Patents Assigned to AstraZeneca
  • Use of melagatran
    Publication number: 20080058303
    Abstract: According to the invention there is provided the use of melagatran, or a pharmaceutically acceptable derivative or prodrug thereof, in the manufacture of a medicament for the treatment of inflammation.
    Type: Application
    Filed: August 29, 2007
    Publication date: March 6, 2008
    Applicant: AstraZeneca AB
    Inventor: Ian Kirk
  • Pharmaceutical Compositions
    Publication number: 20080058353
    Abstract: The present invention relates to pharmaceutical compositions and, more particularly, to a pharmaceutical composition containing the compound {1S-[1?, 2?, 3? (1S*,2R*),5?]}-3-(7-{[2-(3,4-difluorophenyl)cyclopropyl]amino}-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol.
    Type: Application
    Filed: August 20, 2007
    Publication date: March 6, 2008
    Applicant: ASTRAZENECA AB
    Inventor: Simon Banks
  • New Compounds 318
    Publication number: 20080058349
    Abstract: This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
    Type: Application
    Filed: June 11, 2007
    Publication date: March 6, 2008
    Applicants: Astrazeneca AB, Astex Therapeutics Ltd
    Inventors: Stefan Berg, Jorg Holenz, Katharina Hogdin, Jacob Kihlstrom, Karin Kolmodin, Johan Lindstrom, Niklas Plobeck, Didier Rotticci, Fernando Sehgelmeble, Maria Wirstam
  • Pharmaceutical Compositions
    Publication number: 20080058399
    Abstract: The present invention provides pharmaceutical compositions comprising as an active ingredient candesartan or candesartan cilexetil, compositions exhibiting a relative bioavailability, measured as area under the curve, of more than 1.5.
    Type: Application
    Filed: September 5, 2007
    Publication date: March 6, 2008
    Applicant: ASTRAZENECA AB
    Inventors: Bertil Abrahamsson, Jonas Odman
  • Use of quetiapine
    Patent number: 7338948
    Abstract: A method of treating Attention Deficit Hyperactivity Disorder, Conduct Disorder and related disorders which comprises using the atypical antipychotic agent quetiapine.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: March 4, 2008
    Assignee: AstraZeneca AB
    Inventor: John Robertson
  • New Compounds 317
    Publication number: 20080051420
    Abstract: This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
    Type: Application
    Filed: June 11, 2007
    Publication date: February 28, 2008
    Applicants: AstraZeneca AB, Astex Therapeutics Ltd
    Inventors: Stefan Berg, Katharina Hogdin, Jacob Kihlstrom, Niklas Plobeck, Fernando Sehgelmeble, Maria Wirstam
  • Therapeutic Agents
    Publication number: 20080051405
    Abstract: The present invention provides compounds of formula I, processes for preparing such compounds, their use in the treatment of obesity, psychiatric disorders, cognitive disorders, memory disorders, schizophrenia, epilepsy, and related conditions, type II diabetes, Metabolic syndrome and neurological disorders such as dementia, multiple sclerosis, Parkinson's disease, Huntington's chorea, Alzheimer's disease, and pain related disorders, and to pharmaceutical compositions containing them.
    Type: Application
    Filed: August 17, 2007
    Publication date: February 28, 2008
    Applicant: ASTRAZENECA AB
    Inventors: Fabrizio Giordanetto, Tord Inghardt
  • Aryl Sulphonamide Modulators
    Publication number: 20080051441
    Abstract: Compounds of Formula I: wherein R1, R2, R3, R4, R5 Ar1 and X are as described in the specification, pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially for treatment of conditions associated with reductions in nicotinic transmission.
    Type: Application
    Filed: December 23, 2005
    Publication date: February 28, 2008
    Applicant: AstraZeneca AB
    Inventors: Dean Brown, Frances McLaren, Thomas Simpson
  • Novel Process for the Preparation of Substituted Indoles
    Publication number: 20080051586
    Abstract: The invention relates to a novel process for the preparation of substituted indoles which are useful as therapeutic agents.
    Type: Application
    Filed: January 9, 2006
    Publication date: February 28, 2008
    Applicant: ASTRAZENECA AB
    Inventors: Philip Keegan, Eric Merifield, Duncan Gill
  • NOVEL CO-CRYSTAL
    Publication number: 20080045481
    Abstract: The present invention relates to a novel co-crystal of 2-{ethyl[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)amino]quinazolin-7-yl}oxy)propyl]amino}ethyl dihydrogen phosphate (AZD1152) which is an aurora kinase inhibitor that is useful in the treatment of hyperproliferative diseases such as cancer.
    Type: Application
    Filed: May 15, 2007
    Publication date: February 21, 2008
    Applicant: ASTRAZENECA AB
    Inventors: George Sependa, Richard Storey
  • 6H-THIENO[2,3-b]PYRROLE DERIVATIVES AS ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE (GNRH)
    Publication number: 20080045517
    Abstract: The invention relates to a group of novel thieno-pyrrole compounds of Formula (I): wherein: R1, R2, R3, R4 and R5 are as defined in the specification, which are useful as gonadotrophin releasing hormone antagonists. The invention also relates to pharmaceutical formulations of said compounds, methods of treatment using said compounds and to processes for the preparation of said compounds.
    Type: Application
    Filed: May 22, 2007
    Publication date: February 21, 2008
    Applicant: AstraZeneca AB
    Inventors: Kevin Foote, Zbigniew Matusiak, Alexander Dossetter, Jean Claude Arnould, Maryannick Lamorlette, Benedicte Delouvrie, Annie Hamon
  • Pyridine Analogues VI
    Publication number: 20080045494
    Abstract: The present invention relates to certain new pyridin analogues of Formula (I) to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-thrombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.
    Type: Application
    Filed: July 2, 2007
    Publication date: February 21, 2008
    Applicant: ASTRAZENECA AB
    Inventors: Fabrizio Giordanetto, Johan Johansson
  • ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS
    Publication number: 20080045571
    Abstract: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
    Type: Application
    Filed: August 18, 2007
    Publication date: February 21, 2008
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS INC.
    Inventors: Louise Edwards, Methvin Isaac, Martin Johansson, Annika Kers, Johan Malmberg, Donald McLeod, Alexander Mindis, Karin Staaf, Abdelmalik Slassi, Tomislav Stefanac, Thomas Stormann, David Wensbo, Tao Xin, Jalaj Arora
  • Pharmaceutical Compositions
    Publication number: 20080045548
    Abstract: The present invention relates to pharmaceutical compositions, and more particularly, to a pharmaceutical composition containing the compound {1S-[1?,2?,3?(1S*,2R*),5?]}-3-(7-{[2-(3,4-difluorophenyl)cyclopropyl]amino}-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol.
    Type: Application
    Filed: August 20, 2007
    Publication date: February 21, 2008
    Applicant: ASTRAZENECA AB
    Inventor: Simon Banks
  • PHENYLALANINE DERIVATIVES
    Publication number: 20080045521
    Abstract: The present invention relates to compounds that inhibit of a5b1 function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm-blooded animals such as humans of diseases that have a significant angiogenesis or vascular component such as for treatment of solid tumours. The present invention also relates to a5b1 antagonists that also exhibit appropriate selectivity profile(s) against other integrins.
    Type: Application
    Filed: May 10, 2007
    Publication date: February 21, 2008
    Applicant: AstraZeneca AB
    Inventors: Jean-Claude Arnould, Benedicte Delouvrie, Richard Ducray, Christine Marie Paul Van Der Brempt
  • Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by NP Y5 receptor
    Patent number: 7332492
    Abstract: Compounds of formula (I): wherein: X is a group of formula (B): and R1, R2, R4, n, x, y and z are as defined within are described. Processes for their preparation and their use in the treatment of disorders mediated by the neuropeptide Y5 receptor in a warm-blooded animal, such as a human being, are also described.
    Type: Grant
    Filed: May 12, 2005
    Date of Patent: February 19, 2008
    Assignee: AstraZeneca AB
    Inventors: Michael Howard Block, Kevin Michael Foote
  • Indole-amid derivatives which possess glycogen phosphorylase inhibitory activity
    Patent number: 7332515
    Abstract: Heterocyclic amides of formula (1) and pharmaceutically acceptable salts or pro-drugs thereof wherein variable groups are as described herein; which possess glycogen phosphorylase inhibitory activity and accordingly have value in the treatment of disease states associated with increased glycogen phosphorylase activity are described. Processes for the manufacture of said heterocyclic amide derivatives and pharmaceutical compositions containing them are also described.
    Type: Grant
    Filed: November 30, 2006
    Date of Patent: February 19, 2008
    Assignee: AstraZeneca AB
    Inventors: Andrew Stocker, Paul Robert Owen Whittamore
  • Amide derivatives
    Patent number: 7332483
    Abstract: The invention concerns amide derivatives of Formula (Ia) wherein X is —NHCO— or —CONH—; m is 0-3; R1 is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy and carbamoyl; n is 0-2; R2 is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino and carboxy; R3 is hydrogen, halogeno, (1-6C)alkyl or (1-6C)alkoxy; q is 0-4; and Q is a group such as aryl, aryloxy, aryl-(1-6C)alkoxy, arylamino and N-(1-6C)alkyl-arylamino; or pharmaceutically-acceptable salts or in-vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines
    Type: Grant
    Filed: August 18, 2006
    Date of Patent: February 19, 2008
    Assignee: AstraZeneca AB
    Inventor: Dearg S Brown
  • Inhaler Device Counter
    Publication number: 20080035144
    Abstract: Inhaler counter (20) comprising a counter housing (390), a rocker arm (200) with a pawl (210), the rocker arm being pivotally supported by the housing and arranged to perform a rocker movement in response to a linear actuation motion, a return spring (220) for resetting the rocker arm, a ratchet wheel (230) engagable with the pawl to convert the movement of the rocker arm into an incremental rotational motion of an axle arrangement (240) advancing a display means (60), the axle arrangement further comprising a back rotation prevention means (280) in the form of a spring loaded friction brake and a worm gear, the display means comprising rotatable indicator means (120) with teeth that engage the worm-gear and a stationary scale.
    Type: Application
    Filed: April 10, 2006
    Publication date: February 14, 2008
    Applicant: ASTRAZENECA AB
    Inventors: Nic Bowman, Douglas Bradshaw, Lennart Sorby
  • New Pyridine Analogues III
    Publication number: 20080039437
    Abstract: The present invention relates to certain new pyridin analogues of Formula (I) to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-thrombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.
    Type: Application
    Filed: July 2, 2007
    Publication date: February 14, 2008
    Applicant: ASTRAZENECA AB
    Inventors: Thomas Antonsson, Peter Bach, David Brown, Ruth Bylund, Fabrizio Giordanetto, Lotta Jakobsson, Johan Johansson