Abstract: The invention is based on the deletion of 21 amino acids from the C-terminal region of the S2 subunit of SARS-CoV2-S protein and transporting the Si subunit, which is fused to S2 to the cell membranes. In this way, the presentation of the antigenic S1 subunit of SARS-CoV2-S protein in large amounts and in its natural structure in the cell membrane and its use as a whole cell or cell membrane has been determined as a new vaccination protocol for the SARS-CoV-2. Designing the S2 subunit of SARS-CoV2-S protein as a carrier, fusing any bacterial, viral, and tumor proteins with antigenic properties and transporting it to the cell membrane will be a comprehensive vaccination protocol that will cover all bacteria, viruses and even tumors.

Abstract: An electronic device is provided. The electronic device comprises a housing component and a microphone disposed in the housing component. The housing component is provided with a sound pickup channel. The microphone is configured to pick up a sound transmitted through the sound pickup channel. The sound pickup channel includes a first channel section and a second channel section communicated with each other. The first channel section is closer to the microphone than the second channel section. A first central axis of the first channel section and a second central axis of the second channel section do not coincide. The first channel section and the second channel section of the sound pickup channel are staggered from each other, which helps avoid external droplets, or the like, from directly impacting the microphone, thereby extending the service life of the microphone.

Abstract: The present application relates to a modified tumor infiltrating lymphocyte and a use thereof, and specifically relates to a method for culturing a tumor infiltrating lymphocyte (TIL), which comprises causing a reduction of activity and/or expression of two or more proteins of the TIL. The present application also relates to a method for preventing and/or treating a tumor by using the tumor infiltrating lymphocyte.

Abstract: A headphone device of the invention includes a headband, a pair of joining members, a pair of holding members and a pair of sound generating modules. The headband is arc-shaped and has a first end and a second opposite to the first end. The joining members are movably disposed on the headband to approach or apart from the first end and the second end, and each of the joining members includes an upper contact portion extending towards another of the joining member. The holding members are rotatably joined to the joining members respectively, wherein each of the holding members includes a first pivot portion rotatably connected to one of the joining members and a holding portion secured to first pivot portion. The sound generating modules detachably disposed in the holding portion. The holding members rotate between a stretch position and a fold position.

Abstract: An air conditioning disinfection and sterilization device can be detachably installed at an air intake of an air conditioner and cover the air intake. The device includes a housing with a disinfection and sterilization unit centrally arranged in the housing. The sidewall of the housing is uniformly distributed with air inlets along the radial direction, and the housing is also equipped with an air outlet corresponding to the air intake of the air conditioner. This device can be conveniently fixed to the air intake of the air conditioner using a bracket. Under the negative pressure generated by the air intake of the air conditioner, external air is drawn into the housing through air inlets, and then the disinfection and sterilization unit within the housing eliminates bacteria or viruses in the air.

Abstract: An omnidirectional loudspeaker includes a lower horn member having a generally convex, upwardly-facing outer wall, an upper horn member spaced from the lower horn member and having a generally convex, downwardly-facing outer wall, and at least one compression driver connected to one of the lower or upper horn members along a central axis. The at least one compression driver includes a magnet assembly, a diaphragm operably connected to the magnet assembly, a phasing plug adjacent the diaphragm, and a compression chamber defined between the diaphragm and the phasing plug. The lower and upper horn members are coupled via the at least one compression driver in spaced relationship along the central axis to define a passageway for radiating sound waves generated by the compression driver in a generally horizontal 360° radiation pattern.

Abstract: A learned model includes an input layer; intermediate layers connected to the input layer; and an output layer connected to the intermediate layer. The learned model causes a computer to function to perform machine learning based on first data indicating a result detected while a product is produced by an injection molding machine or a result of measuring the product after the product is produced, and ground truth information indicating whether a value included in a section is ground truth for each section obtained by dividing an amount relating to production of the product into sections, and output, from the output layer, a degree to which the value included in the section is the ground truth, when second data is input from the input layer, the second data indicating the result detected while the product is produced or the result of measuring the product after being produced.

Abstract: A sensor patch for attachment to the adhesive surface of a base plate of an ostomy appliance is disclosed. The sensor patch has a proximal surface for attachment to the skin surface of a user and a distal surface for attachment of the sensor patch to the adhesive surface of a base plate. The sensor patch comprises an adhesive layer having a proximal side including a proximal surface for adhering the sensor patch to the skin, and a distal side including a distal surface; and a sensing layer comprising a nonwoven substrate and electrical conductors, the sensing layer arranged on the distal side of the adhesive layer, the sensing layer having a proximal side including a proximal surface and a distal side including a distal surface, the sensing layer being liquid permeable.

Abstract: The technology disclosed herein enables a rotation mechanism for a vehicle display to collapse when a force (e.g., from an impact) is applied to the display. In a particular example, an apparatus includes a motor shaft, wherein a motor rotates the motor shaft to rotate the display. The apparatus further includes a flange positioned to overlap with the motor shaft, wherein the display is connected to the flange. Also included are one or more fasteners positioned to connect the motor shaft to the flange. The dimension and material of the fasteners enable the fasteners to fail when a specified shear force is applied to the fasteners by the flange and the motor shaft. Failure of the fasteners enables the flange to move to overlap further with the motor shaft.

Abstract: Aerosol sprays, methods of generating aerosol sprays, and devices for dispensing aerosol sprays. The aerosol sprays have properties that are highly desirable for products such as air fresheners, including sizes of particles in the sprays and span factors of the particles. The methods and systems that provide the aerosol sprays use a membrane having micropores that forms Rayleigh jets that subsequently break up into the aerosol particles. The systems used to generate the aerosol sprays have a non-pressurized container for the product to be dispensed and a pump to provide the force to push the product through the micropores of the membrane.

Abstract: The disclosure provides a composition containing nylon 66 used in treatment fluids during well stimulation methods for application in reservoirs with very high temperatures. Methods for the application of nylon 66 in treatment fluid as a diverting and bridging agent for high temperature reservoirs are also discussed.

Abstract: Disclosed herein are delivery devices for delivering a volume of a drug product, placebo product, or other product including a fluid. The devices may include a barrel having a longitudinal axis, a proximal end region, and a distal end region. The proximal end region may include an opening, and the barrel may be configured to receive a drug therein. A plunger rod may be disposed at least partially inside the barrel and protruding from the opening. The plunger rod may include a rack having a plurality of teeth. The device may further include a pinion having a plurality of teeth configured to engage with the plurality of teeth of the rack, and rotation of the pinion against the rack may move at least a part of the plunger rod along the longitudinal axis of the barrel.

Abstract: The invention features methods for the identification of genomic aberrations in circulating tumor cells (CTCs) isolated from peripheral blood. In various embodiments of the disclosure, the methods involve isolation of a small number of purified circulating multiple myeloma cells, purification of genomic DNA from the cells, and sequencing of the genomic DNA.

Abstract: Separation media that includes a support substrate and a plurality of separation ligands immobilized on the support substrate. The plurality of separation ligands include an affinity capable of binding to a diol of a target molecule. The affinity group includes a boronic acid or a benzoxaborole. Methods of making the separation media and methods of using the separation media.

Abstract: A concrete screed includes a pair of longitudinal supports having proximal ends that are located opposite distal ends, where the proximal ends are pivotably mounted to an operating machine, such as a skid steer, such that the longitudinal supports extend in a longitudinal direction from the skid steer. A pair of cross members and an end member extend between the longitudinal supports, where the end member is located near the distal ends of the longitudinal supports. A screed blade is pivotably mounted to the end member at a single pivot point, and extends outboard of the longitudinal supports in opposing lateral directions perpendicular to the longitudinal direction. A support platform extends between the cross members and may support a compacting machine. If desired, the screed blade may flexed and/or vibrated during use.

Abstract: A laminated packaging material is provided. The laminated packaging material comprises a bulk layer of paper or paperboard or other cellulose-based material comprising a plurality of longitudinally distributed holes extending through the bulk layer, one or more outside layers being laminated to the bulk layer, one or more inside layers being laminated to the bulk layer, wherein said inside and outside layers covering said holes on the bulk layer and so form the plurality of longitudinally distributed laminated holes, and a plurality of longitudinally distributed primary holes extending through the entire thickness of the of the associated laminated hole and wherein the each primary hole is surrounded by the edges of the laminated hole.

Abstract: A modular decking system comprising at least one extendable joist, at least two extendable beams each connected to the at least one extendable joist, and at least one extendable bearer supporting the at least one extendable joist and the at least two extendable beams. The at least one extendable bearer is connected to the at least one extendable joist. Each extendable joist, each extendable beam, and each extendable bearer are extendable and retractable relative to one another.

Abstract: A process for the purification of a graphite material that includes metal sulfide impurities is provided. The process includes subjecting the graphite material to oxidizing conditions, in the presence of oxygen, to convert the metal sulfide impurities into metal oxides and sulfur dioxide, thereby obtaining a metal sulfide-lean graphite material; subjecting the metal sulfide-lean graphite material to carbochlorination, in the presence of chlorine gas, to convert the metal oxides into metal chlorides and obtain a metal chloride-rich graphite material; and purging the metal chlorides from the metal chloride-rich graphite material, thereby obtaining a purified graphite material.

Abstract: Hybrid buildings, hybrid building systems and methods of constructing hybrid buildings are disclosed. First and second building sections forming part of such buildings are also disclosed. One such hybrid residential building comprises a first building section and a second building section. The first building section is an on-site construction at a final location for the building and comprises a lower storey defining an internal volume that provides a lower living space within the building, and an upper storey defining an internal volume that provides an upper living space within the building. The second building section defines an internal volume and is transportable to the final location in a substantially assembled form. The first and second building sections are connected at the final location to form the building. The second building section defines a circulation space for the building, access between the upper and lower living spaces of the first building section being provided via the circulation space.

Abstract: A water heater system, the system comprising a water boiler including: a metallic spiral tube configured to receive at a top end thereof, from an external source, a fluid in a heated state; to output, at a bottom end thereof, the fluid in a cooled state; and a cylinder adapted to abut the metallic spiral tube; wherein the metallic spiral tube in the heated state, heats the cylinder which conducts the heat through the cylinder to heat water in the water boiler