Abstract: Methods and compositions for treating or preventing inflammatory diseases such as psoriasis or multiple sclerosis are provided, comprising the step of delivering to the site of inflammation an anti-microtubule agent, or analogue or derivative thereof.
Abstract: Anhydrous formulations are formed of a diblock copolymer (X-Y) having a hydrophilic block X comprising residues of monomer x, and a hydrophobic block Y comprising residues of monomer y; an additive selected from a polymer and an organic solvent, where the solvent is water-miscible and biocompatible, and the polymer is hydrophobic or hydrophilic and comprises residues of monomers x and/or y, the polymer optionally having a molecular weight that is less than the molecular weight of the diblock copolymer; and a drug. Upon admixture with water, the anhydrous formulations form drug delivery vehicles, preferably in micellar form. The inclusion of polymer and/or organic solvent provides for the formation of micelles at an enhanced rate, and/or provides the formation of micelles having an enhanced ability to incorporate drug(s), and/or provides the formation of micelles having advantageous physical characteristics, e.g., advantageous viscosity and/or melting point.
Type:
Application
Filed:
August 6, 2007
Publication date:
June 19, 2008
Applicant:
ANGIOTECH INTERNATIONAL AG
Inventors:
Richard Liggins, Larry Murphy, Dechi Guan
Abstract: Medical implants are provided which release an anthracycline, fluoropyrimidine, folic acid antagonist, podophylotoxin, camptothecin, hydroxyurea, and/or platinum complex, thereby inhibiting or reducing the incidence of infection associated with the implant.
Type:
Application
Filed:
July 31, 2007
Publication date:
June 19, 2008
Applicant:
Angiotech International AG
Inventors:
William L. Hunter, David M. Gravett, Philip M. Toleikis, Richard T. Liggins, Troy A. E. Loss
Abstract: Anhydrous formulations are formed of a diblock copolymer (X—Y) having a hydrophilic block X comprising residues of monomer x, and a hydrophobic block Y comprising residues of monomer y; an additive selected from a polymer and an organic solvent, where the solvent is water-miscible and biocompatible, and the polymer is hydrophobic or hydrophilic and comprises residues of monomers x and/or y, the polymer optionally having a molecular weight that is less than the molecular weight of the diblock copolymer; and a drug. Upon admixture with water, the anhydrous formulations form drug delivery vehicles, preferably in micellar form. The inclusion of polymer and/or organic solvent provides for the formation of micelles at an enhanced rate, and/or provides the formation of micelles having an enhanced ability to incorporate drug(s), and/or provides the formation of micelles having advantageous physical characteristics, e.g., advantageous viscosity and/or melting point.
Type:
Application
Filed:
August 6, 2007
Publication date:
June 5, 2008
Applicant:
ANGIOTECH INTERNATIONAL AG
Inventors:
Richard Liggins, Larry Murphy, Dechi Guan
Abstract: The present invention discloses compositions, devices and methods for the production, use and administration of compositions that comprise microparticles that are loaded with a drug at a concentration of greater than 50% (weight drug/weight microparticle).
Type:
Application
Filed:
June 24, 2005
Publication date:
May 29, 2008
Applicant:
Angiotech International AG
Inventors:
Richard T. Liggins, Philip M. Toleikis, Dechi Guan
Abstract: Methods and compositions for treating or preventing inflammatory diseases such as psoriasis or multiple sclerosis are provided, comprising the step of delivering to the site of inflammation an anti-microtubule agent, or analogue or derivative thereof.
Abstract: Medical implants are provided which release an anthracycline, fluoropyrimidine, folic acid antagonist, podophylotoxin, camptothecin, hydroxyurea, and/or platinum complex, thereby inhibiting or reducing the incidence of infection associated with the implant.
Type:
Application
Filed:
July 31, 2007
Publication date:
May 15, 2008
Applicant:
Angiotech International AG
Inventors:
William L. Hunter, David M. Gravett, Philip M. Toleikis, Richard T. Liggins, Troy A.E. Loss
Abstract: Medical implants are provided which release an anthracycline, fluoropyrimidine, folic acid antagonist, podophylotoxin, camptothecin, hydroxyurea, and/or platinum complex, thereby inhibiting or reducing the incidence of infection associated with the implant.
Type:
Application
Filed:
July 31, 2007
Publication date:
April 17, 2008
Applicant:
Angiotech International AG
Inventors:
William Hunter, David Gravett, Philip Toleikis, Richard Liggins, Troy Loss
Abstract: The present invention provides compositions, devices, and methods for maintaining or improving the integrity of body passageways following surgery, such as at a graft site, or injury. Delivery devices including one or more therapeutic agents and a mesh are described. Representative examples of therapeutic agents include microtubule stabilizing agents, anti-angiogenic factors, inhibitors of smooth muscle cell growth or proliferation, non-steroidal anti-inflammatory drugs, and other factors useful preventing and/or reducing a proliferative biological response that may obstruct or hinder the optimal functioning of the passageway or cavity.
Type:
Application
Filed:
August 7, 2007
Publication date:
April 10, 2008
Applicant:
Angiotech International AG
Inventors:
David Gravett, Philip Toleikis, Dechi Guan, Pierre Signore, Thomas Spencer, William Hunter, Kaiyue Wang
Abstract: Medical implants are provided which release an anthracycline, fluoropyrimidine, folic acid antagonist, podophylotoxin, camptothecin, hydroxyurea, and/or platinum complex, thereby inhibiting or reducing the incidence of infection associated with the implant.
Type:
Application
Filed:
July 31, 2007
Publication date:
November 22, 2007
Applicant:
Angiotech International AG
Inventors:
William Hunter, David Gravett, Philip Toleikis, Richard Liggins, Troy Loss
Abstract: Agents, compositions, and implants are provided herein for treating diverticular disease (e.g., diverticulosis and diverticulitis). In particular, fibrosis-inducing agents, hemostatic agents, and/or anti-infective agents, or compositions containing one or more of these agents are provided for use in methods for treating diverticular disease.
Type:
Application
Filed:
July 10, 2007
Publication date:
November 1, 2007
Applicant:
ANGIOTECH INTERNATIONAL AG
Inventors:
William Hunter, Philip Toleikis, David Gravett, Rui Avelar, Dechi Guan
Abstract: Disclosed herein are compositions and methods for treating a variety of inflammatory conditions (e.g., inflammatory arthritis, adhesions, tumor excision sites, and fibroproliferative diseases of the eye). For example, there is provided a composition comprising a protein or polysaccharide containing dispersed (e.g., in micelle or liposome form) anti-microtubule agent, which may be formulated for administration to a patient in need thereof.
Type:
Application
Filed:
March 16, 2007
Publication date:
September 13, 2007
Applicant:
ANGIOTECH INTERNATIONAL AG
Inventors:
William Hunter, David Gravett, Richard Liggins, Philip Toleikis
Abstract: Agents, compositions, and implants are provided herein for treating diverticular disease (e.g., diverticulosis and diverticulitis). In particular, fibrosis-inducing agents, hemostatic agents, and/or anti-infective agents, or compositions containing one or more of these agents are provided for use in methods for treating diverticular disease.
Type:
Grant
Filed:
May 12, 2005
Date of Patent:
July 10, 2007
Assignee:
Angiotech International AG
Inventors:
William L Hunter, Philip M Toleikis, David M Gravett, Rui Avelar, Dechi Guan
Abstract: The present invention provides compositions and methods for improving the integrity of body passageways following surgery or injury. Representative examples of therapeutic agents include microtubule stabilizing agents, fibrosis inducers, angiogenic factors, growth factors and cytokines and other factors involved in the wound healing or fibrosis cascade.
Type:
Application
Filed:
September 14, 2006
Publication date:
May 10, 2007
Applicants:
University of British Columbia, Angiotech International AG
Abstract: The present invention provides a medical device combined with a polymeric coating material comprising a bioerodable diblock copolymer and optionally a therapeutic agent.
Type:
Application
Filed:
May 9, 2006
Publication date:
February 1, 2007
Applicant:
Angiotech International AG
Inventors:
Dechi Guan, Richard Whitbourne, David Gravett
Abstract: Implants are used in combination with a fibrosis-inducing agent in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or increase fibrosis between the implant and the host tissue.
Type:
Grant
Filed:
December 7, 2004
Date of Patent:
January 23, 2007
Assignee:
Angiotech International AG
Inventors:
William L. Hunter, David M. Gravett, Philip M. Toleikis, Arpita Maiti, Pierre E. Signore, Richard T. Liggins, Dechi Guan
Abstract: Electrical devices (e.g., cardiac rhythm management and neurostimulation devices) for contact with tissue are used in combination with an anti-scarring agent (e.g., a cell cycle inhibitor) in order to inhibit scarring that may otherwise occur when the devices are implanted within an animal.
Type:
Application
Filed:
December 7, 2004
Publication date:
December 14, 2006
Applicant:
Angiotech International AG
Inventors:
William Hunter, David Gravett, Philip Toleikis, Arpita Maiti
Abstract: Implants are used in combination with a fibrosis-inducing agent in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or increase fibrosis between the implant and the host tissue.
Type:
Application
Filed:
December 1, 2004
Publication date:
October 26, 2006
Applicant:
Angiotech International AG
Inventors:
William Hunter, David Gravett, Philip Toleikis, Arpita Maiti, Pierre Signore, Richard Liggins
Abstract: Implants are used in combination with a fibrosis-inducing agent in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or increase fibrosis between the implant and the host tissue.
Type:
Application
Filed:
December 1, 2004
Publication date:
October 26, 2006
Applicant:
Angiotech International AG
Inventors:
William Hunter, David Gravett, Philip Toleikis, Arpita Maiti, Pierre Signore, Richard Liggins, Dechi Guan