Abstract: Wavefront measurements of eyes are normally taken when the pupil is relatively large, and the results are often represented by a set of Zernike coefficients. Different sets of Zernike coefficients can be calculated to represent aberrations at smaller pupil sizes. While recently described techniques allow scaling of the expansion coefficients with Zernike polynomials, a more intuitive approach would be desirable. Such an approach may optionally derive an equivalent result as known techniques, but may employ a much simpler and nonrecursive formula between the new and the original sets of Zernike polynomial expansion coefficients of a wavefront when the aperture size is scaled.

Abstract: Systems and methods for fine-tuning refractive shapes for vision treatment are provided. Techniques encompass determining a variable index of refraction for a cornea of the eye, and determining the refractive treatment shape for the eye based on the variable index of refraction. Techniques also encompass determining a variable radius of curvature of an anterior surface of a cornea of the eye, and determining the refractive treatment shape for the eye based on the variable radius of curvature.

Abstract: A single arm optical coherence tomography (OCT) pachymetry system and methods for measuring layers of the eye are disclosed. The system includes an artificial lens for positioning on the eye, a light source emitting a measurement light beam along an optical path posteriorly toward the cornea, and a detector receiving and measuring a combined signal of light reflections anteriorly from a plurality of reflecting surfaces associated with the eye. The reflecting surfaces include a first reflecting surface associated with the artificial lens and one or more second reflecting surfaces corresponding to corneal layers. A processor is coupled to the detector and is configured to determine a distance between two of the corneal layers from the combined signal.

Abstract: Wavefront measurements of eyes are typically taken when the pupil is in a first configuration in an evaluation context. The results can be represented by a set of basis function coefficients. Prescriptive treatments are often applied in a treatment context, which is different from the evaluation context. Hence, the patient pupil can be in a different, second configuration, during treatment. Systems and methods are provided for determining a transformed set of basis function coefficients, based on a difference between the first and second configurations, which can be used to establish the vision treatment.

Abstract: Devices, systems, and methods measure, diagnose, and/or treat one or both eyes of a patient. Adaptive optics systems (such as those having a deformable mirror) may be configured to an aspherical or multi-spherical presbyopia-mitigating prescriptive shape to allow objective and/or subjective measurements of a candidate prescription. A plurality of viewing distances allow subjective and/or objective evaluations of performance using a light spot or a test viewing image. Measurements of aberrations at selected viewing conditions (including distances and/or brightness) with correlating pupil sizes may also be provided. Wavefront measurement systems and methods may help position and isolate the eye from ambient light.

Abstract: Method and system for modifying a refractive profile associated with an eye having a recipient cornea. The method includes obtaining a corneal tissue inlay from a donor cornea, forming a recipient bed in the recipient cornea, and positioning the corneal tissue inlay into the recipient bed to correct the refractive profile of the eye with the refractive profile of the corneal tissue. The system includes a laser assembly outputting a pulsed laser beam, and a controller coupled to the laser assembly. The controller directs the laser assembly to incise a corneal tissue inlay from a donor cornea, form a recipient bed in the recipient cornea having a contour matching the contour of the inlay, register the inlay with the recipient bed, determine a position of the inlay, and determine a position change for the inlay based on the position of the inlay to align the refractive profile of the inlay with the refractive profile of the eye.

Abstract: Systems and methods related to corneal ablation for treatment of one or more high-order optical aberrations are provided. A method includes providing a defect-correcting prescription, determining an ablation profile to impose the prescription on the cornea, and determining a sequence of laser-energy ablations to impose the ablation profile on the cornea. The prescription comprises a high-order optical correction. The ablation profile comprises a first-segment profile and a second-segment profile. The second-segment profile corresponds to at least one high-order optical correction. The ablation sequence comprises applying ablations corresponding to the first-segment profile prior to applying ablations corresponding to the second-segment profile.

Abstract: Systems and methods are provided for sensing a movement of an eye. The system includes a light source configured to illuminate the eye with a first light having a polarization state, an image capture apparatus configured to generate at least one image of the eye based on a reflected light from the eye, an analyzer optically coupled to the image capture apparatus and configured to filter a second light from the reflected light, and a processor coupled to the image capture apparatus and configured to determine the movement of the eye based on the at least one image of the eye. The reflected light is based on the first light, and the second light has the polarization state.

Abstract: A patient interface device adapted to provide an interface between a cornea and a surgical laser system. A frame has an applanation end and an attachment end which is adapted to couple to the surgical laser system. A skirt is affixed to the applanation end of the frame and is adapted to seal against the anterior surface of the cornea to form a chamber. A lens is disposed near the applanation end of the frame and is supported by a flexible support which affixes the lens to the frame.

Abstract: System and method of photoaltering a region of an eye using an enhanced contrast between the iris and the pupil of the imaged eye. The system includes a laser assembly outputting a pulsed laser beam, a user interface displaying one of a first digital image of the eye and a second digital image of the eye, and a controller coupled to the laser assembly and the user interface. The first digital image has a first contrast between the pupil and the iris, and the second digital image has a second contrast between the pupil and the iris. The controller selectively increases the first contrast between the pupil and the iris to the second contrast between the pupil and the iris and directs the pulsed laser beam to the region of the eye based on one of the first and second digital images.

Abstract: A system for laser amplification includes a dual-crystal Pockels cell which is used to control emission of laser pulses from an ultra-fast laser. The Pockels cell is constructed to enable adjustment of the rotational orientation of one crystal relative to the other crystal. The rotational orientation of one or both crystals in the Pockels cell is adjusted to control sidebands in the laser pulse.

Abstract: The present invention provides a method for minimizing fluence distribution of a laser over a predetermined pattern. In particular, the method is useful for minimizing fluence variance over a predetermined pattern for lasers used in ophthalmic surgery.

Abstract: A patient positioning system for use with a patient comprises an optical image sensor. The optical image sensor measures an optical image of a tissue structure of an eye of the patient. An image sensor support supports the image sensor. A patient support supports the patient. A linkage is coupled to the image sensor support with the patient support. A processor is coupled to the optical image sensor to determine a gradient of an illumination level of the optical tissue structure image. The processor is coupled to the linkage and configured to articulate the linkage so as to adjust a separation distance from the tissue structure to the image sensor in response to the gradient of the optical tissue structure image.

Abstract: A system for laser amplification includes a dual-crystal Pockels cell which is used to control emission of laser pulses from an ultra-fast laser. The Pockels cell is constructed to enable adjustment of the rotational orientation of one crystal relative to the other crystal. The rotational orientation of one or both crystals in the Pockels cell is adjusted to control sidebands in the laser pulse.

Abstract: Methods and systems for obtaining an ocular aberration measurement of an eye of a patient are provided. Exemplary techniques involve obtaining a first induced metric for the eye that corresponds to a first accommodation state of the eye, obtaining a second induced metric for the eye that corresponds to a second accommodation state of the eye, and determining a natural metric of the eye based on the first and second induced metrics. An induced metric may include a pupil size or a spherical aberration. Techniques can also include determining a target metric for the eye base on the natural metric, determining whether an actual metric of the eye meets the target metric, obtaining an ocular aberration measurement of the eye if the actual metric meets the target metric, and determining a treatment for the eye based on the ocular aberration measurement.

Abstract: Methods and systems for obtaining an ocular aberration measurement of an eye of a patient are provided. Exemplary techniques involve obtaining a first induced metric for the eye that corresponds to a first accommodation state of the eye, obtaining a second induced metric for the eye that corresponds to a second accommodation state of the eye, and determining a natural metric of the eye based on the first and second induced metrics. An induced metric may include a pupil size or a spherical aberration. Techniques can also include determining a target metric for the eye base on the natural metric, determining whether an actual metric of the eye meets the target metric, obtaining an ocular aberration measurement of the eye if the actual metric meets the target metric, and determining a treatment for the eye based on the ocular aberration measurement.

Abstract: Systems and methods to treat a region of a cornea of an eye having an epithelial layer disposed over a stromal layer. The system comprises a device to map a thickness of the epithelial layer over the region of the cornea to generate a map of epithelial thickness over the region, and a laser to generate a laser beam of an ablative radiation. A movable scan component is coupled to the laser to scan the laser beam over the region. A processor system is coupled to the laser and the movable scan component, and the processor system is configured to arrange pulses of laser beam to ablate the epithelial layer of the region in response to the map of epithelial thickness.

Abstract: Systems and methods for removing an epithelial layer disposed over a stromal layer in a cornea irradiate a region of the epithelial layer with a pulsed beam of ablative radiation. The ablative radiation is scanned to vary the location of the beam within the region in accordance with a pulse sequence. The pulse sequence is arranged to enhance optical feedback based on a tissue fluorescence of the epithelial layer. The penetration of the epithelial layer is detected in response to the optical feedback. The use of scanning with the pulse sequence arranged to enhance optical feedback allows large areas of the epithelium to be ablated such penetration of the epithelial layer can be detected.

Abstract: An interface for coupling an eye to a surgical laser is disclosed. A lens cone includes a base ring opposite an apex ring. The base ring defines a first plane and is adapted to couple to the delivery tip of the laser such that the first plane has a predetermined position relative to the delivery tip. An applanation lens is affixed to the apex ring and has a surface disposed in a second plane such that the second plane is parallel to and has a predetermined position relative to the first plane. A gripper is engagable with the lens cone. An attachment ring is affixed to the gripper and is adapted to couple to the anterior surface of the eye. When the lens cone and gripper are engaged, the applanation lens contacts the anterior surface of the eye, placing the anterior surface in spatial registration with the delivery tip.