Abstract: The present invention provides for the treatment of Alzheimer's disease. More specifically, a recombinant bispecific antibody fragment that simultaneously blocks beta-secretase activity while also promoting alpha-secretase activity, comprising a first portion and a second portion, wherein the first portion blocks beta secretase activity and the second portion promotes alpha-secretase activity.

Abstract: A method of mapping threshold gate cells into a Boolean network is disclosed. In one embodiment, cuts are enumerated within the Boolean network. Next, a subset of the cuts within the Boolean network that are threshold is identified. To minimize power, cuts in the subset of the cuts are selected.

Abstract: Threshold gates and related circuitry are disclosed. In one embodiment, a threshold gate includes a threshold realization element and a magnetic tunnel junction (MTJ) element. The MTJ element is switchable from a first resistive state to a second resistive state. To realize a threshold function with the MTJ element, the threshold realization element is configured to switch the magnetic tunnel junction element from the first resistive state to the second resistive state in accordance with the threshold function. In this manner, the threshold gate may implement a threshold function that provides an output just like a complex Boolean function requiring several Boolean gates.

Abstract: Body sensor networks (BSNs) and methods for monitoring an electrocardiogram using such BSNs include a base station that generates an ECG model and an output ECG signal for displaying on a display device, and a sensor platform in electrical communication with the base station. The sensor platform may be configured to receive a sensed ECG signal from one or more sensors, receive an instance of the ECG model, and produce a model ECG signal from the instance. The sensor platform compares the sensed ECG signal to the model ECG signal and, if a deviation of the sensed ECG signal from the model ECG signal exceeds a threshold, transmits deviation data describing the deviation to the base station module. The sensor platform module does not transmit any data to the base station if there is no such deviation.

Abstract: A nozzle for producing a liquid jet or a single-file stream of droplets of a fluid, methods using the nozzle, and an injector comprising the nozzle of the invention for providing the liquid jet or single-file stream of a fluid to a vacuum system are described.

Abstract: Embodiments of embedded MEMS sensors and related methods are described herein. Other embodiments and related methods are also disclosed herein.

Abstract: The present invention provides methods of immunization against Alzheimer's Disease and compositions for use in such methods.

Abstract: A method is provided for synthesizing silicon-germanium hydride compounds of the formula (H3Ge)4-xSiHx, wherein x=0, 1, 2 or 3. The method includes combining a silane triflate with a compound having a GeH3 ligand under conditions whereby the silicon-germanium hydride is formed. The compound having the GeH3 ligand is selected from the group consisting of KGeH3, NaGeH3 and MR3GeH3, wherein M is a Group IV element and R is an organic ligand. The silane triflate can be HxSi(OSO2CF3)4-x or HxSi(OSO2C4F9)4-x. The method can be used to synthesize trisilane, (H3Si)2SiH2, and the iso-tetrasilane analog, (H3Si)3SiH, by combining a silane triflate with a compound comprising a SiH3 ligand under conditions whereby the silicon hydride is formed. The silane triflate can include HxSi(OSO2CF3)4-x or HxSi(OSO2C4F9)4-x wherein x=1 or 2. A method for synthesizing (H3Ge)2SiH2 includes combining H3GeSiH2(OSO2CF3) with KGeH3 under conditions whereby (H3Ge)2SiH2 is formed.

Abstract: A pulsed voltage bias method and/or pulsed light bias method may be used to reduce, minimize, and/or eliminate external quantum efficiency measurement artifacts of multi-junction solar cells, for example artifacts caused by the shunt effect. In this manner, multi-junction solar cells may be designed and constructed with improved performance, efficiency, and the like.

Abstract: Some embodiments include a connection device for electrically coupling an electrical device to a test system. The connection device can include at least one suction cup configured to be coupled to the electrical device, spring loaded connector pins configured to electrically couple the electrical device to the test system, and a support frame coupled to the at least one suction cup and the spring loaded connector pins. The at least one suction cup can include three suction cups including a first suction cup, a second suction cup, and a third suction cup, and the support frame can include a first end coupled to the first suction cup, a second end opposite the first end and coupled to the second suction cup, and a third end between the first and second ends and coupled to the third suction cup. Other embodiments of related devices and methods are also described herein.

Abstract: Some embodiments include a method of preparing a flexible substrate assembly. Other embodiments of related methods and structures are also disclosed.

Abstract: Embodiments of displays with embedded MEMS sensors and related methods are described herein. Other embodiments and related methods are also disclosed herein.

Abstract: Preparing porous particles includes forming a gel including a first liquid and an oxygen-containing compound of a metal, semi-metal, metalloid, or semi-conductor, including an oxide, hydroxide, alkoxide, oxohydroxide, oxoalkoxide, oxo salt, or oxo salt hydrate of the metal, semi-metal, metalloid, or semi-conductor; contacting the gel with a combustible liquid to form a combustible gel; and initiating combustion of the combustible gel to form a substance including porous metal, semi-metal, metalloid, or semi-conductor oxide particles. The combustible liquid can include a volatile solvent. The porous particles have open pores with a range of nanoscale pore sizes. The porous particles may be treated further to form, for example, a composite.

Abstract: The present disclosure provides biologically active compounds of formula (I): and pharmaceutically acceptable salts thereof: compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.

Abstract: The present invention provides compositions comprising a ligand-nucleic acid nanostructure that promote tumor cell-specific killing and methods of using the compositions. Specially, the invention provides aptamer-nucleic acid nanostructures for treating tumors in a mammal. The methods of making the compositions are also provided.

Abstract: The present invention relates generally to plasmonic structures, methods for making them, and devices including them. In one aspect, a plasmonic structure includes a plurality of metal particles disposed on a substrate; and one or more metal structures electrically coupled to and disposed on a surface of each of the plurality of metal particles. The metal structures have a structure that is different than the structure of the metal particles. The metal structures can be grown, for example, by electrodeposition on the metal particles. Growth of such metal structures can tune the response of the plasmonic structure.

Abstract: The invention relates to PTH variants and uses thereof in the detection, diagnosis, and treatment of various disease states.

Abstract: Embodiments and examples of differential threshold voltage non-volatile memories and related methods are described herein. Other embodiments, examples thereof, and related methods are also disclosed herein.

Abstract: Some embodiments teach a method of preparing a flexible substrate assembly. The method can include: (a) providing a carrier substrate; (b) providing a cross-linking adhesive; (c) providing a plastic substrate; and (d) coupling the carrier substrate to the plastic substrate using the cross-linking adhesive. Other embodiments are disclosed in this application.

Abstract: Embodiments and examples of differential threshold voltage non-volatile memories and related methods are described herein. In one example, a method for providing an integrated circuit can comprise providing a memory cell coupled to a first bitline and to a second bitline, and at least one of (a) providing a read assist mechanism configured to couple to the memory cell via the first and second bitlines, or (b) providing a memory reset mechanism configured to couple to the memory cell via the first and second bitlines. Providing the memory cell can comprise providing a first transistor comprising a first threshold voltage, providing a second transistor comprising a second threshold voltage, and cross-coupling the first and second transistors of the memory cell together. A difference between the first and second threshold voltages can correspond to a logic state of the memory cell. Other embodiments, examples, and related methods are also disclosed herein.