H), diameter (D) and reciprocal spacing (t1, t2) such that lateral capillary flow of said sample is achieved and such that cells can flow through the projections, wherein said retaining zone comprises at least one affinity binding means to which cell structures are bound, b) adding at least one sample to a sample addition zone, and c) reading a result, wherein circulating antibodies directed against cell structures are determined.Type: ApplicationFiled: July 2, 2009Publication date: January 14, 2010Applicant: AMIC ABInventors: Ib Mendel-Hartvig, Christer Pettersson, Gerd Rundström
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Publication number: 20090311805Abstract: There is disclosed an analysis device for the analysis of a liquid sample, said device comprising a substrate, said substrate at least partly having projections substantially vertical to the surface of said substrate, and having a height (H1), diameter (D1) and center-to-center distance (x1, y1) such, that lateral capillary flow of said liquid sample is achieved, wherein that said substrate comprises at least one substrate zone comprising projections substantially vertical to the surface of said substrate, and having a height (H2), diameter (D2) and center-to-center distance (x2, y2), such, that lateral capillary flow of said liquid sample is achieved and wherein at least one substance is applied at least partly between the projections in said at least one substrate zone. Moreover there is provided a method for the analysis of a sample. The device and method provide for instance improved control of the dissolution of a substance.Type: ApplicationFiled: June 12, 2009Publication date: December 17, 2009Applicant: AMIC ABInventors: David BERGMAN, lb MENDEL-HARTVIG, Annika LINDSTROM
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Patent number: 7564045Abstract: An optical reader for an optical assay arrangement including a polymeric sample substrate having a reaction-site surface provided with protruding microstructures and at least one reaction-site area; a light source for illuminating the reaction-site area; and a detector device for detecting light emitted from the reaction-site area. The light source is arranged to inject exciting light rays into the polymeric sample substrate with a controlled angle of incidence such that the protruding microstructures guide the exciting light rays in the direction of the reaction-site area, and the detector device detects light emitted from the at least one reaction-site area.Type: GrantFiled: June 15, 2006Date of Patent: July 21, 2009Assignee: AMIC ABInventors: Per Ove Ohman, Tomas Lindstrom, Ib Mendel-Hartvig
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Publication number: 20080176272Abstract: A device and method for the separation of a component in a liquid sample prior to the detection of an analyte in said sample, wherein a sample is added to a receiving zone on a substrate, said substrate further optionally comprising a reaction zone, a transport or incubation zone connecting the receiving and reaction zone, respectively, forming a flow path on a substrate, wherein said substrate is a non-porous substrate, and at least part of said flow path consists of areas of projections substantially vertical to said surface, and having a height (H), diameter (D) and reciprocal spacing (t1, t2) such, that lateral capillary flow of said liquid sample in said zone is achieved, and where means for separation are provided adjacent to the zone for receiving the sample. Said means for separation are chosen among filter means, optionally enhanced by affinity binding and/or aggregation; magnetic means, also optionally enhanced by affinity binding and/or aggregation; and acoustic means.Type: ApplicationFiled: March 26, 2008Publication date: July 24, 2008Applicant: AMIC ABInventors: David BERGMAN, Ib MENDEL-HARTVIG, Simon UHRBERG
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Publication number: 20070266777Abstract: A device and method for the separation of a component in a liquid sample prior to the detection of an analyte in said sample, wherein a sample is added to a receiving zone on a substrate, said substrate further optionally comprising a reaction zone, a transport or incubation zone connecting the receiving and reaction zone, respectively, forming a flow path on a substrate, wherein said substrate is a non-porous substrate, and at least part of said flow path consists of areas of projections substantially vertical to said surface, and having a height (H), diameter (D) and reciprocal spacing (t1, t2) such, that lateral capillary flow of said liquid sample in said zone is achieved, and where means for separation are provided adjacent to the zone for receiving the sample. Said means for separation are chosen among filter means, optionally enhanced by affinity binding and/or aggregation; magnetic means, also optionally enhanced by affinity binding and/or aggregation; and acoustic means.Type: ApplicationFiled: March 23, 2005Publication date: November 22, 2007Applicant: Amic ABInventors: David Bergman, Ib Mendel-Hartvig, Simon Uhrberg