Abstract: Compositions and methods of use of borole derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.
Type:
Application
Filed:
November 13, 2008
Publication date:
September 24, 2009
Applicant:
Anacor Pharmaceuticals, Inc.
Inventors:
Ving Lee, Jacob J. Plattner, Stephen J. Benkovic, Stephen J. Baker, Kirk R. Maples, Carolyn Bellinger-Kawahara, Tsutomu Akama, Yong-Kang Zhang, Rajeshwar Singh, Vittorio A. Sauro
Abstract: This invention provides, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
Type:
Application
Filed:
June 19, 2008
Publication date:
September 10, 2009
Applicant:
Anacor Pharmaceuticals, Inc.
Inventors:
Stephen J. Baker, Vincent S. Hernandez, Rashmi Sharma, James A. Nieman, Tsutomu Akama, Yong-Kang Zhang, Jacob J. Plattner, Michael Richard Kevin Alley, Rajeshwar Singh, Fernando Rock
Abstract: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
Type:
Grant
Filed:
February 16, 2006
Date of Patent:
September 1, 2009
Assignee:
Anacor Pharmaceuticals, Inc.
Inventors:
Stephen J. Baker, Tsutomu Akama, Carolyn Bellinger-Kawahara, Vincent S. Hernandez, Karin M. Hold, James J. Leyden, Kirk R. Maples, Jacob J. Plattner, Virginia Sanders, Yong-Kang Zhang
Abstract: Compositions and methods of use of borole derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.
Type:
Grant
Filed:
June 15, 2004
Date of Patent:
December 16, 2008
Assignee:
Anacor Pharmaceuticals, Inc.
Inventors:
Ving Lee, Jacob J. Plattner, Stephen J. Benkovic, Stephen J. Baker, Kirk R. Maples, Carolyn Bellinger-Kawahara, Tsutomu Akama, Yong-Kang Zhang, Rajeshwar Singh, Vittorio A. Sauro
Abstract: Compositions and methods of use of borinic acid complexes, especially hydroxyquinoline, imidazole and picolinic acid derivatives, as anti-viral agents as well as therapeutic agents for the treatment of diseases caused by viruses are described.
Type:
Grant
Filed:
June 14, 2005
Date of Patent:
July 1, 2008
Assignee:
Anacor Pharmaceuticals, Inc.
Inventors:
Carolyn Bellinger-Kawahara, Kirk R. Maples, Jocob J. Plattner
Abstract: The structure and preparation of antibiotics incorporating borinic acid complexes are disclosed, especially hydroxyquinoline, imidazole and picolinic acid derivatives, along with compositions of these antibiotics and methods of using the antibiotics and compositions as bactericidal and fungicidal agents as well as therapeutic agents for the treatment of diseases caused by bacteria and fungi.
Type:
Grant
Filed:
June 14, 2004
Date of Patent:
June 24, 2008
Assignee:
Anacor Pharmaceuticals, Inc.
Inventors:
Ving Lee, Stephen J. Benkovic, Stephen J. Baker, Kirk R. Maples, Tsutomu Akama, Yong-Kang Zhang, Rajeshwar Singh, Vittorio A. Sauro, Chetan Pandit, Zhuoyi Su, Zhixiang Yang
Abstract: The present invention relates to the field of boron-containing compounds, particularly boron compounds and pharmaceutical compositions thereof that exhibit with antibacterial and/or anti-inflammatory activities, and uses thereof. Methods for preparing and using these boron compounds and pharmaceutical compositions thereof, are also provided.
Type:
Application
Filed:
December 27, 2006
Publication date:
August 2, 2007
Applicant:
Anacor Pharmaceuticals, Inc.
Inventors:
Kirk Maples, Stephen Baker, Glenn Stahl, Michael DiPierro, Christopher Tokar, Premchandran Ramiya, Siead Zegar