Patents Assigned to Asahi Kasei Medical Co., Ltd.
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Publication number: 20220355002Abstract: An object is to provide a blood processing filter favorable in both of the effectiveness (leukocyte removing performance) and the safety (reduction in the amount of elutable substances). The object can be achieved by a blood processing filter comprising a filtration medium including a polyester fiber, wherein a surface area of the filtration medium is 6.0 m2 or more, and a maximum absorbance of an aqueous extract of the blood processing filter in the range from 240 to 245 nm is 0.03 or less.Type: ApplicationFiled: October 9, 2020Publication date: November 10, 2022Applicant: ASAHI KASEI MEDICAL CO., LTD.Inventor: Nobukazu SHIMADA
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Patent number: 11491446Abstract: A virus removal membrane includes cellulose, and a primary-side surface through which the protein-containing solution is to be applied and a secondary-side surface from which a permeate that has permeated the virus removal membrane is to be flowed, wherein a bubble point is 0.5 MPa or more and 1.0 MPa or less; and when a solution containing gold colloids having a diameter of 30 nm is applied through the primary-side surface to the virus removal membrane to allow the virus removal membrane to capture the gold colloids for measurement of brightness in a cross section of the virus removal membrane, a value obtained by dividing a standard deviation of a value of an area of a spectrum of variation in the brightness by an average of the value of the area of the spectrum of variation in the brightness is 0.01 or more and 0.30 or less.Type: GrantFiled: March 30, 2017Date of Patent: November 8, 2022Assignee: ASAHI KASEI MEDICAL CO., LTD.Inventors: Akika Futamura, Yusuke Kon, Tomoko Hongo
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Patent number: 11471580Abstract: A blood treatment filter comprising a filter element, an inlet-side flexible container and an outlet-side flexible container, an inlet port, and a tubular outlet port, further comprises: an outlet-side frame sheet disposed between the filter element and the outlet-side flexible container; a first seal portion provided by sealing at least the filter element and the outlet-side frame sheet in a belt-shaped manner; and an annular second seal portion provided to surround the first seal portion, wherein on an outlet side of the filter element, a valley portion is formed at the first seal portion, the outlet port includes a protruding portion that protrudes to an inside of the container, and the protruding portion is provided with an opening at least a part of which overlaps with the first seal portion and which can communicate with a gap region formed by the valley portion.Type: GrantFiled: July 15, 2020Date of Patent: October 18, 2022Assignee: ASAHI KASEI MEDICAL CO., LTD.Inventors: Tomohisa Yokomizo, Tomoko Uchiyama
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Publication number: 20220257840Abstract: A blood processing filter includes a flexible container having an inlet and an outlet for blood, a filter medium disposed between the inlet and the outlet, and a flow passage-securing member disposed between the filter medium and the outlet. The filter medium includes a filter layer X1 including a filter component unit A1, and a filter layer Y including a filter component unit B. The filter layer X1 is disposed between the filter layer Y and the flow passage-securing member, a ventilation resistance per thickness of the filter component unit A1 is 5.0 Pa·s/m2 or more and less than 9.0 Pa·s/m2, a ventilation resistance per thickness of the filter component unit B is 9.0 Pa·s/m2 or more, a ventilation resistance of the filter layer X1 is 4.0 kPa·s/m or more and 20.0 kPa·s/m or less, and a ventilation resistance of the filter medium is 55.0 kPa·s/m or more and less than 75.0 kPa·s/m.Type: ApplicationFiled: July 10, 2020Publication date: August 18, 2022Applicant: ASAHI KASEI MEDICAL CO., LTD.Inventors: Nakamura KAZUHIKO, Yokomizo TOMOHISA
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POLYAMIDE MEDIUM FOR PURIFYING PROTEIN-CONTAINING SOLUTION AND METHOD FOR PRODUCING POLYAMIDE MEDIUM
Publication number: 20220212167Abstract: A method for producing a polyamide medium for purifying a protein-containing solution, comprising: a step of treating a polyamide medium before a treatment with an acidic or alkaline aqueous solution, with an acidic or alkaline aqueous solution.Type: ApplicationFiled: April 7, 2020Publication date: July 7, 2022Applicant: ASAHI KASEI MEDICAL CO., LTD.Inventors: Hiroki TANIGUCHI, Junji HIDAKA -
Publication number: 20220177518Abstract: A method for purifying a protein-containing solution comprising a protein of interest, the method comprising the steps of: (a1) contacting the protein-containing solution with a porous medium comprising polyketone; and (a2) passing the protein-containing solution contacted with the porous medium comprising polyketone through a virus removal membrane.Type: ApplicationFiled: March 27, 2020Publication date: June 9, 2022Applicant: ASAHI KASEI MEDICAL CO., LTD.Inventors: Akika FUTAMURA, Hiroki TANIGUCHI, Junji HIDAKA
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Publication number: 20220168490Abstract: Provided is a blood purifier which has a porous molded body with good phosphorus adsorption, which has good cytokine adsorption performance, no hemolysis, and can be used safely. The blood purifier has a porous molded body having a low-melting-point moisture content per gram of dry weight of 0.12 g or more and 1.35 g or less. After three and six months from sealing of a saline solution for injection into the blood purifier, the number of microparticles greater than or equal to 10 ?m is 25 or less and the number of microparticles greater than or equal to 25 ?m is three or less in 1 mL of the saline solution for injection.Type: ApplicationFiled: March 27, 2020Publication date: June 2, 2022Applicant: ASAHI KASEI MEDICAL CO., LTD.Inventors: Teruhiko OISHI, Yusuke TOKIMIZU, Keitaro MATSUYAMA, Naoki MORITA
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Publication number: 20220168694Abstract: The problem is to provide a porous membrane with a reduced phenomenon in which membranes firmly adhere to one another during production of the porous membrane (membrane adhesion). The problem is solved by a porous membrane comprising a hydrophobic polymer and a hydrophilic polymer, wherein an average value T of ratios of the number of counts of ions derived from the hydrophilic polymer to the number of counts of ions derived from the hydrophobic polymer is 1.0 or more when a surface of the porous membrane is measured by time-of-flight secondary ion mass spectrometry (TOF-SIMS).Type: ApplicationFiled: March 27, 2020Publication date: June 2, 2022Applicant: ASAHI KASEI MEDICAL CO., LTD.Inventors: Yasutaka TAKAZONO, Masayasu KOMURO
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Patent number: 11338248Abstract: The object of the present invention is to provide a porous membrane by which a useful component can be recovered while suppressing the clogging during filtration of a protein solution and from which only a small amount of an eluate is eluted even when an aqueous solution is filtered. The present invention provides a porous membrane containing a hydrophobic polymer and a water-insoluble hydrophilic polymer, the porous membrane having a dense layer in the downstream portion of filtration in the membrane, having a gradient asymmetric structure in which the average pore diameter of fine pores increases from the downstream portion of filtration toward the upstream portion of filtration, and having a gradient index of the average pore diameter from the dense layer to the coarse layer of 0.5 to 12.0.Type: GrantFiled: August 25, 2015Date of Patent: May 24, 2022Assignee: ASAHI KASEI MEDICAL CO., LTD.Inventors: Yuzo Kayama, Masayasu Komuro, Tetsuya Hamasaki
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Publication number: 20220126282Abstract: A cation exchange chromatographic matrix comprising a base material, and a copolymer with one monomer unit having at least a sulfonic acid group, the copolymer being immobilized on the base material, wherein: the copolymer forms substantially no cross-linked structure, and the copolymer comprises neither acrylamide nor an acrylamide derivative as a monomer unit, or comprises acrylamide or an acrylamide derivative as a monomer unit in a range which has no substantial influence; the ratio of the mass of the copolymer to the mass of the base material is 5% or more and 200% or less; and the density of the sulfonic acid group is higher than 30 mmol/L and 200 mmol/L or lower.Type: ApplicationFiled: January 7, 2022Publication date: April 28, 2022Applicant: ASAHI KASEI MEDICAL CO., LTD.Inventor: Hiroki TANIGUCHI
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Publication number: 20220111133Abstract: A blood purifier includes a porous molded body; exhibits an excellent blood compatibility wherein platelet adherence is inhibited and exhibits a good cytokine adsorption capacity and a low pressure loss before and after blood treatment; and can be safely used. A blood purifier includes a main vessel and a porous molded body housed in the main vessel. The porous molded body contains a hydrophobic polymer and a hydrophilic polymer. The amount of low-melting-point water per 1 g of dry weight of the porous molded body is 0.12 g to 2.00 g. The contact change ratio for the porous molded body is 0% to 0.2%. The ratio L/D is 1.00 to 2.30 where, for the region taken up by the porous molded body in the main vessel, L is the length in the flow direction and D is the circle-equivalent diameter of the cross section in the direction perpendicular to the flow direction.Type: ApplicationFiled: March 27, 2020Publication date: April 14, 2022Applicant: Asahi Kasei Medical Co., Ltd.Inventors: Teruhiko OISHI, Yusuke TOKIMIZU, Keitaro MATSUYAMA, Naoki MORITA
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Publication number: 20220105454Abstract: Provided is a blood purifier which includes a porous formed body and which has excellent blood compatibility, in which platelets are unlikely to adhere, has good cytokine adsorption capacity, and low pressure loss before and after treating blood, and can be safely used. Disclosed is a blood purifier having a body container, and a porous formed body accommodated in the body container. The porous formed body contains a hydrophobic polymer and a hydrophilic polymer, the low-melting-point water content per 1 g of dry weight of the porous formed body is 0.12-2.00 g, the rate of contact change of the porous formed body is 0-0.2%, and the adhering amount of platelets per 1 mL of blood is 0.400 billion/mL or less when brining the blood into contact with the porous formed body.Type: ApplicationFiled: March 27, 2020Publication date: April 7, 2022Applicant: ASAHI KASEI MEDICAL CO., LTD.Inventors: Teruhiko OISHI, Yusuke TOKIMIZU, Keitaro MATSUYAMA, Naoki MORITA
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Publication number: 20220062522Abstract: An extracorporeal blood circulation device is provided with: a blood component adjuster; a blood purification device; a pipe system provided with a pump for supplying blood from a blood collecting part to the blood component adjuster, a valve for supplying a physiological saline solution, and a pressure gauge for sensing a pressure loss; a bypass pipe system for bypassing the blood component adjuster and supplying blood to the blood purification device; a pipe system for connecting the blood component adjuster and the blood purification device, the pipe system being provided with a pressure gauge for sensing a pressure loss; a pipe system provided with a valve for returning blood from the blood purification device to a reinfusion part and recovering the physiological saline solution, and a pressure gauge for sensing a pressure loss; and a control unit for switching to the bypass pipe system and switching to a reinfusion mode.Type: ApplicationFiled: December 18, 2019Publication date: March 3, 2022Applicant: Asahi Kasei Medical Co., Ltd.Inventors: Teruhiko OISHI, Naoki MORITA, Makoto OZEKI, Toshinori KOIZUMI
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Patent number: 11246970Abstract: Provided is a blood processing filter comprising a container having two spouts serving as an inlet for a liquid to be processed and an outlet for the processed liquid, and a filtration medium contained in the container, the filtration medium comprising a filter material having different CWST values for one surface A and the other surface B.Type: GrantFiled: February 6, 2017Date of Patent: February 15, 2022Assignee: ASAHI KASEI MEDICAL CO., LTD.Inventor: Kazuhiko Nakamura
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Patent number: 11224871Abstract: The present invention provides a phosphate adsorbing agent for blood processing comprising a porous formed article comprising an organic polymer resin and an inorganic ion adsorbent and having a most frequent pore size of 0.08 to 0.70 ?m measured with a mercury porosimeter, the phosphate adsorbing agent for blood processing having a biocompatible polymer in the surface of the porous formed article.Type: GrantFiled: May 17, 2018Date of Patent: January 18, 2022Assignee: ASAHI KASEI MEDICAL CO., LTD.Inventors: Naoki Morita, Hiroshi Tajima, Masashi Kogawa
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Patent number: 11213776Abstract: There is disclosed a leukocyte removal filter material comprising a nonwoven fabric having polybutylene terephthalate fiber. The average fiber diameter of the nonwoven fabric is 0.9 to 1.5 ?m, the formation index corresponding to a thickness of 0.3 mm of the nonwoven fabric is 15 to 70, and when the average fiber diameter of the nonwoven fabric is X and the specific surface area of the nonwoven fabric is Y, X and Y satisfy the following relational expression (1): Y??0.65×X+1.75??(1).Type: GrantFiled: December 12, 2014Date of Patent: January 4, 2022Assignee: ASAHI KASEI MEDICAL CO., LTD.Inventors: Tetsuro Uchimura, Nobukazu Shimada
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Publication number: 20210353845Abstract: Provided is a blood purification device including a porous molded body that has a high phosphorus adsorption capacity and that can be used safely. A blood purification device includes a porous molded body containing an inorganic ion-adsorbing material and is characterized by the following: said blood purification device satisfies the relationship B=?0.02 A+2.175±0.185 (74?A?94) when the moisture content of the porous molded body is denoted by A and the bulk density is denoted by B; and the number of fine particles having a size of 10 ?m or more is 25 or less and the number of fine particles having a size of 25 ?m or more is 3 or less in 1 mL of a physiological saline solution for injection both three months and six months after said physiological saline solution for injection is sealed in the blood purification device.Type: ApplicationFiled: March 29, 2019Publication date: November 18, 2021Applicant: ASAHI KASEI MEDICAL CO., LTD.Inventors: Teruhiko OISHI, Naoki MORITA, Keitaro MATSUYAMA, Hiroshi TAJIMA, Toshinori KOIZUMI
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Publication number: 20210316049Abstract: A blood processing filter includes a container having 2 ports respectively functioning as an inlet for a liquid to be processed and as an outlet for the processed liquid, and a filtration medium filled in the container, wherein an airflow resistance of the filtration medium is 55.0 kPa·s/m or more and less than 85.0 kPa·s/m, the filtration medium includes a filter material A having an airflow resistance per unit basis weight of 0.01 kPa·s·m/g or more and less than 0.04 kPa·s·m/g and a filter material B having an airflow resistance per unit basis weight of 0.04 kPa·s·m/g or more, at least a part of the filter material A is disposed on a side closer to the inlet for a liquid to be processed than the filter material B, and a sum of airflow resistances of the filter material A is 6.0 kPa·s/m or more.Type: ApplicationFiled: August 29, 2019Publication date: October 14, 2021Applicant: ASAHI KASEI MEDICAL CO., LTD.Inventors: Kazuhiko NAKAMURA, Tomohisa YOKOMIZO, Takako KAI
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Publication number: 20210205781Abstract: Provided are beads for blood processing having porous beads and a polymer carried on the surface of the porous beads, wherein: the porous beads are configured from at least one resin selected from the group consisting of acrylic resins, styrene resins, and cellulose resins; and the polymer includes a specific monomer defined in the description as a monomer unit.Type: ApplicationFiled: February 5, 2021Publication date: July 8, 2021Applicant: Asahi Kasei Medical Co., Ltd.Inventors: Yusuke TOKIMIZU, Satoru INOUE, Yoshihiro HATANAKA
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Publication number: 20210197133Abstract: A porous membrane containing a hydrophobic polymer and a water-insoluble hydrophilic polymer, the porous membrane having a dense layer in the downstream portion of filtration in the membrane, having a gradient asymmetric structure in which the average pore diameter of fine pores increases from the downstream portion of filtration toward the upstream portion of filtration, and having a gradient index of the average pore diameter from the dense layer to the coarse layer of 0.5 to 12.0.Type: ApplicationFiled: March 17, 2021Publication date: July 1, 2021Applicant: ASAHI KASEI MEDICAL CO., LTD.Inventors: Yuzo KAYAMA, Masayasu KOMURO, Tetsuya HAMASAKI