Patents Assigned to AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.P.A.
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Publication number: 20140057922Abstract: A process of production of trazodone or trazodone hydrochloride that comprises: (a) preparing an organic phase comprising trazodone in at least one organic solvent; (b) preparing an aqueous phase comprising at least one basic compound; (c) mixing said aqueous phase with said organic phase; (d) heating at a temperature of at least 40° C. for at least 30 minutes; (e) recovering said trazodone; and, optionally, (f) treating said trazodone with hydrochloric acid to obtain trazodone hydrochloride. Trazodone or trazodone hydrochloride comprising less than 15 ppm of allylating substances, and a pharmaceutical composition comprising said trazodone hydrochloride.Type: ApplicationFiled: November 6, 2013Publication date: February 27, 2014Applicant: AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.p.A.Inventors: Marcello MARCHETTI, Tommaso Iacoangeli, Giovanni Battista Ciottoli, Giuseppe Biondi
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Publication number: 20130267704Abstract: The present invention relates to novel 1-benzyl-3-hydroxymethylindazole derivatives according to formula (I) described in the claims, and to a pharmaceutical composition comprising them, together with a pharmaceutically acceptable vehicle. In addition, the present invention relates to the use of 1-benzyl-3-hydroxymethylindazole derivatives for the preparation of a pharmaceutical composition that is active in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40, and to their use in a method for treating or preventing diseases based on the expression of MCP-1, CX3CR1 and p40.Type: ApplicationFiled: May 21, 2013Publication date: October 10, 2013Applicant: AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.p.A.Inventors: Angelo GUGLIELMOTTI, Guido FURLOTTI, Giorgina MANGANO, Nicola CAZZOLLA
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Publication number: 20130203771Abstract: A process of production of trazodone or trazodone hydrochloride that comprises: (a) preparing an organic phase comprising trazodone in at least one organic solvent; (b) preparing an aqueous phase comprising at least one basic compound; (c) mixing said aqueous phase with said organic phase; (d) heating at a temperature of at least 40° C. for at least 30 minutes; (e) recovering said trazodone; and, optionally, (f) treating said trazodone with hydrochloric acid to obtain trazodone hydrochloride. Trazodone or trazodone hydrochloride comprising less than 15 ppm of alkylating substances, and a pharmaceutical composition comprising said trazodone hydrochloride.Type: ApplicationFiled: March 15, 2013Publication date: August 8, 2013Applicant: AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.p.A.Inventor: AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.p.A.
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Publication number: 20130012520Abstract: A process of production of trazodone or trazodone hydrochloride that comprises: (a) preparing an organic phase comprising trazodone in at least one organic solvent; (b) preparing an aqueous phase comprising at least one basic compound; (c) mixing said aqueous phase with said organic phase; (d) heating at a temperature of at least 40° C. for at least 30 minutes; (e) recovering said trazodone; and, optionally, (f) treating said trazodone with hydrochloric acid to obtain trazodone hydrochloride. Trazodone or trazodone hydrochloride comprising less than 15 ppm of alkylating substances, and a pharmaceutical composition comprising said trazodone hydrochloride.Type: ApplicationFiled: September 14, 2012Publication date: January 10, 2013Applicant: AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.p.A.Inventors: Marcello Marchetti, Tommaso Iacoangeli, Giovanni Battista Ciottoli, Giuseppe Biondi
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Publication number: 20120302618Abstract: Use of benzydamine in the treatment of inflammatory diseases, in particular Crohn's disease, rheumatoid arthritis, psoriatic arthritis, and psoriasis, caused by an expression or overexpression of the cytokine subunit p40.Type: ApplicationFiled: June 23, 2010Publication date: November 29, 2012Applicant: AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.p.A.Inventors: Angelo Guglielmotti, Giorgina Mangano, Giuseppe Biondi, Roberta Petrosemolo, Enrica Biondi, Iacopo Biondi
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Publication number: 20120220547Abstract: The present invention relates to a food formulation for the controlled release of glucose comprising glycogen and at least one other edible component, as well the use of glycogen for its preparation.Type: ApplicationFiled: July 29, 2010Publication date: August 30, 2012Applicant: AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.p.A.Inventors: Vincenzo Russo, Elisa Liberati, Giuseppe Biondi, Roberta Petrosemolo, Enrica Biondi, Iacopo Biondi
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Publication number: 20120184752Abstract: The present invention relates to the process for the preparation of 1-benzyl-3-hydroxymethyl-1H-indazole according ing to formula (II), to be used in a subsequent process for the preparation of 1-benzyl-3-hydroxymethyl-1H-indazole according to formula (I).Type: ApplicationFiled: July 28, 2010Publication date: July 19, 2012Applicant: AZIENDE CHIM, RIUN, ANG, FRANC. A.C.R.A.F. S.p.A.Inventors: Giuliano Caracciolo Torchiarolo, Tommaso Iacoangeli, Guido Furlotti
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Publication number: 20120149912Abstract: The present invention relates to the process for the conversion of 1-benzyl-3-hydroxymethyl-1H-indazole according to formula (II), to the 1-benzyl-3-hydroxylmethyl-1H-indazole according to formula (I).Type: ApplicationFiled: July 28, 2010Publication date: June 14, 2012Applicant: AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.p.A.Inventors: Giuliano Caracciolo Torchiarolo, Tommaso Iacoangeli, Guido Furlotti
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Publication number: 20120142699Abstract: A process of production of trazodone or trazodone hydrochloride that comprises: (a) preparing an organic phase comprising trazodone in at least one organic solvent; (b) preparing an aqueous phase comprising at least one basic compound; (c) mixing said aqueous phase with said organic phase; (d) heating at a temperature of at least 40° C. for at least 30 minutes; (e) recovering said trazodone; and, optionally, (f) treating said trazodone with hydrochloric acid to obtain trazodone hydrochloride. Trazodone or trazodone hydrochloride comprising less than 15 ppm of alkylating substances, and a pharmaceutical composition comprising said trazodone hydrochloride.Type: ApplicationFiled: February 10, 2012Publication date: June 7, 2012Applicant: AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.p.A.Inventors: Marcello MARCHETTI, Tommaso Iacoangeli, Giovanni Battista Ciottoli, Giuseppe Biondi
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Publication number: 20120115958Abstract: The present invention relates to a sugar-free liquid pharmaceutical formulation comprising an aqueous solution of paracetamol, a solubilizing agent containing polyethylene glycol, a thickening agent containing xanthan gum, and a sweetening system containing sucralose and a mixture of polyols containing glycerol, sorbitol and xylitol in a total amount between approx. 15% and 35% w/v relative to the total volume of said pharmaceutical formulation.Type: ApplicationFiled: September 28, 2009Publication date: May 10, 2012Applicant: Aziende Chim. Riun. Ang. Franc. A.C.R.A.F. S.p.A.Inventors: Francesca Mariotti, Paolo Scarpetti, Lorella Ragni, Mauro Valenti
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Publication number: 20110318321Abstract: The present invention relates to a controlled release pharmaceutical or food formulation comprising at least one active pharmaceutical or food ingredient dispersed in a mixture of a glycogen with a polysaccharide, and the process for its preparation. The invention also relates to a slow release system represented by a mixture of a glycogen with a polysaccharide, and its use for the preparation of slow release pharmaceutical or food formulations.Type: ApplicationFiled: January 8, 2010Publication date: December 29, 2011Applicant: AZIENDE CHIM.RIUN.ANG.FRANC.A.C.R.A.F. S.p.A.Inventors: Stefano Selva, Leonardo Marchitto, Giovanni Battista Ciottoli, Lorella Ragni, Vincenzo Russo, Elisa Liberati
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Publication number: 20110253577Abstract: It is disclosed a packaging material (1) for a pharmaceutical product. The packaging material comprises a coloured element (2) which at a predetermined temperature, below which the pharmaceutical product must be kept, discolours partially, revealing a marking. The element is formed by a first portion forming the marking (2?) printed with conventional ink, and a second portion (2?) printed with thermochromic ink. The thermochromic ink is coloured below the predetermined temperature and becomes colourless when this predetermined temperature is reached or exceeded. The two portions are arranged so that the first portion is invisible below the predetermined temperature, but becomes visible when this temperature is reached or exceeded.Type: ApplicationFiled: November 13, 2009Publication date: October 20, 2011Applicant: AZIENDE CHIM. RIUN. ANG. FRANC.A.C.R.A.F.S.p.A.Inventor: Roberto Masciambruni
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Publication number: 20110160205Abstract: The present invention relates to novel 1-benzyl-3-hydroxymethylindazole derivatives according to formula (I) described in the claims, and to a pharmaceutical composition comprising them, together with a pharmaceutically acceptable vehicle. In addition, the present invention relates to the use of 1-benzyl-3-hydroxymethylindazole derivatives for the preparation of a pharmaceutical composition that is active in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40, and to their use in a method for treating or preventing diseases based on the expression of MCP-1, CX3CR1 and p40.Type: ApplicationFiled: March 7, 2011Publication date: June 30, 2011Applicant: AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.p.A.Inventors: Angelo GUGLIELMOTTI, Guido Furlotti, Giorgina Mangano, Nicola Cazzolla, Barbara Garofalo
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Publication number: 20110082141Abstract: The present invention relates to novel 1-benzyl-3-hydroxymethylindazole derivatives according to Formula (I) described in the claims, and to a pharmaceutical composition comprising them, together with a pharmaceutically acceptable vehicle. In addition, the present invention relates to the use of 1-benzyl-3-hydroxymethylindazole derivatives for the preparation of a pharmaceutical composition that is active in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40, and to their use in a method for treating or preventing diseases based on the expression of MCP-1, CX3CR1 and p40.Type: ApplicationFiled: March 5, 2009Publication date: April 7, 2011Applicant: AZIENDE CHIM. RIUN.ANG.FRANC. A.C.R.A.F. S.p.A.Inventors: Angelo Guglielmotti, Guido Furlotti, Giorgina Mangano, Nicola Cazzolla
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Publication number: 20110060025Abstract: The present invention relates to novel benzoyl derivatives of 3-aminocarbazole, to a pharmaceutical composition containing them, to a method for preparing them and to the use of such compounds for the production of a drug that is useful in the treatment or prevention of disturbances associated with the production of prostaglandin E2 (PGE2), for instance inflammatory processes, pain, fever, tumours, Alzheimer's disease and atherosclerosis.Type: ApplicationFiled: May 11, 2009Publication date: March 10, 2011Applicant: AZIENDE CHIM. RIUN.ANG.FRANC. A.C.R.A.F S.p.A.Inventors: Maria Alessandra Alisi, Nicola Cazzolla, Isabella Coletta, Patrizia Dragone, Guido Furlotti, Barbara Garofalo, Angelo Guglielmotti, Giorgina Mangano, Caterina Maugeri
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Publication number: 20110003874Abstract: The present invention relates to novel 1-benzyl-3-hydroxymethylindazole derivatives according to Formula (I) described in the claims, and to a pharmaceutical composition comprising them, together with a pharmaceutically acceptable vehicle. In addition, the present invention relates to the use of 1-benzyl-3-hydroxymethylindazole derivatives for the preparation of a pharmaceutical composition that is active in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40, and to their use in a method for treating or preventing diseases based on the expression of MCP-1, CX3CR1 and p40.Type: ApplicationFiled: March 5, 2009Publication date: January 6, 2011Applicant: Aziende Chim. Riun. Ang. Franc. A.C.R.A.F. S.p.A.Inventors: Angelo Guglielmotti, Guido Furlotti, Giorgina Mangano, Nicola Cazzolla, Barbara Garofalo
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Publication number: 20100311744Abstract: The present invention relates to novel 1-benzyl-3-hydroxymethylindazole derivatives according to formula (I) described in the claims, and to a pharmaceutical composition comprising them, together with a pharmaceutically acceptable vehicle. In addition, the present invention relates to the use of 1-benzyl-3-hydroxymethylindazole derivatives for the preparation of a pharmaceutical composition that is active in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40, and to their use in a method for treating or preventing diseases based on the expression of MCP-1, CX3CR1 and p40.Type: ApplicationFiled: March 5, 2009Publication date: December 9, 2010Applicant: AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.p.A.Inventors: Angelo Guglielmotti, Guido Furlotti, Giorgina Mangano, Nicola Cazzolla, Barbara Garofalo
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Publication number: 20100286189Abstract: An (aza)indole derivative substituted in position 5, of formula (I) in which X, Y, Z, G1, G2, G3, R1, W, and R2 have the meanings given in the description, a pharmaceutical composition comprising it, and also intermediate compounds and a preparation process therefor.Type: ApplicationFiled: December 16, 2008Publication date: November 11, 2010Applicant: Aziende Chim. Riun.Ang.Franc. A.C.R.A.F.S.P.A.Inventors: Maria Alessandra Alisi, Guido Furlotti, Nicola Cazzolla, Caterina Maugeri, Patrizia Dragone, Barbara Garofalo, Isabella Coletta, Giorgina Mangano, Beatrice Garrone
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Publication number: 20100273736Abstract: This invention relates to a cosmetic composition for skin application having a velvet effect on the skin comprising, as the cosmetic active ingredient, a glycogen having less than 1,000 ppm of nitrogen and less than 1% by weight of reducing sugars, in at least one cosmetically-acceptable vehicle.Type: ApplicationFiled: January 21, 2009Publication date: October 28, 2010Applicant: Aziende Chim. Riun. Ang. Franc. A.C.R.A.F. S.P.A.Inventors: Leonardo Marchitto, Lorella Ragni, Francesca Mariotti
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Publication number: 20100256159Abstract: A stable liquid pharmaceutical composition comprising an aqueous solution of a pharmaceutically acceptable salt of acid addition of trazodone, characterized in that said pharmaceutical composition has a pH value between 5.0 and 6.0, and comprises at least two cosolvents selected from the group comprising glycols and polyglycols.Type: ApplicationFiled: July 22, 2008Publication date: October 7, 2010Applicant: Aziende Chim. Riun. Ang. Franc. A.C.R.A.F. S.p.A.Inventors: Marcello Marchetti, Francesca Mariotti, Lorella Ragni, Paolo Scarpetti, Mauro Valenti