Patents Assigned to Applera Corporation
  • Patent number: 8246806
    Abstract: An electrophoresis apparatus includes a multi-capillary array having a liquid or solid disposed between the capillaries of the array. The liquid or solid exhibits a refractive index higher than that of air and less than that of water and reduces the amount of laser beams scattered by the capillaries. Also provided are methods of adjusting refracted and reflected excitation light beams passing through capillaries of a multi-capillary array, to reduce loss of intensity of the laser beams and increase irradiation of respective samples disposed in the capillaries.
    Type: Grant
    Filed: March 6, 2007
    Date of Patent: August 21, 2012
    Assignees: Applera Corporation, Hitachi, Ltd.
    Inventors: Ryoji Inaba, Tomohiro Shoji, Shozo Kasai, Masaya Kojima, Yasushi Shimizu, Seiichi Ugai, Eric S. Nordman
  • Publication number: 20120190714
    Abstract: The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
    Type: Application
    Filed: July 27, 2011
    Publication date: July 26, 2012
    Applicants: Applera Corporation, ViroBay, Inc.
    Inventors: Michael Graupe, John O. Link, Michael G. Roepel
  • Publication number: 20120122104
    Abstract: The present disclosure relates to compositions and methods of using triplex structures generated by a duplex of a polypurine tract and complementary polypyrimidine tract and a triplex-forming nucleobase polymer that hydrogen bonds to both the purine and pyrimidine bases of the polypurine-polypyrimidine duplex.
    Type: Application
    Filed: March 23, 2007
    Publication date: May 17, 2012
    Applicant: Applera Corporation
    Inventors: Neil Straus, Stefan Matysiak, Eric Anderson
  • Publication number: 20110315870
    Abstract: Systems and methods for analyzing compounds in a sample. In one embodiment, the present technology is directed towards a method of analyzing a sample, comprising: emitting ions from the sample; selectively filtering the emitted ions for at least one designated trigger ion; fragmenting the designated trigger ions; scanning for a designated trigger ion fragment; and upon detecting the designated trigger ion fragment, scanning for at least one confirmatory ion fragment.
    Type: Application
    Filed: September 9, 2011
    Publication date: December 29, 2011
    Applicants: Applera Corporation, MDS Analytical Technologies, a business unit of MDS Inc., doing buiness through its Sciex division
    Inventors: Chris M. LOCK, Nic Bloomfield
  • Patent number: 8043493
    Abstract: An electrophoresis apparatus includes a multi-capillary array having a liquid or solid disposed between the capillaries of the array. The liquid or solid exhibits a refractive index higher than that of air and less than that of water and reduces the amount of laser beams scattered by the capillaries. Also provided are methods of adjusting refracted and reflected excitation light beams passing through capillaries of a multi-capillary array, to reduce loss of intensity of the laser beams and increase irradiation of respective samples disposed in the capillaries.
    Type: Grant
    Filed: March 6, 2007
    Date of Patent: October 25, 2011
    Assignees: Hitachi, Ltd., Applera Corporation
    Inventors: Ryoji Inaba, Tomohiro Shoji, Shozo Kasai, Masaya Kojima, Yasushi Shimizu, Seiichi Ugai
  • Publication number: 20110206667
    Abstract: This invention relates to nucleotide polymorphisms in the human Apo(a) gene and to the use of Apo(a) nucleotide polymorphisms in identifying whether a human subject will respond or not to treatment with acetylsalicylic acid.
    Type: Application
    Filed: April 19, 2011
    Publication date: August 25, 2011
    Applicants: The Brigham and Women's Hospital, Inc., Applera Corporation
    Inventors: Paul Ridker, Daniel Chasman, Dov Shiffman
  • Patent number: 7943317
    Abstract: This invention relates to nucleotide polymorphisms in the human Apo(a) gene and to the use of Apo(a) nucleotide polymorphisms in identifying whether a human subject will respond or not to treatment with acetylsalicylic acid.
    Type: Grant
    Filed: May 9, 2008
    Date of Patent: May 17, 2011
    Assignees: The Brigham and Women's Hospital, Inc., Applera Corporation
    Inventors: Paul Ridker, Daniel Chasman, Dov Shiffman
  • Publication number: 20110045516
    Abstract: This invention pertains to methods, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.
    Type: Application
    Filed: January 16, 2007
    Publication date: February 24, 2011
    Applicant: Applera Corporation
    Inventors: Darryl J.C. Pappin, Michael Bartlet-Jones
  • Publication number: 20110028685
    Abstract: This invention pertains to methods, mixtures, kits and compositions pertaining to analyte determination and/or quantification by mass spectrometry using compounds comprising a reporter moiety and a non-encoded detectable label. The compounds can be used in sets for the analysis of mixtures of labeled analytes.
    Type: Application
    Filed: June 28, 2007
    Publication date: February 3, 2011
    Applicant: Applera Corporation.
    Inventors: Subhasish Purkayastha, Subhakar Dey
  • Publication number: 20110003281
    Abstract: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.
    Type: Application
    Filed: June 11, 2007
    Publication date: January 6, 2011
    Applicant: Applera Corporation
    Inventors: Timothy Woudenberg, Michael Albin, Reid B. Kowallis, Yefim Raysberg, Robert P. Ragusa, Emily S. Winn-Deen
  • Publication number: 20100291548
    Abstract: The present disclosure relates to methods of identifying target nucleic acids by using coded molecules and its analysis by translocation through a nanopore. Generally, coded molecules are subject to a target polynucleotide dependent modification. The modified coded molecule is detected by isolating the modified coded molecules from the unmodified coded molecules prior to analysis through the nanopore or by detecting a change in the signal pattern of the coded molecule when analyzed through the nanopore.
    Type: Application
    Filed: March 12, 2007
    Publication date: November 18, 2010
    Applicant: Applera Corporation
    Inventors: Muhammad A. Sharaf, Timothy M. Woudenberg, Khairuzzaman Bashar Mullah
  • Publication number: 20100280246
    Abstract: Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers facilitate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R28 where R21 is a C1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z1 is either NH, sulfur or oxygen, R22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R28 includes a functional group which attaches the linker to the acceptor dye.
    Type: Application
    Filed: December 28, 2006
    Publication date: November 4, 2010
    Applicant: Applera Corporation
    Inventors: Linda G. Lee, Sandra L. Spurgeon, Barnett Rosenblum
  • Publication number: 20100237236
    Abstract: A method of processing multiple precursor ions in a tandem mass spectrometer includes generating a plurality of precursor ions with an ion source. At least some of the plurality of precursor ions is trapped in an ion trap. At least two precursor ions of interest are isolated from the plurality of precursor ions with a filtered noise field. Precursor ions of interest are sequentially ejected toward a collision cell. The sequentially ejected precursor ions of interest are fragmented in a collision cell. The mass-to-charge ratio spectra of the fragmented ions are then determined with a mass spectrometer.
    Type: Application
    Filed: March 20, 2009
    Publication date: September 23, 2010
    Applicants: Applera Corporation, MDS, Inc.
    Inventors: Bruce Thomson, Bruce Collings
  • Patent number: 7679053
    Abstract: A method for introducing samples through a boundary member partially defining a chamber at an entrance point coaxial to a sampling inlet of a mass spectrometer is described. Field-free conditions can be established in at least one region of the chamber. The sample can be introduced adjacent to the sampling inlet, and introducing at least a second sample can be introduced through at least one other entrance point in the chamber not adjacent to the sampling inlet. An apparatus having a sampling inlet and a boundary member partially defining a chamber is also described. Field-free conditions can be established in at least one region of the chamber, and there can be a first aperture in the boundary member through which a source emits sample. Related devices, uses and mass spectrometers are also described.
    Type: Grant
    Filed: September 25, 2007
    Date of Patent: March 16, 2010
    Assignees: MDS Analytical Technologies, A Business Unit of MDS Inc., Applera Corporation
    Inventors: Bradley B. Schneider, Thomas R. Covey
  • Publication number: 20090321264
    Abstract: Embodiments of a device and method are described which provide for concentration and purification of analytes, e.g., polynucleotides, in channel devices using AC and DC electric fields.
    Type: Application
    Filed: March 3, 2009
    Publication date: December 31, 2009
    Applicant: Applera Corporation
    Inventors: Michael Harrold, Eric S. Nordman
  • Publication number: 20090305238
    Abstract: A fluid processing device is provided that comprises a substrate including a surface and a fluid processing pathway at least partially formed in or on the surface. The fluid processing pathway can comprise a channel, a reaction region in fluid communication with the channel, a microarray in fluid communication with the channel, and optionally a deformable valve. The microarray can comprise binding and/or detection sites, and each site can comprise a binding moiety. A method and a system using the fluid processing device, are also provided.
    Type: Application
    Filed: January 22, 2007
    Publication date: December 10, 2009
    Applicant: Applera Corporation
    Inventor: David M. Cox
  • Publication number: 20090236513
    Abstract: Systems and methods for analyzing compounds in a sample. In one embodiment, the present technology is directed towards a method of analyzing a sample, comprising: emitting ions from the sample; selectively filtering the emitted ions for at least one designated trigger ion; fragmenting the designated trigger ions; scanning for a designated trigger ion fragment; and upon detecting the designated trigger ion fragment, scanning for at least one confirmatory ion fragment.
    Type: Application
    Filed: March 12, 2009
    Publication date: September 24, 2009
    Applicants: MDS Analytical Technologies, a business unit of MDS Inc., doing buiness through its Sciex division, Applera Corporation
    Inventors: Chris M. LOCK, Nic BLOOMFIELD
  • Patent number: 7579585
    Abstract: A mass spectrometer system having an ion trap and a downstream mass spectrometer is provided. A plurality of groups of ions are provided to the ion trap and a first mass-to-charge ratio is selected. The downstream mass spectrometer is configured to filter out one of (i) ions having a first unselected mass-to-charge ratio different from the first mass-to-charge ratio, and (ii) mass signals for ions having the first unselected mass-to-charge ratio different from the first mass-to-charge ratio. A first group of ions is ejected of the first mass-to-charge ratio from the ion trap to the downstream mass spectrometer.
    Type: Grant
    Filed: October 25, 2006
    Date of Patent: August 25, 2009
    Assignees: Sciex Division of MDS Inc., Applera Corporation
    Inventor: James W. Hager
  • Publication number: 20090186779
    Abstract: An array comprising a probe covalently attached to a diamond substrate is fabricated, for example, by treating the diamond substrate with an aryl diazonium compound and covalently attaching the probe to the aryl group. Some embodiments are useful in DNA-based sensing applications.
    Type: Application
    Filed: April 3, 2009
    Publication date: July 23, 2009
    Applicant: Applera Corporation
    Inventors: Timothy Z. Liu, Timothy Woudenberg, Jer-Kang Chen
  • Patent number: 7557344
    Abstract: The applicants' teachings provide methods, systems, and apparatus useful in operating mass spectrometers and other devices incorporating multipole rod sets or other multi-electrode devices to simultaneously contain ions of both positive and negative charges through the simultaneous application to the rods or other electrodes of both radio-frequency (RF) and alternating (AC) currents.
    Type: Grant
    Filed: July 9, 2007
    Date of Patent: July 7, 2009
    Assignees: MDS Analytical Technologies, a business unit of MDS Inc., Applera Corporation
    Inventors: Igor Chernushevich, Alexandre Loboda