Abstract: A method is presented for providing a medical device with antibacterial activity, whereby a substrate material coated with a hydrophilic polymer is provided, the hydrophilic polymer exhibiting a low friction when wetted; also provided is a colloidal solution comprising chemically reduced particles of an oligodynamic metal and a hydrophilic polymer, the hydrophilic polymer being the same as in the coating of the substrate material; and the step of dipping the substrate material in the solution. A medical device prepared accordingly is also provided.

Abstract: A catheter, and preferably a urinary catheter, is disclosed, comprising an elongate shaft with a catheter insertion end and a flared connector connected to the elongated shaft opposite to the catheter insertion end. The flared connector forms a catheter connector end. Further, a gripping sleeve is fixedly connected to the flared connector, and arranged to enclose at least part of, and preferably essentially the whole, flared connector, apart from the catheter connector end. Hereby, a standard catheter can easily be customized for various use situations and users with different needs, in terms of e.g. gripping and manipulation possibilities. A method for producing such a customized catheter is also disclosed.

Abstract: A medical device is disclosed, comprising a substrate and a hydrophilic surface coating arranged on said substrate. The substrate has, on its surface coated with said hydrophilic surface coating, a surface texture with an arithmetical mean deviation of the surface profile (Ra) of at least 3 ?m and/or a profile section height difference (Rdc (1-99%)) of at least 18 ?m. It has surprisingly been found that the increased surface roughness of the substrate provides significant improvements in e.g. water retention for the hydrophilic coating.

Abstract: A bone implant for implantation into bone tissue includes a metallic material having a surface that is covered by an oxide layer wherein the oxide layer has a thickness within the range of from 2 to 100 nm and includes strontium ions homogenously dispersed in the oxide layer. The oxide layer is a metal oxide layer formed from the metallic surface of the implant. The local administration of strontium ions in bone tissue has been found to improve the bone formation and bone mass upon implantation of a bone tissue implant in the bone tissue.

Abstract: A catheter assembly includes a hydrophilic catheter; a wetting fluid for wetting of the catheter; and a receptacle enclosing at least the insertable part of the catheter and the wetting fluid. The wetting fluid is a solution incorporating at least one osmolality-increasing compound, and the total concentration of the osmolality-increasing compound(s) preferably exceeds 600 mOsm/dm3. The wetting fluid could either be arranged in contact with the hydrophilic surface layer of the catheter in the receptacle, for preservation of the hydrophilic surface layer in a wetted state during accommodation in said receptacle and provision of a ready-to-use catheter assembly, or be arranged to keep the wetting fluid separated from the hydrophilic surface layer of the catheter during storage, but to be brought into contact with said hydrophilic surface layer upon activation before an intended use of the catheter.

Abstract: The present invention is based on that local administration of strontium ions in bone tissue has been found to improve the bone formation and bone mass upon implantation of a bone tissue implant in said bone tissue. In particular, the invention relates to a bone tissue implant having an implant surface covered by an oxide layer comprising strontium ions and a method for the manufacture thereof. A blasting powder comprising strontium ions, a method for locally increasing bone formation, and the use of strontium ions or a salt thereof for manufacturing a pharmaceutical composition for locally increasing bone formation are also provided by the present invention.

Abstract: A catheter assembly includes a catheter, preferably having a hydrophilic surface coating; and a package accommodating said catheter. The package preferably also accommodates a wetting fluid. The package includes a first and a second sheet material connected around the edges; a perforation line extending along a non-closed loop in one of said sheet materials, which defines a flap opening; a third sheet material connected by means of an adhesive over said flap opening. The third sheet material with a margin covers the entire flap opening. The adhesive is adapted to maintain a sterile closure of the package before use, and to be resealable after use. The third sheet material forms a tab not provided with adhesive and the tab provides a grip portion for peel opening of the package.

Abstract: The invention relates to a method for modification of a biocompatible component. The method of the invention includes the steps of a) providing a biocompatible component at least partly covered by metallic oxide; and b) treating at least a part of the component, which part is covered by the metallic oxide, with an aqueous composition that includes oxalic acid; whereby a modified metallic oxide, is obtained. The invention also relates to a biocompatible component-including a substrate having a surface with a) a microstructure including pits separated by plateus and/or ridges; and b) a primary nanostructure being superimposed on the microstructure, the primary nanostructure having depressions arranged in a wave-like formation.

Abstract: A flushable medical device for short term use, such as a urinary catheter, is disclosed, and also a method for producing such a medical device. The medical device comprises at least an elongate shaft made of a degradable material, the degradability being such that the material becomes essentially totally dissolved if maintained in turbulent water at room temperature for at least 6 hours, but retains its structural integrity in water for at least 5 minutes, and preferably at least 10 minutes. Hereby, the medical device can be used for the intended short term use, and then be flushed in an ordinary toilet after use. The degradable material preferably comprises at least one of monosaccharide, disaccharide, oligosaccharide and polysaccharide. In a preferred embodiment, the degradable material primarily comprises water, at least one of sugar and starch and gelatin.

Abstract: A medical device is disclosed, comprising a substrate, having on its surface, on at least a part thereof, a hydrophilic surface layer providing low-friction surface character of the medical device when wetted by a wetting fluid. The substrate is made of a polymer blend comprising a polyolefin and a composition having molecules with active hydrogen(s), such as polyamide or polyurethane. The hydrophilic surface layer is preferably adhered to the substrate by a polyurea network, whereby said polyurea network forms a covalent bond to said active hydrogen(s) in the substrate. The new substrate material is environmentally acceptable and cost effective, has adequate mechanical and chemical properties and enables the hydrophilic coating to be adequately adhered.

Abstract: A catheter assembly includes a catheter, part of which forms an insertable length to be inserted through a body opening and a catheter receptacle to accommodate at least part of the catheter such that an insertable portion of the catheter is enclosed but part of the catheter is left outside of the receptacle. Also disclosed is a method for producing a catheter assembly which includes providing a receptacle having an opening, providing a catheter which has a catheter tube and a connector on one end thereof, arranging the catheter tube in the receptacle, and connecting the receptacle to the connector to close the opening.

Abstract: A catheter, and preferably a urinary catheter, is disclosed, comprising an elongate shaft with a catheter insertion end and a flared connector connected to the elongated shaft opposite to the catheter insertion end. The flared connector forms a catheter connector end. Further, a gripping sleeve is fixedly connected to the flared connector, and arranged to enclose at leat part of, and preferably essentially the whole, flared connector, apart from the catheter connector end. Hereby, a standard catheter can easily be customized for various use situations and users with different needs, in terms of e.g. gripping and manipulation possibilities. A method for producing such a customized catheter is also disclosed.

Abstract: A catheter, and preferably a urinary catheter, is disclosed, comprising an elongate shaft with a catheter insertion end and a flared connector connected to the elongated shaft opposite to the catheter insertion end. The flared connector forms a catheter connector end. Further, a gripping sleeve is fixedly connected to the flared connector, and arranged to enclose at leat part of, and preferably essentially the whole, flared connector, apart from the catheter connector end. Hereby, a standard catheter can easily be customized for various use situations and users with different needs, in terms of e.g. gripping and manipulation possibilities. A method for producing such a customized catheter is also disclosed.

Abstract: Disclosed are medical prosthetic device or medical implants which exhibit improved biocompatibility. The devices or implants include a metal material, e.g., titanium, in which the metal surfaces are coated with a corresponding hydride material that contains one or more biomolecule substance. The biomolecule substance may contain one or more biologically active molecules, e.g., bio-adhesives, biopolymers, blood proteins, enzymes, extracellular matrix proteins, extracellular matrix biomolecules, growth factors and hormones, peptide hormones, deoxyribonucleic acids, ribonucleic acids, receptors, inhibitors, drugs, biologically active anions and cations; vitamins; adenosine monophosphate (AMP), adenosine diphosphate (ADP) or adenosine triphosphate (ATP), marker biomolecules, amino acids, fatty acids, nucleotides (RNA and DNA bases), or sugars.

Abstract: A catheter assembly is provided comprising a catheter including a catheter tube and a connector arranged in one end of the catheter tube. The catheter is preferably a urinary, hydrophilic catheter. Further, the assembly comprises a catheter receptacle, a compartment accommodating the wetting fluid, the compartment being an integrated part of the receptacle but is separated from the cavity, the separation between the wetting fluid compartment and the cavity accommodating the catheter providing a rupturable sealed enclosure with at least one point of weakness.

Abstract: A medical device is disclosed, comprising a substrate and a hydrophilic surface coating arranged on said substrate. The substrate has, on its surface coated with said hydrophilic surface coating, a surface texture with an arithmetical mean deviation of the surface profile (Ra) of at least 3 ?m and/or a profile section height difference (Rdc (1-99%)) of at least 18 ?m. It has surprisingly been found that the increased surface roughness of the substrate provides significant improvements in e.g. water retention for the hydrophilic coating.

Abstract: A medical device is disclosed, comprising a substrate and a hydrophilic surface coating arranged on said substrate. The substrate has, on its surface coated with said hydrophilic surface coating, a surface texture with an arithmetical mean deviation of the surface profile (Ra) of at least 3 ?m and/or a profile section height difference (Rdc (1-99%)) of at least 18 ?m. It has surprisingly been found that the increased surface roughness of the substrate provides significant improvements in e.g. water retention for the hydrophilic coating.