Abstract: Systems, methods, and apparatuses to restore degraded speech via a modified diffusion model are described. An exemplary system is specially configured to train a diffusion-based vocoder containing an upsampler, based on pairing original speech x and degraded speech mel-spectrum mT samples; train a deep convoluted neural network (CNN) upsampler based on a mean absolute error loss to match the estimated original speech {circumflex over (x)}? outputted by the diffusion-based vocoder by extracting the upsampler, generating a reference conditioner, and generating a weighted altered conditioner cTn?. The system further optimizes speech quality to invert non-linear transformation and estimate lost data by feeding the degraded mel-spectrum mT through the CNN upsampler and feeding the degraded mel-spectrum mT through the diffusion-based vocoder. The system then generates estimated original speech {circumflex over (x)}? based on the corresponding degraded speech mel-spectrum mT. Other related embodiments are described.

Abstract: Systems, devices and methods for predicting binding on an array such as a peptide array. Certain methods utilize a peptide array having a plurality of peptides with one or more defined parameters and contacting the peptide array with a training sample containing one or more molecules of interest. Interactions between the plurality of peptides and the one or more molecules of interest are processed according to a data fitting model, which model is then is applied to interactions between the plurality of peptides and a test sample to predict binding associated with the one or more molecules of interest.

Abstract: Provided herein, are methods of identifying neoantigens for treating and preventing cancer. Also disclosed are methods and compositions for administering identified neoantigens for the treatment and prevention of cancer.

Abstract: A bioproduct manufacturing system is disclosed. The system comprises a hollow-fiber primary membrane gas absorber comprising a shell side and a lumen, wherein the primary membrane gas absorber is configured to receive a carbonate salt-based solvent on the shell side and a gas mixture comprising oxygen, nitrogen, and carbon dioxide in the lumen, at least one runway algal cassette reactor-photobioreactor, and a growth medium circulating between the primary membrane gas absorber and the at least one runway algal cassette reactor-photobioreactor. The at least one runway algal cassette reactor-photobioreactor comprises at least one growth chamber coupled to and in fluid communication with a headspace channel so as to define and interior volume, a first condenser coupled to and in fluid communication with the headspace channel, and a harvest line in fluid communication with the at least one growth chamber and coupled to a filter.

Abstract: An adapter for a container that provides an integrated photoacoustic microscopy system that is capable of real time imaging of samples within the container. The adapter allows a researcher or investigator to evaluate a sample using the photoacoustic effect, with or without a microscope. The adapter comprises a support portion, a planar portion, and a tube. The support portion includes a channel formed therein, the channel including a first surface, a second surface opposite the first surface, and an intermediate surface positioned between the first surface and the second surface, the channel configured to receive the rim of the container such that the intermediate surface of the channel is positioned adjacent a top surface of the rim and the first surface and the second surface extend along opposite sides of the sidewall. The planar portion is coupled to the support portion and extends across the opening of the container.

Abstract: Solvent free epoxy systems are disclosed that can include a hardener compound H comprising: a molecular structure (R1—(Y1)n), wherein R1 is an ionic moiety, Y1 is a nucleophilic group, n is a between 2 and 10; and an ionic moiety A acting as a counter ion to R1; and an epoxy compound E comprising: a molecular structure (R2—Z1)n), wherein R2 is an ionic moiety, Z1 comprises an epoxide group, n is a between 2 and 10, and an ionic moiety B acting as a counter ion to R2. In embodiments, the epoxy compound E and/or the hardener H is comprised in a solvent-less ionic liquid. The systems can further include accelerators, crosslinkers, plasticizers, inhibitors, ionic hydrophobic and/or super-hydrophobic compounds, ionic hydrophilic compounds, ionic transitional hydrophobic/hydrophilic compounds, biological active compounds, and/or plasticizer compounds. Polymers made from the disclosed epoxy systems and their methods of use are described.

Abstract: A method of calculating an abundance of an mRNA sequence within a gene comprises storing an index table of the gene in a non-volatile memory, obtaining a short read of the mRNA sequence, generating a set of input fragments from the mRNA sequence, initializing a compatibility table in a volatile memory, for each input fragment in the set of input fragments, searching for an exact match of the input fragment in the index table, calculating a final result from the compatibility table, and calculating an abundance of the mRNA sequence in the gene by aggregating the transcripts compatible with the short read, wherein the calculating step is performed on the same integrated circuit as the non-volatile memory. A system for in-memory calculation of an abundance of an mRNA sequence within a gene is also disclosed.

Abstract: A system for in-memory computing comprises a volatile memory comprising at least a first layered subarray, wherein each subarray comprises a plurality of memory cells, and a plurality of sub-sense amplifiers connected to a read bitline of the first subarray of the memory, configured to compare a measured voltage of the read bitline to at least one threshold and provide at least one binary output corresponding to a logic operation based on whether the voltage of the read bitline is above or below the threshold. A method for in-memory computing is also disclosed.

Abstract: Disclosed herein are methods and systems for membrane carbonation for cultivating microalgae and other microorganisms that utilize a gaseous substrate, as well as to upgrade the quality of mixed-gas streams.

Abstract: Provided herein are methods for classifying how a subject having a cancer will respond to immunotherapeutic (IT) therapy based on the subject's immunosignature or frameshift signature. Also provided herein are methods for classifying a subject having a cancer as having a good prognosis or a poor prognosis based on the subject's immunosignature or frameshift signature.

Abstract: A single-switch-per-bit topology for reconfigurable reflective surfaces (RRSs) is provided. Novel multi-bit unit-cell configurations are presented for radio-frequency (RF) RRSs with improved radiation efficiency and compact designs. Embodiments described herein realize a multi-bit RRS using an antenna array with multiple integrated switches at the ports of every antenna element (e.g., one at each port, providing one control bit per switch). By manipulating the states of the switches, the impinging waves on the surface are modulated, leading to beamforming in the desired direction. Some embodiments utilize a single switch-per-bit topology integrating single-pole-single-throw (SPST) switches (e.g., PIN diodes) into the unit-cell design, achieving up to 4 bits of phase quantization with only 4 switches. The exhibited radiation efficiency of the multi-bit RRS is significantly improved compared to lower bit configurations.

Abstract: Tetradentate platinum and palladium complexes based on biscarbazole and analogues for full color displays and lighting applications.

Abstract: A method of training a machine learning algorithm comprises providing a set of input data, performing transforms on the input data to generate augmented data, to provide transformed base paths into machine learning algorithm encoders, segmenting the augmented data, calculating main base path outputs by applying a weighting to the segmented augmented data, calculating pruning masks from the input and augmented data to apply to the base paths of the machine learning algorithm encoders, the pruning masks having a binary value for each segment in the segmented augmented data, calculating sparse conditional path outputs by performing a computation on the segments of the segmented augmented data, and calculating a final output as a sum of the main base path outputs and the sparse conditional path outputs. A computer-implemented system for learning sparse features of a dataset is also disclosed.

Abstract: A low-pass and band-pass delta-sigma (??) analog-to-digital converter (ADC) device for sensor interface is disclosed. The device includes a first stage comprising a low-resolution passive integrator-based noise-shaping successive approximation register (SAR) ADC and a second stage comprising a voltage-controlled oscillator (VCO)-ADC.

Abstract: A multi junction solar cell includes one or more upper cells and a thin-film, polycrystalline, low-bandgap bottom cell. A single-junction solar cell includes a polycrystalline semiconductor thin film, wherein a bandgap of the solar cell is greater than 1.2 eV or less than 1.2 eV, and the solar cell is configured to receive light through two surfaces, such that the bottom cell has bifacial operation.

Abstract: Described are fibrous materials comprising a plurality of fibers having a longitudinal alignment gradient and/or a longitudinal composition gradient. Also described are methods of preparing the fibrous materials thereof and methods of treating organ or tissue damage with the fibrous materials.

Abstract: A curved origami-based metamaterial includes a panel of material having a plurality of curved creases each disposed within a plane of the panel. The panel is configured to be folded along one of the plurality of creases, and the panel is also configured to be bent about an axis disposed outside the plane of the panel. Stiffness manipulation is configured to be achieved in situ by activating a different one of the plurality of curved creases.

Abstract: A computing system includes a processor having access to data associated with a plurality of devices of a network. The processor is configured to leverage the data to execute a loss model that estimates cyber risk loss distribution of the network associated with healthcare environment and infrastructure using bond percolation on a mixed random graphs approach.

Abstract: A single molecule sensing or detecting device includes a first electrode and a second electrode separated from the first electrode by a gap. The first electrode and the second electrode have an opening formed therethrough. At least one of the first electrode and the second electrode is functionalized with a recognition molecule. The recognition molecule has an effective length LI and is configured to selectively bind to a target molecule having an effective length L2. The size of the gap is configured to be greater than L2, but less than or equal to the sum of LI and L2.

Abstract: High-temperature thermochemical energy storage materials using doped magnesium-transition metal spinel oxides are provided. —transition metal spinel oxides, such as magnesium manganese oxide (MgMn)3O4, are promising candidates for high-temperature thermochemical energy storage applications. However, the use of these materials has been constrained by the limited extent of their endothermic reaction. Embodiments described herein provide for doping magnesium-transition metal spinel oxides to produce a material of low material costs and with high energy densities, creating an avenue for plausibly sized modules with high energy storing capacities.