Abstract: In various embodiments, drug-loaded extracellular vesicles and methods of making the same are disclosed. In various embodiments, the EVs comprise natural exosomes or exomeres derived from cells that take part in the pathogenesis of a disease or a condition to which the drug-loaded EVs are targeted. In various embodiments, extracellular vesicles are surface modified, comprising bound biomolecules such as proteins or antibodies that can target ACE2 receptors. Surface modified EVs find use in the treatment and prevention of viral infections, such as COVID-19 caused by a SARS-CoV-2 infection in a human individual.

Abstract: A method for communicating with a legacy terminal supporting a legacy air interface and a new terminal supporting a next generation air interface including: assigning a same carrier to the legacy terminal and the new terminal; receiving a terminal identifier and an optional payload for transmission at a MAC/RLC layer; determining if the terminal identifier is associated with the legacy terminal or the new terminal; composing, based on the determining, a burst header; formatting, a burst including the burst header and the optional payload; and transmitting the burst. In the method, the burst header is set to one of the one or more valid burst headers when the burst is associated with the legacy terminal, and the burst header is set to one of the one or more undefined burst headers when the burst is associated with the new terminal.

Abstract: A package sort cell includes a robot with an end of arm tool for transporting packages from an in-feed conveyor to a selected one of a plurality of out-feed conveyors or bins, the robot receiving instruction from the package reader as to which of the plurality of conveyors or bins to hand-off the package. An end of arm tool may be in the configuration of a conveyor which may be aligned with the out-feed conveyor on a bottom up movement. The end of arm tool may also be in the configuration of a hanging carriage frame suspending a conveyor in a top down movement. A worker platform may be provided which may be movable between in-use and out-of-use positions whereby upon robot downtime, the platform may move into the in-use position for a worker to temporarily takeover the transfer functions of the robot. A plurality of sort cells may be arranged in side by side relation adjacent a like plurality of package delivery points (e.g.

Abstract: Upon determining a first vehicle is moving on a two-way road in a first direction of travel in an only lane of the two-way road, vehicle sensor data is input to a first neural network that identifies a yield area along the two-way road via image segmentation. A second vehicle is detected traveling toward the first vehicle on the only lane of the two-way road. Then, upon determining the first vehicle is to yield to the second vehicle, one or more vehicle components are actuated to move the first vehicle to the yield area.

Abstract: The present invention discloses a multiple-chamber airbag structure where the airbag design has at least a stiff lower section to reduce the chest velocity and a soft upper section to meet the HIC requirements. Although stowed and deployed as a unitary airbag, the present invention includes separate chambers, which allows for independent gas inflation and stiffness control with venting.

Abstract: Aspects of the disclosure provide methods and apparatuses for video encoding/decoding. In some examples, an apparatus for video decoding includes processing circuitry. For example, the processing circuitry generates first reconstructed samples of a block, and applies a filter to multiple color components of the first reconstructed samples of the block to determine offsets to be applied to one or more color components. Then, the processing circuitry generates second reconstructed samples of the block based on the offsets for the one or more color components and the first reconstructed samples of the block.

Abstract: Disclosed herein are methods for performing downhole operations. The methods include determining, at the earth surface, a first depth value of a downhole component in a borehole, transmitting to the downhole component in the borehole a first signal indicating the first depth value, changing a depth of the downhole component in the borehole, determining, at the earth surface, a second depth value of the downhole component in the borehole, transmitting, to the downhole component in the borehole, a second signal indicating the second depth value, and updating a downhole operation performed by the downhole component based on at least one of the first depth value and the second depth value.

Abstract: A method and system for producing video-segments of a live-action event involving monitoring a live-action event for detection of event-segments, detecting one or more event-triggers with detectors, determining if an event-segment occurred based on the detected event-triggers, and editing one or more video feeds into a video-segment to encompass the event-segment.

Abstract: There is disclosed in one example a home router, including: a hardware platform including a processor and a memory; a local area network (LAN) interface; a data store including rules for domain name-based services; and instructions encoded within the memory to instruct the processor to: provision a certificate and key pair to provide domain name system (DNS) over hypertext transfer protocol secure (DoH) or DNS over transport layer security (DoT) services; receive on the LAN interface an encrypted DNS request; decrypt the DNS request; query the data store according to the DNS request; receive a rule for the DNS request; and execute the rule.

Abstract: A method for data communication between a first node and a second node includes forming one or more redundancy messages from data messages at the first node using an error correcting code and transmitting first messages from the first node to the second node over a data path, the transmitted first messages including the data messages and the one or more redundancy messages. Second messages are received at the first node from the second node, which are indicative of: (i) a rate of arrival at the second node of the first messages, and (ii) successful and unsuccessful delivery of the first messages. A transmission rate limit and a window size are maintained according to the received second messages. Transmission of additional messages from the first node to the second node is limited according to the maintained transmission rate limit and window size.

Abstract: A load control device adapted to be coupled between an AC power source and an electrical load for controlling the power delivered to the load includes a controller, an actuator for turning the electrical load on and off, an occupancy detection circuit, and an ambient light detector. The load control device automatically turns on the electrical load in response to the presence of an occupant only if the detected ambient light is below a predetermined ambient light level threshold. After first detecting the presence of an occupant, the load control device monitors actuations of the actuator to determine whether a user has changed the state of the load. The load control device automatically adjusts the predetermined ambient light level threshold in response to the user actuations that change the state of the load.

Abstract: Fittings that generally include a unitary body having an outer surface and an inner lumen forming a void within said unitary body. The lumen is configured to receive threads for mating with the threads of a female sub end of a pipe or tube. The outer surface includes at least one aperture for receiving a tool that can be inserted within said aperture so as to rotate the fitting about an axis that extends through the lumen of the unitary body. The at least one apertures provide a safe and convenient way to tighten and loosen the fitting during the process of coupling pipe or tubing.

Abstract: A touch sensor system includes touch sensors, drive-sense circuits (DSCs), memory, and a processing module. A DSC drives a first signal via a single line coupling to a touch sensor and simultaneously senses, when present, a second signal that is uniquely associated with a user. The DSC processes the first signal and/or the second signal to generate a digital signal that is representative of an electrical characteristic of the touch sensor. The processing module executes operational instructions (stored in the memory) to process the digital signal to detect interaction of the user with the touch sensor and to determine whether the interaction of the user with the touch sensor compares favorably with authorization. When not authorized, the processing module aborts execution of operation(s) associated with the interaction of the user with the touch sensor. Alternatively, when authorized, the processing module facilitates execution of the operation(s).

Abstract: In one aspect, an angle sensor includes a first linear sensor and a second linear sensor. A first magnetic-field direction of a target magnet measured by the first linear sensor is substantially equal to a second magnetic-field direction of the target magnet measured by the second linear sensor. The first linear sensor, the second linear sensor and the target magnet are on an axis. The angle sensor determines an angle of a magnetic field.

Abstract: A computer, including a processor and a memory, the memory including instructions to be executed by the processor to obtain velocity lidar point cloud data acquired with a frequency modulated continuous wave (FMCW) lidar sensor, wherein the velocity lidar point cloud data includes a speed with which a data point is moving with respect to the FMCW lidar sensor, filter the velocity lidar point cloud data to select static velocity data points, wherein the static velocity data points are velocity data points each correspond to a point on a roadway around a vehicle. The instructions can include further instructions to determine FMCW lidar sensor accelerations in six degrees of freedom based on the static velocity lidar data points and determine FMCW lidar sensor rotations and translations in six degrees of freedom based on the FMCW lidar sensor accelerations in six degrees of freedom.

Abstract: A preform configured to form a container by stretch blow molding. A finish portion of the preform is at a first end of the preform. The finish portion is a container finish of the container A support flange is at the finish portion. A tip portion is at a second end of the preform opposite to the first end and is configured to form a container base. A neck portion is adjacent to the support flange, and is configured to form a neck portion. An external stretch radius is at an outer surface of the neck portion. An internal stretch radius is at an inner surface of the neck portion. A first distance is between the internal stretch radius and the external stretch radius and is equal to, or greater than, four times a second distance between the external stretch radius and the support flange.

Abstract: Provided are aqueous fluororesin coating compositions including a water-soluble polyamideimide resin, a polyetherimide, and a fluororesin. Also provided are coatings on substrates formed from the coating composition and coated substrates, the coatings being strongly adhered to the substrates and having excellent water vapor and corrosion resistance. The coatings are of utility for metal substrates, for example cookware such as a frying pans and rice cookers.

Abstract: A method for treating non-refractory status epilepticus includes administering together before onset of refractory status epilepticus, a therapeutically effective amount of a combination of halothane or a flurane, an anti-seizure benzodiazepine, and a barbiturate anti-convulsant. The flurane may selected from one or more of isoflurane, desflurane and sevoflurane. The anti-seizure benzodiazepine may be diazepam and the barbiturate anti-convulsant may be phenobarbital.

Abstract: An electrical computer system processing architecture for providing an indication of activity in the electrical computer system, the electrical computer system processing architecture comprising a plurality of client computers connected to at least one server by a computer network. Each of the client computers is configured to provide requests to the at least one server. The or each server comprises a store for storing requests provided by the plurality of client computers. The or each server is configured to match complementary requests from the plurality of client computers stored in the store. Following the matching of complementary requests, the or each server counts unmatched requests corresponding to one or other of the complementary requests in the store, and outputs the counted number of unmatched requests to provide the indication of activity in the computer system.

Abstract: A method for preparing a borehole for fracturing including inserting an assembly comprising a fracture plug, a setting tool, a perforating gun and a controller into a borehole, delivering the assembly to a target location, automatically recognizing the target location, automatically setting the plug of the assembly at the target location, and automatically initiating the gun of the assembly to perforate the borehole.