Patents Assigned to Anacor Pharmaceuticals, Inc.
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Publication number: 20200024289Abstract: This application describes compounds, compositions, and methods which are useful in treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite.Type: ApplicationFiled: March 1, 2018Publication date: January 23, 2020Applicants: Anacor Pharmaceuticals, Inc., The Government of the United States, as represented by the Secretary of the Army, The Government of the United States, as represented by the Secretary of the ArmyInventors: Robert Toms Jacobs, Yang Liu, Richard J. Sciotti, Jason D. Speake, Gavin Alistair Whitlock, Paul Alan Glossop, Charles Eric Mowbray, Delphine Françoise Monique Launay, Stephen John Robinson
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Publication number: 20200017531Abstract: The present invention provides oxaborole ester compounds and compositions thereof which are useful to treat diseases associated with parasites, such as Chagas Disease and African Animal Trypanosomosis.Type: ApplicationFiled: September 24, 2019Publication date: January 16, 2020Applicant: Anacor Pharmaceuticals, Inc.Inventors: Tsutomu AKAMA, David Scott CARTER, Jason S. HALLADAY, Robert T. JACOBS, Yang LIU, Jacob J. PLATTNER, Yong-Kang ZHANG, Michael John WITTY
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Patent number: 10533021Abstract: This invention provides, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.Type: GrantFiled: September 28, 2017Date of Patent: January 14, 2020Assignee: Anacor Pharmaceuticals, Inc.Inventors: Stephen J. Baker, Vincent S. Hernandez, Rashmi Sharma, James A. Nieman, Tsutomu Akama, Yong-Kang Zhang, Jacob J. Plattner, Michael Richard Kevin Alley, Rajeshwar Singh, Fernando Rock
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Patent number: 10526352Abstract: Compounds of Formula II, wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or —CH(CH3)2; compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.Type: GrantFiled: April 16, 2019Date of Patent: January 7, 2020Assignees: GlaxoSmithKline Intellectual Property (No.2) Limited, Anacor Pharmaceuticals, Inc.Inventors: Michael Richard Kevin Alley, Vincent S. Hernandez, Jacob J. Plattner, Xianfeng Li, David Barros-Aguirre, Ilaria Giordano
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Publication number: 20190330245Abstract: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.Type: ApplicationFiled: July 12, 2019Publication date: October 31, 2019Applicant: Anacor Pharmaceuticals, Inc.Inventors: Stephen J. Baker, Tsutomu Akama, Carolyn Bellinger-Kawahara, Vincent S. Hernandez, Karin M. Hold, James J. Leyden, Kirk R. Maples, Jacob J. Plattner, Virginia Sanders, Yong-Kang Zhang
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Publication number: 20190308994Abstract: Topical pharmaceutical formulations, and methods of treating inflammatory conditions with these formulations, are disclosed.Type: ApplicationFiled: June 25, 2019Publication date: October 10, 2019Applicant: Anacor Pharmaceuticals Inc.Inventors: Tejal Merchant, Dina Jean Coronado, Charles Edward Lee, Delphine Caroline Imbert, Sylvia Zarela Yep
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Publication number: 20190282594Abstract: Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.Type: ApplicationFiled: May 31, 2019Publication date: September 19, 2019Applicant: Anacor Pharmaceuticals, Inc.Inventors: Stephen J. Baker, Virginia Sanders, Tsutomo Akama, Carolyn Bellinger-Kawahara, Yvonne Freund, Kirk R. Maples, Jacob J. Plattner, Yong-Kang Zhang, Huchen Zhou, Vincent S. Hernandez
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Patent number: 10308668Abstract: Compounds of Formula II, wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or —CH(CH3)2; compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.Type: GrantFiled: October 24, 2017Date of Patent: June 4, 2019Assignees: GlaxoSmithKline Intellectual Property (No. 2) Limited, Anacor Pharmaceuticals, Inc.Inventors: Michael Richard Kevin Alley, Vincent Hernandez, Jacob J. Plattner, Xianfeng Li, David Barros-Aguirre, Ilaria Giordano
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Publication number: 20190160081Abstract: Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.Type: ApplicationFiled: February 1, 2019Publication date: May 30, 2019Applicant: Anacor Pharmaceuticals, Inc.Inventors: Stephen J. Baker, Virginia Sanders, Tsutomo Akama, Carolyn Bellinger-Kawahara, Yvonne Freund, Kirk R. Maples, Jacob J. Plattner, Yong-Kang Zhang, Huchen Zhou, Vincent S. Hernandez
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Patent number: 10301329Abstract: This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.Type: GrantFiled: August 3, 2016Date of Patent: May 28, 2019Assignee: Anacor Pharmaceuticals, Inc.Inventors: Daitao Chen, Matthew Orr, Jessica Sligar, Robert Jacobs, Jacob J. Plattner
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Patent number: 10214548Abstract: This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.Type: GrantFiled: November 1, 2017Date of Patent: February 26, 2019Assignee: Anacor Pharmaceuticals, Inc.Inventors: Tsutomu Akama, Eric Easom, Yvonne Freund, Jacob J. Plattner, Jessica Sligar, Daitao Chen, Jennifer Freeman, Joe Perales
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Publication number: 20190048026Abstract: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.Type: ApplicationFiled: October 18, 2018Publication date: February 14, 2019Applicant: Anacor Pharmaceuticals, Inc.Inventors: Stephen J. Baker, Tsutomu Akama, Carolyn Bellinger-Kawahara, Vincent S. Hernandez, Karin M. Hold, James J. Leyden, Kirk R. Maples, Jacob J. Plattner, Virginia Sanders, Yong-Kang Zhang
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Publication number: 20180044353Abstract: Substituted benzoxaboroles whose structure comprises Formula (III), wherein R3 is selected from —CH3, —CH2CH3, —CH2?CH2, —CH2CH2CH3, —CH(CH3)2, —CH2CH2?CH2, and cyclopropyl, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, and —CH(CH3)2; compositions containing such compounds, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.Type: ApplicationFiled: February 12, 2016Publication date: February 15, 2018Applicants: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED, ANACOR PHARMACEUTICALS, INC.Inventors: Carlos ALEMPARTE-GALLARDO, M.R.K.(dickon) ALLEY, David BARROS-AGUIRRE, Ilaria GIORDANO, Vincent HERNANDEZ, Xianfeng LI, Jacob J. PLATTNER
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Publication number: 20180044355Abstract: Compounds of Formula II, wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or —CH(CH3)2; compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.Type: ApplicationFiled: October 24, 2017Publication date: February 15, 2018Applicants: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED, ANACOR PHARMACEUTICALS INC.Inventors: M. R. K. (DICKON) ALLEY, VINCENT S. HERNANDEZ, JACOB PLATTNER, XIANFENG LI, DAVID BARROS-AGUIRRE, ILARIA GIORDANO
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Patent number: 9889146Abstract: Norvaline and/or other amino acids that are capable of being acylated onto tRNALeu by LeuRS, in combination with substituted benzoxaboroles, such as a compound having a structure according to formula III: and methods for decreasing the frequency of resistance and/or reducing the rate of resistance and/or suppressing the emergence of resistance that develops in bacteria exposed to a substituted benzoxaborole or salt thereof by administering a combination of a substituted benzoxaborole such as a compound of formula III or salt thereof and an amino acid or a salt thereof.Type: GrantFiled: May 23, 2016Date of Patent: February 13, 2018Assignee: Anacor Pharmaceuticals, Inc.Inventors: Michael Richard Kevin Alley, Katherine Widdowson
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Publication number: 20180037595Abstract: Compounds whose structure comprises Formula II, or a compound whose structure comprises Formula III wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or —CH(CH3)2, compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.Type: ApplicationFiled: February 12, 2016Publication date: February 8, 2018Applicants: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED, ANACOR PHARMACEUTICALS, INC.Inventors: M.R.K. (dickon) ALLEY, David BARROS-AGUIRRE, Ilaria GIORDANO, Vincent HERNANDEZ, Xianfeng LI, Jacob J. PLATTNER
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Publication number: 20170327519Abstract: The present invention provides oxaborole ester compounds and compositions thereof which are useful to treat diseases associated with parasites, such as Chagas Disease and African Animal Trypanosomosis.Type: ApplicationFiled: May 9, 2017Publication date: November 16, 2017Applicant: Anacor Pharmaceuticals, Inc.Inventors: Tsutomu AKAMA, David Scott CARTER, Jason S. HALLADAY, Robert T. JACOBS, Yang LIU, Jacob J. PLATTNER, Yong-Kang ZHANG, Michael John WITTY
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Patent number: 9815857Abstract: This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.Type: GrantFiled: February 22, 2017Date of Patent: November 14, 2017Assignee: Anacor Pharmaceuticals, Inc.Inventors: Tsutomu Akama, Eric Easom, Yvonne Freund, Jacob J. Plattner, Jessica Sligar, Daitao Chen, Jennifer Freeman, Joe Perales
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Patent number: 9796735Abstract: The compounds are of the class of 3,7 substituted benzoxaboroles, useful for killing and/or inhibiting the growth of microorganisms.Type: GrantFiled: November 7, 2014Date of Patent: October 24, 2017Assignee: Anacor Pharmaceuticals, Inc.Inventors: Stephen J. Baker, Vincent S. Hernandez, Rashmi Sharma, James A. Nieman, Tsutomu Akama, Yong-Kang Zhang, Jacob J. Plattner, Michael Richard Kevin Alley, Rajeshwar Singh, Fernando Rock
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Patent number: 9751898Abstract: This invention relates to, among other items, benzoxaborole compounds and their use for treating bacterial infections.Type: GrantFiled: March 21, 2014Date of Patent: September 5, 2017Assignee: Anacor Pharmaceuticals, Inc.Inventors: Vincent S. Hernandez, Charles Ding, Jacob J. Plattner, Michael Richard Kevin Alley, Fernando Rock, Suoming Zhang, Eric Easom, Xianfeng Li, Ding Zhou