Patents Assigned to Arizona Board of Regents on Behalf of The University of Arizona
  • Patent number: 12020453
    Abstract: A microscopic technique for generating high-clarity, large volume 3D images of fluorescent tissue structure at subcellular resolution and capture transient activities. The technique includes capturing two orthogonal 2D projection of the sample volume by performing a projection scan with an excitation laser sweeping through the volume at up to 100 vps, tracking the scan depth using an electrically tuned lens to keep the emission image in focus and generate an xy plane volume projection image at the camera; and placing a PMT behind the excitation lens to collect emission passed through the excitation lens, wherein signals from the PMT form a focus scan projection at the yz plane; and then merging the xy and yz projections.
    Type: Grant
    Filed: January 29, 2020
    Date of Patent: June 25, 2024
    Assignee: Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Leilei Peng, Jun Ding, Dongli Xu
  • Patent number: 12018045
    Abstract: Disclosed are compounds suitable for enhancing cancer treatment, for example, a compound of formula (I): (I) wherein R1 is as defined herein. Also disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with an apoptosis inducing ligand, a method of inducing apoptosis in cancer cells in a mammal, and a method of treating prostate cancer in mammal in need thereof comprising administration of a compound described herein.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: June 25, 2024
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Thomas J. Sayers, Poonam Tewary, Leslie Gunatilaka, Alan D. Brooks, Kithsiri Wijeratne, Yaming Xu
  • Patent number: 12019981
    Abstract: A machine reading system is described herein that includes a framework in which grammar rules can be developed using a concise language that combines syntax and semantics. The resulting technology thus reduces the development time for new grammars in a new domain. An enormous amount of information appears in the form of natural language across millions of academic papers and other literature sources. For example, in the biological domain, there is a tremendous ongoing effort to extract individual chemical interactions from these texts, but these interactions are only isolated fragments of larger causal mechanisms such as protein signaling pathways. The proposed rule-based event extraction framework can model underlying syntactic representations of events in order to extract signaling pathway fragments. Though application to the biomedical domain is herein described, the framework is domain-independent and is expressive enough to capture most complex events annotated by domain experts.
    Type: Grant
    Filed: June 10, 2021
    Date of Patent: June 25, 2024
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Mihai Surdeanu, Marco A. Valenzuela Escarcega, Gustave Hahn-Powell, Dane Bell, Thomas Hicks, Enrique Noriega, Clayton Morrison, Rebecca Sharp, Robert Ionut Vacareanu, George Barbosa
  • Patent number: 12016973
    Abstract: Methods, systems, and devices for enhancing cancer immunotherapy featuring co-transplantation of encapsulated xenogeneic cells with separately encapsulated autologous or allogeneic cells, e.g., autologous or allogeneic tumor cells. For example, both a first cellular transplantation device housing a patient's own tumor cells and a second cellular transplantation device housing xenogeneic cells may be implanted into a patient. The presence of the xenogeneic cells elicits an enhanced immune response, e.g., the xenogeneic cells will draw in a large number of immune cells. Shed tumor antigens from the first cellular transplantation may then be taken up by the immune cells that were drawn to the xenogeneic cells. This will generate an anti-tumor immune response that is amplified relative to a response elicited by the encapsulated tumor cells alone.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: June 25, 2024
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventor: Klearchos K. Papas
  • Patent number: 12018943
    Abstract: Devices and associated methods for measuring orientation using an optical gyroscope are disclosed. One example optical gyroscope includes a spherical component configured to allow propagation of light in one or more confined modes inside the spherical component. The spherical component includes a gain medium for enhancing a sustained confinement of light within the spherical component. The optical gyroscope also includes one or more detectors positioned outside of the spherical component to detect at least one characteristic of the light, or a change thereto, in response to a rotation of the optical gyroscope.
    Type: Grant
    Filed: April 22, 2020
    Date of Patent: June 25, 2024
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventor: Stanley Pau
  • Publication number: 20240194920
    Abstract: A redox flow battery including: a catholyte including a radical dication of a conjugated heterocyclic carbenium compound; and an anolyte including a neutral radical of a conjugated heterocyclic carbenium compound; wherein the conjugated heterocyclic carbenium compounds present in the catholyte and anolyte are the same compound; and the redox flow battery has an open circuit potential of greater than about 2 V. A redox flow battery including: a catholyte including a conjugated heterocyclic cationic compound in a first oxidation state; and an anolyte including a conjugated heterocyclic cationic compound in a second oxidation state; wherein the first oxidation state is a higher oxidation state than the second oxidation state.
    Type: Application
    Filed: April 23, 2021
    Publication date: June 13, 2024
    Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Thomas Gianetti, Jules Moutet
  • Patent number: 12010223
    Abstract: The present disclosure is directed to systems and methods of providing a secure quantum key distribution cryptosystem in which the quantum key data is exchanged between Alice and Bob using a quantum channel and the parity bits associated with the quantum key data are encrypted using a post-quantum computing (PQC) encryption method and communicated between Alice and Bob using a public channel.
    Type: Grant
    Filed: July 12, 2021
    Date of Patent: June 11, 2024
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventor: Ivan Djordjevic
  • Patent number: 12009447
    Abstract: Linear acylindrical lens (and array/system employing a plurality of such lens elements) containing liquid silicone rubber material for use in solar applications, as well as a low-cost silicone based optical lightguide(s) configured to channel and concentrate solar light with about 90% optical efficiency. The lens includes a transparent glass substrate (with an optional coating), which mechanically supports a moldable flexible silicone lenslet optical quality and is bonded to it with the use of plasma and in absence of adhesive material. When injection molding of lightguide(s) is employed, the lightguide shape can be formed variably to provide for integration of multiple lightguide s into an array with alignment tolerances that are looser than in a solar concentrator employing glass waveguides. Optical system employing such (arrayed) linear lens(es) concatenated with corresponding (arrayed) lightguides, juxtaposed with micro-CPV cells and conventional PV-cell(s) to capture diffused light.
    Type: Grant
    Filed: November 1, 2019
    Date of Patent: June 11, 2024
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Liliana Ruiz Diaz, Sifang Cui, Robert Norwood, Kyung-Jo Kim
  • Patent number: 12006549
    Abstract: Methods involving analysis of pretreatment leukocyte expression profiles for prognostic assessment of seizure outcome following a treatment or medical procedure, such as stereotactic laser amygdalohippocampotomy (SLAH). In one aspect, RNA sequencing (RNA-Seq) on whole blood leukocyte samples is taken from a patient with intractable epilepsy prior to SLAH. Differential expression (DE) analysis revealed 24 significantly dysregulated genes (?2.0-fold change, p-value <0.05, and False Discovery Rate, FDR <0.05) useful in prognostic assessment.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: June 11, 2024
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Martin E. Weinand, Ryan Sprissler, Michael F. Hammer
  • Publication number: 20240181136
    Abstract: The present invention provides a biocompatible low molecular weight (LMW) hydrogel having a high storage modulus that comprises water and thioglycolipid. The invention also provides a carrier material and an article of manufacture comprising said LMW hydrogel. The present invention also provides methods for producing and using the same. The LMW hydrogels are made of aggregates of thioglycolipid via noncovalent interactions.
    Type: Application
    Filed: March 25, 2022
    Publication date: June 6, 2024
    Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Jeanne E. PEMBERTON, Laurel L. KEGEL, Yu-Cheng WANG
  • Publication number: 20240166910
    Abstract: A photonic device including a first waveguide and a second waveguide is provided. The device includes an interconnect coupled with the first waveguide and the second waveguide. The interconnect includes a substrate. The interconnect includes a film including a refractive index contrast (RIC) polymer and a core. The core includes a first domain having a first refractive index. The core includes a second domain adjacent to the first domain and having a second refractive index. The second refractive index is less than the first refractive index. The core includes a third domain adjacent to the second domain and having a third refractive index. The third refractive index is less than the second refractive index. The second domain is disposed between the first domain and the third domain. The refractive index of the substrate is less than the first refractive index, the second refractive index, and the third refractive index.
    Type: Application
    Filed: April 8, 2022
    Publication date: May 23, 2024
    Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Robert Norwood, Dong-Chul Pyun, Stanley Pau, Roland Himmelhuber, Linan Jiang, Thomas Koch, Kyungjo Kim, Sasaan Showgi, Tristan Kleine, Abhinav Nishant, Julie Frish
  • Publication number: 20240168281
    Abstract: In an aspect of the present invention, a new active optic is provided, namely, a photo-magnetically actuated deformable mirror (PMADM) made of a magnetic composite structure and an optical quality substrate layer. The magnetic layer is composed of Polydimethylsiloxane (PDMS) and powdered ferromagnetic CrO2. A magnet may be used to deform the mirror surface. The powdered CrO2 has a low Curie temperature (preferably around 395 K) which allows changing the magnetization of the magnetic layer using a laser heating source, thus providing control over the deformation. In one embodiment, the structure has an overall dimension of 1.2 inch 1.2 inch 175 ?m with an optical pupil diameter of 8 mm. The PMADM is estimated to deform to a maximum stroke of 8.7731 ?m before failure with a 3 safety factor.
    Type: Application
    Filed: March 3, 2022
    Publication date: May 23, 2024
    Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Ewan S. Douglas, Amit Kumar Jha
  • Patent number: 11987564
    Abstract: Disclosed are small molecule PTPRD inhibitors and uses thereof. Methods of using the PTPRD inhibitors include methods of treating, preventing, or delaying the progression of a disorder responsive to PTPRD inhibition, including for example nicotine dependence, addiction, obesity, metabolic syndrome, and substance-use disorders such as stimulant-use disorders and opioid-use disorders.
    Type: Grant
    Filed: May 2, 2022
    Date of Patent: May 21, 2024
    Assignees: Arizona Board of Regents on Behalf of the University of Arizona, The United States Government as respresented by the Department of Veterans Affairs, The University of Kentucky Research Foundation
    Inventors: George Richard Uhl, Ian M. Henderson, Wei Wang, Thomas Prisinzano
  • Publication number: 20240160001
    Abstract: Imaging a distribution of one or more optical sources includes: receiving respective optical signals from a spatial mode sorter during each of two or more detection intervals of time; after each of the two or more detection intervals of time, processing information based at least in part on: (1) the respective optical signal received in the corresponding detection interval of time, and (2) a first set of models comprising a set of distributions related to one or more optical sources, each model corresponding to a different number of optical sources in the distribution, and configuring the spatial mode sorter based at least in part on the processing; and providing an estimated measurement characterizing the distribution of one or more optical sources based at least in part on the processed information. The processing after at least one of the two or more detection intervals of time includes computing an eigen-projection.
    Type: Application
    Filed: May 6, 2022
    Publication date: May 16, 2024
    Applicant: Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Kwan Kit Lee, Michael Grace, Amit Ashok, Saikat Guha
  • Publication number: 20240159432
    Abstract: A system for providing a contour map of the surface of a heliostat from reflected sunlight using a fly's eye camera. The system includes an entrance screen configured to receive sunlight reflected by said heliostat; an array of imaging apertures extending across the entrance screen, each aperture forming an image of said heliostat from a different viewpoint to provide a plurality of heliostat images; one or more digital cameras configured to view all of said plurality of heliostat images; an image processor configured to map out from the plurality of heliostat images a location of sunlight delivered to the entrance screen to obtain a plurality of maps, and to provide, based on centroids of said maps a tip and tilt of each said subsection The reflecting surface profile of the heliostat is obtained by integration of the subsection tilts across all the subsections.
    Type: Application
    Filed: March 8, 2022
    Publication date: May 16, 2024
    Applicant: Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Ryker EADS, James Roger P . Angel
  • Patent number: 11980698
    Abstract: Disclosed herein are contractile cell constructs, methods for using them to treat disease, and methods for making them.
    Type: Grant
    Filed: June 1, 2021
    Date of Patent: May 14, 2024
    Assignees: Arizona Board of Regents on Behalf of the University of Arizona, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Jordan J. Lancaster, Steven Goldman
  • Patent number: 11981421
    Abstract: A system and method for controlling boundary layer transition for a high-speed vehicle are disclosed. The method includes determining a location of onset of boundary-layer transition that naturally develops during high-speed flight of the high-speed vehicle, and providing a pair of flow control strips at a surface/wall/skin of the high-speed vehicle such that the boundary-layer transition is delayed or prevented during high-speed flight of the high-speed vehicle. The delayed or prevented locations of the transition result in a change in the high-speed boundary layer during the high-speed flight of the high-speed vehicle. The change in the high-speed boundary layer transition affects skin friction drag, aero-thermodynamic heating, and pressure fluctuations in the boundary layer of the high-speed vehicle.
    Type: Grant
    Filed: December 24, 2020
    Date of Patent: May 14, 2024
    Assignee: Arizona Board of Regents on behalf of the University of Arizona
    Inventors: Hermann F. Fasel, Christoph Hader
  • Patent number: 11977047
    Abstract: This present disclosure is directed to a silver metal wire coated with silver sulfide reference electrode, the preparation via anodization of a silver metal wire in a sodium and/or potassium sulfide solution and use thereof, including test methods to measure corrosion in test articles such as metal pipes. The reference electrode exhibits good stability characteristics, including stability under high temperature conditions.
    Type: Grant
    Filed: August 30, 2021
    Date of Patent: May 7, 2024
    Assignee: Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Dominic Francis Gervasio, Kalin Denton, Gil-Pyo Kim, Vlad Alex Sasaran, Nicholas Michael McEvoy, Alexis Gray
  • Patent number: 11969401
    Abstract: The disclosure provides methods for treating or limiting development age-related macular degeneration, comprising (a) a GPR143 receptor agonist, including but not limited to L-DOPA, L-DOPA analogues, or a pharmaceutically acceptable salt thereof, and (b) melatonin, a melatonin analogue, or a pharmaceutically acceptable salt thereof, and related compositions.
    Type: Grant
    Filed: January 30, 2020
    Date of Patent: April 30, 2024
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Robert Snyder, Brian McKay
  • Patent number: 11970521
    Abstract: Peptide analogues of ?-amyloid and methods of using said analogues for neuroprotection are described herein. The ?-amyloid peptide analogues have a sequence that is at least 50% identical to an N-terminal ?-amyloid core fragment. A pharmaceutical composition of the ?-amyloid peptide analogues in a pharmaceutically acceptable carrier can be administered to a subject for neuromodulation. The ?-amyloid peptide analogues, while lacking neurotoxicity, effectively provides for protective activity against ?-amyloid toxicity.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: April 30, 2024
    Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, UNIVERSITY OF HAWAII
    Inventors: Robert A. Nichols, Kelly Forest, Victor J. Hruby