Abstract: Invented are methods of inhibiting the production of cytokines, particularly inhibiting the production of interleukin-1 and inhibiting the production of tumor necrosis factor in a mammal in need thereof which comprises administering to such mammal an effective amount of an azaspirane derivative.
Type:
Grant
Filed:
January 7, 1997
Date of Patent:
May 4, 1999
Assignee:
AnorMED, Inc.
Inventors:
Alison Mary Badger, Wanda Bernadette High
Abstract: Macrocyclic compounds having 1, 4, 8, 11-tetraazacyclotetradecanyl group, show good selectivity against HIV-1 and HIV-2, in in vitro tests are disclosed.
Type:
Grant
Filed:
June 6, 1996
Date of Patent:
October 6, 1998
Assignee:
Anormed Inc.
Inventors:
Gary J. Bridger, Sreenivasan Padmanabhan, Renato T. Skerlj, Pedro E. Hernandez-Abad, Milind P. Sant