Abstract: A system for image reconstruction comprises a memory for storing data and instructions and a processor system. The system obtains measured data y defined in a dual space, the measured data relating to a primal space. The system determines dual parameters defined in the dual space based on the measured data and primal parameters defined in the primal space based on back-projection of the dual parameters. The system updates the primal parameters and the dual parameters, by obtaining auxiliary dual parameters by forward-projecting the primal parameters, applying a dual-space learned invertible operator to the dual parameters, based on the auxiliary dual parameters, obtaining auxiliary primal parameters by back-projecting the dual parameters, and applying a primal-space learned invertible operator to the primal parameters, based on the auxiliary primal parameters. The system determines an image in the primal space based on the updated primal parameters.

Abstract: The present invention relates to a combination therapy of an inhibitor of the Bel-2 family of proteins selected from navitoclax, venetoclax, A-1331852, AZD5991, or A-1155463, together with an aurora kinase inhibitor for use in a method of treatment of a cancer selected from breast, ovarian, pancreatic, or prostate cancer in a patient.

Abstract: The present invention relates to a combination therapy a CHEK1 inhibitor and a TOP1 inhibitor for use in a method of treatment of colorectal cancer in a patient.

Abstract: The generation of antigen specific T cells by controlled ex vivo induction or expansion can provide highly specific and beneficial T cell therapies. The present disclosure provides T cell manufacturing methods and therapeutic T cell compositions which can be used for treating subjects with cancer and other conditions, diseases and disorders personal antigen specific T cell therapy.

Abstract: The present invention relates to a combination therapy of an IGF1R inhibitor together with an Akt inhibitor for the treatment of cancer, such as colorectal cancer, ovarian cancer, and endometrial cancer.

Abstract: The invention relates to isolated populations of CD4+GPA33high regulatory T cells, to methods for detecting and/or isolating CD4+GPA33high cells, methods for enriching for CD4+GPA33high cells and to uses of CD4+GPA33high cells and populations of such cells. The invention further relates to methods for classifying an individual suffering from cancer and typing a tumor sample as well as for determining the etiology of autoimmune diseases.

Abstract: A surgical forceps comprises a first jaw (101) and a second jaw (102), the first jaw (101) and the second jaw (102) being configured to be rotated relative to each other around an axis of rotation (104). A position sensor (105) is capable of sensing a first orientation with respect to a first axis (106) and a second orientation with respect to a second axis (107) different from the first axis (106), wherein the first axis (106) and the second axis (107) are orthogonal to the axis of rotation (104). The surgical forceps comprises a stapler (108) for stapling a tissue grasped by the surgical forceps (100) and a cutter (103) for cutting the tissue grasped by the surgical forceps (100) along a line.

Abstract: A heat and moisture exchanger, comprises a rigid monolithic body (101). The rigid monolithic body (101) comprises a circumferential wall (102); and a structure of interconnected elements (106) surrounded by the circumferential wall (102). The structure (106) is open to fluid communication through the structure (106) between a first side (114) of the structure and a second side (115) of the structure (106) opposite the first side (114) of the structure (106). The circumferential wall (102) extends from the first side (114) to the second side (115) of the structure (106). The heat and moisture exchanger (100) is open on both of the first side (114) and the second side (115) of the structure (106), to allow fluid communication between the structure (106) and an exterior of the heat and moisture exchanger (100) on both sides (114, 115).

Abstract: A personalized implant for bone replacement comprises an implant body as a reconstruction of a bone portion. The implant body comprises a closed cavity and a solid impervious layer of material defining an outside surface of the implant body exposed to an exterior of the implant. The solid impervious layer fully encloses the closed cavity inside the implant body. The closed hollow interior can comprise an open support structure to reinforce the solid outside layer.

Abstract: A first surgical instrument cooperates with a second surgical instrument. The first instrument comprising a needle having a form of a hollow shaft comprising an outer wall around an inner cavity, an interior of the needle providing a space for positioning the second surgical instrument coaxially to the needle at least partly inside the needle and movable with respect to the needle in an axial direction of the needle. A tissue analysis device comprising an analysis sensor to analyse non-removed tissue at a distal tip of the needle. The tissue analysis device is configured to provide a sensor signal representative of an analysed characteristic of the tissue, in particular for the presence of unhealthy tissue or cancer cells within the tissue.

Abstract: The invention relates to the field of medicine and medicinal chemistry, more in particular to the design, manufacture and use of anti-cancer drugs that can be activated by an external stimulus that can be applied in a spatiotemporal fashion. Provided herein is a compound having the chemical structure or a pharmaceutically acceptable salt thereof.

Abstract: A convertible garment may be converted between a top configuration for covering the torso of a person and bottom configuration for covering the lower half of the person, and vice-versa. The garment has in the top configuration a removable front panel having a right side having a first elongate fastener half extending along the right side and a left side having a second elongate fastener half extending along the left side. Preferably, the bottom configuration has a front portion, a back portion, a right side having a third elongate fastener and a left side having a fourth elongate fastener. The front and the back portions of the bottom configuration form the back of the top configuration when the third and fourth fasteners are at least partially undone. Methods of converting between the two configurations are also disclosed.

Abstract: A tumor sensor system having an implantable probe and an auxiliary device, the probe having at least one sensor configured to generate an electric signal in response to a physical stimulus, the at least one sensor having a position sensor configured to sense a signal from a position tracking system, the sensed signal indicative of a position of the probe in a space, the position sensor having at least one electromagnetic sensor configured to cooperate with an external electromagnetic field generator, and the at least one electromagnetic sensor is configured to detect a property of the electromagnetic field and send it as an electric signal to the processing circuit, at least one antenna for data communication by means of inductive communication, an energy harvesting coil, and transmitting the data via the at least one antenna to the auxiliary device.

Abstract: A surgical forceps comprises a first jaw (101) and a second jaw (102), the first jaw (101) and the second jaw (102) being configured to be rotated relative to each other around an axis of rotation (104). A position sensor (105) is capable of sensing a first orientation with respect to a first axis (106) and a second orientation with respect to a second axis (107) different from the first axis (106), wherein the first axis (106) and the second axis (107) are orthogonal to the axis of rotation (104). The surgical forceps comprises a stapler (108) for stapling a tissue grasped by the surgical forceps (100) and a cutter (103) for cutting the tissue grasped by the surgical forceps (100) along a line.

Abstract: A heat and moisture exchanger, comprises a rigid monolithic body (101). The rigid monolithic body (101) comprises a circumferential wall (102); and a structure of interconnected elements (106) surrounded by the circumferential wall (102). The structure (106) is open to fluid communication through the structure (106) between a first side (114) of the structure and a second side (115) of the structure (106) opposite the first side (114) of the structure (106). The circumferential wall (102) extends from the first side (114) to the second side (115) of the structure (106). The heat and moisture exchanger (100) is open on both of the first side (114) and the second side (115) of the structure (106), to allow fluid communication between the structure (106) and an exterior of the heat and moisture exchanger (100) on both sides (114, 115).

Abstract: The present invention relates to TWEAK-receptor agonists for use in the treatment of a cancer, wherein the TWEAK-receptor agonist is combined with immunotherapy of the cancer. The TWEAK-receptor agonist preferably is a multivalent ligand that causes clustering of TWEAK-receptors at the cell surface. A suitable TWEAK-receptor agonist is an agonistic anti-Fn14 antibody. The TWEAK-receptor agonist and immunotherapy be can further be combined with a SMAC mimetic in the treatment of cancer. The TWEAK-receptor agonist is useful, optionally in combination with a SMAC mimetic, to prevent resistance of a cancer to immunotherapy and/or to treat a cancer comprising tumor cells that are resistant to immunotherapy.

Abstract: In a method to determine a patient (radiation) dose distribution (13), it is provided to calculate, from a measured signal (7) of a detector (6) placed behind a region of interest, a dose distribution (11) for a patient-shaped water equivalent phantom (12) and to compute from this a patient dose distribution (13) that takes into account inhomogeneities of a matter distribution of the patient (4).

Abstract: A convertible garment may be converted between a top configuration for covering the torso of a person and bottom configuration for covering the lower half of the person, and vice-versa. The garment has in the top configuration a removable front panel having a right side having a first elongate fastener half extending along the right side and a left side having a second elongate fastener half extending along the left side. Preferably, the bottom configuration has a front portion, a back portion, a right side having a third elongate fastener and a left side having a fourth elongate fastener. The front and the back portions of the bottom configuration form the back of the top configuration when the third and fourth fasteners are at least partially undone. Methods of converting between the two configurations are also disclosed.

Abstract: In a method and system for providing visual information about a tumour location in human or animal body, an electromagnetic tumour sensor is provided in the tumour and tracked to determine its location in space, which is mapped to a tumour model. A surgical tool sensor is provided on a surgical tool, and tracked to determine its location in space, which is mapped to a surgical tool model. The body is scanned to obtain information about an anatomical structure. A reference sensor is provided on the body, and tracked to determine its location in space, which is mapped to the anatomical structure. A virtual image is displayed showing the tumour model, located with the at least one tumour sensor, in spatial relationship to the surgical tool model, located with the at least one surgical tool sensor, and the anatomical structure, located with the at least one reference sensor.

Abstract: The invention is concerned with use of oral inorganic pyrophosphate for preventing and/or reducing tissue calcification, particularly soft tissue calcification, and/or diseases or disorders characterized by low plasma PPi levels, as, e.g.