Abstract: The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof. The present disclosure further relates to methods of inhibiting viral replication including contacting one or more cells that have been infected with a virus with an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the virus comprises a flavivirus. Also disclosed is a method of treating and/or preventing a flavivirus infection and/or a condition resulting from a flavivirus infection including administering an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof under conditions effective to treat and/or prevent a flavivirus infection and/or a condition resulting from a flavivirus infection.

Abstract: Various examples of methods and systems are provided for real-time signal processing. In one example, a method for processing data to select a pattern includes receiving data via a sensor, evaluating the data including waveforms over a time domain, averaging the waveforms to obtain a mean waveform, selecting a pattern based on the mean waveform, and generating a notification regarding the selected pattern. The pattern can include a start time, a hold time, and an end time. In another example, a system includes one or more sensors that detect the data and a mobile platform that evaluates the data, averages the waveforms to obtain the mean waveform and selects a pattern based on the mean waveform. A user interface can be used to communicate the notification regarding the selected pattern. The patterns can include breathing patterns, which can be used to reduce stress in a subject being monitored by the sensor.

Abstract: The present invention provides a method of calibrating gamma-ray and photon counting detectors, including, but not limited to, monolithic crystal detectors. The method of the present invention is based on the observation that measurement of fan beam datasets allows the synthesis of collimated beam data to derive MDRFs by use of an algorithm that finds the common or intersecting data subsets of two or more orthogonal calibration datasets. This makes the calibration process very efficient while still allowing the full benefits of maximum-likelihood event-parameter estimation that incorporates the statistical nature of the light sensor measurements.

Abstract: Methods and systems for measuring viability and function of islet cells or stem cell-derived beta cells in an implantable device featuring setting the temperature of the cells in the implantable device to a low temperature to reduce metabolic levels of the cells and reduce oxygen requirements of the cells, and measuring oxygen consumption rates. An oxygen sensor at the inlet of the implantable device and an oxygen sensor at the outlet of the implantable device are used to calculate oxygen consumption rates of the cells, which in turn are indicative of viability. The reduction in temperature can also be used for loading cells into the implantable devices to help reduce ischemic and/or physical injury. The present invention may be used with other cell types, e.g. hepatocytes, heart cells, muscle cells, etc.

Abstract: Various examples related to power sources for implantable sensors and/or devices are provided. In one example, a device for implantation in a subject includes circuitry for sensing an observable parameter of the subject and a power source comprising a nanowired ultra-capacitor (NUC), the power source having a volume of 10 mm3 or less. The NUC can have a surface capacitance density in a range from about 25 mF/cm2 to about 29 mF/cm2 or greater. Such devices can be used for, e.g., ocular diagnostic sensors or other implantable sensors that may be constrained by size limitations.

Abstract: The present disclosure is directed to methods (e.g., in vitro methods) for use of nicotinamide phosphoribosyltransferase (NAMPT) as a biomarker in radiation-induced lung injury (RILI). Provided herein is an in vitro method for the diagnosis, prognosis, and/or monitoring of RILI in a human subject by providing a tissue or plasma sample from the subject and detecting the level of NAMPT therein, wherein a higher level of NAMPT in the tissue or plasma sample from the subject compared to a healthy control or a reference value is indicative for the presence of RILI in the subject. Further provided herein is a method of detecting NAMPT in a human subject by obtaining a biological sample from the subject, detecting the presence of NAMPT in the sample by contacting the sample with a capture agent that specifically binds NAMPT, and detecting binding between NAMPT and the capture agent.

Abstract: A training system uses a physical model of a head and neck with a first tracker, a second tracker on a physical laryngoscope model, a third tracker on a physical endotracheal tube model, and a fourth tracker on a VR goggle; the system uses the trackers to determine positions of the physical models. A simulation system has corresponding digital 3D models of a laryngoscope, an endotracheal tube, and an airway, the airway including 3D models of surfaces of tongue, epiglottis, larynx, pharynx, and trachea. The physical model locations are registered to the digital models. In embodiments, the physical laryngoscope model has sensors measure strain or pressure along its blade and the simulation system has instructions to distort the digital 3D model of the airway according to readings of the sensors. The system can render the digital 3D model viewed from the VR goggle or a camera of the laryngoscope.

Abstract: An encapsulation device system for therapeutic applications such as but not limited to regulating blood glucose. The system may comprise an encapsulation device with a first oxygen sensor integrated inside the device and a second oxygen sensor disposed on an outer surface of the device, wherein the sensors allow for real-time measurements (such as oxygen levels) related to cells (e.g., islet cells, stem cell derived beta cells, etc.) housed in the encapsulation device. The system may also feature an exogenous oxygen delivery system operatively connected to the encapsulation device via a channel, wherein the exogenous oxygen delivery system is adapted to deliver oxygen to the encapsulation device.

Abstract: A delta sigma modulator includes a summation circuit, at least one integrator, a multi-bit quantizer and a negative feedback circuit. The summation circuit is configured to produce a difference signal between a unipolar or bipolar analog input signal and an analog feedback signal. The integrator is operatively coupled to the summation circuit to integrate the difference signal. The multi-bit quantizer is operatively coupled to the integrator to digitize the integrated signal to generate an N-bit digital output signal, N being an integer greater than 1. The negative feedback circuit operatively couples the multi-bit quantizer to the summation circuit. The negative feedback circuit includes a digital-to-analog converter arrangement for receiving the N-bit digital output signal and providing the analog feedback signal such that digital values of the N-bit digital output signal and values of the analog feedback encoded by the digital values have a non-linear relationship to one another.

Abstract: An optical device includes first and second 45° Faraday rotators. A 45° polarizer is located between the first and second Faraday rotators such that light in a prescribed polarization state that is incident on the first 45° Faraday rotator traverses the first 45° Faraday rotator as well as the 45° polarizer and the second 45° Faraday rotator. In one implementation the optical device is operable to receive a light beam traveling in a first direction and output a light beam that is in a predetermined polarization state. Likewise, the optical device is operable to receive an unpolarized light beam traveling in a second direction opposite the first direction and outputs a light beam that is in a predetermined polarization state. The polarization state in which the two output beams are arranged may be the same or orthogonal to one another.

Abstract: Provided are methods for replication (copying) of volume Holographic Optical Elements (HOE) using a master hologram in optical contact with a prism, wherein the master hologram comprises distinct object and reference beam coupling elements, and wherein in the replication process light is coupled from one face of the prism and transmitted through another face of the prism using the distinct object and reference beam coupling elements. Methods for making the master hologram by sequentially forming the distinct object and reference beam coupling elements therein are provided. Further methods for encoding aperture functions directly to the master hologram are provided. Yet further methods provide for forming a copy HOE in an array configuration using a step-and-repeat method wherein the copy HOE is translated laterally by a specified distance before the next exposure is made.

Abstract: The present invention provides modified stem cells (SCs) and use of the SCs to treat disease.

Abstract: A miniaturized integrated frequency locked optical whispering evanescent resonator comprises: an optical source; an optical path having a first end and a second end, the optical path coupled to the optical source at the first end; an optical resonator disposed along a side of the optical path between the first and second ends, the optical resonator coupled to the optical path through an evanescent field to excite an optical whispering-gallery mode; an optical receiver coupled to the second end of the optical path; and a digital data processor configured to communicate with the optical receiver and the optical source, wherein the digital data processor comprises a frequency locking system and a data acquisition system, wherein the frequency locking system tunes the frequency of the optical source to the optical whispering-gallery mode of the optical resonator, and wherein the resonator weighs less than 15 kg and is containable within a volume less than 30 liters.

Abstract: A diffractive multifocal lens is disclosed, comprising an optical element having at least one diffractive surface, the surface profile comprising a plurality of annular concentric zones. The optical thickness of the surface profile changes monotonically with radius within each zone, while a distinct step in optical thickness at the junction between adjacent zones defines a step height. The step heights for respective zones may differ from one zone to another periodically so as to tailor diffraction order efficiencies of the optical element, in one example of a trifocal lens, step heights alternate between two values, the even-numbered step heights being lower than the odd-numbered step heights.

Abstract: The invention disclosed herein generally relates to genotyping one or more single nucleotide polymorphisms (SNPs) to stratify cancer risk and/or prognosis.

Abstract: A lung function analysis system includes motion sensing devices each including accelerometers, gyros, battery, processor, and ireless transmitter, the processor configured to read motion data from the accelerometers and gyros and transmit the motion data over the wireless transmitter. The system includes a data collection device receiving the motion data and recording the motion data in a database; and a computing device with a lung function data analysis routine adapted to analyze the motion data to provide information useful in treating pulmonary disease. In embodiments, the lung function analysis routine includes a classifier trained on a database of motion data and diagnoses. In embodiments, the accelerometers and gyros are three-axis and/or the devices include electromyographic sensors. In embodiments, the system includes remote sensors such as a stereo camera with or without markers, millimeter-wave radar, or an ultrasonic echolocation device.

Abstract: The present invention provides certain polymeric materials, precursors thereof as well as the preparation and uses thereof.

Abstract: A versatile space telescope for quantum key distribution and adapted for interfacing with a spacecraft and an instrument module. The telescope includes diamond turned aluminum mirrors at its entrance and exit, adjacent the spacecraft and instrument module, respectively.

Abstract: Methods of vulcanization using a high content sulfur polymer, instead of elemental sulfur, have been developed. These high sulfur content polymers are referred to as Chalcogenide Hybrid Inorganic/Organic Polymers (CHIP) materials and have good polymer compatibility in that they are soluble in a number of polymers. Furthermore, CHIP materials may have weaker bonds than the S—S bonds of elemental sulfur and thus provide for a higher crosslinking efficiency vulcanization.

Abstract: Methods for identifying animals that are genetically superior, drugs, nutritional strategies, or physiological manipulations that improve feed efficiency or productivity of animals, e.g., selecting animals that are genetically superior for feed efficiency or productivity based on metabolic rates of particular tissues, wherein metabolic rates of certain tissues such as skeletal muscle are inversely proportional to feed efficiency, while metabolic rates of other tissues such as mammary gland are directly proportional to milk production. Thus, animals with low skeletal muscle metabolic rates are generally more feed efficient, e.g., gain more weight per unit of food. The methods herein may be used to improve the genetics, nutrition, and handling or animals more efficiently produced animal products, e.g., meat production, milk, production, egg production, wool production, etc. The methods herein may also be used to determine estimated breeding values of animals for feed efficiency, growth, or production.