Patents Assigned to AstraZeneca
  • MGluR5 modulators V
    Publication number: 20070259860
    Abstract: The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
    Type: Application
    Filed: April 25, 2007
    Publication date: November 8, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS, INC.
    Inventors: Andreas Wallberg, Karolina Nilsson, Kenneth Granberg, Saswati Ghosal, Abdelmalik Slassi, Louise Edwards, Methvin Isaac, Tao Xin, Tomislav Stefanac, Peter Dove
  • Novel Compounds
    Publication number: 20070259888
    Abstract: Compounds of Formulae I, or pharmaceutically acceptable salts thereof: wherein X, R1, R2 and R3 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
    Type: Application
    Filed: April 30, 2007
    Publication date: November 8, 2007
    Applicant: ASTRAZENECA AB
    Inventors: Yun-Xing Cheng, Xuehong Luo, Miroslaw Tomaszewski
  • MGluR5 modulators I
    Publication number: 20070259862
    Abstract: The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
    Type: Application
    Filed: April 25, 2007
    Publication date: November 8, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS, INC.
    Inventors: Andreas Wallberg, Karolina Nilsson, Bjorn Holm, Mats Nagard, Kenneth Granberg, Abdelmalik Slassi, Louise Edwards, Methvin Isaac, Tao Xin, Tomislav Stefanac
  • MGluR5 modulators IV
    Publication number: 20070259923
    Abstract: The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
    Type: Application
    Filed: April 25, 2007
    Publication date: November 8, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS, INC.
    Inventors: Methvin Isaac, Abdelmalik Slassi, Louise Edwards, Tao Xin, Andreas Wallberg, Tomislav Stefanac
  • MGluR5 modulators VI
    Publication number: 20070259895
    Abstract: The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
    Type: Application
    Filed: April 25, 2007
    Publication date: November 8, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS, INC.
    Inventors: Methvin Isaac, Abdelmalik Slassi, Louise Edwards, Tao Xin, Tomislav Stefanac, Peter Dove, Mats Nagard
  • Novel Oxabispidine Compounds and Their Use in the Treatment of Cardiac Arrhythmias
    Publication number: 20070259864
    Abstract: There is provided compounds of formula I, wherein R1, R2, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
    Type: Application
    Filed: June 13, 2005
    Publication date: November 8, 2007
    Applicant: ASTRAZENECA AB
    Inventors: Annika Bjore, Ulrik Gran, Gert Strandlund
  • Azine-Carboxamides as Anti-Cancer Agents
    Publication number: 20070259849
    Abstract: The invention relates to chemical compounds, of the formula (I): or pharmaceutically acceptable salts thereof, which possess B-Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.
    Type: Application
    Filed: June 29, 2005
    Publication date: November 8, 2007
    Applicant: ASTRAZENECA AB
    Inventors: Brian Aquila, Stephanos Ioannidis, Paul Lyne, Timothy Pontz
  • mGluR5 modulators II
    Publication number: 20070259916
    Abstract: The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
    Type: Application
    Filed: April 25, 2007
    Publication date: November 8, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS, INC.
    Inventors: Methvin Isaac, Abdelmalik Slassi, Louise Edwards, Tao Xin, Tomislav Stefanac
  • Gnal Splice Variant and Uses Thereof
    Publication number: 20070254313
    Abstract: The present invention relates to a novel splice form of the GNAL gene product and methods for identifying modulators of G protein coupled receptors.
    Type: Application
    Filed: November 11, 2004
    Publication date: November 1, 2007
    Applicant: AstraZeneca AB
    Inventors: James Bostwick, Thomas Defay, Stephen Furlong, Lee Hirata, Vipa Ravyn, Alan Robbins, John Corradi
  • 5-Fluoro-, Chloro-and Cyano-Pyridin-2-Yl-Tetrazoles as Ligands of the Metabotropic Glutamate Receptor-5
    Publication number: 20070255061
    Abstract: The present invention relates to new compounds of formula I, wherein Z, Q, X1, X2, R1 and R2, are as defined as in formula I, or salts, solvates or solvated salts thereof, processes for their preparation, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
    Type: Application
    Filed: December 13, 2004
    Publication date: November 1, 2007
    Applicants: AstraZeneca AB, NPS Pharmaceuticals, Inc.
    Inventors: David Wensbo, Louise Edwards, Methvin Isaac, Donald McLeod, Abdelmalik Slassi, Tao Xin, Thomas Stormann
  • 4(Phenyl-Piperazinyl-Methyl) Benzamide Derivatives and Their Use for the Treatment of Pain or Gastrointestinal Disorders
    Publication number: 20070254890
    Abstract: Compounds of general formula: wherein R1, R2 and R3 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
    Type: Application
    Filed: July 9, 2007
    Publication date: November 1, 2007
    Applicant: ASTRAZENECA AB
    Inventors: William Brown, Andrew Griffin, Paul Jones, Daniel Page, Niklas Plobeck, Christopher Walpole
  • ADH1C
    Patent number: 7288377
    Abstract: The present invention relates to a method for identifying individuals with Parkinson's disease and/or individuals at risk for developing Parkinson's disease, comprising screening nucleic acids from the individual for a mutation in the ADH1C gene, as well as different uses thereof.
    Type: Grant
    Filed: February 12, 2004
    Date of Patent: October 30, 2007
    Assignee: AstraZeneca AB
    Inventors: Silvia Burvenich, Andrea Carmine, Dagmar Galter, Lars Olson, Olof Sydow
  • Salts of substituted methylene bisphosphonic acids
    Patent number: 7288673
    Abstract: A salt of substituted or unsubstituted methylene bisphosphonic acid of formula I wherein X1 and X2 are both chlorine or one of X1 and X2 is hydrogen and one is chlorine and the salt is selected from the group consisting of a C1-16 straight or branched primary, secondary or tertiary alkyl amine salt, an aralkyl amine salt, and a basic N-containing heterocycle salt. The salts are used for preparing pharmaceutically relevant compounds.
    Type: Grant
    Filed: December 1, 2003
    Date of Patent: October 30, 2007
    Assignee: AstraZeneca UK Limited
    Inventor: Mark Purdie
  • Selected Fused Heterocyclics and Uses Thereof
    Publication number: 20070249636
    Abstract: This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.
    Type: Application
    Filed: August 16, 2005
    Publication date: October 25, 2007
    Applicant: ASTRAZENECA AB
    Inventors: Brian Aquila, Michael Block, Audrey Davies, Jayachandran Ezhuthachan, Timothy Pontz, Daniel Russell, Marie-Elena Theoclitou, XiaoLan Zheng
  • Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof
    Publication number: 20070249619
    Abstract: Compounds of general formula: as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain, depression and anxiety.
    Type: Application
    Filed: July 27, 2005
    Publication date: October 25, 2007
    Applicant: AstraZeneca AB
    Inventors: William Brown, Andrew Griffin, Thomas Hudzik, Carla Maciag, Gennady Smagin, Christopher Walpole
  • Novel Piperidine Derivatives as Histamine H3 Receptor Ligands for Treatment of Depression
    Publication number: 20070249618
    Abstract: Compounds of formula (I) wherein Ar1 and Q are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the treatment of depression.
    Type: Application
    Filed: July 27, 2005
    Publication date: October 25, 2007
    Applicant: AstraZeneca AB
    Inventors: James Folmer, Simon Hunt, Peter Hamley, Steven Wesolowski
  • Method of Treating Substance Abuse with Quetiapine
    Publication number: 20070249582
    Abstract: This invention relates to a method of treating Substance Use such as Substance Abuse or Substance Dependence and in particular to the use of quetiapine in treating such disorders.
    Type: Application
    Filed: July 6, 2007
    Publication date: October 25, 2007
    Applicant: ASTRAZENECA AB
    Inventor: Sherwood Brown
  • Nicotinic Acetylcholine Receptor Ligands
    Publication number: 20070249588
    Abstract: Acetylcholine receptor ligands of formula (I), wherein D, Ar1, E and Ar2 are as described in the specification, diastereoisomers, enantiomers, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
    Type: Application
    Filed: December 20, 2004
    Publication date: October 25, 2007
    Applicant: AstraZeneca AB
    Inventors: Glen Ernst, William Frietze, Robert Jacobs, Eifion Phillips
  • Modulators of Crth-2 Receptor Activity for the Treatment of Prostaglandin D2 Mediated Diseases
    Publication number: 20070249686
    Abstract: The invention relates to substituted acids as useful pharmaceutical compounds for treating respiratory disorders as asthma, pharmaceutical compositions containing them, and processes for their preparation.
    Type: Application
    Filed: October 3, 2005
    Publication date: October 25, 2007
    Applicant: ASTRAZENECA AB
    Inventors: Roger Bonnert, Timothy Luker, Garry Pairaudeau, Stephen Thom
  • New amidino derivatives and their use as thrombin inhibitors
    Publication number: 20070249578
    Abstract: There is provided compounds of formula I wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
    Type: Application
    Filed: June 6, 2007
    Publication date: October 25, 2007
    Applicant: AstraZeneca AB
    Inventors: Tord Inghardt, Olle Karlsson, Marcel Linschoten, Jan-Erik Nystrom