Patents Assigned to Aventis
-
Patent number: 11571509Abstract: A medicament delivery device comprises a needle configured to move between a retracted position and an inserted position; an insertion mechanism to move the needle from the retracted position to the inserted position when activated; a locking arm which, in a locked position, is engaged with the insertion mechanism to prevent activation of the insertion mechanism and, in an unlocked position, is disengaged from the insertion mechanism; a retraction mechanism to move the needle from the inserted position to the retracted position when activated; and a trigger configured to move between a disengaged position and an engaged position. On moving from the disengaged position to the engaged position, the trigger is configured to move the locking arm from the locked position to the unlocked position. On moving from the engaged position to the disengaged position, the trigger is configured to activate the retraction mechanism.Type: GrantFiled: July 28, 2017Date of Patent: February 7, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventors: Stefan Verlaak, Ilario Melzi
-
Patent number: 11565036Abstract: An assembly nest for transporting a tubular sub assembly of a drug delivery device on an automated production line, in which the tubular sub assembly includes a tubular body and a cap that is wider than the tubular body. The assembly nest includes a base against which a sub assembly of a drug delivery device is mountable to orientate said sub assembly in a predetermined position; and locking mechanism having a resilient member to urge the locking mechanism into one of: an unlocked position, in which a sub assembly of a drug delivery device can be mounted to the base; or a locked position, in which the locking mechanism engages a mounted sub assembly to retain it in its predetermined position on the base.Type: GrantFiled: February 6, 2018Date of Patent: January 31, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventors: Matthias Rau, Winfried Huthmacher, Sebastian Braun, Marc Schader, Markus Janiak, Michael Kneip, Martin Baumeyer, Peter Nober
-
Patent number: 11565056Abstract: A method and system for detecting a limit of use of a medical device is disclosed. The method includes starting a timer of a medical device when said medical device is used for the first time, detecting the limit of use of the medical device and indicating the limit of use of the medical device. The limit of use is reached when at least one of a first criterion and a second criterion is met, wherein the first criterion is that the timer reaches or exceeds a time limit and wherein the second criterion is that at least one operation of a drive train of said medical device reaches or exceeds a limit.Type: GrantFiled: September 15, 2021Date of Patent: January 31, 2023Assignee: Sanofi-Aventis Deutschland GmbHInventors: Ilona Eggert, Michael Caspers, Richard James Vincent Avery, Shane Alistair Day
-
Patent number: 11559628Abstract: A dose setting mechanism for a drug delivery device is disclosed. The mechanism comprises an outer housing and an inner housing having an external groove and a helical spline. The inner housing helical spline guides a driver to dispense a set dose. A dial sleeve is disposed between the outer and inner housing and is rotatably engaged with the inner housing. When a dose is set, the dial sleeve is rotated and translates away from both the outer housing and the inner housing.Type: GrantFiled: August 16, 2019Date of Patent: January 24, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventor: David Plumptre
-
Patent number: 11559630Abstract: An auto-injector for administering a dose of a liquid medicament (M) is presented having an elongate case, a carrier subassembly comprising a tubular carrier slidably arranged inside the case, where the carrier adapted to contain a syringe with a hollow injection needle. The injector also has, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for advancing the needle beyond a proximal end of the auto-injector, and a trigger button is used for releasing the control spring on actuation.Type: GrantFiled: August 13, 2019Date of Patent: January 24, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventors: Simon Francis Brereton, Thomas Kemp, Rosemary Burnell, Matthew Ekman
-
Patent number: 11560402Abstract: The invention relates to a method for the cleavage of a solid phase-bound polypeptide from the solid phase, the method comprising contacting the solid phase, to which the polypeptide is bound, with a composition consisting essentially of trifluoroacetic acid and 1,2-ethanedithiol, at a temperature in the range of about 23° C. to about 29° C.Type: GrantFiled: April 10, 2019Date of Patent: January 24, 2023Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: Wolfgang Fiedler, Norbert Pleuss, Bernd Henkel, Manfred Gerken
-
Patent number: 11554217Abstract: A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. The drive mechanism may include a housing, a dose dial sleeve, and a drive sleeve. A clutch is configured to permit rotation of the drive sleeve and the dose dial sleeve with respect to the housing when the dose dial sleeve and drive sleeve are coupled through the clutch. Conversely, when the dose dial sleeve and drive sleeve are in a de-coupled state, rotation of the dose dial sleeve with respect to the housing is permitted and rotation of the drive sleeve with respect to the housing is prevented. In the de-coupled state, axial movement of the drive sleeve transfers force in a longitudinal direction for actuation of a drug delivery device.Type: GrantFiled: April 14, 2020Date of Patent: January 17, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventors: Robert Frederick Veasey, Robert Perkins, David Aubrey Plumptre
-
Patent number: 11547806Abstract: A data collection device comprising an attachment assembly for attaching the data collection device to a dose setting dial of a medicament administration device, a light source configured to illuminate a portion of a surface of an internal component of the medicament administration device including a pattern of relatively reflective and non-reflecting regions formed on the surface of the internal component, and an optical sensor configured to receive light reflected by at least the relatively reflective regions.Type: GrantFiled: September 8, 2017Date of Patent: January 10, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventors: Christian Rehbein, Sven Hagebusch, Chris Knorr, Maurice Toporek, Matthias Felber, Alexander Heinrich
-
Patent number: 11547791Abstract: The present disclosure relates to a medicament delivery device. The medicament delivery device comprises a housing, a needle and a reservoir. The needle is configured to project from a distal end of the housing. The reservoir is disposed in the housing and has a flexible wall. The medicament delivery device further comprises a dispensing member and a biasing member. The dispensing member is disposed in the housing and the biasing member is configured to bias the dispensing member to move in an arcuate path relative to the housing such that the dispensing member moves across the flexible wall of the reservoir to dispense medicament from the reservoir when the reservoir contains medicament.Type: GrantFiled: September 20, 2017Date of Patent: January 10, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventors: Michael Schabbach, Beate Franke, Giuliano Pradel, Ilario Melzi, Stefan Verlaak, Andrew Nelson
-
Patent number: 11547803Abstract: The present invention relates to a drive mechanism for a drug delivery device, comprising: a piston rod to operably engage with a piston of a cartridge to displace the piston in a distal direction during a dose dispensing action, at least one actuation member mechanically coupled with the piston rod to induce a distally directed displacement of the piston rod when actuated by a user, a control to ascertain at least one predefined condition of use, and at least one interlock member coupled with the control to mechanically obstruct displacement of the piston rod if the condition of use is not fulfilled.Type: GrantFiled: July 10, 2018Date of Patent: January 10, 2023Assignee: Sanofi-Aventis Deutschland GmbHInventors: Hardy Kietzmann, Jasmin Groeschke, Hanno Juhnke, Jan-Peter Spengler, Matthias Scharf, Christoph Dette, Michael Schrack, Olaf Zeckai
-
Patent number: 11541188Abstract: An autoinjector includes a case adapted to hold a medicament container having a needle, a needle shroud telescopically coupled to the case, and a plunger rotationally and slidably disposed in the case. The needle shroud is movable between a first extended position relative to the case in which the needle is covered and a retracted position relative to the case in which the needle is exposed. The plunger is rotatable relative to the case between a first rotational position in which the plunger is engaged to the case and a second rotational position in which the plunger disengages the case. The needle shroud is operably coupled to the plunger. When the needle shroud translates from the first extended position to the retracted position, the plunger rotates from the first rotational position to the second rotational position.Type: GrantFiled: July 24, 2019Date of Patent: January 3, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventors: Carsten Mosebach, Thomas Kemp
-
Patent number: 11534557Abstract: According to the invention a safety device for a pre-filled syringe comprises a substantially cylindrical and hollow support body and a hollow needle shield slideably arranged relative to the support body. The support body comprises at least one resilient arm and the hollow needle shield or a needle shield assembly comprises at least one curved actuation ramp. The curved actuation ramp protrudes in a lateral direction (L) perpendicular to a central axis (A) of the safety device. The curved actuation ramp comprises a first lateral dimension (L1) at a proximal end of the needle shield and a second lateral dimension (L2) exceeding the first lateral dimension (L1) at a distal end of the needle shield. The resilient arm engages the curved actuation ramp when the needle shield is slid relative to the support body.Type: GrantFiled: March 13, 2019Date of Patent: December 27, 2022Assignee: Sanofi-Aventis Deutschland GMBHInventors: Gareth Roberts, Chris Ward, Matthew Ekman
-
Patent number: 11524112Abstract: A computerized electro-mechanical drug delivery device configured to deliver at least one dose of two or more medicaments. The device comprises a control unit. An electro-mechanical drive unit is operably coupled to the control unit and a primary reservoir for a first medicament and a secondary reservoir for a fluid agent, e.g. a second medicament. An operator interface is in communication with the control unit. A single dispense assembly is configured for fluid communication with the primary and the secondary reservoir. Activation of the operator panel sets a first dose from the primary reservoir and based on the first dose and a therapeutic dose profile, the control unit is configured to determine a dose or range of the fluid agent. Alternatively, the control unit determines or calculates a dose or range of a third medicament. Further, a dispense interface for use with a drug delivery device is disclosed.Type: GrantFiled: October 10, 2019Date of Patent: December 13, 2022Assignee: Sanofi-Aventis Deutschland GmbHInventors: Shane Alistair Day, Daniel Thomas De Sausmarez Lintell, Steven Wimpenny, Christopher Jones, Aidan Michael O'Hare, Barry Yates, Robert Frederick Veasey, Christopher James Smith, Malcolm Boyd, David Martin Leak, Carmen Patricia Keating, David Sanders, Elizabeth Anne Marshall
-
Patent number: 11524122Abstract: Implementations of the present disclosure are directed to a module for attachment to an injection device that includes a flexible carrier foil configured to be attached to a surface of the injection device independent of a geometry of the surface, at least one light emitting diode attached to the flexible carrier foil in a first position and configured to emit a light signal in a direction based on the first position through a transparent wall of the injection device, at least one photodiode attached to the flexible carrier foil in a second position relative to the first position, the at least one photodiode being configured to detect at least a portion of the light signal from a direction based on the second position and being configured to emit an electrical signal based on the light signal to a microprocessor, and wherein the microprocessor is configured to receive the electrical signal emitted by the photodiode and to determine the position of a stopper and the amount of the fluid within the injection devType: GrantFiled: January 25, 2018Date of Patent: December 13, 2022Assignee: Sanofi-Aventis Deutschland GMBHInventors: Dietmar Hammen, Thomas Klemm
-
Patent number: 11518988Abstract: The present invention relates to polypeptide variants of porcine trypsin, to nucleic acid molecules encoding these variants, and to host cells comprising such nucleic acid molecules. It also relates to the use of these variants in methods for producing insulin. The invention further relates to the use of these variants as medicaments, as food ingredients, or as feed ingredients and to the use of these variants within a process of manufacturing a food ingredient or a feed ingredient.Type: GrantFiled: February 22, 2019Date of Patent: December 6, 2022Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: Thomas Stillger, Sebastian Rissom, Claudia Feller, Andreas Vogel
-
Patent number: 11511043Abstract: Described is a syringe carrier comprising a body adapted to receive a barrel of a syringe. The body includes two sections having distal ends with shoulder sections. The shoulder sections are adapted to engage a circumferential gap between the barrel of the syringe and a needle shield covering a needle of the syringe.Type: GrantFiled: July 21, 2021Date of Patent: November 29, 2022Assignee: Sanofi-Aventis Deutschland GMBHInventors: Yannick Hourmand, Douglas Ivan Jennings, Matthew Ekman
-
Patent number: 11511048Abstract: The present disclosure relates to a drug delivery device for setting and injecting of a dose of an injectable medicament, the drug delivery device comprising: an elongated housing extending along a longitudinal axis and having a sidewall with at least a first aperture, at least one number sleeve rotatably supported inside the housing and comprising an outer surface, wherein a first portion of the outer surface is visible through the first aperture and wherein the number sleeve comprises a non-visible code in the region of the first portion.Type: GrantFiled: December 9, 2016Date of Patent: November 29, 2022Assignee: Sanofi-Aventis Deutschland GMBHInventors: Thomas Klemm, Alexander Allerdings, Markus Ploch
-
Patent number: 11511047Abstract: A data collection device comprises: a first portion having one or more features configured for attaching of the first portion to a dosage knob of an injection device; a second portion rotatably coupled with the first portion, wherein at least part of the second portion is movable axially relative to the first portion; a sensor arrangement configured to detect rotation of the first portion relative to the second portion; and a processor arrangement configured to, based on said detected movement, determine a medicament amount expelled by the injection device, wherein the coupling arrangement is configured to provide a non-permanent coupling between the first portion and the dosage knob of the injection device.Type: GrantFiled: September 16, 2021Date of Patent: November 29, 2022Assignee: Sanofi-Aventis Deutschland GMBHInventors: Maurice Toporek, Matthias Felber, Christoph Matthias Gugl, Marcus-Meinolf Dittrich, Christian Nessel, Stephan Riedel, Armin Koller, Alexander Heinrich, Florian Eberli, Philipp Muller, Sven Zwicker
-
Patent number: 11504475Abstract: Auto-injector for administering a dose of a liquid medicament includes a housing to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament, the housing having a distal end and a proximal end with an orifice to apply against an injection site. A spring means, upon activation, can push the needle from inside the housing through the orifice and past the proximal end, operate the syringe to supply the dose of medicament, and retract the syringe with the needle after delivering the medicament. An activating means can lock the spring means in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means for injection.Type: GrantFiled: July 1, 2022Date of Patent: November 22, 2022Assignee: Sanofi-Aventis Deutschland GMBHInventors: Matthew Ekman, Yannick Hourmand, Timothy Donald Barrow-Williams
-
Patent number: 11484658Abstract: A drug delivery device comprising: a housing; a cylindrical member rotatably supported within the housing; and a plurality of sensors; wherein: the outer surface of the cylindrical member is provided with a single track, the track forming an encoder and having a plurality of first track segments and a plurality of second track segments arranged along the length of the track which are respectively capable of inducing first and second responses in the sensors; and in each rotational position of the cylindrical member relative to the housing at least one different first track segment is capable of inducing a first response in at least one said sensor, thereby enabling the rotational position of the cylindrical member relative to the housing to be determined.Type: GrantFiled: April 13, 2020Date of Patent: November 1, 2022Assignee: Sanofi-Aventis Deutschland GMBHInventors: Samuel Keir Steel, Paul Richard Draper, George Cave