Abstract: The present invention relates to a controlled-release pharmaceutical formulation comprising at least one active ingredient dispersed in a matrix comprising at least one slow-release excipient comprising an association of at least one glycogen and at least one alginate with alkaline-earth metal salts, and a process for its preparation. The invention also relates to a slow-release excipient comprising an association of at least one glycogen and at least one alginate with alkaline-earth metal salts, and the process for its preparation, and its use for the preparation of slow-release pharmaceutical formulations.
Type:
Application
Filed:
December 23, 2008
Publication date:
October 7, 2010
Applicant:
AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.P.A.
Abstract: A 2-arylindole compound substituted in position 5, of formula (I): in which X, Y, Z, W, A, R and R? have the meanings given in the description, a pharmaceutical composition comprising it, and also intermediate compounds and a preparation process therefor.
Type:
Application
Filed:
June 14, 2007
Publication date:
July 23, 2009
Applicant:
AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.p.A.
Inventors:
Maria Alessandra Alisi, Nicola Cazzolla, Barbara Garofalo, Guido Furlotti, Caterina Maugeri, Rosella Ombrato, Isabella Coletta, Lorenzo Polenzani, Giorgina Mangano, Beatrice Garrone, Angelo Guglielmotti
Abstract: A process for preparing an orally dispersible solid pharmaceutical form comprises the following steps: a) coating the active ingredient with at least one hydrophilic carboxylate polymer, b) granulating the coated active ingredient obtained in step (a) with at least one lipid compound having a melting point lower than that of the active ingredient, c) mixing the granulate obtained in step (b) with at least one hydrophilic natural polymer having high molecular weight, and d) mixing the granulate obtained in step (c) with ingredients suitable for obtaining an orally dispersible solid pharmaceutical form. An orally dispersible solid pharmaceutical form comprises an active ingredient coated with at least one hydrophilic carboxylate polymer and at least one lipid compound, in which the said coated active ingredient is embedded in a matrix comprising at least one hydrophilic natural polymer having high molecular weight.
Abstract: Use of a 1-(3-chlorophenyl)-3-alkylpiperazine of formula (I), in racemic (R, S) form or in the form of the (S) enantiomer, in which R is a linear or branched alkyl group having from 1 to 3 carbon atoms, or of an addition salt thereof with a pharmaceutically acceptable organic or inorganic acid, for treating apetite disorder A pharmaceutical composition that comprises a therapeutically effective amount of a 1-(3-chlorophenyl)-3-alkylpiperazine of formula (I) as previously defined or of an addition salt thereof with a pharmaceutically acceptable organic or inorganic acid, and at least one pharmaceutically acceptable excipient.
Type:
Application
Filed:
June 2, 2006
Publication date:
February 26, 2009
Applicant:
AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.P.A.
Abstract: Oral pharmaceutical dosage form comprising tromethamine and a NSAID selected from the group comprising ibuprofen, naproxen and flurbiprofen, characterized in that it also comprises a compound selected from the group comprising glycine, vitamin B6 and mixtures thereof.
Type:
Application
Filed:
December 16, 2004
Publication date:
November 27, 2008
Applicant:
AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F.S.P.A.
Abstract: Use of a benzoyl derivative of 3-aminocarbazole to produce a drug for the preventive or therapeutic treatment of a disorder selected form the group comprising inflammatory processes, pain, fever, tumours, Alzheimer's disease and atherosclerosis. Method for the preventive or therapeutic treatment of a disorder selected from the group comprising inflammatory processes, pain, fever, tumours, Alzheimer's disease and atherosclerosis in which a therapeutically effective quantity of a benzoyl derivative of 3-aminocarbazole according to the invention is administered to an individual.
Type:
Application
Filed:
May 3, 2006
Publication date:
November 20, 2008
Applicant:
AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.P.A.
Inventors:
Lorenzo Polenzani, Giorgina Mangano, Isabella Coletta, Maria Alessandra Alisi, Nicola Cazzolla, Guido Furlotti, Caterina Maugeri
Abstract: A disposable container for centrifuging and treating a fluid biological material. The container includes an open top end and a closed bottom end, the top end including a lid having: a) a first opening passed through by a first cannula that can be connected operationally to the external environment to control entry and exit of air in conjunction with the transfer of a fluid biological material into or from the container; b) a second opening passed through by a second cannula that can be accessed by a hollow needle to transfer a fluid biological material into or from the container through the hollow needle; and c) a third opening passed through by a third cannula operationally connected to an attachment able to receive and accommodate one end of a syringe to transfer a fluid biological material into or from the container through the third cannula.
Type:
Application
Filed:
October 6, 2004
Publication date:
August 2, 2007
Applicant:
AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.P.A.
Abstract: Use of a compound of formula (I), wherein R is H, a linear or branched alkyl chain having from 1 to 12 carbon atoms or an arylalkyl group, and of the acid addition salts thereof with pharmaceutically acceptable organic or inorganic acids, to prepare a pharmaceutical composition active in the treatment of neuropathic pain.
Type:
Application
Filed:
July 8, 2004
Publication date:
September 21, 2006
Applicant:
AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.P.A.
Inventors:
Angelo Guglielmotti, Lorenzo Polenzani, Alessandra Alisi, Nicola Cazzolla