Abstract: The present invention relates to means and methods for producing crystals or crystalline substances. In particular, crystals or crystalline substances which are useful as pharmaceutical ingredients can be manufactured.

Abstract: A device for checking the seal-tightness of closure caps on medical hollow bodies has a drive, a retaining element for the hollow body, and a retaining device for the closure cap. The retaining device is pivotably supported relative to the retaining element. The device further includes a sensor for the relative rotation of the retaining device with respect to the retaining element. A torque may be applied to the closure cap by the drive, the retaining element, and the retaining device. A hollow body and a closure cap are gripped by the retaining device and the retaining element from the same side, as viewed along the longitudinal axis of a hollow body.

Abstract: The use of a neutral protease (NP) together with a collagenase consists in that a neutral protease which is not contained in a collagenase enzyme preparation and which is not produced by a recombinant production is mixed before the beginning of a tissue dissociation with a collagenase or a collagenase enzyme preparation with an individual dosage of the quantitative proportions of neutral protease and collagenase for improving the isolation results with respect to yield, viability and integrity of the cells.

Abstract: The present invention relates to means and methods for producing crystals or crystalline substances. In particular, crystals or crystalline substances which are useful as pharmaceutical ingredients can be manufactured.

Abstract: The use of a neutral protease (NP) together with a collagenase consists in that a neutral protease which is not contained in a collagenase enzyme preparation and which is not produced by a recombinant production ia mixed before the beginning of a tissue dissociation with a collagenase or a collagenase enzyme preparation with an individual dosage of the quantitative proportions of neutral protease and collagenase for improving the isolation results with respect to yield, viability and integrity of the cells.

Abstract: The present invention pertains in general to Bromelain and particularly to the different active compounds contained in this complex mixture of proteins. The present invention provides recombinant expressed cysteine proteases, which are found in Bromelain. It has been found that the method for expression of the recombinant proteins is superior to the purification from Bromelain itself.

Abstract: The invention relates to a method for producing pancreatin with reduced viral and microbial contamination, comprising the steps of (a) providing the pancreatin in solid form with a residual moisture of 0.5 weight % or less, down to almost zero, based on the pancreatin provided; (b) subjecting the pancreatin provided in step (a) to a heat treatment at a temperature of 84° C., preferably 80° C. and below; wherein, the biological activity of the pancreatin obtained in step (b) corresponds to at least 50% of the biological activity of the pancreatin provided in step (a); and the viral infectiousness of the pancreatin obtained in step (b) has been reduced by a factor of more than 1 log10 in comparison with the viral infectiousness of the pancreatin provided in step (a), as well as a pancreatin produced according to this method and its use for producing a medicine or a nutritional supplement.

Abstract: The invention relates to an attachment for a syringe or cartridge having a cannula, wherein the attachment comprises a sealing element, which is molded onto the cannula.

Abstract: The object of the invention is therefore to provide an x-ray device that is simple to construct and can be inexpensively produced. This object is achieved by the proposed x-ray device for examining syringe caps having a cannula and having the features that is an x-ray source, an x-ray detector, and a holder. The x-ray device is characterized in that the syringe cap is arranged in the beam path so that its longitudinal axis coincides with the main axis of the beam path. The syringe cap is thus impinged from above and from below with x-rays, in order to examine the position of the cannula.

Abstract: The use of cinnarizine and dimenhydrinate or their physiologically compatible salts in combination is described for the treatment of vertigo of any genesis.

Abstract: It pertains to a composition which comprises a combination of Aronia extract in an amount of at least about 10 ?g/mg and seleniumin in an amount from about 0.0001 ?g/mg to about 2.0 ?g/mg. The composition may further comprise zinc as additional micronutrient. The composition may be formulated as a pharmaceutical or a nutraceutical composition.

Abstract: The invention relates to a phosphate-free pharmaceutical composition which comprises at least one FP prostanoid receptor agonist and/or at least one prostamide receptor agonist and also citrate salts and/or citric acid.

Abstract: A piston for a medical hollow body such as a syringe or a carpule includes at least one sliding surface for contact with the hollow body. The piston has at least one receiving area in which a lubricant can be received, and at least one dispensing mechanism for dispensing the at least one lubricant from the at least one receiving area to the at least one sliding surface.

Abstract: The invention relates to an attachment or a cartridge comprising a sealing element having an opening for a medium located in the syringe or cartridge or to be introduced into the syringe or cartridge. The attachment is characterized by an actuating device which, in a first functional position, exerts a force on the wall of the opening in such a way that the opening is closed, and leaves the opening open in a second functional position.

Abstract: A syringe includes a syringe cylinder, a sealing plug movably disposed within the syringe cylinder, and with a plunger cooperating with the sealing plug. A safety device prevents a sliding back of the sealing plug within the syringe cylinder in any position the sealing plug assumes within the syringe cylinder. The safety device has a locking element which engages at the plunger in any position the plunger assumes within the syringe cylinder. The locking element is attached to a retaining fixture and protrudes from the retaining fixture same such that an attachment point of the locking element is closer to the sealing plug at the retaining fixture than the free end of the locking element opposite of the attachment point.

Abstract: A syringe cylinder comprising an interior space, having a stopper that can be displaced in the interior space and delimits an active ingredient space, is proposed. The syringe cylinder is characterized by an indicator device biuniquely indicating a longitudinal movement of the stopper occurring in one direction.

Abstract: The present invention relates to a method of treating sepsis, systemic inflammatory response syndrome (SIRS), and/or septic shock in a patient. The method comprises administering (a) a pharmaceutical composition comprising a selenium-containing active substance, (b) a pharmaceutical composition comprising a corticoid-containing active substance, and (c) a pharmaceutical composition comprising insulin.

Abstract: A syringe includes a syringe cylinder and a distal end designed as a syringe cone. The distal end comprises a region set back in a radial direction such that an edge extending in the circumferential direction is formed. The edge has a first chamfer, and comprises an attachment piece having a clamping region. Holding forces are introduced from the attachment piece via the clamping region in the region of the syringe set back in a radial direction. The clamping region comprises a distal edge. The the distal edge of the clamping region has a second chamfer.

Abstract: The present invention pertains in general to Bromelain and particularly to the active compounds contained in this complex mixture of proteins. The present invention provides recombinant expressed Bromelain inhibitor precursor and Bromelain inhibitors, which are found in Bromelain. It has been found that the recombinant expressed inhibitors have superior effects in terms of treatment of disorders and conditions than Bromelain or its protein fractions from plant extracts.

Abstract: A device for checking the seal-tightness of closure caps on medical hollow bodies has a drive, a retaining element for the hollow body, and a retaining device for the closure cap. The retaining device is pivotably supported relative to the retaining element. The device further includes a sensor for the relative rotation of the retaining device with respect to the retaining element. A torque may be applied to the closure cap by the drive, the retaining element, and the retaining device. A hollow body and a closure cap are gripped by the retaining device and the retaining element from the same side, as viewed along the longitudinal axis of a hollow body.