Abstract: Peptidomimetic macrocycles that comprise all-D configuration ?-amino acids and bind mouse double minute 2 (MDM2 aka E3 ubiquitin-protein ligase) and MDMX (aka MDM4) are described. These all-D configuration ?-amino acid peptidomimetic macrocycles are protease resistant, cell permeable without inducing membrane disruption, and intracellularly activate p53 by binding MDM2 and MDMX thereby antagonizing MDM2 and MDMX binding to p53. These peptidomimetic macrocycles may be useful in anticancer therapies, particularly in combination with chemotherapy or radiation therapy.

Abstract: A booth that is available for use when reserved and that is installed with an image forming apparatus accommodated therein, the booth including a panel having a first opening through which the image forming apparatus accommodated in the booth is operable by a person who has entered the booth; and a panel having a second opening through which the image forming apparatus accommodated in the booth is operable by a person from outside the booth.

Abstract: An image forming apparatus includes an image forming unit that forms an image on a recording medium and an image forming apparatus body in which the image forming unit is provided, and on which a first manual feeding tray and a second manual feeding tray having a configuration different from the first manual feeding tray are selectively mountable at a same mounting position.

Abstract: A booth is made usable by making a reservation, and has an opening that allows a user to enter and exit, in which a top plate of a desk is installed in a space surrounded by a floor and a side wall. A development area or a development position of the top plate is changeable in the space.

Abstract: A clip device includes a sheath having a lumen with at least one open end and a plurality of clip arms movable between a first configuration in which the plurality of clip arms are opened to receive a target tissue, and a second configuration in which the plurality of clip arms are closed to grip the target tissue. Locking mechanisms respectively provided on the plurality of clip arms engage one another for maintaining the second configuration. A restraining mechanism is optionally configured to be associated with the locking mechanisms to prevent the target tissue from being pinched between the locking mechanisms.

Abstract: Disclosed are embodiments directed to security methods applied to connections between components in a distributed (networked) system including medical and non-medical devices, providing secure authentication, authorization, patient and device data transfer, and patient data association and privacy for components of the system.

Abstract: Disclosed herein are methods for preparing and/or dispensing lyospheres of pharmaceutical compositions of biologics (e.g., vaccines, therapeutic proteins such as monoclonal antibodies) or small molecules (e.g., chemical compounds). Also described are assemblies and systems for preparing and/or dispensing the lyospheres.

Abstract: Embodiments of the present application provide an access control method and apparatus, and a terminal device, where the method includes: a terminal device receiving first configuration information sent by a network device, the first configuration information including at least one set of access control parameters; and the terminal device determining a first access category and a first access identity corresponding to a first type of service, determining a first set of access control parameters corresponding to the first access category from the first configuration information, and executing an access control operation corresponding to the first type of service according to the first access identity and the first set of access control parameters, the first type of service being a service for an IOT device.

Abstract: The disclosure provides an image processing device. An image processing device includes a neural network circuit, a gain control circuit, and an image merge circuit. The neural network circuit is configured to receive an input image, and perform an image processing operation on the input image according to fixed parameters to output a first intermediate image. The gain control circuit, coupled to the neural network circuit, is configured to receive the first intermediate image from the neural network circuit, and multiply the first intermediate image by at least one amplitude gain to output a second intermediate image. The image merge circuit, coupled to the gain control circuit, configured to receive the second intermediate image and the input image, and combine the second intermediate image and the input image to obtain an output image. In addition, a method for image enhancement is also provided.

Abstract: Treatment device for ultrasonic treatment and high frequency treatment procedure is equipped with an ultrasonic transducer including piezoelectric elements converting electrical power into ultrasonic vibrations. The treatment device includes a transmission rod with a treatment probe and jaw for clasping objects. The transmission rod includes features for damping, such as a sheath, a coating, a geometry of the outer surface of the transmission rod, or combinations of such features, to minimize or prevent excess vibrations and to, among other things, decrease frictional heat caused by the friction between the damping features and the transmission rod arising from attenuating the ultrasonic vibrations.

Abstract: A circuit includes a set of multiple bit generating cells. One or more adjustable current sources is coupled to introduce perturbations into outputs of the bit generating cells. Based on the perturbations, the outputs of a subset less than all of the bit generating cells are selected, and applied as a control.

Abstract: A resistive random-access memory (RRAM) device includes a bottom electrode, a high work function layer, a resistive material layer, a top electrode and high work function spacers. The bottom electrode, the high work function layer, the resistive material layer and the top electrode are sequentially stacked on a substrate, wherein the resistive material layer includes a bottom part and a top part. The high work function spacers cover sidewalls of the bottom part, thereby constituting a RRAM cell. The present invention also provides a method of forming a RRAM device.

Abstract: A vibration transmission member for an ultrasonic treatment tool includes: a main body including a central axis, a distal end (DE), and a proximal end (PE), a center moving portion (CMP) at a distal side of a node where the DE meets the CMP, the node being at a most DE of the main body, and a curved portion (CP) at a distal side of the CMP. In a direction from a PE of the CP toward a DE of the CP, the CP is curved in a first direction. The center of gravity of the CMP moves along the CMP toward the DE of the CMP, the center of gravity moves relative to the central axis in a second direction. The CP extends from the DE of the main body to the PE of the CP. The CP includes a plurality of notches along a periphery of the CP.

Abstract: Treatment device for ultrasonic treatment and high frequency treatment procedure is equipped with an ultrasonic transducer including piezoelectric elements converting electrical power into ultrasonic vibrations. The treatment device includes a transmission rod with a treatment probe and jaw for clasping objects. The transmission rod includes one or more features for damping, to minimize or prevent excess vibrations and to, among other things, decrease frictional heat caused by the friction between the damping features and the transmission rod arising from attenuating the ultrasonic vibrations.

Abstract: A method for manufacturing a laminated substrate includes removing a portion not covered with a resist layer from a laminated substrate with an etchant to form a wiring, the laminated substrate including: a base layer including a mesa portion having a trapezoidal cross section, the mesa portion having a first inclined surface extending downward and outward from a top surface and a second inclined surface having an eaves-shaped portion protruding outward from the top surface; a wiring layer formed on an upper surface of the base layer; and the resist layer formed on an upper surface of the wiring layer and having a shape corresponding to a shape of the wiring, and the wiring is arranged at a position where the wiring covers a whole of the eaves-shaped portion of the second inclined surface.

Abstract: A vehicle proximity monitoring system includes an operator area portion comprising a computer processor programmed for receiving and processing both wireless-based data communications and wire-based data communications. A proximity detection portion of the monitoring system may include a condition monitoring device and associated components for wirelessly transmitting data collected by the condition monitoring device to the operator area portion. The proximity detection portion may be configured for communication with a controller area network (CAN) bus operatively associated with the vehicle, and a power line of the vehicle for pairing at least one component of the proximity detection portion with at least one component of the operator area portion.

Abstract: The present application relates to the technical field of communications, and provides an uplink data transmission method and apparatus, a terminal, and a storage medium. The method comprises: if a first physical uplink control channel (PUCCH) and a second PUCCH to be transmitted overlap in a time domain, selecting a third PUCCH from a PUCCH set; transmitting first uplink information in wherein first PUCCH and second uplink information in wherein second PUCCH in the third PUCCH; and transmitting the first uplink information and the second uplink information to a network device by means of the third PUCCH. Both first uplink transmission data and second uplink transmission data are transmitted in the third PUCCH, so that the first uplink transmission data and the second uplink transmission data are subjected to multiplex transmission, thereby improving the reliability of data transmission, reducing time delay, and avoiding unnecessary retransmission.

Abstract: A method includes receiving an access request at a first computing device from a second computing device, the access request specifying a data structure, the data structure including first data stored in a first portion of the data structure and second data stored in a second portion of the data structure. The method also includes extracting a first key from the access request and identifying a data rights definition that is associated with the data structure and that is associated with a second key, the data rights definition indicating that the first data but not the second data is shared with an entity associated with the second computing device. The method further includes comparing the first key to the second key, and, based on the comparison, determining whether to grant the second computing device access to the first data but not the second data.

Abstract: A method for link reconfiguration includes that: the terminal device selects a target signal from a second signal set when a beam failure occurs, where the beam failure includes that quality of a signal in a first signal set satisfies a first condition, the first condition includes that the quality of the signal is worse than a threshold, and quality of the target signal is good enough to satisfy a second condition; the terminal device determines a physical random access channel (PRACH) sequence the resource corresponding to the target signal according to associations between signals in the second signal set and PRACH sequences and resources; and the terminal device sends a first request to a network device through the PRACH sequence and resource corresponding to the target signal, where the first request is used to notify the network device of information about the target signal selected by the terminal device.

Abstract: A gas turbine engine includes rotor having a hub, and a plurality of blades extending generally radially from the hub. Each of the blades has an airfoil portion. The airfoil portion has a leading edge and a trailing edge defining a chordwise direction, and a root and a tip defining a spanwise direction. Only a sub-set of the blades has a cutback at at least one of the trailing edge and the leading edge. A method of designing and a method of assembling a rotor having noise reduction properties in a gas turbine engine is also presented.