Abstract: Sodium amoxycillin, of use for example by parenteral administration, is prepared by:(a) suspending amoxycillin trihydrate in a mixture comprising an aprotic organic solvent and a lower alcohol;(b) solubilizing the amoxycillin trihydrate by the addition of a low molecular weight amine of the group of cyclic or heterocyclic aliphatics;(c) adding to such solution the sodium salt of diethyloxalacetic acid, agitating the reaction mixture at a temperature of from -10.degree. C. to ambient temperature and finally isolating the sodium amoxycillin by filtration after its precipitation in the reaction medium by the addition of an aprotic organic solvent.

Abstract: Novel salts of the formula ##STR1## are disclosed wherein n is 1 or 2; both OR groups are O.sup.- when n is 2, or one is O.sup.- and one is OH when n is 1; and R.sub.1, R.sub.2, R.sub.3, and R.sub.4 independently represent hydrogen, alkyl, aryl, amino-alkyl, hydroxy-alkyl, or hydroxy-alkyl-amino. These salts are useful in treatment of microbial infecting in mammals, and use of the salts in composition for oral and parenteral administration is also disclosed.

Abstract: A process for the preparation of alpha-(N-pyrrolyl)-derivative acids, the salts and esters thereof, of the formula ##STR1## in which R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are hydrogen atoms or substituted or unsubstituted alkyl, aryl, alkylaryl or heterocyclic radicals and R' is a metal cation, an organic base or an organic radical, wherein the corresponding amino ester is reacted with a dialkoxytetrahydrofuran or a derivative thereof. Certain compounds comprised among those corresponding to the above formula, particularly the DL, D and L-alpha-(N-pyrrolyl)-phenylacetic acids and certain esters thereof. Therapeutical compositions containing such compounds as active ingredient and therapeutical applications of said compounds.

Abstract: A process for the activation of carboxylic acids which is useful for the subsequent conversion of said carboxylic acids into their corresponding amides or esters, based on reacting a 2-oxazolidinone with phosphorus pentachloride and subsequent addition of a salt of the carboxylic acid to be activated.